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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK ABL1 203
Other AURKA 133
Other AURKB 77
Other AURKC 43
TK BLK 241
TK BMX 422
TK BTK 402
CAMK CAMK1G 23
CAMK CAMK2A 13
CAMK CAMK4 46
CMGC CDC2 4
CMGC CDC2L6 20
CMGC CDK2 4
CMGC CDK3 4
CMGC CDK4 6
CMGC CDK6 13
CMGC CDK8 2.7.11.23
CMGC CDK9 2.7.11.23
CMGC CDKL1 5
CMGC CDKL2 4
CAMK CHEK1 9
CAMK CHEK2 220
CMGC CSNK2A1 39
CAMK DAPK1 13
CAMK DAPK2 23
CAMK DAPK3 13
CAMK DCLK3 356
Other EIF2AK2 267
TK EPHB1 619
TK EPHB2 621
TK EPHB4 615
TK FER 563
TK FES 561
AGC GRK1 190
AGC GRK4 187
AGC GRK5 186
AGC GRK6 186
AGC GRK7 191
TK HCK 241
CMGC HIPK1 190
CMGC HIPK2 199
CMGC HIPK3 197
CMGC HIPK4 -1
CMGC ICK 4
TK JAK1 875
TK JAK2 849
CMGC MAK 4
CMGC MAPK1 13
CMGC MAPK10 64
CMGC MAPK12 27
CMGC MAPK14 24
CMGC MAPK8 26
CAMK MAPKAPK2 64
CMGC NLK 126
AGC PDPK1 82
CAMK PIM1 38
CAMK PIM3 40
AGC PKN2 657
AGC PRKACA 44
AGC PRKACB 44
AGC PRKACG 44
AGC PRKCD 349
AGC PRKCI 245
AGC PRKCQ 380
AGC PRKCZ 252
CAMK PRKD1 583
CAMK PRKD2 551
CAMK PRKD3 576
AGC PRKG1 375
AGC PRKG2 453
AGC PRKX 49
AGC RPS6KB1 91
AGC RPS6KB2 67
Other SBK1 53
STE SLK 34
STE STK24 24
STE STK25 20
CAMK STK33 116
Other STK36 4
Other TBK1 9
Other TLK2 440
Other ULK3 14
TK ZAP70 338
----ITMKHKLGGGQYGEVYEGVW---K----KYSL---TVAVKTLK-ED-TM----EV--EE-FL-K------EAAVMKEI-K-----HPN-----LVQLLGVCT--R-----------------------------EPP--FYIITEFMTYG-NLLDYLR----------ECNRQEV---NAVVLLYMATQISSAMEYLEKK--NFIHRDLAARNCL--VG----ENHLV---------KVADFGLSRLM----------T--GDTYTAHAGAKFPIKWTAPESLA--------YNKFSIKSDVWAFGVLLWEIATYGM-SP---------------YP-GI---------DLSQV-YELLEKDYRMERPEGCP-----------------------------------------------------------------------------EKVYE-LMRACWQWNPSDRPS------FA-EIHQA--F------------------------------------------------------
----FEIGRPLGKGKFGNVYLARE---K----QSKF---ILALKVLFKAQLEKA---GV--EH-QLRR------EVEIQSHL-R-----HPN-----ILRLYGYFH--D-----------------------------ATR--VYLILEYAPLG-TVYRELQ---------KLS---KF---DEQRTATYITELANALSYCHSK--RVIHRDIKPENLL--LG----SAGEL---------KIADFGWSV------------HAPSSRRTT---LCGTLDYLPPEMIE--------GRMHDEKVDLWSLGVLCYEFLV-GK-PP---------------FE-AN------------TY-QETYKRISRVEFTFPDFVT---------------------------------------------------------------------------EGARD-LISRLLKHNPSQRPM------LR-EVLEHPWI------------------------------------------------------
----FEIGRPLGKGKFGNVYLARE---K----KSHF---IVALKVLFKSQ-IEK---EG--VE-HQLR-----REIEIQAHL-H-----HPN-----ILRLYNYFY--D-----------------------------RRR--IYLILEYAPRG-ELYKELQ---------KSC---TF---DEQRTATIMEELADALMYCHGK--KVIHRDIKPENLL--LG----LKGEL---------KIADFGWSV------------HAPSLRRKT---MCGTLDYLPPEMIE--------GRMHNEKVDLWCIGVLCYELLV-GN-PP---------------FE-SA------------SH-NETYRRIVKVDLKFPASVP---------------------------------------------------------------------------MGAQD-LISKLLRHNPSERLP------LA-QVSAHPWV------------------------------------------------------
----FEIGRPLGKGKFGNVYLARL---K----ESHF---IVALKVLFKSQ-IEK---EG--LE-HQLR-----REIEIQAHL-Q-----HPN-----ILRLYNYFH--D-----------------------------ARR--VYLILEYAPRG-ELYKELQ---------KSE---KL---DEQRTATIIEELADALTYCHDK--KVIHRDIKPENLL--LG----FRGEV---------KIADFGWSV------------HTPSLRRKT---MCGTLDYLPPEMIE--------GRTYDEKVDLWCIGVLCYELLV-GY-PP---------------FE-SA------------SH-SETYRRILKVDVRFPLSMP---------------------------------------------------------------------------LGARD-LISRLLRYQPLERLP------LA-QILKHPWV------------------------------------------------------
---L-RLVRKLGSGQFGEVWMGYY---K-----NNM---KVAIKTLK-EG-TM----SP--EA-FL-G------EANVMKAL-Q-----HER-----LVRLYAVVT--------------------------------KEP--IYIVTEYMARG-CLLDFLK----------TDEGSRL---SLPRLIDMSAQIAEGMAYIERM--NSIHRDLRAANIL--VS----EALCC---------KIADFGLARII-------------DSEYTAQEGAKFPIKWTAPEAIH--------FGVFTIKADVWSFGVLLMEVVTYGR-VP---------------YP-GM---------SNPEV-IRNLERGYRMPRPDTCP-----------------------------------------------------------------------------PELYRGVIAECWRSRPEERPT------FE-FLQSV--L------------------------------------------------------
----ITLLKELGSGQFGVVQLGKW---K-----GQY---DVAVKMIK-EG-SM----SE--DE-FF-Q------EAQTMMKL-S-----HPK-----LVKFYGVCS--K-----------------------------EYP--IYIVTEYISNG-CLLNYLR----------SH-GKGL---EPSQLLEMCYDVCEGMAFLESH--QFIHRDLAARNCL--VD----RDLCV---------KVSDFGMTRYV----------L--DDQYVSSVGTKFPVKWSAPEVFH--------YFKYSSKSDVWAFGILMWEVFSLGK-QP---------------YD-LY---------DNSQV-VLKVSQGHRLYRPHLAS-----------------------------------------------------------------------------DTIYQ-IMYSCWHELPEKRPT------FQ-QLLSS--I------------------------------------------------------
----LTFLKELGTGQFGVVKYGKW---R-----GQY---DVAIKMIK-EG-SM----SE--DE-FI-E------EAKVMMNL-S-----HEK-----LVQLYGVCT--K-----------------------------QRP--IFIITEYMANG-CLLNYLR----------EM-RHRF---QTQQLLEMCKDVCEAMEYLESK--QFLHRDLAARNCL--VN----DQGVV---------KVSDFGLSRYV----------L--DDEYTSSVGSKFPVRWSPPEVLM--------YSKFSSKSDIWAFGVLMWEIYSLGK-MP---------------YE-RF---------TNSET-AEHIAQGLRLYRPHLAS-----------------------------------------------------------------------------EKVYT-IMYSCWHEKADERPT------FK-ILLSN--I------------------------------------------------------
--FI--FMEVLGSGAFSEVFLVKQ---R----LTGK---LFALKCIKKSP-AFR---DS--SL-E--N------EIAVLKKI-K-----HEN-----IVTLEDIYE--S-----------------------------TTH--YYLVMQLVSGG-ELFDRIL---------ERG---VY---TEKDASLVIQQVLSAVKYLHEN--GIVHRDLKPENLL--YLT-PEENSKI---------MITDFGLSK------------MEQNGIMST---ACGTPGYVAPEVLA--------QKPYSKAVDCWSIGVITYILLC-GY-PP---------------FY-EE------------TE-SKLFEKIKEGYYEFESPFWDDIS-----------------------------------------------------------------------ESAKD-FICHLLEKDPNERYT------CE-KALSHPWI------------------------------------------------------
