KIDFamMap

Allelic Variants
There are no related allelic variants

Related diseases of KIF 1BYGA_STU (PDB code: 1BYG, chain A)
Number of involved diseases in the family	123
Number of PKN1 related diseases	1

All kinase in this family PKN1

Allelic Variants	Disease Description	Involved kinases (This family)	Inhibitor of Involved Kinases	Search Disease
	Prostate cancer	AKT2, AKT3, EGFR, EPHB2, ERBB2, FGFR1, FGFR2, IGF1R, INSRR, MAPK1, PDGFRA, PDGFRB, RAF1	42	Link
	Leukemia	ABL1, ABL2, AKT2, AKT3, JAK2, KIT, MAPK1, PDGFRB, RAF1, RPS6KB1, RPS6KB2, TGFBR1	16	Link
	Melanoma	AKT2, AKT3, EGFR, FGFR1, IGF1R, MAPK1, PDGFRA, PDGFRB, RAF1	42	Link
n/a	Influenza A	AKT2, AKT3, IRAK4, JAK2, MAPK1, PRKCA, PRKCB, RAF1	60	Link
n/a	Tuberculosis	AKT2, AKT3, IRAK4, JAK2, MAPK1, RAF1, SRC, SYK	21	Link
n/a	Measles	AKT2, AKT3, FYN, IRAK4, JAK2, JAK3, PRKCQ	16	Link
	Lung cancer	AKT2, AKT3, ALK, EGFR, PTK2, ROS1	40	Link
n/a	Hepatitis C	AKT2, AKT3, EGFR, MAPK1, RAF1	39	Link
n/a	Epstein-Barr virus infection	AKT2, AKT3, FGR, JAK3, SYK	16	Link
	Diabetes mellitus	AKT2, MAPK1, PRKCD, PRKCE, PRKCZ	15	Link
n/a	Toxoplasmosis	AKT2, AKT3, IRAK4, JAK2, MAPK1	12	Link
n/a	Chagas disease	AKT2, AKT3, IRAK4, MAPK1, TGFBR1	9	Link
n/a	Leishmaniasis	IRAK4, JAK2, MAPK1, PRKCB	16	Link
	Gastric cancer	EGFR, ERBB2, FGFR2	39	Link
n/a	Glioma	EGFR, PDGFRA, PDGFRB	41	Link
n/a	Salmonella infection	MAPK1, PKN1, PKN2	13	Link
n/a	Alcoholism	CAMKK2, MAPK1, RAF1	12	Link
n/a	Epithelial cell signaling in Helicobacter pylori infection	CSK, EGFR, SRC	41	Link
n/a	Amoebiasis	PRKCA, PRKCB, PTK2	57	Link
n/a	Viral myocarditis	ABL1, ABL2, FYN	13	Link
n/a	Pathogenic Escherichia coli infection	ABL1, FYN, PRKCA	61	Link
n/a	Bladder cancer	EGFR, ERBB2, FGFR3	38	Link
n/a	Immunodeficiencies	JAK3, LCK, ZAP70	16	Link
n/a	Shigellosis	ABL1, MAPK1, SRC	20	Link
n/a	Cervical cancer	EGFR, ERBB2, FGFR3	38	Link
n/a	Myeloproliferative disorder	JAK2, PDGFRB	12	Link
	Adenocarcinoma of lung	EGFR, ERBB2	38	Link
n/a	Pertussis	IRAK4, MAPK1	6	Link
n/a	Prion diseases	FYN, MAPK1	11	Link
n/a	Choriocarcinoma	EGFR, ERBB2	38	Link
	SCID	JAK3, LCK	16	Link
	Crouzon syndrome	FGFR2, FGFR3	8	Link
n/a	Thyroid cancer	NTRK1, RET	18	Link
n/a	Vibrio cholerae infection	PRKCA, PRKCB	55	Link
	Neuroblastoma	ALK, NTRK1	16	Link
n/a	African trypanosomiasis	PRKCA, PRKCB	55	Link
	Pfeiffer syndrome	FGFR1, FGFR2	9	Link
n/a	Pancreatic cancer	ACVR1B, ERBB2	3	Link
	Ovarian cancer	AKT2, ERBB2	7	Link
n/a	Medullary thyroid carcinoma	NTRK1, RET	18	Link
	Jackson-Weiss syndrome	FGFR1, FGFR2	9	Link
	Gastrointestinal stromal tumor	KIT, PDGFRA	12	Link
	LADD syndrome	FGFR2, FGFR3	8	Link
	Trigonocephaly	FGFR1	9	Link
	Breast cancer	ERBB2	2	Link
	Glioblastoma	ERBB2	2	Link
n/a	Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis	FGFR2	8	Link
	Osteoglophonic dysplasia	FGFR1	9	Link
n/a	Cholangiocarcinoma	ERBB2	2	Link
	Kallmann syndrome	FGFR1	9	Link
	Endometrial Cancer	ERBB2	2	Link
