KIDFamMap

Allelic Variants
There are no related allelic variants

Related diseases of KIF 2XYNA_VX6 (PDB code: 2XYN, chain A)
Number of involved diseases in the family	105
Number of PKN1 related diseases	1

All kinase in this family PKN1

Allelic Variants	Disease Description	Involved kinases (This family)	Inhibitor of Involved Kinases	Search Disease
n/a	Epstein-Barr virus infection	CDC2, CDK2, FGR, JAK3, LYN, MAPK14, RIPK1, SYK	19	Link
	Leukemia	ABL1, ABL2, JAK2, KIT, PDGFRB, TGFBR1	17	Link
n/a	Measles	CDK2, FYN, IRAK4, JAK2, JAK3, PRKCQ	34	Link
	Prostate cancer	CDK2, EPHB2, FGFR1, FGFR2, PDGFRA, PDGFRB	13	Link
n/a	Tuberculosis	IRAK4, JAK2, MAPK14, SRC, SYK	27	Link
n/a	Epithelial cell signaling in Helicobacter pylori infection	CSK, LYN, MAPK14, SRC	15	Link
n/a	Leishmaniasis	IRAK4, JAK2, MAPK14	16	Link
n/a	Toxoplasmosis	IRAK4, JAK2, MAPK14	16	Link
n/a	Influenza A	IRAK4, JAK2, MAPK14	16	Link
n/a	Chagas disease	IRAK4, MAPK14, TGFBR1	3	Link
	Melanoma	FGFR1, PDGFRA, PDGFRB	2	Link
n/a	Herpes simplex infection	CDC2, CDK2, JAK2	25	Link
n/a	Salmonella infection	MAPK14, PKN1, PKN2	4	Link
	Lung cancer	ALK, CDK2, ROS1	14	Link
n/a	Viral myocarditis	ABL1, ABL2, FYN	5	Link
n/a	Shigellosis	ABL1, MAPK14, SRC	17	Link
n/a	Myeloproliferative disorder	JAK2, PDGFRB	14	Link
	LADD syndrome	FGFR2, FGFR3	2	Link
n/a	Immunodeficiencies	JAK3, LCK	9	Link
n/a	Type I diabetes mellitus	ERBB3, PRKCQ	10	Link
	Gastrointestinal stromal tumor	KIT, PDGFRA	3	Link
n/a	Pathogenic Escherichia coli infection	ABL1, FYN	5	Link
	Crouzon syndrome	FGFR2, FGFR3	2	Link
n/a	Pertussis	IRAK4, MAPK14	3	Link
	SCID	JAK3, LCK	9	Link
	Colon cancer	AURKA, SRC	71	Link
	Jackson-Weiss syndrome	FGFR1, FGFR2	2	Link
n/a	Glioma	PDGFRA, PDGFRB	2	Link
n/a	Cardiomyopathy	PRKAA1, PRKAA2	2	Link
n/a	Hepatitis C	MAPK14, RIPK1	4	Link
	Pfeiffer syndrome	FGFR1, FGFR2	2	Link
	Kallmann syndrome	FGFR1	2	Link
	Beare-Stevenson cutis gyrata syndrome	FGFR2	2	Link
	Apert syndrome	FGFR2	2	Link
	Gastric cancer	FGFR2	2	Link
	Bent bone dysplasia syndrome	FGFR2	2	Link
	Craniosynostosis	FGFR2	2	Link
	Craniofacial-skeletal-dermatologic dysplasia	FGFR2	2	Link
	Trigonocephaly	FGFR1	2	Link
	Osteoglophonic dysplasia	FGFR1	2	Link
n/a	Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis	FGFR2	2	Link
n/a	Epileptic encephalopathy	CDKL5	1	Link
	Hypogonadotropic hypogonadism	FGFR1	2	Link
n/a	Agammaglobulinemias	BTK	2	Link
n/a	Pituitary Dwarfism	BTK	2	Link
n/a	Chrondrodysplasia	BMPR1B	1	Link
