KIDFamMap

Allelic Variants
There are no related allelic variants

Related diseases of KIF 2IVUA_ZD6 (PDB code: 2IVU, chain A)
Number of involved diseases in the family	121
Number of RET related diseases	9

All kinase in this family RET

Allelic Variants	Disease Description	Involved kinases (This family)	Inhibitor of Involved Kinases	Search Disease
	Prostate cancer	EGFR, ERBB2, FGFR1, FGFR2, MAP2K1, PDGFRA, PDGFRB, PDPK1	156	Link
n/a	Measles	FYN, IRAK4, JAK2, JAK3, MAP3K7, PRKCQ, TYK2	12	Link
	Leukemia	ABL1, ABL2, JAK2, KIT, MAP2K1, PDGFRB	29	Link
	Melanoma	EGFR, FGFR1, MAP2K1, MET, PDGFRA, PDGFRB	155	Link
n/a	Epstein-Barr virus infection	FGR, JAK3, MAP3K7, SYK, TYK2	12	Link
n/a	Tuberculosis	IRAK4, JAK2, SRC, SYK	136	Link
	Neuroblastoma	ALK, NTRK1, NTRK2, NTRK3	8	Link
n/a	Influenza A	IRAK4, JAK2, MAP2K1, TYK2	12	Link
n/a	Epithelial cell signaling in Helicobacter pylori infection	CSK, EGFR, MET, SRC	267	Link
n/a	Toxoplasmosis	IRAK4, JAK2, MAP3K7, TYK2	7	Link
	Gastric cancer	EGFR, ERBB2, FGFR2, MET	149	Link
n/a	Immunodeficiencies	JAK3, LCK, ZAP70	21	Link
n/a	Leishmaniasis	IRAK4, JAK2, MAP3K7	7	Link
n/a	Bladder cancer	EGFR, ERBB2, FGFR3	149	Link
n/a	Herpes simplex infection	JAK2, MAP3K7, TYK2	3	Link
n/a	Glioma	EGFR, PDGFRA, PDGFRB	149	Link
n/a	Cervical cancer	EGFR, ERBB2, FGFR3	149	Link
	Lung cancer	ALK, EGFR, PTK2	149	Link
n/a	Viral myocarditis	ABL1, ABL2, FYN	25	Link
n/a	Choriocarcinoma	CSF1R, EGFR, ERBB2	159	Link
	Gastrointestinal stromal tumor	KIT, PDGFRA	14	Link
	Colon cancer	AURKA, SRC	137	Link
n/a	Cholangiocarcinoma	ERBB2, MET	25	Link
n/a	Salmonella infection	PKN1, PKN2	1	Link
	Pfeiffer syndrome	FGFR1, FGFR2	33	Link
	SCID	JAK3, LCK	21	Link
n/a	Prion diseases	FYN, MAP2K1	12	Link
n/a	Pathogenic Escherichia coli infection	ABL1, FYN	25	Link
n/a	Shigellosis	ABL1, SRC	136	Link
n/a	Type I diabetes mellitus	ERBB3, PRKCQ	6	Link
n/a	Myeloproliferative disorder	JAK2, PDGFRB	10	Link
	LADD syndrome	FGFR2, FGFR3	5	Link
n/a	Thyroid cancer	NTRK1, RET	11	Link
	Adenocarcinoma of lung	EGFR, ERBB2	149	Link
	Jackson-Weiss syndrome	FGFR1, FGFR2	33	Link
n/a	Medullary thyroid carcinoma	NTRK1, RET	11	Link
n/a	Hepatitis C	EGFR, TYK2	149	Link
	Crouzon syndrome	FGFR2, FGFR3	5	Link
n/a	Alcoholism	MAP2K1, NTRK2	9	Link
	Beare-Stevenson cutis gyrata syndrome	FGFR2	5	Link
n/a	Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis	FGFR2	5	Link
	Apert syndrome	FGFR2	5	Link
	Kallmann syndrome	FGFR1	33	Link
n/a	Saethre-Chotzen syndrome	FGFR2	5	Link
	Craniosynostosis	FGFR2	5	Link
	Craniofacial-skeletal-dermatologic dysplasia	FGFR2	5	Link
	Bent bone dysplasia syndrome	FGFR2	5	Link
	Breast cancer	ERBB2	25	Link
	Trigonocephaly	FGFR1	33	Link
n/a	Agammaglobulinemia and isolated hormone deficiency	BTK	9	Link
n/a	Leukoencephalopathy, diffuse hereditary, with spheroids	CSF1R	18	Link