----YQLFEELGKGAFSVVRRCVK---V----LAGQ---EYAAKIINTKK-LSA---RD--HQ-KLER------EARICRLL-K-----HPN-----IVRLHDSIS--E-----------------------------EGH--HYLIFDLVTGG-ELFEDIV---------ARE---YY---SEADASHCIQQILEAVLHCHQM--GVVHRDLKPENLL--LA----SKLKGA------AVKLADFGLAIEV----------EGEQQAWFG---FAGTPGYLSPEVLR--------KDPYGKPVDLWACGVILYILLV-GY-PP---------------FW-DE------------DQ-HRLYQQIKAGAYDFPSPEWDTVT-----------------------------------------------------------------------PEAKD-LINKMLTINPSKRIT------AA-EALKHPWI------------------------------------------------------
----FEVESELGRGATSIVYRCKQ---K----GTQK---PYALKVLKKTV-DKK---IV--R-----T------EIGVLLRL-S-----HPN-----IIKLKEIFE--T-----------------------------PTE--ISLVLELVTGG-ELFDRIV---------EKG---YY---SERDAADAVKQILEAVAYLHEN--GIVHRDLKPENLL--YA----T-PAPDA-----PLKIADFGLSKI-----------VEHQVLMKT---VCGTPGYCAPEILR--------GCAYGPEVDMWSVGIITYILLC-GF-EP---------------FY-DE-----------RGD-QFMFRRILNCEYYFISPWWDEVS-----------------------------------------------------------------------LNAKD-LVRKLIVLDPKKRLT------TF-QALQHPWV------------------------------------------------------
----YTKIEKIGEGTYGVVYKGRH---K----TTGQ---VVAMKKIRLES-EEE---GV--PS-TAIR------EISLLKEL-R-----HPN-----IVSLQDVLM--Q-----------------------------DSR--LYLIFEFLSM--DLKKYLDS------IPPGQ---YM---DSSLVKSYLYQILQGIVFCHSR--RVLHRDLKPQNLL--ID----DKGTI---------KLADFGLARAF----------GIPIRVYTH---EVVTLWYRSPEVLL-------GSARYSTPVDIWSIGTIFAELAT-KK-PL---------------FH-GD---------SEIDQ-LFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------------------------------------------GSLASHVKNLDENGLD-LLSKMLIYDPAKRIS------GK-MALNHPYF------------------------------------------------------
-EGC-----KVGRGTYGHVYKARR---K----DGKDE-KEYALKQIEGTG-ISM---SA--C-----R------EIALLREL-K-----HPN-----VIALQKVFL--SH---------------------------SDRK--VWLLFDYAEH--DLWHIIKFHR--ASKANKK---PMQ-LPRSMVKSLLYQILDGIHYLHAN--WVLHRDLKPANIL--VMGEGPERGRV---------KIADMGFARLFN-------SPLKPLADLDP---VVVTFWYRAPELLL-------GARHYTKAIDIWAIGCIFAELLT-SE-PI---------------FH-CRQEDIKTSNPFHHDQ-LDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYA----------------------------------------NSSLIKYMEKHKVKPDSKVFL-LLQKLLTMDPTKRIT------SE-QALQDPYF------------------------------------------------------
----FQKVEKIGEGTYGVVYKARN---K----LTGE---VVALKKIRLDT-ETE---GV--PS-TAIR------EISLLKEL-N-----HPN-----IVKLLDVIH--T-----------------------------ENK--LYLVFEFLHQ--DLKKFMDA-------SALT---GI---PLPLIKSYLFQLLQGLAFCHSH--RVLHRDLKPQNLL--IN----TEGAI---------KLADFGLARAF----------GVPVRTYTH---EVVTLWYRAPEILL-------GCKYYSTAVDIWSLGCIFAEMVT-RR-AL---------------FP-GD---------SEIDQ-LFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------------------------------------------QDFSKVVPPLDEDGRS-LLSQMLHYDPNKRIS------AK-AALAHPFF------------------------------------------------------
----FQKVEKIGEGTYGVVYKAKN---R----ETGQ---LVALKKIRLDL-EME---GV--PS-TAIR------EISLLKEL-K-----HPN-----IVRLLDVVH--N-----------------------------ERK--LYLVFEFLSQ--DLKKYMDS-------TPGS---EL---PLHLIKSYLFQLLQGVSFCHSH--RVIHRDLKPQNLL--IN----ELGAI---------KLADFGLARAF----------GVPLRTYTH---EVVTLWYRAPEILL-------GSKFYTTAVDIWSIGCIFAEMVT-RK-AL---------------FP-GD---------SEIDQ-LFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTR-------------------------------------------------KGLEEIVPNLEPEGRD-LLMQLLQYDPSQRIT------AK-TALAHPYF------------------------------------------------------
---Y-EPVAEIGVGAYGTVYKARD---P----HSGH---FVALKSVRVPN-GGGGGGGL--PI-STVR------EVALLRRL-EA--FEHPN-----VVRLMDVCA--TSR------------------------TDREIK--VTLVFEHVDQ--DLRTYLDK-------APPP---GL---PAETIKDLMRQFLRGLDFLHAN--CIVHRDLKPENIL--VT----SGGTV---------KLADFGLARI-----------YSYQMALTP---VVVTLWYRAPEVLL--------QSTYATPVDMWSVGCIFAEMFR-RK-PL---------------FC-GN---------SEADQ-LGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR---------------------------------------------------PVQSVVPEMEESGAQ-LLLEMLTFNPHKRIS------AF-RALQHSYL------------------------------------------------------
----YECVAEIGEGAYGKVFKARD---L----KNGG--RFVALKRVRVQT-GEE---GM--PL-STIR------EVAVLRHL-ET--FEHPN-----VVRLFDVCT--VSR------------------------TDRETK--LTLVFEHVDQ--DLTTYLDK-------VPEP---GV---PTETIKDMMFQLLRGLDFLHSH--RVVHRDLKPQNIL--VT----SSGQI---------KLADFGLARI-----------YSFQMALTS---VVVTLWYRAPEVLL--------QSSYATPVDLWSVGCIFAEMFR-RK-PL---------------FR-GS---------SDVDQ-LGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ---------------------------------------------------PIEKFVTDIDELGKD-LLLKCLTFNPAKRIS------AY-SALSHPYF------------------------------------------------------
-EGC-----KVGRGTYGHVYKAKR---K----DGKDD-KDYALKQIEGTG-ISM---SA--C-----R------EIALLREL-K-----HPN-----VISLQKVFL--SH---------------------------ADRK--VWLLFDYAEH--DLWHIIKFHRASKANKKPV---QL---PRGMVKSLLYQILDGIHYLHAN--WVLHRDLKPANIL--VMGEGPERGRV---------KIADMGFARLFN-------SPLKPLADLDP---VVVTFWYRAPELLL-------GARHYTKAIDIWAIGCIFAELLT-SE-PI---------------FH-CRQEDIKTSNPYHHDQ-LDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYT----------------------------------------NCSLIKYMEKHKVKPDSKAFH-LLQKLLTMDPIKRIT------SE-QAMQDPYF------------------------------------------------------
----YEKLAKIGQGTFGEVFKARH---R----KTGQ---KVALKKVLMEN-EKE---GF--PI-TALR------EIKILQLL-K-----HEN-----VVNLIEICR--TKASP---------------------YNRCKGS--IYLVFDFCEH--DLAGLLS--------NVLV---KF---TLSEIKRVMQMLLNGLYYIHRN--KILHRDMKAANVL--IT----RDGVL---------KLADFGLARAFSL------AKNSQPNRYTN---RVVTLWYRPPELLL-------GERDYGPPIDLWGAGCIMAEMWT-RS-PI---------------MQ-GN---------TEQHQ-LALISQLCGSITPEVWPNVDNYELYEKLELVKGQK----------------------------------------------RKVKDRLKAYVRDPYALD-LIDKLLVLDPAQRID------SD-DALNHDFF------------------------------------------------------
----YEKIGKIGEGSYGVVFKCRN---R----DTGQ---IVAIKKFLESE-DDP---VI--KK-IALR------EIRMLKQL-K-----HPN-----LVNLLEVFR--R-----------------------------KRR--LHLVFEYCDHT-VLHELDR---------YQR---GV---PEHLVKSITWQTLQAVNFCHKH--NCIHRDVKPENIL--IT----KHSVI---------KLCDFGFARLL----------AGPSDYYTD---YVATRWYRSPELLV-------GDTQYGPPVDVWAIGCVFAELLS-GV-PL---------------WP-GK---------SDVDQ-LYLIRKTLGDLIPRHQQVFSTNQYFSGVKIPDPED-----------------------------------------------MEPLELKFPNISYPALG-LLKGCLHMDPTQRLT------CE-QLLHHPYF------------------------------------------------------
