Allelic Variants
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There are no related allelic variants
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| Number of involved diseases in the family |
103 |
| Number of PKN1 related diseases |
1 |
All kinase in this family
PKN1
Allelic
Variants |
Disease Description |
Involved kinases
(This family) |
Inhibitor of
Involved Kinases |
Search
Disease |
| Prostate cancer | CDK2, CHEK2, EGFR, FGFR1,
FGFR2, IGF1R, PDPK1 | 6 | Link | | n/a | Measles | CDK2, CDK6, EIF2AK2, IRAK4,
JAK2, JAK3, PRKCQ | 6 | Link | | Lung cancer | ALK, CDK2, CDK6, EGFR, PTK2,
ROS1 | 6 | Link | | n/a | Tuberculosis | CAMK2B, CAMK2D, CAMK2G,
IRAK4, JAK2, PLK3 | 4 | Link | | n/a | Epstein-Barr virus infection | CDC2, CDK2, EIF2AK2, JAK3,
PRKACA | 9 | Link | | n/a | Alcoholism | CAMK4, CAMKK1, CAMKK2,
NTRK2, PRKACA | 6 | Link | | n/a | Influenza A | EIF2AK2, IRAK4, JAK2, PRKCA | 6 | Link | | Melanoma | CDK6, EGFR, FGFR1, IGF1R | 5 | Link | | n/a | Herpes simplex infection | CDC2, CDK2, EIF2AK2, JAK2 | 8 | Link | | Neuroblastoma | ALK, NTRK1, NTRK2, NTRK3 | 4 | Link | | Leukemia | ABL1, CDK6, JAK2, RPS6KB1 | 4 | Link | | n/a | Amoebiasis | PRKACA, PRKCA, PTK2 | 2 | Link | | Gastric cancer | EGFR, FGFR2 | 4 | Link | | n/a | Toxoplasmosis | IRAK4, JAK2 | 4 | Link | | n/a | Hepatitis C | EGFR, EIF2AK2 | 5 | Link | | n/a | Cervical cancer | EGFR, FGFR3 | 5 | Link | | Jackson-Weiss syndrome | FGFR1, FGFR2 | 4 | Link | | n/a | Leishmaniasis | IRAK4, JAK2 | 4 | Link | | LADD syndrome | FGFR2, FGFR3 | 4 | Link | | Crouzon syndrome | FGFR2, FGFR3 | 4 | Link | | Pfeiffer syndrome | FGFR1, FGFR2 | 4 | Link | | n/a | Thyroid cancer | NTRK1, RET | 3 | Link | | n/a | Bladder cancer | EGFR, FGFR3 | 5 | Link | | n/a | Salmonella infection | PKN1, PKN2 | 3 | Link | | n/a | Vibrio cholerae infection | PRKACA, PRKCA | 2 | Link | | Diabetes mellitus | PRKCD, PRKCE | 3 | Link | | n/a | Pathogenic Escherichia coli infection | ABL1, PRKCA | 3 | Link | | n/a | Cocaine addiction | CDK5, PRKACA | 5 | Link | | n/a | Medullary thyroid carcinoma | NTRK1, RET | 3 | Link | | Bent bone dysplasia syndrome | FGFR2 | 3 | Link | | Beare-Stevenson cutis gyrata syndrome | FGFR2 | 3 | Link | | Apert syndrome | FGFR2 | 3 | Link | | Colon cancer | AURKA | 4 | Link | | n/a | Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis | FGFR2 | 3 | Link | | Craniofacial-skeletal-dermatologic dysplasia | FGFR2 | 3 | Link | | Kallmann syndrome | FGFR1 | 4 | Link | | n/a | Saethre-Chotzen syndrome | FGFR2 | 3 | Link | | n/a | Myotonic dystrophy | DMPK | 2 | Link | | n/a | Shigellosis | ABL1 | 3 | Link | | Craniosynostosis | FGFR2 | 3 | Link | | n/a | Viral myocarditis | ABL1 | 3 | Link | | n/a | Oral cancer | EGFR | 1 | Link | | Scaphocephaly | FGFR2 | 3 | Link | | n/a | Epithelial cell signaling in Helicobacter pylori infection | EGFR | 1 | Link | | n/a | Laryngeal