KIDFamMap

Allelic Variants
There are no related allelic variants

Related diseases of KIF 1SM2A_STU (PDB code: 1SM2, chain A)
Number of involved diseases in the family	128
Number of RPS6KA2 related diseases	0

All kinase in this family RPS6KA2

Allelic Variants	Disease Description	Involved kinases (This family)	Inhibitor of Involved Kinases	Search Disease
	Prostate cancer	AKT2, AKT3, CDK2, EGFR, ERBB2, FGFR2, IGF1R, INSRR, MAP2K1, PDGFRA, PDGFRB	45	Link
n/a	Measles	AKT2, AKT3, CDK2, CDK6, FYN, IRAK4, JAK2, JAK3, PRKCQ, TYK2	18	Link
	Leukemia	ABL1, ABL2, AKT2, AKT3, CDK6, JAK2, KIT, MAP2K1, PDGFRB	15	Link
n/a	Epstein-Barr virus infection	AKT2, AKT3, CDC2, CDK2, FGR, JAK3, SYK, TYK2	18	Link
	Melanoma	AKT2, AKT3, CDK6, EGFR, IGF1R, MAP2K1, PDGFRA, PDGFRB	43	Link
	Lung cancer	AKT2, AKT3, ALK, CDK2, CDK6, EGFR, ROS1	43	Link
n/a	Tuberculosis	AKT2, AKT3, IRAK4, JAK2, SRC, SYK	21	Link
n/a	Influenza A	AKT2, AKT3, IRAK4, JAK2, MAP2K1, TYK2	12	Link
n/a	Toxoplasmosis	AKT2, AKT3, IRAK4, JAK2, TYK2	11	Link
n/a	Bladder cancer	DAPK1, EGFR, ERBB2, FGFR3	39	Link
n/a	Herpes simplex infection	CDC2, CDK2, JAK2, TYK2	14	Link
	Neuroblastoma	ALK, NTRK1, NTRK2, NTRK3	16	Link
n/a	Hepatitis C	AKT2, AKT3, EGFR, TYK2	40	Link
n/a	Epithelial cell signaling in Helicobacter pylori infection	EGFR, PAK1, SRC	42	Link
n/a	Cervical cancer	EGFR, ERBB2, FGFR3	38	Link
	Gastric cancer	EGFR, ERBB2, FGFR2	39	Link
n/a	Immunodeficiencies	JAK3, LCK, ZAP70	16	Link
n/a	Glioma	EGFR, PDGFRA, PDGFRB	41	Link
	Diabetes mellitus	AKT2, INSR, PRKCD	15	Link
n/a	Viral myocarditis	ABL1, ABL2, FYN	13	Link
n/a	Chagas disease	AKT2, AKT3, IRAK4	8	Link
	Hemangioma	FLT4, KDR	54	Link
	Gastrointestinal stromal tumor	KIT, PDGFRA	12	Link
	LADD syndrome	FGFR2, FGFR3	8	Link
n/a	Prion diseases	FYN, MAP2K1	11	Link
	Adenocarcinoma of lung	EGFR, ERBB2	38	Link
n/a	Leishmaniasis	IRAK4, JAK2	11	Link
	Crouzon syndrome	FGFR2, FGFR3	8	Link
n/a	Myeloproliferative disorder	JAK2, PDGFRB	12	Link
	SCID	JAK3, LCK	16	Link
n/a	Choriocarcinoma	EGFR, ERBB2	38	Link
n/a	Shigellosis	ABL1, SRC	20	Link
	Ovarian cancer	AKT2, ERBB2	7	Link
n/a	Medullary thyroid carcinoma	NTRK1, RET	18	Link
n/a	Pathogenic Escherichia coli infection	ABL1, FYN	12	Link
n/a	Thyroid cancer	NTRK1, RET	18	Link
n/a	Alcoholism	MAP2K1, NTRK2	10	Link
	Mental retardation	PAK3, RPS6KA3	10	Link
n/a	Non-syndromic X-linked mental retardation	PAK3, RPS6KA3	10	Link
	Hypoinsulinemic hypoglycemia	AKT2	7	Link
	Craniosynostosis	FGFR2	8	Link
	Bent bone dysplasia syndrome	FGFR2	8	Link
	Craniofacial-skeletal-dermatologic dysplasia	FGFR2	8	Link
	Jackson-Weiss syndrome	FGFR2	8	Link
n/a	Familial partial lipodystrophy	AKT2	7	Link
n/a	Multiple myeloma	FGFR3	7	Link
n/a	FGFR3-related short limb skeletal dysplasias	FGFR3	7	Link
n/a	Scaphocephaly and Axenfeld-Rieger anomaly	FGFR2	8	Link
	Scaphocephaly	FGFR2	8	Link
	Beare-Stevenson cutis gyrata syndrome	FGFR2	8	Link
	Pfeiffer syndrome	FGFR2	8	Link
n/a	Saethre-Chotzen syndrome	FGFR2	8	Link
	Glioblastoma	ERBB2	2	Link
