KIDFamMap

Allelic Variants
There are no related allelic variants

Related diseases of KIF 1XBBA_STI (PDB code: 1XBB, chain A)
Number of involved diseases in the family	75
Number of SYK related diseases	2

All kinase in this family SYK

Allelic Variants	Disease Description	Involved kinases (This family)	Inhibitor of Involved Kinases	Search Disease
	Leukemia	ABL1, ABL2, BRAF, JAK2, KIT, PDGFRB	86	Link
n/a	Epstein-Barr virus infection	FGR, JAK3, LYN, SYK, TYK2	47	Link
	Melanoma	BRAF, EGFR, FGFR1, PDGFRA, PDGFRB	29	Link
	Prostate cancer	BRAF, EGFR, FGFR1, PDGFRA, PDGFRB	29	Link
n/a	Measles	FYN, JAK2, JAK3, TYK2	22	Link
n/a	Tuberculosis	JAK2, SRC, SYK	65	Link
n/a	Hepatitis C	BRAF, EGFR, TYK2	7	Link
n/a	Influenza A	JAK2, PRKCA, TYK2	24	Link
n/a	Glioma	EGFR, PDGFRA, PDGFRB	27	Link
n/a	Epithelial cell signaling in Helicobacter pylori infection	EGFR, LYN, SRC	57	Link
	Lung cancer	ALK, BRAF, EGFR	8	Link
n/a	Pathogenic Escherichia coli infection	ABL1, FYN, PRKCA	59	Link
n/a	Viral myocarditis	ABL1, ABL2, FYN	56	Link
n/a	Immunodeficiencies	JAK3, LCK	68	Link
	SCID	JAK3, LCK	68	Link
n/a	Herpes simplex infection	JAK2, TYK2	18	Link
n/a	Myeloproliferative disorder	JAK2, PDGFRB	31	Link
n/a	Toxoplasmosis	JAK2, TYK2	18	Link
	Adenocarcinoma of lung	BRAF, EGFR	7	Link
	Gastrointestinal stromal tumor	KIT, PDGFRA	20	Link
n/a	Choriocarcinoma	CSF1R, EGFR	15	Link
n/a	Thyroid cancer	BRAF, RET	7	Link
n/a	Shigellosis	ABL1, SRC	99	Link
n/a	Laryngeal cancer	EGFR	5	Link
	Hypogonadotropic hypogonadism	FGFR1	2	Link
n/a	Leukoencephalopathy, diffuse hereditary, with spheroids	CSF1R	14	Link
n/a	Oral cancer	EGFR	5	Link
	Gastric cancer	EGFR	5	Link
n/a	Bladder cancer	EGFR	5	Link
n/a	Esophageal cancer	EGFR	5	Link
n/a	Cervical cancer	EGFR	5	Link
	Colorectal cancer	BRAF	5	Link
	Noonan syndrome	BRAF	5	Link
n/a	Noonan syndrome and related disorders	BRAF	5	Link
n/a	Malignant melanoma	BRAF	5	Link
n/a	Maturity onset diabetes of the young	BLK	3	Link
	Neuroblastoma	ALK	1	Link
n/a	Alcoholism	BRAF	5	Link
n/a	Tyrosine kinase 2 deficiency	TYK2	1	Link
	LEOPARD syndrome	BRAF	5	Link
	Osteoglophonic dysplasia	FGFR1	2	Link
	Cardiofaciocutaneous syndrome	BRAF	5	Link
	Colon cancer	SRC	46	Link
	Pfeiffer syndrome	FGFR1	2	Link
	Trigonocephaly	FGFR1	2	Link
n/a	Hypereosinophilic syndrome	PDGFRA	16	Link
n/a	Vibrio cholerae infection	PRKCA	6	Link
	Mastocytosis with associated hematologic disorder	KIT	14	Link
	Mast cell leukemia	KIT	14	Link
	Piebaldism	KIT	14	Link
n/a	Germ cell tumors	KIT	14	Link
n/a	African trypanosomiasis	PRKCA	6	Link
n/a	Amoebiasis	PRKCA	6	Link
	Central hypoventilation syndrome	RET	2	Link
n/a	Medullary thyroid carcinoma	RET	2	Link
n/a	Congenital central hypoventilation syndrome	RET	2	Link
	Hirschsprung disease	RET	2	Link
n/a	Pituitary tumor	PRKCA	6	Link
n/a	Renal agenesis and Renal adysplasia	RET	2	Link
	Thrombocythemia	JAK2	17	Link
	Myelofibrosis	JAK2	17	Link
n/a	Prion diseases	FYN	4	Link
	Pheochromocytoma	RET	2	Link
	Renal agenesis	RET	2	Link
	Multiple endocrine neoplasia	RET	2	Link
	Jackson-Weiss syndrome	FGFR1	2	Link
	Kallmann syndrome	FGFR1	2	Link
n/a	Leprechaunism	INSR	29	Link
	Rabson-Mendenhall syndrome	INSR	29	Link
n/a	Leishmaniasis	JAK2	17	Link
n/a	Budd-Chiari syndrome	JAK2	17	Link
	Polycythemia vera	JAK2	17	Link
	Lymphoproliferative syndrome	ITK	3	Link
	Diabetes mellitus	INSR	29	Link
	Hyperinsulinemic hypoglycemia	INSR	29	Link

BioXGEM.

KIDFamMap

Allelic Variants