n/a	Spondylometaepiphyseal dysplasia	DDR2	5	Link
	Agammaglobulinemia	BTK	9	Link
n/a	Pituitary Dwarfism	BTK	9	Link
n/a	Dopamine receptor D2	ANKK1	1	Link
n/a	Maturity onset diabetes of the young	BLK	12	Link
n/a	Agammaglobulinemias	BTK	9	Link
n/a	Oral cancer	EGFR	149	Link
n/a	Esophageal cancer	EGFR	149	Link
n/a	Lethal congenital contractural syndrome	ERBB3	6	Link
	Hypogonadotropic hypogonadism	FGFR1	33	Link
	Osteoglophonic dysplasia	FGFR1	33	Link
	Glioblastoma	ERBB2	25	Link
	Scaphocephaly	FGFR2	5	Link
n/a	Laryngeal cancer	EGFR	149	Link
n/a	Pancreatic cancer	ERBB2	25	Link
	Endometrial Cancer	ERBB2	25	Link
	Ovarian cancer	ERBB2	25	Link
n/a	Nevus	FGFR3	4	Link
n/a	Scaphocephaly and Axenfeld-Rieger anomaly	FGFR2	5	Link
n/a	Hypereosinophilic syndrome	PDGFRA	8	Link
n/a	Amoebiasis	PTK2	3	Link
n/a	Renal agenesis and Renal adysplasia	RET	10	Link
	Hirschsprung disease	RET	10	Link
n/a	Obesity	NTRK2	2	Link
n/a	Insensitivity to pain	NTRK1	2	Link
	Retinitis pigmentosa	MERTK	7	Link
	Renal cell carcinoma	MET	10	Link
n/a	Malaria	MET	10	Link
	Hepatocellular carcinoma	MET	10	Link
n/a	Autism suseptibility	MET	10	Link
n/a	Congenital central hypoventilation syndrome	RET	10	Link
	Central hypoventilation syndrome	RET	10	Link
n/a	Basal cell carcinoma	STK36	6	Link
n/a	Transient erythroblastopenia of childhood	TEC	4	Link
n/a	Tyrosine kinase 2 deficiency	TYK2	1	Link
	Selective T-cell defect	ZAP70	1	Link
	Mental retardation	RPS6KA3	1	Link
n/a	Coffin-Lowry syndrome	RPS6KA3	1	Link
	Multiple endocrine neoplasia	RET	10	Link
	Pheochromocytoma	RET	10	Link
	Renal agenesis	RET	10	Link
n/a	Non-syndromic X-linked mental retardation	RPS6KA3	1	Link
n/a	Popliteal pterygium syndrome	RIPK4	1	Link
	Cardiofaciocutaneous syndrome	MAP2K1	8	Link
n/a	Noonan syndrome and related disorders	MAP2K1	8	Link
n/a	Spermatocytic seminoma	FGFR3	4	Link
n/a	Thanatophoric dysplasia	FGFR3	4	Link
n/a	Cancer progression/metastasis	FGFR4	2	Link
n/a	Pertussis	IRAK4	6	Link
n/a	Muenke syndrome	FGFR3	4	Link
n/a	Hypochondroplasia	FGFR3	4	Link
n/a	Multiple myeloma	FGFR3	4	Link
n/a	FGFR3-related short limb skeletal dysplasias	FGFR3	4	Link
n/a	CATSHL syndrome	FGFR3	4	Link
	Colorectal cancer	FGFR3	4	Link
n/a	Achondroplasia	FGFR3	4	Link
n/a	Chagas disease	IRAK4	6	Link
n/a	Invasive pneumococcal disease	IRAK4	6	Link
n/a	Germ cell tumors	KIT	13	Link
	Mast cell leukemia	KIT	13	Link
	Mastocytosis with associated hematologic disorder	KIT	13	Link
n/a	Parkinson disease	LRRK2	2	Link
n/a	Lewy body dementia	LRRK2	2	Link
	Piebaldism	KIT	13	Link
	Thrombocythemia	JAK2	2	Link
	IRAK4 deficiency	IRAK4	6	Link
	Lymphoproliferative syndrome	ITK	4	Link
	Polycythemia vera	JAK2	2	Link
	Myelofibrosis	JAK2	2	Link
n/a	Budd-Chiari syndrome	JAK2	2	Link

BioXGEM.

KIDFamMap

Allelic Variants