----YENLGLVGEGSYGMVMKCRN---K----DTGR---IVAIKKFLESD-DDK---MV--KK-IAMR------EIKLLKQL-R-----HEN-----LVNLLEVCK--K-----------------------------KKR--WYLVFEFVDHT-ILDDLEL---------FPN---GL---DYQVVQKYLFQIINGIGFCHSH--NIIHRDIKPENIL--VS----QSGVV---------KLCDFGFARTL----------AAPGEVYTD---YVATRWYRAPELLV-------GDVKYGKAVDVWAIGCLVTEMFM-GE-PL---------------FP-GD---------SDIDQ-LYHIMMCLGNLIPRHQELFNKNPVFAGVRLPEIKE-----------------------------------------------REPLERRYPKLSEVVID-LAKKCLHIDPDKRPF------CA-ELLHHDFF------------------------------------------------------
---W-DLVQTLGEGAYGEVQLAVN---R----VTEE---AVAVKIVDMKR-AVD---CP--EN-I-KK------EICINKML-N-----HEN-----VVKFYGHRR--E-----------------------------GNI--QYLFLEYCSGG-ELFDRIE---------PDI---GM---PEPDAQRFFHQLMAGVVYLHGI--GITHRDIKPENLL--LD----ERDNL---------KISDFGLATVFR--------YNNRERLLNK---MCGTLPYVAPELLK-------RREFHAEPVDVWSCGIVLTAMLA-GE-LP---------------WD-QP-----------SDS-CQEYSDWKEKKTYLNPWKKI--D-----------------------------------------------------------------------SAPLA-LLHKILVENPSARIT------IP-DIKKDRW-Y-----------------------------------------------------
--YI--MSKTLGSGACGEVKLAFE---R----KTCK---KVAIKIISKRK-FAI---GS--AR-EADPALNVETEIEILKKL-N-----HPC-----IIKIKNFF---D-----------------------------AED--YYIVLELMEGG-ELFDKVV---------GNK---RL---KEATCKLYFYQMLLAVQYLHEN--GIIHRDLKPENVL--LS----SQEEDC------LIKITDFGHSKI-----------LGETSLMRT---LCGTPTYLAPEVLVS-----VGTAGYNRAVDCWSLGVILFICLS-GY-PP---------------FS-EH-----------RTQ-VSLKDQITSGKYNFIPEVWAEVS-----------------------------------------------------------------------EKALD-LVKKLLVVDPKARFT------TE-EALRHPWL------------------------------------------------------
----YQLVRKLGRGKYSEVFEAIN---I----TNNE---KVVVKILKPVK-KKK---IK--R------------EIKILENLRG-----GPN-----IITLADIVK--DP---------------------------VSRT--PALVFEHVNNT-DFKQLY------------Q---TL---TDYDIRFYMYEILKALDYCHSM--GIMHRDVKPHNVM--ID---HEHRKL---------RLIDWGLAEF-----------YHPGQEYNV---RVASRYFKGPELLV-------DYQMYDYSLDMWSLGCMLASMIF-RK-EP---------------FFHGH---------DNYDQ-LVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK-----------------------------------------RWERFVHSENQHLVSPEALD-FLDKLLRYDHQSRLT------AR-EAMEHPYF------------------------------------------------------
----YDTGEELGSGQFAVVKKCRE---K----STGL---QYAAKFIKKRR-TKS---SR--RG-VSREDI--EREVSILKEI-Q-----HPN-----VITLHEVYE--N-----------------------------KTD--VILILELVAGG-ELFDFLA---------EKE---SL---TEEEATEFLKQILNGVYYLHSL--QIAHFDLKPENIM--LL----DRNVPKP-----RIKIIDFGLAHK-----------IDFGNEFKN---IFGTPEFVAPEIVN--------YEPLGLEADMWSIGVITYILLS-GA-SP---------------FL-GD------------TK-QETLANVSAVNYEFEDEYFSNTS-----------------------------------------------------------------------ALAKD-FIRRLLVKDPKKRMT------IQ-DSLQHPWI------------------------------------------------------
----YDIGEELGSGQFAIVKKCRE---K----STGL---EYAAKFIKKRQ-SRA---SR--RG-VSREEI--EREVSILRQV-L-----HHN-----VITLHDVYE--N-----------------------------RTD--VVLILELVSGG-ELFDFLA---------QKE---SL---SEEEATSFIKQILDGVNYLHTK--KIAHFDLKPENIM--LL----DKNIPIP-----HIKLIDFGLAHE-----------IEDGVEFKN---IFGTPEFVAPEIVN--------YEPLGLEADMWSIGVITYILLS-GA-SP---------------FL-GD------------TK-QETLANITAVSYDFDEEFFSQTS-----------------------------------------------------------------------ELAKD-FIRKLLVKETRKRLT------IQ-EALRHPWI------------------------------------------------------
----YEMGEELGSGQFAIVRKCRQ---K----GTGK---EYAAKFIKKRR-LSS---SR--RG-VSREEI--EREVNILREI-R-----HPN-----IITLHDIFE--N-----------------------------KTD--VVLILELVSGG-ELFDFLA---------EKE---SL---TEDEATQFLKQILDGVHYLHSK--RIAHFDLKPENIM--LL----DKNVPNP-----RIKLIDFGIAHK-----------IEAGNEFKN---IFGTPEFVAPEIVN--------YEPLGLEADMWSIGVITYILLS-GA-SP---------------FL-GE------------TK-QETLTNISAVNYDFDEEYFSNTS-----------------------------------------------------------------------ELAKD-FIRRLLVKDPKRRMT------IA-QSLEHSWI------------------------------------------------------
----YETGRVIGDGNFAVVKECRH---R----ETRQ---AYAMKIIDKSR-LKG---KE--DM-V-DS------EILIIQSL-S-----HPN-----IVKLHEVYE--T-----------------------------DME--IYLILEYVQGG-DLFDAII---------ESV---KF---PEPDAALMIMDLCKALVHMHDK--SIVHRDLKPENLL--VQ----RNEDKST-----TLKLADFGLAK-------------HVVRPIFT---VCGTPTYVAPEILS--------EKGYGLEVDMWAAGVILYILLC-GF-PP---------------FR-SP----------ERDQ-DELFNIIQLGHFEFLPPYWDNIS-----------------------------------------------------------------------DAAKD-LVSRLLVVDPKKRYT------AH-QVLQHPWI------------------------------------------------------
---F-KEIELIGSGGFGQVFKAKH---R----IDGK---TYVIKRVKYNN-EKA---ER---------------EVKALAKL-D-----HVN-----IVHYNGCWD--GFDYDPETSDDSLESSDYDPENSKNSSRSKTKC--LFIQMEFCDKG-TLEQWIEK-------RRGE---KL---DKVLALELFEQITKGVDYIHSK--KLIHRDLKPSNIF--LV----DTKQV---------KIGDFGLVTS-----------LKNDGKRTR---SKGTLRYMSPEQIS--------SQDYGKEVDLYALGLILAELLH-VCDTA---------------FE-T-----------------SKFFTDLRDGIISDIFDK----------------------------------------------------------------------------KEKT-LLQKLLSKKPEDRPN------TS-EILR----TLT---------------------------------------------------
---V-KIEEVIGAGEFGEVYKGRL---K-LPGKREI---YVAIKTLK-AG-YS----EKQRRD-FL-S------EASIMGQF-D-----HPN-----IIRLEGVVT--K-----------------------------SRP--VMIITEFMENG-ALDSFLR----------QN-DGQF---TVIQLVGMLRGIAAGMKYLAEM--NYVHRDLAARNIL--VN----SNLVC---------KVSDFGLSRYLQ--DDT----S--DPTYTSSLGGKIPVRWTAPEAIA--------YRKFTSASDVWSYGIVMWEVMSFGE-RP---------------YW-DM---------SNQDV-INAIEQDYRLPPPMDCP-----------------------------------------------------------------------------AALHQ-LMLDCWQKDRNSRPR------FA-EIVNTL--------------------------------------------------------
---V-KIEQVIGAGEFGEVCSGHL---K-LPGKREI---FVAIKTLK-SG-YT----EKQRRD-FL-S------EASIMGQF-D-----HPN-----VIHLEGVVT--K-----------------------------STP--VMIITEFMENG-SLDSFLR----------QN-DGQF---TVIQLVGMLRGIAAGMKYLADM--NYVHRDLAARNIL--VN----SNLVC---------KVSDFGLSRFLE--DDT----S--DPTYTSALGGKIPIRWTAPEAIQ--------YRKFTSASDVWSYGIVMWEVMSYGE-RP---------------YW-DM---------TNQDV-INAIEQDYRLPPPMDCP-----------------------------------------------------------------------------SALHQ-LMLDCWQKDRNHRPK------FG-QIVNTL--------------------------------------------------------
