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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK ABL1 203
TK ABL2 288
TKL ACVR1 208
TK BLK 241
TK BMX 422
CAMK BRSK1 50
CAMK BRSK2 19
TK BTK 402
CMGC CDC2 4
CMGC CDC2L5 705
CMGC CDK2 4
CMGC CDK3 4
CMGC CDK5 4
CMGC CDKL2 4
CMGC CDKL3 4
CAMK CHEK1 9
TK CSF1R 582
TK CSK 195
CAMK DAPK1 13
CAMK DAPK2 23
TK EGFR 712
TK EPHA8 635
TK EPHB1 619
TK EPHB2 621
TK EPHB4 615
TK EPHB6 670
TK FGFR1 478
TK FGFR2 481
TK FGFR3 472
TK FGFR4 467
TK FGR 263
TK FRK 234
TK FYN 271
TK HCK 241
CMGC ICK 4
TK JAK2 849
CAMK KIAA0999 66
TK KIT 589
TK LCK 245
TK LYN 247
CMGC MAK 4
CMGC MAPK14 24
CAMK MARK2 53
CAMK MARK4 59
TK MATK 235
CAMK MGC42105 74
CAMK NUAK1 55
CAMK NUAK2 97
TK PDGFRA 593
TK PDGFRB 600
AGC PDPK1 82
AGC PKN1 615
AGC PRKCA 339
AGC PRKCE 408
CAMK PRKD1 583
CAMK PRKD2 551
CAMK PRKD3 576
TK PTK2 422
TK PTK6 191
Other SBK1 53
CAMK SIK1 27
CAMK SIK2 20
CAMK SNRK 16
TK SRC 270
TK SRMS 230
CAMK STK17A 61
CAMK STK17B 33
TK SYK 371
TK TNK1 116
TK TNK2 150
CAMK TSSK2 12
TK YES1 277
TK ZAP70 338
-----ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTL---K-E--DTM-EV---EE-FL-K----EAAVMKEI--K---HPNLVQLLGVCT--R----------EPPFYIITEFMTYGNLLDYLR----EC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKK--------NFIHRDLAARNCLVG--ENHLV----KVADFGLSRLM-------T--GDTY-TAHAGAKFPIKWTAPESLA------YNKFSIKSDVWAFGVLLWEIATYGM----------SP---------------YPGI-----DLSQV-YELL-EKDYRMERPEGCP-------------------------------EKVYE-LMRACWQWNPSDRPS-------FAEIHQA--F--------------
-----ITMKHKLGGGQYGEVYVGVWK-------KYSLTVAVKTL---K-E--DTM-EV---EE-FL-K----EAAVMKEI--K---HPNLVQLLGVCT--L----------EPPFYIVTEYMPYGNLLDYLR----EC-------------------------------------------------------------------------------------------------NREEVTAVVLLYMATQISSAMEYLEKK--------NFIHRDLAARNCLVG--ENHVV----KVADFGLSRLM-------T--GDTY-TAHAGAKFPIKWTAPESLA------YNTFSIKSDVWAFGVLLWEIATYGM----------SP---------------YPGI-----DLSQV-YDLL-EKGYRMEQPEGCP-------------------------------PKVYE-LMRACWKWSPADRPS-------FAETHQA--F--------------
----I-TLLECVGKGRYGEVWRGSWQ-------GEN--VAVKIF---SSR--DEKSWF---RE-T-------ELYNTVML--R---HENILGFIASDM--TSR------HSSTQLWLITHYHEMGSLYDYLQ----LT----------------------------------------------------------------------------------------------------TLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVK--KNGQC----CIADLGLAVMHSQ---STNQLDVGN-NP---RVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVAR-RMVSNGIVEDYKPP---------------FYDVVPNDPSFEDM-RKVV-CVDQQRPNIPNRWFSDPTL-------------------------TSLAK-LMKECWYQNPSARLT-------ALRIKK----TL------------
