Allelic Variants

There are no related allelic variants
Related diseases of KIF 1OKZA_UCN (PDB code: 1OKZ, chain A)
Number of involved diseases in the family 109
Number of PDPK1 related diseases 1
All kinase in this family  PDPK1
Allelic
Variants		 Disease Description Involved kinases
(This family)		 Inhibitor of
Involved Kinases		 Search
Disease
n/aEpstein-Barr virus infectionAKT1, AKT2, AKT3, CDC2,
CDK2, CSNK2A1, CSNK2A2,
EIF2AK2, EIF2AK4, GSK3B,
JAK3, LYN, MAPK10, MAPK12,
MAPK13, MAPK14, MAPK8,
MAPK9, PRKACA, PRKACB,
PRKACG, PRKX		19Link
n/aTuberculosisAKT1, AKT2, AKT3, CAMK2A,
CAMK2B, CAMK2D, IRAK4, JAK2,
MAPK1, MAPK10, MAPK12,
MAPK13, MAPK14, MAPK3,
MAPK8, MAPK9, PLK3		13Link
n/aInfluenza AAKT1, AKT2, AKT3, EIF2AK2,
EIF2AK4, GSK3B, IRAK4, JAK2,
MAPK1, MAPK10, MAPK12,
MAPK13, MAPK14, MAPK3,
MAPK8, MAPK9, PRKCB		15Link
n/aHepatitis CAKT1, AKT2, AKT3, EGFR,
EIF2AK2, EIF2AK4, GSK3B,
MAPK1, MAPK10, MAPK12,
MAPK13, MAPK14, MAPK3,
MAPK8, MAPK9		42Link
n/aMeaslesAKT1, AKT2, AKT3, CDK2,
CDK4, CDK6, CSNK2A1,
CSNK2A2, EIF2AK2, EIF2AK4,
GSK3B, IRAK4, JAK2, JAK3,
PRKCQ		17Link
LeukemiaABL1, ABL2, AKT1, AKT2,
AKT3, CDK4, CDK6, JAK2,
MAPK1, MAPK3, PIM1, PIM2,
RPS6KB1, RPS6KB2		14Link
n/aToxoplasmosisAKT1, AKT2, AKT3, IRAK4,
JAK2, MAPK1, MAPK10, MAPK12,
MAPK13, MAPK14, MAPK3,
MAPK8, MAPK9		12Link
n/aChagas diseaseAKT1, AKT2, AKT3, IRAK4,
MAPK1, MAPK10, MAPK12,
MAPK13, MAPK14, MAPK3,
MAPK8, MAPK9		10Link
Prostate cancerAKT1, AKT2, AKT3, CDK2,
CHEK2, EGFR, FGFR2, GSK3B,
MAPK1, MAPK3, PDPK1		44Link
n/aHerpes simplex infectionCDC2, CDK2, CSNK2A1,
CSNK2A2, EIF2AK2, EIF2AK4,
JAK2, MAPK10, MAPK8, MAPK9		15Link
n/aEpithelial cell signaling in Helicobacter pylori infectionCSK, EGFR, LYN, MAPK10,
MAPK12, MAPK13, MAPK14,
MAPK8, MAPK9, PAK1		43Link
n/aSalmonella infectionMAPK1, MAPK10, MAPK12,
MAPK13, MAPK14, MAPK3,
MAPK8, MAPK9, PKN2		12Link
n/aPertussisIRAK4, MAPK1, MAPK10,
MAPK12, MAPK13, MAPK14,
MAPK3, MAPK8, MAPK9		10Link
n/aShigellosisABL1, MAPK1, MAPK10, MAPK12,
MAPK13, MAPK14, MAPK3,
MAPK8, MAPK9		10Link
MelanomaAKT1, AKT2, AKT3, CDK4,
CDK6, EGFR, MAPK1, MAPK3,
STK11		40Link
Diabetes mellitusAKT2, MAPK1, MAPK10, MAPK3,
MAPK8, MAPK9, PRKCD, PRKCZ		13Link
n/aLeishmaniasisIRAK4, JAK2, MAPK1, MAPK12,
MAPK13, MAPK14, MAPK3, PRKCB		13Link
Lung cancerAKT1, AKT2, AKT3, CDK2,
CDK4, CDK6, EGFR		41Link
n/aPrion diseasesMAPK1, MAPK3, PRKACA,
PRKACB, PRKACG, PRKX		9Link
n/aCardiomyopathyPRKAA1, PRKAA2, PRKACA,
PRKACB, PRKACG, PRKX		9Link
n/aVibrio cholerae infectionPRKACA, PRKACB, PRKACG,
PRKCB, PRKX		10Link
n/aAmoebiasisPRKACA, PRKACB, PRKACG,
PRKCB, PRKX		10Link
n/aCocaine addictionCDK5, PRKACA, PRKACB,
PRKACG, PRKX		8Link
n/aAmyotrophic lateral sclerosisMAP3K5, MAPK12, MAPK13,
MAPK14		6Link
Mental retardationDYRK1A, PAK3, RPS6KA310Link
n/aAlcoholismMAPK1, MAPK3, PRKACA8Link
n/aBasal cell carcinomaGSK3B, STK369Link
n/aNon-syndromic X-linked mental retardationPAK3, RPS6KA39Link