---V-KIEEVIGAGEFGEVCRGRL---K-APGKKES---CVAIKTLK-GG-YT----ERQRRE-FL-S------EASIMGQF-E-----HPN-----IIRLEGVVT--N-----------------------------SMP--VMILTEFMENG-ALDSFLR----------LN-DGQF---TVIQLVGMLRGIASGMRYLAEM--SYVHRDLAARNIL--VN----SNLVC---------KVSDFGLSRFLE--ENS----S--DPTYTSSLGGKIPIRWTAPEAIA--------FRKFTSASDAWSYGIVMWEVMSFGE-RP---------------YW-DM---------SNQDV-INAIEQDYRLPPPPDCP-----------------------------------------------------------------------------TSLHQ-LMLDCWQKDRNARPR------FP-QVVSAL--------------------------------------------------------
--VI--LGELLGKGNFGEVYKGTL---K-----DKT---SVAVKTCK-ED-LP----QELKIK-FL-Q------EAKILKQY-D-----HPN-----IVKLIGVCT--Q-----------------------------RQP--VYIIMELVSGG-DFLTFLR----------RK-KDEL---KLKQLVKFSLDAAAGMLYLESK--NCIHRDLAARNCL--VG----ENNVL---------KISDFGMSRQE----------D--GGVYSSSGLKQIPIKWTAPEALN--------YGRYSSESDVWSFGILLWETFSLGV-CP---------------YP-GM---------TNQQA-REQVERGYRMSAPQHCP-----------------------------------------------------------------------------EDISK-IMMKCWDYKPENRPK------FS-ELQKEL--------------------------------------------------------
---L-VLGEQIGRGNFGEVFSGRL---R----ADNT---LVAVKSCR-ET-LP----PDLKAK-FL-Q------EARILKQY-S-----HPN-----IVRLIGVCT--Q-----------------------------KQP--IYIVMELVQGG-DFLTFLR----------TE-GARL---RVKTLLQMVGDAAAGMEYLESK--CCIHRDLAARNCL--VT----EKNVL---------KISDFGMSREE-----A----D--GVYAASGGLRQVPVKWTAPEALN--------YGRYSSESDVWSFGILLWETFSLGA-SP---------------YP-NL---------SNQQT-REFVEKGGRLPCPELCP-----------------------------------------------------------------------------DAVFR-LMEQCWAYEPGQRPS------FS-TIYQEL--------------------------------------------------------
FLDF----RVLGKGGFGEVSACQM---K----ATGK---LYACKKLNKKR-LKK---RK--GY-QGAM-----VEKKILMKV-H-----SRF-----IVSLAYAFE--T-----------------------------KAD--LCLVMTIMNGG-DIRYHIYNV-----NEENP---GF---PEPRALFYTAQIICGLEHLHQR--RIVYRDLKPENVL--LD----NDGNV---------RISDLGLAVEL----------LDGQSKTKG---YAGTPGFMAPELLQ--------GEEYDFSVDYFALGVTLYEMIA-AR-GP---------------FR-AR--------GEKVEN-KELKHRIISEPVKYPDKFS---------------------------------------------------------------------------QASKD-FCEALLEKDPEKRLG------FR-D-------ETCDKLRAHPLF------------------------------------------
--FR--HYRVLGKGGFGEVCACQV---R----ATGK---MYACKKLQKKR-IKK---RK--GE-AMAL-----NEKRILEKV-Q-----SRF-----VVSLAYAYE--T-----------------------------KDA--LCLVLTIMNGG-DLKFHIYN-------LGNP---GF---DEQRAVFYAAELCCGLEDLQRE--RIVYRDLKPENIL--LD----DRGHI---------RISDLGLATE-----------IPEGQRVRG---RVGTVGYMAPEVVN--------NEKYTFSPDWWGLGCLIYEMIQ-GH-SP---------------FK-KY---------KEKVK-WEEVDQRIKNDTEEYSE---KFS-----------------------------------------------------------------------EDAKS-ICRMLLTKNPSKRLGCR-GEGAA-GVKQHPV-F-----------------------------------------------------
---F-RQYRVLGKGGFGEVCACQV---R----ATGK---MYACKRLEKKR-IKK---RK--GE-SMAL-----NEKQILEKV-N-----SQF-----VVNLAYAYE--T-----------------------------KDA--LCLVLTIMNGG-DLKFHIYN-------MGNP---GF---EEERALFYAAEILCGLEDLHRE--NTVYRDLKPENIL--LD----DYGHI---------RISDLGLAVK-----------IPEGDLIRG---RVGTVGYMAPEVLN--------NQRYGLSPDYWGLGCLIYEMIE-GQ-SP---------------FR-GR------------KE-KVKREEVDRRVLETEEVYSHKFS-----------------------------------------------------------------------EEAKS-ICKMLLTKDAKQRLGCQ-EEGAA-EVKRHPFF------------------------------------------------------
---F-RQYRVLGKGGFGEVCACQV---R----ATGK---MYACKKLEKKR-IKK---RK--GE-AMAL-----NEKQILEKV-N-----SRF-----VVSLAYAYE--T-----------------------------KDA--LCLVLTLMNGG-DLKFHIYH-------MGQA---GF---PEARAVFYAAEICCGLEDLHRE--RIVYRDLKPENIL--LD----DHGHI---------RISDLGLAVH-----------VPEGQTIKG---RVGTVGYMAPEVVK--------NERYTFSPDWWALGCLLYEMIA-GQ-SP---------------FQ-QR---------KKKIK-REEVERLVK-EVPEEYSER--FS-----------------------------------------------------------------------PQARS-LCSQLLCKDPAERLGCR-GGSAR-EVKEHPLF------------------------------------------------------
---F-TEFRVLGKGGFGEVCAVQV---K----NTGK---MYACKKLDKKR-LKK---KG--GE-KMAL-----LEKEILEKV-S-----SPF-----IVSLAYAFE--S-----------------------------KTH--LCLVMSLMNGG-DLKFHIYN-------VGTR---GL---DMSRVIFYSAQIACGMLHLHEL--GIVYRDMKPENVL--LD----DLGNC---------RLSDLGLAVE-----------MKGGKPITQ---RAGTNGYMAPEILM-------EKVSYSYPVDWFAMGCSIYEMVA-GR-TP---------------FK-DY--------KEKVSK-EDLKQRTLQDEVKFQHDNF---T-----------------------------------------------------------------------EEAKD-ICRLFLAKKPEQRLG------SR-E-------KSDDPR------------------------------------------------
----LKLEKKLGAGQFGEVWMATY---N-----KHT---KVAVKTMK-PG-SM----SV--EA-FL-A------EANVMKTL-Q-----HDK-----LVKLHAVVT--------------------------------KEP--IYIITEFMAKG-SLLDFLK----------SDEGSKQ---PLPKLIDFSAQIAEGMAFIEQR--NYIHRDLRAANIL--VS----ASLVC---------KIADFGLARVI----------E--DNEYTAREGAKFPIKWTAPEAIN--------FGSFTIKSDVWSFGILLMEIVTYGR-IP---------------YP-GM---------SNPEV-IRALERGYRMPRPENCP-----------------------------------------------------------------------------EELYN-IMMRCWKNRPEERPT------FE-YIQSV--L------------------------------------------------------
----YEVLEFLGRGTFGQVAKCWK---R----STKE---IVAIKILKNHP-SYA---RQ--GQ-I---------EVSILSRL-S-----SENADEYNFVRSYECFQ--H-----------------------------KNH--TCLVFEMLEQ--NLYDFLKQ-------NKFS---PL---PLKYIRPILQQVATALMKLKSL--GLIHADLKPENIM--LV----DPVRQPY-----RVKVIDFGSAS------------HVSKAVCST---YLQSRYYRAPEIIL--------GLPFCEAIDMWSLGCVIAELFL-GW-PL---------------YP-GA---------SEYDQ-IRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKE------ARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYID-LLKKMLTIDADKRIT------PL-KTLNHQFV------------------------------------------------------