----L-RLVRKLGSGQFGEVWMGYYK--------NNMKVAIKTL---K-E--GTM-SP---EA-FL-G----EANVMKAL--Q---HERLVRLYAVVT-------------KEPIYIVTEYMARGCLLDFLK----TD-------------------------------------------------------------------------------------------------EGSRLSLPRLIDMSAQIAEGMAYIERM--------NSIHRDLRAANILVS--EALCC----KIADFGLARII----------DSEY-TAQEGAKFPIKWTAPEAIH------FGVFTIKADVWSFGVLLMEVVTYGR----------VP---------------YPGM-----SNPEV-IRNL-ERGYRMPRPDTCP-------------------------------PELYRGVIAECWRSRPEERPT-------FEFLQSV--L--------------
-----ITLLKELGSGQFGVVQLGKWK--------GQYDVAVKMI---K-E--GSM-SE---DE-FF-Q----EAQTMMKL--S---HPKLVKFYGVCS--K----------EYPIYIVTEYISNGCLLNYLR----SH--------------------------------------------------------------------------------------------------GKGLEPSQLLEMCYDVCEGMAFLESH--------QFIHRDLAARNCLVD--RDLCV----KVSDFGMTRYV-------L--DDQY-VSSVGTKFPVKWSAPEVFH------YFKYSSKSDVWAFGILMWEVFSLGK----------QP---------------YDLY-----DNSQV-VLKV-SQGHRLYRPHLAS-------------------------------DTIYQ-IMYSCWHELPEKRPT-------FQQLLSS--I--------------
-----YRLEKTLGKGQTGLVKLGVHC-------ITGQKVAIKIV---NRE--KLSESV---LM-KVER----EIAILKLI--E---HPHVLKLHDVYE--N----------KKYLYLVLEHVSGGELFDYLV---KKG----------------------------------------------------------------------------------------------------RLTPKEARKFFRQIVSALDFCHSY--------SICHRDLKPENLLLD--EKNNI----RIADFGMASL--------QVGDSLL-ET---SCGSPHYACPEVIK-----GEKYDGRRADMWSCGVILFALLV-GA----------LP---------------FDDD--------NL-RQLL-EKVKRGVFHMPHFIP-----------------------------PDCQS-LLRGMIEVEPEKRLS-------LEQIQKHPW-Y-------------
-----YRLEKTLGKGQTGLVKLGVHC-------VTCQKVAIKIV---NRE--KLSESV---LM-KVER----EIAILKLI--E---HPHVLKLHDVYE--N----------KKYLYLVLEHVSGGELFDYLV---KKG----------------------------------------------------------------------------------------------------RLTPKEARKFFRQIISALDFCHSH--------SICHRDLKPENLLLD--EKNNI----RIADFGMASL--------QVGDSLL-ET---SCGSPHYACPEVIR-----GEKYDGRKADVWSCGVILFALLV-GA----------LP---------------FDDD--------NL-RQLL-EKVKRGVFHMPHFIP-----------------------------PDCQS-LLRGMIEVDAARRLT-------LEHIQKHIW-Y-------------
-----LTFLKELGTGQFGVVKYGKWR--------GQYDVAIKMI---K-E--GSM-SE---DE-FI-E----EAKVMMNL--S---HEKLVQLYGVCT--K----------QRPIFIITEYMANGCLLNYLR----EM--------------------------------------------------------------------------------------------------RHRFQTQQLLEMCKDVCEAMEYLESK--------QFLHRDLAARNCLVN--DQGVV----KVSDFGLSRYV-------L--DDEY-TSSVGSKFPVRWSPPEVLM------YSKFSSKSDIWAFGVLMWEIYSLGK----------MP---------------YERF-----TNSET-AEHI-AQGLRLYRPHLAS-------------------------------EKVYT-IMYSCWHEKADERPT-------FKILLSN--I--------------