	Apert syndrome	FGFR2	8	Link
	Agammaglobulinemia	BTK	5	Link
n/a	Pituitary Dwarfism	BTK	5	Link
n/a	CATSHL syndrome	FGFR3	7	Link
n/a	Agammaglobulinemia and isolated hormone deficiency	BTK	5	Link
n/a	Spondylometaepiphyseal dysplasia	DDR2	3	Link
n/a	Oral cancer	EGFR	38	Link
n/a	Esophageal cancer	EGFR	38	Link
n/a	Agammaglobulinemias	BTK	5	Link
n/a	Maturity onset diabetes of the young	BLK	8	Link
n/a	Cholangiocarcinoma	ERBB2	2	Link
n/a	Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis	FGFR2	8	Link
	Breast cancer	ERBB2	2	Link
	Endometrial Cancer	ERBB2	2	Link
n/a	Laryngeal cancer	EGFR	38	Link
n/a	Dopamine receptor D2	ANKK1	2	Link
n/a	Pancreatic cancer	ERBB2	2	Link
n/a	Spermatocytic seminoma	FGFR3	7	Link
n/a	Achondroplasia	FGFR3	7	Link
n/a	Nephronophthisis	NEK8	1	Link
n/a	Insensitivity to pain	NTRK1	15	Link
n/a	Obesity	NTRK2	9	Link
n/a	Salmonella infection	PKN2	9	Link
n/a	Hypereosinophilic syndrome	PDGFRA	10	Link
n/a	Nephronophthisis-medullary cystic kidney disease	NEK8	1	Link
n/a	Short rib-polydactyly syndorme	NEK1	3	Link
	REtinitis pigmentosa	MAK	1	Link
n/a	Noonan syndrome and related disorders	MAP2K1	4	Link
	Cardiofaciocutaneous syndrome	MAP2K1	4	Link
n/a	Myasthenic syndrome	MUSK	5	Link
n/a	Congenital myasthenic syndrome	MUSK	5	Link
n/a	Type I diabetes mellitus	PRKCQ	8	Link
n/a	Renal agenesis and Renal adysplasia	RET	11	Link
n/a	Transient erythroblastopenia of childhood	TEC	2	Link
	Venous malformations	TEK	32	Link
n/a	Rheumatoid arthritis	TEK	32	Link
	Selective T-cell defect	ZAP70	10	Link
n/a	Tyrosine kinase 2 deficiency	TYK2	8	Link
	Colon cancer	SRC	19	Link
n/a	Coffin-Lowry syndrome	RPS6KA3	8	Link
n/a	Congenital central hypoventilation syndrome	RET	11	Link
	Hirschsprung disease	RET	11	Link
	Central hypoventilation syndrome	RET	11	Link
	Multiple endocrine neoplasia	RET	11	Link
	Renal agenesis	RET	11	Link
	Pheochromocytoma	RET	11	Link
n/a	Parkinson disease	LRRK2	5	Link
n/a	Lewy body dementia	LRRK2	5	Link
n/a	Lymphedema	FLT4	17	Link
n/a	Endocrine-cerebroosteodysplasia	ICK	2	Link
n/a	Malignant pleural mesothelioma	IGF1R	5	Link
	Insulin-like growth factor I	IGF1R	5	Link
n/a	Synovial sarcoma	IGF1R	5	Link
n/a	Lymphedemas	FLT4	17	Link
n/a	Cancer progression/metastasis	FGFR4	3	Link
	Colorectal cancer	FGFR3	7	Link
n/a	Hypochondroplasia	FGFR3	7	Link
n/a	Muenke syndrome	FGFR3	7	Link
n/a	Thanatophoric dysplasia	FGFR3	7	Link
n/a	Nevus	FGFR3	7	Link
n/a	Leprechaunism	INSR	5	Link
	Rabson-Mendenhall syndrome	INSR	5	Link
	Thrombocythemia	JAK2	10	Link
	Piebaldism	KIT	12	Link
n/a	Germ cell tumors	KIT	12	Link
	Mastocytosis with associated hematologic disorder	KIT	12	Link
	Mast cell leukemia	KIT	12	Link
	Myelofibrosis	JAK2	10	Link
n/a	Budd-Chiari syndrome	JAK2	10	Link
n/a	Pertussis	IRAK4	4	Link
	Hyperinsulinemic hypoglycemia	INSR	5	Link
n/a	Invasive pneumococcal disease	IRAK4	4	Link
	IRAK4 deficiency	IRAK4	4	Link
	Polycythemia vera	JAK2	10	Link
	Lymphoproliferative syndrome	ITK	6	Link

BioXGEM.

KIDFamMap

Allelic Variants