----YEVLEFLGRGTFGQVVKCWK---R----GTNE---IVAIKILKNHP-SYA---RQ--GQ-I---------EVSILARL-STESADDYN-----FVRAYECFQ--H-----------------------------KNH--TCLVFEMLEQ--NLYDFLKQ-------NKFS---PL---PLKYIRPVLQQVATALMKLKSL--GLIHADLKPENIM--LV----DPSRQPY-----RVKVIDFGSAS------------HVSKAVCST---YLQSRYYRAPEIIL--------GLPFCEAIDMWSLGCVIAELFL-GW-PL---------------YP-GA---------SEYDQ-IRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKE------ARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFID-LLKKMLTIDADKRIT------PI-ETLNHPFV------------------------------------------------------
----YEVLDFLGRGTFGQVVKCWK---R----GTNE---IVAIKILKNHP-SYA---RQ--GQ-I---------EVSILARL-S-----TENADEYNFVRAYECFQ--H-----------------------------RNH--TCLVFEMLEQ--NLYDFLKQ-------NKFS---PL---PLKVIRPILQQVATALKKLKSL--GLIHADLKPENIM--LV----DPVRQPY-----RVKVIDFGSAS------------HVSKTVCST---YLQSRYYRAPEIIL--------GLPFCEAIDMWSLGCVIAELFL-GW-PL---------------YP-GA---------LEYDQ-IRYISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKE------ARKYIFNSLDDVAHVNTVMDLEGSDLLAEKADRREFVS-LLKKMLLIDADLRIT------PA-ETLNHPFV------------------------------------------------------
----YDIIEVLGKGTFGEVAKGWR---R----STGE---MVAIKILKNDA-YRN---RI--IK-N---------ELKLLHCM-RGLDPEEAH-----VIRFLEFFH--D-----------------------------ALK--FYLVFELLEQ--NLFEFQK----------EN---NFAPLPARHIRTVTLQVLTALARLKEL--AIIHADLKPENIM--LV----DQTRCPF-----RVKVIDFGSASIF----------SEVRYVKEP---YIQSRFYRAPEILL--------GLPFCEKVDVWSLGCVMAELHL-GW-PL---------------YP-GN---------NEYDQ-VRYICETQGLPKPHLLHAACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTFPDREALAEHADLKSMVE-LIKRMLTWESHERIS------PS-AALRHPFV------------------------------------------------------
----YTTIRQLGDGTYGSVLLGRS---I----ESGE---LIAIKKMKRKF-YSW---EE--C--MNLR------EVKSLKKL-N-----HAN-----VVKLKEVIR--E-----------------------------NDH--LYFIFEYMKE--NLYQLIK--------ERNK---LF---PESAIRNIMYQILQGLAFIHKH--GFFHRDLKPENLL--CM----GPELV---------KIADFGLARE-----------IRSKPPYTD---YVSTRWYRAPEVLL-------RSTNYSSPIDVWAVGCIMAEVYT-LR-PL---------------FP-GA---------SEIDT-IFKICQVLGTPKKTDWPEGYQLSSAMNFRWPQCV------------------------------------------------PNNLKTLIPNASSEAVQ-LLRDMLQWDPKKRPT------AS-QALRYPYF------------------------------------------------------
---L-KRIRDLGEGHFGKVELCRY---DPEGDNTGE---QVAVKSLK-PE-SG----GNHIAD-LK-K------EIEILRNL-Y-----HEN-----IVKYKGICT-ED------------------------------GGNGIKLIMEFLPSG-SLKEYLP----------KN-KNKI---NLKQQLKYAVQICKGMDYLGSR--QYVHRDLAARNVL--VE----SEHQV---------KIGDFGLTKAI----ET----D--KEYYTVKDDRDSPVFWYAPECLM--------QSKFYIASDVWSFGVTLHELLTYCD-SDSSPMALF-LKMIGPTHG-QM---------TVTRL-VNTLKEGKRLPCPPNCP-----------------------------------------------------------------------------DEVYQ-LMRKCWEFQPSNRTS------FQ-NLIE---GF-----------------------------------------------------
----LKFLQQLGKGNFGSVEMCRY---DPLQDNTGE---VVAVKKLQ-HS-TE-----EHLRD-FE-R------EIEILKSL-Q-----HDN-----IVKYKGVCYSAG-----------------------------RRN--LKLIMEYLPYG-SLRDYLQ----------KH-KERI---DHIKLLQYTSQICKGMEYLGTK--RYIHRDLATRNIL--VE----NENRV---------KIGDFGLTKVL----PQ----D--KEYYKVKEPGESPIFWYAPESLT--------ESKFSVASDVWSFGVVLYELFTYIE-KSKSPPAEFMRMIGNDKQG-QM---------IVFHL-IELLKNNGRLPRPDGCP-----------------------------------------------------------------------------DEIYM-IMTECWNNNVNQRPS------FR-DLA----LRV----------------------------------------------------
----YTTMRQLGDGTYGSVLMGKS---N----ESGE---LVAIKRMKRKF-YSW---DE--CM--NLR------EVKSLKKL-N-----HAN-----VIKLKEVIR--E-----------------------------NDH--LYFIFEYMKE--NLYQLMK--------DRNK---LF---PESVIRNIMYQILQGLAFIHKH--GFFHRDMKPENLL--CM----GPELV---------KIADFGLARE-----------LRSQPPYTD---YVSTRWYRAPEVLL-------RSSVYSSPIDVWAVGSIMAELYM-LR-PL---------------FP-GT---------SEVDE-IFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCV------------------------------------------------PINLKTLIPNASNEAIQ-LMTEMLNWDPKKRPT------AS-QALKHPYF------------------------------------------------------
----YTNLSYIGEGAYGMVCSAYD---N----VNKV---RVAIKKISPFE-HQT---YC--QR-T-LR------EIKILLRF-R-----HEN-----IIGINDIIR--APT------------------------IEQMKD--VYIVQDLMET--DLYKLLK----------TQ---HL---SNDHICYFLYQILRGLKYIHSA--NVLHRDLKPSNLL--LN----TTCDL---------KICDFGLARVAD-------PDHDHTGFLTE---YVATRWYRAPEIML-------NSKGYTKSIDIWSVGCILAEMLS-NR-PI---------------FP-GK---------HYLDQ-LNHILGILGSPSQEDLNCIINLKARNYLLSLPHKN-----------------------------------------------KVPWNRLFPNADSKALD-LLDKMLTFNPHKRIE------VE-QALAHPYL------------------------------------------------------
----YQNLKPIGSGAQGIVCAAYD---A----VLDR---NVAIKKLSRPF-QNQ---TH--AK-RAYR------ELVLMKCV-N-----HKN-----IISLLNVFT--PQKT-----------------------LEEFQD--VYLVMELMDA--NLCQVIQ-----------M---EL---DHERMSYLLYQMLCGIKHLHSA--GIIHRDLKPSNIV--VK----SDCTL---------KILDFGLART-----------AGTSFMMTP---YVVTRYYRAPEVIL--------GMGYKENVDIWSVGCIMGEMVR-HK-IL---------------FP-GR---------DYIDQ-WNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPK------------------------------------LFPDSLFPADSEHNKLKASQARD-LLSKMLVIDPAKRIS------VD-DALQHPYI------------------------------------------------------
----YRDLQPVGSGAYGAVCSAVD---G----RTGA---KVAIKKLYRPF-QSE---LF--AK-RAYR------ELRLLKHM-R-----HEN-----VIGLLDVFT--PDET-----------------------LDDFTD--FYLVMPFMGT--DLGKLMK----------HE---KL---GEDRIQFLVYQMLKGLRYIHAA--GIIHRDLKPGNLA--VN----EDCEL---------KILDFGLAR-------------QADSEMTG---YVVTRWYRAPEVIL-------NWMRYTQTVDIWSVGCIMAEMIT-GK-TL---------------FK-GS---------DHLDQ-LKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELE-----------------------------------------------KKDFASILTNASPLAVN-LLEKMLVLDAEQRVT------AG-EALAHPYF------------------------------------------------------
----YQNLSPVGSGAYGSVCAAFD---T----KTGL---RVAVKKLSRPF-QSI---IH--AK-RTYR------ELRLLKHM-K-----HEN-----VIGLLDVFT--PARS-----------------------LEEFND--VYLVTHLMGA--DLNNIVK----------CQ---KL---TDDHVQFLIYQILRGLKYIHSA--DIIHRDLKPSNLA--VN----EDCEL---------KILDFGLAR-------------HTDDEMTG---YVATRWYRAPEIML-------NWMHYNQTVDIWSVGCIMAELLT-GR-TL---------------FP-GT---------DHIDQ-LKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------------------------------------------KMNFANVFIGANPLAVD-LLEKMLVLDSDKRIT------AA-QALAHAYF------------------------------------------------------