-----YTKIEKIGEGTYGVVYKGRHK-------TTGQVVAMKKI---RLE--SEEEGV---PS-TAIR----EISLLKEL--R---HPNIVSLQDVLM--Q----------DSRLYLIFEFLSM-DLKKYLDSIPPGQ----------------------------------------------------------------------------------------------------YMDSSLVKSYLYQILQGIVFCHSR--------RVLHRDLKPQNLLID--DKGTI----KLADFGLARAF-------GIPIRVY-TH---EVVTLWYRSPEVLL-----GSARYSTPVDIWSIGTIFAELAT-KK----------PL---------------FHGD-----SEIDQ-LFRI-FRALGTPNNEVWPEVESLQDYKNTFPKWKP---GSLASHVKNLDENGLD-LLSKMLIYDPAKRIS-------GKMALNHPYF--------------
----F-DIIGIIGEGTYGQVYKARDK-------DTGEMVALKKV---RLD--NEKEGF---PI-TAIR----EIKILRQL--T---HQSIINMKEIVT--DKEDALDFKKDKGAFYLVFEYMDH-DLMGLLE--SGLV----------------------------------------------------------------------------------------------------HFNENHIKSFMRQLMEGLDYCHKK--------NFLHRDIKCSNILLN--NRGQI----KLADFGLARLY------SSEESRPY-TN---KVITLWYRPPELLL-----GEERYTPAIDVWSCGCILGELFT-KK----------PI---------------FQAN-----QELAQ-LELI-SRICGSPCPAVWPDVIKLPYFNTMKPKKQY--RRKLREEFVFIPAAALD-LFDYMLALDPSKRCT-------AEQALQCEF-L-------------
-----FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKI---RLD--TETEGV---PS-TAIR----EISLLKEL--N---HPNIVKLLDVIH--T----------ENKLYLVFEFLHQ-DLKKFMDA-SALT----------------------------------------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSH--------RVLHRDLKPQNLLIN--TEGAI----KLADFGLARAF-------GVPVRTY-TH---EVVTLWYRAPEILL-----GCKYYSTAVDIWSLGCIFAEMVT-RR----------AL---------------FPGD-----SEIDQ-LFRI-FRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---QDFSKVVPPLDEDGRS-LLSQMLHYDPNKRIS-------AKAALAHPFF--------------
-----FQKVEKIGEGTYGVVYKAKNR-------ETGQLVALKKI---RLD--LEMEGV---PS-TAIR----EISLLKEL--K---HPNIVRLLDVVH--N----------ERKLYLVFEFLSQ-DLKKYMDS-TPGS----------------------------------------------------------------------------------------------------ELPLHLIKSYLFQLLQGVSFCHSH--------RVIHRDLKPQNLLIN--ELGAI----KLADFGLARAF-------GVPLRTY-TH---EVVTLWYRAPEILL-----GSKFYTTAVDIWSIGCIFAEMVT-RK----------AL---------------FPGD-----SEIDQ-LFRI-FRMLGTPSEDTWPGVTQLPDYKGSFPKWTR---KGLEEIVPNLEPEGRD-LLMQLLQYDPSQRIT-------AKTALAHPYF--------------
-----YEKLEKIGEGTYGTVFKAKNR-------ETHEIVALKRV---RLD--DDDEGV---PS-SALR----EICLLKEL--K---HKNIVRLHDVLH--S----------DKKLTLVFEFCDQ-DLKKYFD--SCNG----------------------------------------------------------------------------------------------------DLDPEIVKSFLFQLLKGLGFCHSR--------NVLHRDLKPQNLLIN--RNGEL----KLADFGLARAF-------GIPVRCY-SA---EVVTLWYRPPDVLF-----GAKLYSTSIDMWSAGCIFAELANAGR----------PL---------------FPGN-----DVDDQ-LKRI-FRLLGTPTEEQWPSMTKLPDYKPYPMYPAT---TSLVNVVPKLNATGRD-LLQNLLKCNPVQRIS-------AEEALQHPYF--------------