n/aEarly infantile epileptic encephalopathyCDKL5, MAPK106Link
n/aGliomaCDK4, EGFR39Link
n/aEpileptic encephalopathyCDKL5, MAPK106Link
n/aCervical cancerCDK4, EGFR39Link
Gastric cancerEGFR, FGFR239Link
n/aBladder cancerDAPK1, EGFR39Link
n/aViral myocarditisABL1, ABL28Link
Breast cancerAKT1, CHEK28Link
Ovarian cancerAKT1, AKT27Link
n/aOral cancerEGFR38Link
Hypoinsulinemic hypoglycemiaAKT27Link
Colon cancerAURKA8Link
n/aSchizophreniaAKT17Link
n/aEsophageal cancerEGFR38Link
n/aPathogenic Escherichia coli infectionABL18Link
Adenocarcinoma of lungEGFR38Link
n/aLaryngeal cancerEGFR38Link
n/aChoriocarcinomaEGFR38Link
n/aFamilial partial lipodystrophyAKT27Link
OsteosarcomaCHEK25Link
Li-Fraumeni syndromeCHEK25Link
Colorectal cancerAKT17Link
AgammaglobulinemiaBTK4Link
n/aMalignant melanomaCDK45Link
n/aAgammaglobulinemia and isolated hormone deficiencyBTK4Link
n/aPrader-Willi and Angelman syndromesCDKL51Link
n/aPituitary DwarfismBTK4Link
n/aProteus syndromeAKT17Link
n/aAntley-Bixler syndrome without genital anomalies or disordered steroidogenesisFGFR28Link
n/aAngelman syndrome-likeCDKL51Link
n/aAgammaglobulinemiasBTK4Link
n/aPTEN hamartoma tumor syndromeAKT17Link
Crouzon syndromeFGFR28Link
Apert syndromeFGFR28Link
n/aCerebral infarctionPRKCH10Link
n/aType I diabetes mellitusPRKCQ8Link
n/aThyroid cancerRET8Link
n/aRenal agenesis and Renal adysplasiaRET8Link
n/aAfrican trypanosomiasisPRKCB6Link
Glycogen storage diseasePHKG28Link
n/aNephronophthisis-medullary cystic kidney diseaseNEK81Link
n/aNephronophthisisNEK81Link
n/aGlycogen storage diseasesPHKG28Link
n/aCirrhosis due to liver phosphorylase kinase deficiencyPHKG28Link
Hirschsprung diseaseRET8Link
n/aCongenital central hypoventilation syndromeRET8Link
n/aPancreatic cancerSTK116Link
n/aPeutz-Jeghers syndromeSTK116Link
n/aTesticular tumorSTK116Link
n/aTransient erythroblastopenia of childhoodTEC2Link
n/aCoffin-Lowry syndromeRPS6KA37Link
Renal agenesisRET8Link
Central hypoventilation syndromeRET8Link
n/aMedullary thyroid carcinomaRET8Link
Multiple endocrine neoplasiaRET8Link
PheochromocytomaRET8Link
n/aShort rib-polydactyly syndormeNEK13Link
n/a46XY sex reversal 6MAP3K11Link
Pfeiffer syndromeFGFR28Link
n/aSaethre-Chotzen syndromeFGFR28Link
ScaphocephalyFGFR28Link
n/aScaphocephaly and Axenfeld-Rieger anomalyFGFR28Link
LADD syndromeFGFR28Link
Jackson-Weiss syndromeFGFR28Link
Beare-Stevenson cutis gyrata syndromeFGFR28Link
Bent bone dysplasia syndromeFGFR28Link
Craniofacial-skeletal-dermatologic dysplasiaFGFR28Link
CraniosynostosisFGFR28Link
n/aCongenital stationary night blindnessGRK14Link
n/aOguchi diseaseGRK14Link
ThrombocythemiaJAK29Link
n/aImmunodeficienciesJAK313Link
SCIDJAK313Link
REtinitis pigmentosaMAK1Link
n/aMyeloproliferative disorderJAK29Link
MyelofibrosisJAK29Link
n/aEndocrine-cerebroosteodysplasiaICK2Link
n/aInvasive pneumococcal diseaseIRAK44Link
IRAK4 deficiencyIRAK44Link
n/aBudd-Chiari syndromeJAK29Link
Polycythemia veraJAK29Link