----YQNLKPIGSGAQGIVCAAYD---A----ILER---NVAIKKLSRPF-QNQ---TH--AK-RAYR------ELVLMKCV-N-----HKN-----IIGLLNVFT--PQKS-----------------------LEEFQD--VYIVMELMDA--NLCQVIQ-----------M---EL---DHERMSYLLYQMLCGIKHLHSA--GIIHRDLKPSNIV--VK----SDCTL---------KILDFGLART-----------AGTSFMMTP---YVVTRYYRAPEVIL--------GMGYKENVDLWSVGCIMGEMVC-HK-IL---------------FP-GR---------DYIDQ-WNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEK------------------------------------LFPDVLFPADSEHNKLKASQARD-LLSKMLVIDASKRIS------VD-EALQHPYI------------------------------------------------------
-KVT---SQVLGLGINGKVLQIFN---K----RTQE---KFALKMLQDCP-KAR-------------R------EVELHWRASQ-----CPH-----IVRIVDVYE--NLY-------------------------AGRKC--LLIVMECLDGG-ELFSRIQD-------RGDQ---AF---TEREASEIMKSIGEAIQYLHSI--NIAHRDVKPENLL--YT----SKRPNA------ILKLTDFGFAKE-----------TTSHNSLTT---PCYTPYYVAPEVLG--------PEKYDKSCDMWSLGVIMYILLC-GY-PP---------------FY-SN--------HGLAIS-PGMKTRIRMGQYEFPNPEWSEVS-----------------------------------------------------------------------EEVKM-LIRNLLKTEPTQRMT------IT-EFMNHPWI------------------------------------------------------
-IEP---DRPIGYGAFGVVWSVTD---P----RDGK---RVALKKMPNVF-QNL---VS--CK-RVFR------ELKMLCFF-K-----HDN-----VLSALDILQ--PPH------------------------IDYFEE--IYVVTELMQS--DLHKIIV---------SPQ---PL---SSDHVKVFLYQILRGLKYLHSA--GILHRDIKPGNLL--VN----SNCVL---------KICDFGLARVE---------ELDESRHMTQ---EVVTQYYRAPEILM-------GSRHYSNAIDIWSVGCIFAELLG-RR-IL---------------FQ-AQ---------SPIQQ-LDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQP----------------------------------------------SLPVLYTLSSQATHEAVH-LLCRMLVFDPSKRIS------AK-DALAHPYL------------------------------------------------------
---F-KFGKILGEGSFSTVVLARE---L----ATSR---EYAIKILEKRH-IIK---EN--KVPYVTR------ERDVMSRL-D-----HPF-----FVKLYFTFQ--D-----------------------------DEK--LYFGLSYAKNG-ELLKYIR---------KIG---SF---DETCTRFYTAEIVSALEYLHGK--GIIHRDLKPENIL--LN----EDMHI---------QITDFGTAKVLS--------PESKQARANS---FVGTAQYVSPELLT--------EKSACKSSDLWALGCIIYQLVA-GL-PP---------------FR-AG------------NE-YLIFQKIIKLEYDFPEKFF---------------------------------------------------------------------------PKARD-LVEKLLVLDATKRLG------CE-EM------EGYGPLKAHPF-------------------------------------------
----YQVGPLLGSGGFGSVYSGIR---V----SDNL---PVAIKHVEKDR-ISD---WG--EL-PNGTRV--PMEVVLLKKV-S-----SGFS---GVIRLLDWFE--R-----------------------------PDS--FVLILERPEPVQDLFDFIT---------ERG---AL---QEELARSFFWQVLEAVRHCHNC--GVLHRDIKDENIL--ID---LNRGEL---------KLIDFGSGA------------LLKDTVYTD---FDGTRVYSPPEWIR-------YHRYHGRSAAVWSLGILLYDMVC-GD-IP---------------FE-HD-------------------EEIIRGQVFFRQRVS---------------------------------------------------------------------------SECQH-LIRWCLALRPSDRPT------FE-EIQNHPWM------------------------------------------------------
----YQVGAVLGSGGFGTVYAGSR---I----ADGL---PVAVKHVVKER-VTE---WG--SL-GGATV---PLEVVLLRKV-GAA-GGARG-----VIRLLDWFE--R-----------------------------PDG--FLLVLERPEPAQDLFDFIT---------ERG---AL---DEPLARRFFAQVLAAVRHCHSC--GVVHRDIKDENLL--VD---LRSGEL---------KLIDFGSGA------------LLKDTVYTD---FDGTRVYSPPEWIR-------YHRYHGRSATVWSLGVLLYDMVC-GD-IP---------------FE-QD-------------------EEILRGRLLFRRRVS---------------------------------------------------------------------------PECQQ-LIRWCLSLRPSERPS------LD-QIAAHPWM------------------------------------------------------
--FR--CCAVLGRGHFGKVLLAEY---K----NTNE---MFAIKALKKGD-IVA---RD--EV-DSLM-----CEKRIFETV-NS--VRHPF-----LVNLFACFQ--T-----------------------------KEH--VCFVMEYAAGG-DLMMHIH----------TD---VF---SEPRAVFYAACVVLGLQYLHEH--KIVYRDLKLDNLL--LD----TEGFV---------KIADFGLCKEG----------MGYGDRTST---FCGTPEFLAPEVLT--------ETSYTRAVDWWGLGVLIYEMLV-GE-SP---------------FP-GD------------DE-EEVFDSIVNDEVRYPRFLS---------------------------------------------------------------------------TEAIS-IMRRLLRRNPERRLGAS-EKDAE-DVKKHPFF------------------------------------------------------
---F-ERIKTLGTGSFGRVMLVKH---K----ETGN---HYAMKILDKQK-VVK---LK--QI-EHTL-----NEKRILQAV-N-----FPF-----LVKLEFSFK--D-----------------------------NSN--LYMVMEYVPGG-EMFSHLR---------RIG---RF---SEPHARFYAAQIVLTFEYLHSL--DLIYRDLKPENLL--ID----QQGYI---------QVTDFGFAK-------------RVKGRTWT---LCGTPEYLAPEIIL--------SKGYNKAVDWWALGVLIYEMAA-GY-PP---------------FF-AD------------QP-IQIYEKIVSGKVRFPSHFS---------------------------------------------------------------------------SDLKD-LLRNLLQVDLTKRFGNL-KNGVN-DIKNHKWF------------------------------------------------------
---F-ERKKTLGTGSFGRVMLVKH---K----ATEQ---YYAMKILDKQK-VVK---LK--QI-EHTL-----NEKRILQAV-N-----FPF-----LVRLEYAFK--D-----------------------------NSN--LYMVMEYVPGG-EMFSHLR---------RIG---RF---SEPHARFYAAQIVLTFEYLHSL--DLIYRDLKPENLL--ID----HQGYI---------QVTDFGFAK-------------RVKGRTWT---LCGTPEYLAPEIIL--------SKGYNKAVDWWALGVLIYEMAA-GY-PP---------------FF-AD------------QP-IQIYEKIVSGKVRFPSHFS---------------------------------------------------------------------------SDLKD-LLRNLLQVDLTKRFGNL-KNGVS-DIKTHKWF------------------------------------------------------
----FERLRTLGMGSFGRVMLVRH---Q----ETGG---HYAMKILNKQK-VVK---MK--QV-EHIL-----NEKRILQAI-D-----FPF-----LVKLQFSFK--D-----------------------------NSY--LYLVMEYVPGG-EMFSRLQ---------RVG---RF---SEPHACFYAAQVVLAVQYLHSL--DLIHRDLKPENLL--ID----QQGYL---------QVTDFGFAK-------------RVKGRTWT---LCGTPEYLAPEIIL--------SKGYNKAVDWWALGVLIYEMAV-GF-PP---------------FY-AD------------QP-IQIYEKIVSGRVRFPSKLS---------------------------------------------------------------------------SDLKH-LLRSLLQVDLTKRFGNL-RNGVG-DIKNHKWF------------------------------------------------------
--FI--FHKVLGKGSFGKVLLGEL---K----GRGE---YFAIKALKKDV-VLI---DD--DV-ECTM-----VEKRVLTLAAE-----NPF-----LTHLICTFQ--T-----------------------------KDH--LFFVMEFLNGG-DLMYHIQ---------DKG---RF---ELYRATFYAAEIMCGLQFLHSK--GIIYRDLKLDNVL--LD----RDGHI---------KIADFGMCKEN----------IFGESRAST---FCGTPDYIAPEILQ--------GLKYTFSVDWWSFGVLLYEMLI-GQ-SP---------------FH-GD------------DE-DELFESIRVDTPHYPRWIT---------------------------------------------------------------------------KESKD-ILEKLFEREPTKRLG-----VTG-NIKIHPFF------------------------------------------------------