-----YENLGLVGEGSYGMVMKCRNK-------DTGRIVAIKKF---LES--DDDKMV---KK-IAMR----EIKLLKQL--R---HENLVNLLEVCK--K----------KKRWYLVFEFVDHTILDDLEL---FPN----------------------------------------------------------------------------------------------------GLDYQVVQKYLFQIINGIGFCHSH--------NIIHRDIKPENILVS--QSGVV----KLCDFGFARTL-------AAPGEVY-TD---YVATRWYRAPELLV-----GDVKYGKAVDVWAIGCLVTEMFM-GE----------PL---------------FPGD-----SDIDQ-LYHI-MMCLGNLIPRHQELFNKNPVFAGVRLPEIKE-REPLERRYPKLSEVVID-LAKKCLHIDPDKRPF-------CAELLHHDFF--------------
-----YETLGKVGEGSYGTVMKCKHK-------NTGQIVAIKIF---YER--PEQSVN---K--IAMR----EIKFLKQF--H---HENLVNLIEVFR--Q----------KKKIHLVFEFIDHTVLDELQH---YCH----------------------------------------------------------------------------------------------------GLESKRLRKYLFQILRAIDYLHSN--------NIIHRDIKPENILVS--QSGIT----KLCDFGFARTL-------AAPGDIY-TD---YVATRWYRAPELVL-----KDTSYGKPVDIWALGCMIIEMAT-GN----------PY---------------LPSS-----SDLDL-LHKI-VLKVGN-LSPHLQNIFSKSPIFAGVVLPQVQHPKNARKKYPKLNGLLAD-IVHACLQIDPADRIS-------SSDLLHHEYF--------------
----W-DLVQTLGEGAYGEVQLAVNR-------VTEEAVAVKIV---DMK--RAVDCP---EN-I-KK----EICINKML--N---HENVVKFYGHRR--E----------GNIQYLFLEYCSGGELFDRIE---PDI----------------------------------------------------------------------------------------------------GMPEPDAQRFFHQLMAGVVYLHGI--------GITHRDIKPENLLLD--ERDNL----KISDFGLATVFR-----YNNRERLL-NK---MCGTLPYVAPELLK-----RREFHAEPVDVWSCGIVLTAMLA-GE----------LP---------------WDQP-------SDS-CQEY-SDWKEKKTYLNPWKKI--D-------------------------SAPLA-LLHKILVENPSARIT-------IPDIKKDRW-Y-------------
-----LQFGKTLGAGAFGKVVEATAFG--LGKEDAVLKVAVKML---K-S--TAH-ADE-KEA-LM-S----ELKIMSHLG-Q---HENIVNLLGACT--H----------GGPVLVITEYCCYGDLLNFLR----RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASK--------NCIHRDVAARNVLLT--NGHVA----KIGDFGLARDI----M--N--DSNY-IVKGNARLPVKWMAPESIF------DCVYTVQSDVWSYGILLWEIFSLGL----------NP---------------YPGI-L---VNSKF-YKLV-KDGYQMAQPAFAP-------------------------------KNIYS-IMQACWALEPTHRPT-------FQQICSFL----------------
-----LKLLQTIGKGEFGDVMLGDYR---------GNKVAVKCI---K-N--DAT-AQ----A-FL-A----EASVMTQL--R---HSNLVQLLGVIV-EE----------KGGLYIVTEYMAKGSLVDYLR----SR-------------------------------------------------------------------------------------------------GRSVLGGDCLLKFSLDVCEAMEYLEGN--------NFVHRDLAARNVLVS--EDNVA----KVSDFGLTKEA-------------S-STQDTGKLPVKWTAPEALR------EKKFSTKSDVWSFGILLWEIYSFGR----------VP---------------YPRI-----PLKDV-VPRV-EKGYKMDAPDGCP-------------------------------PAVYE-VMKNCWHLDAAMRPS-------FLQLREQL----------------
