Summary of query kinase
Query kinase AAK1 (Q2M2I8)
Kinase group Other
Number of inhibitors 61
Index Target Inhibitor Inhibitor 2D Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) POC Source Link
0 AAK1 CHEMBL162 BD50059889 n/a n/a 1.2 n/a n/a BindingDB BindingDB
1 AAK1 Staurosporine Staurosporine n/a n/a 1.2 n/a n/a NB2008 NB2008
2 AAK1 Staurosporine Staurosporine n/a n/a 1.2 n/a n/a NB2011DRx NB2011DRx
3 AAK1 Staurosporine BD00002579 n/a n/a 1.3 n/a n/a BindingDB BindingDB
4 AAK1 SU11248 BD00004814 n/a n/a 11 n/a n/a BindingDB BindingDB
5 AAK1 Sunitinib Sunitinib n/a n/a 11 n/a n/a NB2008 NB2008
6 AAK1 Sunitinib Sunitinib n/a n/a 11 n/a n/a NB2011DRx NB2011DRx
7 AAK1 INCB18424 INCB18424 n/a n/a 120 n/a n/a NB2011DRx NB2011DRx
8 AAK1 cid_451705 BD00031096 n/a n/a 1200 n/a n/a BindingDB BindingDB
9 AAK1 Tarceva BD00005446 n/a n/a 1200 n/a n/a BindingDB BindingDB
10 AAK1 AG_013736 AG_013736 n/a n/a 1200 n/a n/a NB2011DRx NB2011DRx
11 AAK1 Erlotinib Erlotinib n/a n/a 1200 n/a n/a NB2008 NB2008
12 AAK1 Erlotinib Erlotinib n/a n/a 1200 n/a n/a NB2011DRx NB2011DRx
13 AAK1 PP_242 PP_242 n/a n/a 1600 n/a n/a NB2011DRx NB2011DRx
14 AAK1 CHEMBL522892 BD50265677 n/a n/a 170 n/a n/a BindingDB BindingDB
15 AAK1 CHIR_258 CHIR_258 n/a n/a 170 n/a n/a NB2008 NB2008
16 AAK1 CHIR_258 CHIR_258 n/a n/a 170 n/a n/a NB2011DRx NB2011DRx
17 AAK1 JNJ-7706621 BD00006866 n/a n/a 200 n/a n/a BindingDB BindingDB
18 AAK1 JNJ_7706621 JNJ_7706621 n/a n/a 200 n/a n/a NB2008 NB2008
19 AAK1 cid_6445562 BD00031090 n/a n/a 2300 n/a n/a BindingDB BindingDB
20 AAK1 CHEBI:259924 BD50119072 n/a n/a 2300 n/a n/a BindingDB BindingDB
21 AAK1 Crizotinib Crizotinib n/a n/a 2300 n/a n/a NB2011DRx NB2011DRx
22 AAK1 SKI_606 SKI_606 n/a n/a 2300 n/a n/a NB2011DRx NB2011DRx
23 AAK1 LY_317615 LY_317615 n/a n/a 2700 n/a n/a NB2011DRx NB2011DRx
24 AAK1 BI_2536 BI_2536 n/a n/a 2800 n/a n/a NB2011DRx NB2011DRx
25 AAK1 VX-680 BD00013534 n/a n/a 290 n/a n/a BindingDB BindingDB
26 AAK1 VX_680 VX_680 n/a n/a 290 n/a n/a NB2008 NB2008
27 AAK1 VX_680 VX_680 n/a n/a 290 n/a n/a NB2011DRx NB2011DRx
28 AAK1 Pazopanib BD00026474 n/a n/a 2900 n/a n/a BindingDB BindingDB
29 AAK1 GW_786034 GW_786034 n/a n/a 2900 n/a n/a NB2008 NB2008
30 AAK1 Pazopanib Pazopanib n/a n/a 2900 n/a n/a NB2011DRx NB2011DRx
31 AAK1 CHEMBL603469 BD50308060 n/a n/a 3.1 n/a n/a BindingDB BindingDB
32 AAK1 CEP_701 CEP_701 n/a n/a 3.1 n/a n/a NB2011DRx NB2011DRx
33 AAK1 AZD_1152HQPA AZD_1152HQPA n/a n/a 3000 n/a n/a NB2011DRx NB2011DRx
34 AAK1 PHA_665752 PHA_665752 n/a n/a 320 n/a n/a NB2011DRx NB2011DRx
35 AAK1 SP600125 BD00016018 n/a n/a 35 n/a n/a BindingDB BindingDB
36 AAK1 TG_101348 TG_101348 n/a n/a 35 n/a n/a NB2011DRx NB2011DRx
37 AAK1 EKB_569 EKB_569 n/a n/a 3500 n/a n/a NB2008 NB2008
38 AAK1 R406 R406 n/a n/a 410 n/a n/a NB2011DRx NB2011DRx
39 AAK1 A_674563 A_674563 n/a n/a 43 n/a n/a NB2011DRx NB2011DRx
40 AAK1 TAE_684 TAE_684 n/a n/a 470 n/a n/a NB2011DRx NB2011DRx
41 AAK1 CHEBI:668343 BD50298227 n/a n/a 48 n/a n/a BindingDB BindingDB
42 AAK1 CHEMBL608533 BD50326053 n/a n/a 48 n/a n/a BindingDB BindingDB
43 AAK1 KW_2449 KW_2449 n/a n/a 48 n/a n/a NB2011DRx NB2011DRx
44 AAK1 PKC_412 PKC_412 n/a n/a 48 n/a n/a NB2008 NB2008
45 AAK1 PKC_412 PKC_412 n/a n/a 48 n/a n/a NB2011DRx NB2011DRx
46 AAK1 JNJ_28312141 JNJ_28312141 n/a n/a 520 n/a n/a NB2011DRx NB2011DRx
47 AAK1 CHEMBL516312 BD50273541 n/a n/a 53 n/a n/a BindingDB BindingDB
48 AAK1 FLAVOPIRIDOL BD50088605 n/a n/a 5300 n/a n/a BindingDB BindingDB
49 AAK1 Flavopiridol Flavopiridol n/a n/a 5300 n/a n/a NB2008 NB2008
50 AAK1 Flavopiridol Flavopiridol n/a n/a 5300 n/a n/a NB2011DRx NB2011DRx
51 AAK1 BIBF_1120der BIBF_1120der n/a n/a 63 n/a n/a NB2011DRx NB2011DRx
52 AAK1 cid_10138259 BD00031095 n/a n/a 66 n/a n/a BindingDB BindingDB
53 AAK1 SU_14813 SU_14813 n/a n/a 66 n/a n/a NB2008 NB2008
54 AAK1 SU_14813 SU_14813 n/a n/a 66 n/a n/a NB2011DRx NB2011DRx
55 AAK1 TG_100_115 TG_100_115 n/a n/a 870 n/a n/a NB2011DRx NB2011DRx
56 AAK1 LY333531 BD00017055 n/a n/a 900 n/a n/a BindingDB BindingDB
57 AAK1 LY_333531 LY_333531 n/a n/a 900 n/a n/a NB2008 NB2008
58 AAK1 LY_333531 LY_333531 n/a n/a 900 n/a n/a NB2011DRx NB2011DRx
59 AAK1 GDC_0941 GDC_0941 n/a n/a 9100 n/a n/a NB2011DRx NB2011DRx
60 AAK1 CHEMBL1240703 BD50326054 n/a n/a 960 n/a n/a BindingDB BindingDB