---F-DLLRVIGRGSYAKVLLVRL---K----KTDR---IYAMKVVKKEL-VND---DE--DI-DWVQ-----TEKHVFEQASN-----HPF-----LVGLHSCFQ--T-----------------------------ESR--LFFVIEYVNGG-DLMFHMQ---------RQR---KL---PEEHARFYSAEISLALNYLHER--GIIYRDLKLDNVL--LD----SEGHI---------KLTDYGMCKEG----------LRPGDTTST---FCGTPNYIAPEILR--------GEDYGFSVDWWALGVLMFEMMA-GR-SP---------------FD-IVGSS---DNPDQNTE-DYLFQVILEKQIRIPRSLS---------------------------------------------------------------------------VKAAS-VLKSFLNKDPKERLGCHPQTGFA-DIQGHPF-F-----------------------------------------------------
--FI--LHKMLGKGSFGKVFLAEF---K----KTNQ---FFAIKALKKDV-VLM---DD--DV-ECTM-----VEKRVLSLAWE-----HPF-----LTHMFCTFQ--T-----------------------------KEN--LFFVMEYLNGG-DLMYHIQ---------SCH---KF---DLSRATFYAAEIILGLQFLHSK--GIVYRDLKLDNIL--LD----KDGHI---------KIADFGMCKEN----------MLGDAKTNT---FCGTPDYIAPEILL--------GQKYNHSVDWWSFGVLLYEMLI-GQ-SP---------------FH-GQ------------DE-EELFHSIRMDNPFYPRWLE---------------------------------------------------------------------------KEAKD-LLVKLFVREPEKRLG------VRGDIRQHPLF------------------------------------------------------
---F-DLIRVIGRGSYAKVLLVRL---K----KNDQ---IYAMKVVKKEL-VHD---DE--DI-DWVQ-----TEKHVFEQASS-----NPF-----LVGLHSCFQ--T-----------------------------TSR--LFLVIEYVNGG-DLMFHMQ---------RQR---KL---PEEHARFYAAEICIALNFLHER--GIIYRDLKLDNVL--LD----ADGHI---------KLTDYGMCKEG----------LGPGDTTST---FCGTPNYIAPEILR--------GEEYGFSVDWWALGVLMFEMMA-GR-SP---------------FD-IITD-----NPDMNTE-DYLFQVILEKPIRIPRFLS---------------------------------------------------------------------------VKASH-VLKGFLNKDPKERLGCRPQTGF----------SDIKSHAFF---------------------------------------------
--PD----EVLGSGQFGIVYGGKH---R----KTGR---DVAIKIIDKLR-FPT---KQ--ES-QLRN------EVAILQNL-H-----HPG-----VVNLECMFE--T-----------------------------PER--VFVVMEKLHGD-MLEMILS--------SEKG---RL---PEHITKFLITQILVALRHLHFK--NIVHCDLKPENVL--LA----SADPFP------QVKLCDFGFARI-----------IGEKSFRRS---VVGTPAYLAPEVLR--------NKGYNRSLDMWSVGVIIYVSLS-GT-FP---------------FN-ED---------------EDIHDQIQNAAFMYPPNPWKEIS-----------------------------------------------------------------------HEAID-LINNLLQVKMRKRYS------VD-KTLSHPWL------------------------------------------------------
--PD----EVLGSGQFGVVYGGKH---R----KTGR---DVAVKVIDKLR-FPT---KQ--ES-QLRN------EVAILQSL-R-----HPG-----IVNLECMFE--T-----------------------------PEK--VFVVMEKLHGD-MLEMILS--------SEKG---RL---PERLTKFLITQILVALRHLHFK--NIVHCDLKPENVL--LA----SADPFP------QVKLCDFGFARI-----------IGEKSFRRS---VVGTPAYLAPEVLL--------NQGYNRSLDMWSVGVIMYVSLS-GT-FP---------------FN-ED---------------EDINDQIQNAAFMYPASPWSHIS-----------------------------------------------------------------------AGAID-LINNLLQVKMRKRYS------VD-KSLSHPWL------------------------------------------------------
-FAD----EVLGSGQFGIVYGGKH---R----KTGR---DVAIKVIDKMR-FPT---KQ--ES-QLRN------EVAILQNL-H-----HPG-----IVNLECMFE--T-----------------------------PER--VFVVMEKLHGD-MLEMILS--------SEKS---RL---PERITKFMVTQILVALRNLHFK--NIVHCDLKPENVL--LA----SAEPFP------QVKLCDFGFARI-----------IGEKSFRRS---VVGTPAYLAPEVLR--------SKGYNRSLDMWSVGVIIYVSLS-GT-FP---------------FN-ED---------------EDINDQIQNAAFMYPPNPWREIS-----------------------------------------------------------------------GEAID-LINNLLQVKMRKRYS------VD-KSLSHPWL------------------------------------------------------
---F-NIIDTLGVGGFGRVELVQL---KS---EESK---TFAMKILKKRH-IVD---TR--QQ-EHIR-----SEKQIMQGA-H-----SDF-----IVRLYRTFK--D-----------------------------SKY--LYMLMEACLGG-ELWTILR---------DRG---SF---EDSTTRFYTACVVEAFAYLHSK--GIIYRDLKPENLI--LD----HRGYA---------KLVDFGFAKK-----------IGFGKKTWT---FCGTPEYVAPEIIL--------NKGHDISADYWSLGILMYELLT-GS-PP---------------FS-GP------------DP-MKTYNIILRGIDMIEFPKKIA-------------------------------------------------------------------------KNAAN-LIKKLCRDNPSERLGNL-KNGVK-DIQKHKWF------------------------------------------------------
---L-EIIATLGVGGFGRVELVKV---K----NENV---AFAMKCIRKKH-IVD---TK--QQ-EHVY-----SEKRILEEL-C-----SPF-----IVKLYRTFK--D-----------------------------NKY--VYMLLEACLGG-ELWSILR---------DRG---SF---DEPTSKFCVACVTEAFDYLHRL--GIIYRDLKPENLI--LD----AEGYL---------KLVDFGFAKK-----------IGSGQKTWT---FCGTPEYVAPEVIL--------NKGHDFSVDFWSLGILVYELLT-GN-PP---------------FS-GV------------DQ-MMTYNLILKGIEKMDFPRKIT-------------------------------------------------------------------------RRPED-LIRRLCRQNPTERLGNL-KNGIN-DIKKHRWL------------------------------------------------------
--FD--TLATVGTGTFGRVHLVKE---K----TAKH---FFALKVMSIPD-VIR---LK--QE-QHVH-----NEKSVLKEV-S-----HPF-----LIRLFWTWH--D-----------------------------ERF--LYMLMEYVPGG-ELFSYLR---------NRG---RF---SSTTGLFYSAEIICAIEYLHSK--EIVYRDLKPENIL--LD----RDGHI---------KLTDFGFAKK-------------LVDRTWT---LCGTPEYLAPEVIQ--------SKGHGRAVDWWALGILIFEMLS-GF-PP---------------FF-DD------------NP-FGIYQKILAGKIDFPRHLD---------------------------------------------------------------------------FHVKD-LIKKLLVVDRTRRLGNM-KNGAN-DVKHHRWF------------------------------------------------------
----FELLRVLGKGGYGKVFQVRKVTGA----NTGK---IFAMKVLKKAM-IVR---NA--KD-TAHTK----AERNILEEV-K-----HPF-----IVDLIYAFQ--T-----------------------------GGK--LYLILEYLSGG-ELFMQLE---------REG---IF---MEDTACFYLAEISMALGHLHQK--GIIYRDLKPENIM--LN----HQGHV---------KLTDFGLCKES----------IHDGTVTHT---FCGTIEYMAPEILM--------RSGHNRAVDWWSLGALMYDMLT-GA-PP---------------FT-GE------------NR-KKTIDKILKCKLNLPPYLT---------------------------------------------------------------------------QEARD-LLKKLLKRNAASRLGAG-PGDAG-EVQAHPFF------------------------------------------------------