	Brachydactyly	BMPR1B	1	Link
	Fibrodysplasia ossificans progressiva	ACVR1	2	Link
	Neuroblastoma	ALK	2	Link
n/a	Maturity onset diabetes of the young	BLK	2	Link
	Agammaglobulinemia	BTK	2	Link
n/a	Agammaglobulinemia and isolated hormone deficiency	BTK	2	Link
n/a	Leukoencephalopathy, diffuse hereditary, with spheroids	CSF1R	2	Link
n/a	Lethal congenital contractural syndrome	ERBB3	1	Link
n/a	Choriocarcinoma	CSF1R	2	Link
n/a	Angelman syndrome-like	CDKL5	1	Link
n/a	Cocaine addiction	CDK5	1	Link
n/a	Prader-Willi and Angelman syndromes	CDKL5	1	Link
n/a	Early infantile epileptic encephalopathy	CDKL5	1	Link
n/a	Achondroplasia	FGFR3	2	Link
n/a	Saethre-Chotzen syndrome	FGFR2	2	Link
n/a	Thyroid cancer	RET	3	Link
n/a	Renal agenesis and Renal adysplasia	RET	3	Link
	Hirschsprung disease	RET	3	Link
	Diabetes mellitus	PRKCD	9	Link
n/a	Hypereosinophilic syndrome	PDGFRA	2	Link
n/a	Germ cell tumors	KIT	3	Link
	Mast cell leukemia	KIT	3	Link
	Mastocytosis with associated hematologic disorder	KIT	3	Link
n/a	Amyotrophic lateral sclerosis	MAPK14	2	Link
n/a	Congenital central hypoventilation syndrome	RET	3	Link
	Central hypoventilation syndrome	RET	3	Link
n/a	Rheumatoid arthritis	TEK	3	Link
	Loeys-Dietz syndrome	TGFBR1	1	Link
n/a	Familial thoracic aortic aneurysm and dissection	TGFBR1	1	Link
	Multiple self-healing squamous epithelioma	TGFBR1	1	Link
	Venous malformations	TEK	3	Link
n/a	Transient erythroblastopenia of childhood	TEC	1	Link
n/a	Medullary thyroid carcinoma	RET	3	Link
	Multiple endocrine neoplasia	RET	3	Link
	Pheochromocytoma	RET	3	Link
	Renal agenesis	RET	3	Link
	Piebaldism	KIT	3	Link
	Thrombocythemia	JAK2	14	Link
n/a	Cervical cancer	FGFR3	2	Link
	Colorectal cancer	FGFR3	2	Link
n/a	Hypochondroplasia	FGFR3	2	Link
n/a	CATSHL syndrome	FGFR3	2	Link
n/a	FGFR3-related short limb skeletal dysplasias	FGFR3	2	Link
	Scaphocephaly	FGFR2	2	Link
n/a	Scaphocephaly and Axenfeld-Rieger anomaly	FGFR2	2	Link
n/a	Multiple myeloma	FGFR3	2	Link
n/a	Bladder cancer	FGFR3	2	Link
n/a	Muenke syndrome	FGFR3	2	Link
n/a	Nevus	FGFR3	2	Link
	Lymphoproliferative syndrome	ITK	2	Link
	Polycythemia vera	JAK2	14	Link
n/a	Budd-Chiari syndrome	JAK2	14	Link
	Myelofibrosis	JAK2	14	Link
	IRAK4 deficiency	IRAK4	1	Link
n/a	Invasive pneumococcal disease	IRAK4	1	Link
n/a	Spermatocytic seminoma	FGFR3	2	Link
n/a	Thanatophoric dysplasia	FGFR3	2	Link
n/a	Cancer progression/metastasis	FGFR4	2	Link
n/a	Prion diseases	FYN	2	Link

BioXGEM.

KIDFamMap

Allelic Variants