cancer | EGFR | 1 | Link | | n/a | Glioma | EGFR | 1 | Link | | n/a | Choriocarcinoma | EGFR | 1 | Link | | Breast cancer | CHEK2 | 1 | Link | | Adenocarcinoma of lung | EGFR | 1 | Link | | Li-Fraumeni syndrome | CHEK2 | 1 | Link | | Trigonocephaly | FGFR1 | 4 | Link | | Osteosarcoma | CHEK2 | 1 | Link | | Osteoglophonic dysplasia | FGFR1 | 4 | Link | | Hypogonadotropic hypogonadism | FGFR1 | 4 | Link | | n/a | Esophageal cancer | EGFR | 1 | Link | | n/a | Achondroplasia | FGFR3 | 4 | Link | | n/a | Scaphocephaly and Axenfeld-Rieger anomaly | FGFR2 | 3 | Link | | n/a | Obesity | NTRK2 | 2 | Link | | n/a | Prion diseases | PRKACA | 1 | Link | | n/a | Cardiomyopathy | PRKACA | 1 | Link | | n/a | African trypanosomiasis | PRKCA | 1 | Link | | n/a | Insensitivity to pain | NTRK1 | 1 | Link | | n/a | Nephronophthisis | NEK8 | 1 | Link | | n/a | Congenital myasthenic syndrome | MUSK | 1 | Link | | n/a | Myasthenic syndrome | MUSK | 1 | Link | | n/a | Short rib-polydactyly syndorme | NEK1 | 1 | Link | | n/a | Nephronophthisis-medullary cystic kidney disease | NEK8 | 1 | Link | | n/a | Pituitary tumor | PRKCA | 1 | Link | | n/a | Type I diabetes mellitus | PRKCQ | 3 | Link | | Renal agenesis | RET | 3 | Link | | n/a | Non-syndromic X-linked mental retardation | RPS6KA3 | 2 | Link | | n/a | Coffin-Lowry syndrome | RPS6KA3 | 2 | Link | | Mental retardation | RPS6KA3 | 2 | Link | | Pheochromocytoma | RET | 3 | Link | | Multiple endocrine neoplasia | RET | 3 | Link | | n/a | Renal agenesis and Renal adysplasia | RET | 3 | Link | | Hirschsprung disease | RET | 3 | Link | | n/a | Congenital central hypoventilation syndrome | RET | 3 | Link | | Central hypoventilation syndrome | RET | 3 | Link | | SCID | JAK3 | 4 | Link | | n/a | Immunodeficiencies | JAK3 | 4 | Link | | n/a | Nevus | FGFR3 | 4 | Link | | n/a | Spermatocytic seminoma | FGFR3 | 4 | Link | | n/a | Thanatophoric dysplasia | FGFR3 | 4 | Link | | n/a | Cancer progression/metastasis | FGFR4 | 1 | Link | | n/a | Muenke syndrome | FGFR3 | 4 | Link | | n/a | Hypochondroplasia | FGFR3 | 4 | Link | | n/a | Multiple myeloma | FGFR3 | 4 | Link | | n/a | FGFR3-related short limb skeletal dysplasias | FGFR3 | 4 | Link | | n/a | CATSHL syndrome | FGFR3 | 4 | Link | | Colorectal cancer | FGFR3 | 4 | Link | | n/a | Malignant pleural mesothelioma | IGF1R | 1 | Link | | n/a | Synovial sarcoma | IGF1R | 1 | Link | | n/a | Budd-Chiari syndrome | JAK2 | 4 | Link | | Myelofibrosis | JAK2 | 4 | Link | | n/a | Myeloproliferative disorder | JAK2 | 4 | Link | | Thrombocythemia | JAK2 | 4 | Link | | Polycythemia vera | JAK2 | 4 | Link | | IRAK4 deficiency | IRAK4 | 1 | Link | | Insulin-like growth factor I | IGF1R | 1 | Link | | n/a | Pertussis | IRAK4 | 1 | Link | | n/a | Chagas disease | IRAK4 | 1 | Link | | n/a | Invasive pneumococcal disease | IRAK4 | 1 | Link |
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