----FELLRVLGKGGYGKVFQVRK---V----QGTNLGKIYAMKVLRKAK-IVR---NA--KD-TAHTR----AERNILESV-K-----HPF-----IVELAYAFQ--T-----------------------------GGK--LYLILECLSGG-ELFTHLE---------REG---IF---LEDTACFYLAEITLALGHLHSQ--GIIYRDLKPENIM--LS----SQGHI---------KLTDFGLCKES----------IHEGAVTHT---FCGTIEYMAPEILV--------RSGHNRAVDWWSLGALMYDMLT-GS-PP---------------FT-AE------------NR-KKTMDKIIRGKLALPPYLT---------------------------------------------------------------------------PDARD-LVKKFLKRNPSQRIGGG-PGDAA-DVQRHPFF------------------------------------------------------
----YELVRELGKGTYGKVDLVVY---K----GTGT---KMALKFVNKSK-TKL---KN--F----LR------EVSITNSLSS-----SPF-----IIKVFDVVF--E----------------------------TEDC--YVFAQEYAPAG-DLFDIIP---------PQV---GL---PEDTVKRCVQQLGLALDFMHGR--QLVHRDIKPENVL--LFD--RECRRV---------KLADFGMTR-------------RVGCRVKR---VSGTIPYTAPEVCQAG---RADGLAVDTGVDVWAFGVLIFCVLT-GN-FP---------------WE-AA---------SGADAFFEEFVRWQRGRLPGLPSQWRRFT-----------------------------------------------------------------------EPALR-MFQRLLALEPERRGP------AK-EVF-----RFLKH-------------------------------------------------
----WEIIGELGDGAFGKVYKAQN---K----ETSV---LAAAKVIDTKS-EEE---LE--DY-M--V------EIDILASC-D-----HPN-----IVKLLDAFY--Y-----------------------------ENN--LWILIEFCAGG-AVDAVML--------ELER---PL---TESQIQVVCKQTLDALNYLHDN--KIIHRDLKAGNIL--FT----LDGDI---------KLADFGVSAKN----------TRTIQRRDS---FIGTPYWMAPEVVMCE---TSKDRPYDYKADVWSLGITLIEMAE-IE-PP---------------HH-EL---------NPMRV-LLKIAKSEPPTLAQPSRWS---------------------------------------------------------------------------SNFKD-FLKKCLEKNVDARWT------TS-QLLQHPFV------------------------------------------------------
----FTKLEKIGKGSFGEVFKGID---N----RTQK---VVAIKIIDLEE-AED---EI--ED-IQ-Q------EITVLSQC-D-----SPY-----VTKYYGSYL--K-----------------------------DTK--LWIIMEYLGGG-SALDLLE----------PG---PL---DETQIATILREILKGLDYLHSE--KKIHRDIKAANVL--LS----EHGEV---------KLADFGVAGQL----------TDTQIKRNT---FVGTPFWMAPEVIK--------QSAYDSKADIWSLGITAIELAR-GE-PP---------------HS-EL---------HPMKV-LFLIPKNNPPTLEGNYS-----------------------------------------------------------------------------KPLKE-FVEACLNKEPSFRPT------AK-ELLKHKFI------------------------------------------------------
---F-TKLDRIGKGSFGEVYKGID---N----HTKE---VVAIKIIDLEE-AED---EI--ED-IQ-Q------EITVLSQC-D-----SPY-----ITRYFGSYL--K-----------------------------STK--LWIIMEYLGGG-SALDLLK----------PG---PL---EETYIATILREILKGLDYLHSE--RKIHRDIKAANVL--LS----EQGDV---------KLADFGVAGQL----------TDTQIKRNT---FVGTPFWMAPEVIK--------QSAYDFKADIWSLGITAIELAK-GE-PP---------------NS-DL---------HPMRV-LFLIPKNSPPTLEGQHS-----------------------------------------------------------------------------KPFKE-FVEACLNKDPRFRPT------AK-ELLKHKFI------------------------------------------------------
----YTFGRILGKGSFGIVIEATD---K----ETET---KWAIKKVNKEK-AGS---SA--VK-LLER------EVNILKSV-K-----HEH-----IIHLEQVFE--T-----------------------------PKK--MYLVMELCEDG-ELKEILD---------RKG---HF---SENETRWIIQSLASAIAYLHNN--DIVHRDLKLENIM--VK----SSLIDDNNEINLNIKVTDFGLAVKK---------QSRSEAMLQA---TCGTPIYMAPEVIS--------AHDYSQQCDIWSIGVVMYMLLR-GE-PP---------------FL-AS------------SE-EKLFELIRKGELHFENAVWNSIS-----------------------------------------------------------------------DCAKS-VLKQLMKVDPAHRIT------AK-ELLDNQWL------------------------------------------------------
----YHVLEMIGEGSFGRVYKGRR---K----YSAQ---VVALKFIPKLG-RSE---KE--LR-NLQR------EIEIMRGL-R-----HPN-----IVHMLDSFE--T-----------------------------DKE--VVVVTDYAEG--ELFQILE---------DDG---KL---PEDQVQAIAAQLVSALYYLHSH--RILHRDMKPQNIL--LA----KGGGI---------KLCDFGFARAM----------STNTMVLTS---IKGTPLYMSPELVE--------ERPYDHTADLWSVGCILYELAV-GT-PP---------------FY-AT------------SI-FQLVSLILKDPVRWPSTIS---------------------------------------------------------------------------PCFKN-FLQGLLTKDPRQRLS------WP-DLLYHPFI------------------------------------------------------
-WLL---SDILGQGATANVFRGRH---K----KTGD---LFAIKVFNNIS-FLR---PV--DV-Q-MR------EFEVLKKL-N-----HKN-----IVKLFAIEE--ET---------------------------TTRH--KVLIMEFCPCG-SLYTVLEE------PSNAY---GL---PESEFLIVLRDVVGGMNHLREN--GIVHRDIKPGNIMRVIG----EDGQSV-------YKLTDFGAARE-----------LEDDEQFVS---LYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAAT-GS-LP---------------FR-PF--------EGPRRN-KEVMYKIITGKPSGAISGVQKAENGPIDWSGDM--------------------------------------------------PVSCSLSRGLQV-------------------------------------LLTPVLANILEADQEKCWGFDQFFAETSDILHRMVIHVFSLQQMTAHKIYIHSY
--YL--LLHLLGRGGFSEVYKAFD---L----TEQR---YVAVKIHQLNK-NWR---DE--KK-ENYHKH-ACREYRIHKEL-D-----HPR-----IVKLYDYFS--L----------------------------DTDS--FCTVLEYCEGN-DLDFYLK---------QHK---LM---SEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNIL--LV----NGTACG------EIKITDFGLSKIMDDD---SYNSVDGMELTSQ---GAGTYWYLPPECFVV----GKEPPKISNKVDVWSVGVIFYQCLY-GR-KP---------------FG-HN----------QSQQ-DILQENTILKATEVQFPPKPVVT-----------------------------------------------------------------------PEAKA-FIRRCLAYRKEDRID------VQ-QLACDPYL------------------------------------------------------
--FI--LTERLGSGTYATVYKAYA---KK---DTRE---VVAIKCVAKKS-LNK---AS--VE-NLLT------EIEILKGI-R-----HPH-----IVQLKDFQW--D-----------------------------SDN--IYLIMEFCAGG-DLSRFIH---------TRR---IL---PEKVARVFMQQLASALQFLHER--NISHLDLKPQNIL--LSS--LEKPHL---------KLADFGFAQH-----------MSPWDEKHV---LRGSPLYMAPEMVC--------QRQYDARVDLWSMGVILYEALF-GQ-PP---------------FA-SR---------SFSEL-EEKIRSNRVIELPLRPLLS---------------------------------------------------------------------------RDCRD-LLQRLLERDPSRRIS------FQ-DFFAHPWV------------------------------------------------------
LIAD----IELGCGNFGSVRQGVY---R--MRKKQI---DVAIKVLK-QG-TE----KADTEE-MM-R------EAQIMHQL-D-----NPY-----IVRLIGVCQ--------------------------------AEA--LMLVMEMAGGG-PLHKFLV----------GK-REEI---PVSNVAELLHQVSMGMKYLEEK--NFVHRDLAARNVL--LV----NRHYA---------KISDFGLSKAL----GA----D--DSYYTARSAGKWPLKWYAPECIN--------FRKFSSRSDVWSYGVTMWEALSYGQ-KP---------------YK-KM---------KGPEV-MAFIEQGKRMECPPECP-----------------------------------------------------------------------------PELYA-LMSDCWIYKWEDRPD------FL-TVEQR--M------------------------------------------------------
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