	Hypogonadotropic hypogonadism	FGFR1	9	Link
n/a	Agammaglobulinemias	BTK	5	Link
n/a	Laryngeal cancer	EGFR	38	Link
n/a	Juvenile polyposis syndrome	BMPR1A	2	Link
n/a	Polyposis	BMPR1A	2	Link
n/a	Maturity onset diabetes of the young	BLK	8	Link
	Hypoinsulinemic hypoglycemia	AKT2	7	Link
	Fibrodysplasia ossificans progressiva	ACVR1	3	Link
n/a	Familial partial lipodystrophy	AKT2	7	Link
	Brachydactyly	BMPR1B	1	Link
n/a	Chrondrodysplasia	BMPR1B	1	Link
n/a	Oral cancer	EGFR	38	Link
n/a	Esophageal cancer	EGFR	38	Link
n/a	Spondylometaepiphyseal dysplasia	DDR2	3	Link
n/a	Agammaglobulinemia and isolated hormone deficiency	BTK	5	Link
	Apert syndrome	FGFR2	8	Link
n/a	Pituitary Dwarfism	BTK	5	Link
	Agammaglobulinemia	BTK	5	Link
	Scaphocephaly	FGFR2	8	Link
	Beare-Stevenson cutis gyrata syndrome	FGFR2	8	Link
n/a	Pituitary tumor	PRKCA	55	Link
n/a	Cerebral infarction	PRKCH	12	Link
n/a	Type I diabetes mellitus	PRKCQ	8	Link
	LEOPARD syndrome	RAF1	2	Link
n/a	Hypereosinophilic syndrome	PDGFRA	10	Link
n/a	Insensitivity to pain	NTRK1	15	Link
	Piebaldism	KIT	12	Link
n/a	Germ cell tumors	KIT	12	Link
	Mast cell leukemia	KIT	12	Link
	REtinitis pigmentosa	MAK	1	Link
	Mastocytosis with associated hematologic disorder	KIT	12	Link
	Noonan syndrome	RAF1	2	Link
n/a	Renal agenesis and Renal adysplasia	RET	11	Link
n/a	Basal cell carcinoma	STK36	3	Link
	Loeys-Dietz syndrome	TGFBR1	2	Link
n/a	Familial thoracic aortic aneurysm and dissection	TGFBR1	2	Link
	Selective T-cell defect	ZAP70	10	Link
	Multiple self-healing squamous epithelioma	TGFBR1	2	Link
	Colon cancer	SRC	19	Link
	Renal agenesis	RET	11	Link
	Hirschsprung disease	RET	11	Link
n/a	Congenital central hypoventilation syndrome	RET	11	Link
	Central hypoventilation syndrome	RET	11	Link
	Pheochromocytoma	RET	11	Link
	Multiple endocrine neoplasia	RET	11	Link
	Thrombocythemia	JAK2	10	Link
	Myelofibrosis	JAK2	10	Link
n/a	CATSHL syndrome	FGFR3	7	Link
n/a	Achondroplasia	FGFR3	7	Link
	Colorectal cancer	FGFR3	7	Link
n/a	Hypochondroplasia	FGFR3	7	Link
n/a	FGFR3-related short limb skeletal dysplasias	FGFR3	7	Link
n/a	Multiple myeloma	FGFR3	7	Link
	Bent bone dysplasia syndrome	FGFR2	8	Link
	Craniofacial-skeletal-dermatologic dysplasia	FGFR2	8	Link
	Craniosynostosis	FGFR2	8	Link
n/a	Scaphocephaly and Axenfeld-Rieger anomaly	FGFR2	8	Link
n/a	Saethre-Chotzen syndrome	FGFR2	8	Link
n/a	Muenke syndrome	FGFR3	7	Link
n/a	Nevus	FGFR3	7	Link
n/a	Invasive pneumococcal disease	IRAK4	4	Link
	IRAK4 deficiency	IRAK4	4	Link
	Polycythemia vera	JAK2	10	Link
n/a	Budd-Chiari syndrome	JAK2	10	Link
n/a	Herpes simplex infection	JAK2	10	Link
	Insulin-like growth factor I	IGF1R	5	Link
n/a	Synovial sarcoma	IGF1R	5	Link
n/a	Spermatocytic seminoma	FGFR3	7	Link
n/a	Thanatophoric dysplasia	FGFR3	7	Link
n/a	Cancer progression/metastasis	FGFR4	3	Link
n/a	Malignant pleural mesothelioma	IGF1R	5	Link
n/a	Endocrine-cerebroosteodysplasia	ICK	2	Link

BioXGEM.

KIDFamMap

Allelic Variants