-----YDTGEELGSGQFAVVKKCREK-------STGLQYAAKFI---KKR--RTKSSR---RG-VSREDIEREVSILKEI--Q---HPNVITLHEVYE--N----------KTDVILILELVAGGELFDFLA---EKE----------------------------------------------------------------------------------------------------SLTEEEATEFLKQILNGVYYLHSL--------QIAHFDLKPENIMLL--DRNVPKPRIKIIDFGLAHK--------IDFGNEF-KN---IFGTPEFVAPEIVN------YEPLGLEADMWSIGVITYILLS-GA----------SP---------------FLGD--------TK-QETL-ANVSAVNYEFEDEYFSNTS-------------------------ALAKD-FIRRLLVKDPKKRMT-------IQDSLQHPWI--------------
-----YDIGEELGSGQFAIVKKCREK-------STGLEYAAKFI---KKR--QSRASR---RG-VSREEIEREVSILRQV--L---HHNVITLHDVYE--N----------RTDVVLILELVSGGELFDFLA---QKE----------------------------------------------------------------------------------------------------SLSEEEATSFIKQILDGVNYLHTK--------KIAHFDLKPENIMLL--DKNIPIPHIKLIDFGLAHE--------IEDGVEF-KN---IFGTPEFVAPEIVN------YEPLGLEADMWSIGVITYILLS-GA----------SP---------------FLGD--------TK-QETL-ANITAVSYDFDEEFFSQTS-------------------------ELAKD-FIRKLLVKETRKRLT-------IQEALRHPWI--------------
----F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKEL---R-E--ATS-PKA-NKE-IL-D----EAYVMASV--D---NPHVCRLLGICL-------------TSTVQLITQLMPFGCLLDYVR----EH--------------------------------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDR--------RLVHRDLAARNVLVK--TPQHV----KITDFGLAKLL----G--A--EEKE-YHAEGGKVPIKWMALESIL------HRIYTHQSDVWSYGVTVWELMTFGS----------KP---------------YDGI-----PASEI-SSIL-EKGERLPQPPICT-------------------------------IDVYM-IMVKCWMIDADSRPK-------FRELI----IEF------------
-----IHIEKIIGSGDSGEVCYGRLR----VPGQRDVPVAIKAL---K-A--GYT-ERQ-RRD-FL-S----EASIMGQF--D---HPNIIRLEGVVT--R----------GRLAMIVTEYMENGSLDTFLR----TH--------------------------------------------------------------------------------------------------DGQFTIMQLVGMLRGVGAGMRYLSDL--------GYVHRDLAARNVLVD--SNLVC----KVSDFGLSRVL----E--D--DPDAAYTTTGGKIPIRWTAPEAIA------FRTFSSASDVWSFGVVMWEVLAYGE----------RP---------------YWNM-----TNRDV-ISSV-EEGYRLPAPMGCP-------------------------------HALHQ-LMLDCWHKDRAQRPR-------FSQIVSVL----------------
----V-KIEEVIGAGEFGEVYKGRLK----LPGKREIYVAIKTL---K-A--GYS-EKQ-RRD-FL-S----EASIMGQF--D---HPNIIRLEGVVT--K----------SRPVMIITEFMENGALDSFLR----QN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLAEM--------NYVHRDLAARNILVN--SNLVC----KVSDFGLSRYLQ-DDT--S--DPTY-TSSLGGKIPVRWTAPEAIA------YRKFTSASDVWSYGIVMWEVMSFGE----------RP---------------YWDM-----SNQDV-INAI-EQDYRLPPPMDCP-------------------------------AALHQ-LMLDCWQKDRNSRPR-------FAEIVNTL----------------
----V-KIEQVIGAGEFGEVCSGHLK----LPGKREIFVAIKTL---K-S--GYT-EKQ-RRD-FL-S----EASIMGQF--D---HPNVIHLEGVVT--K----------STPVMIITEFMENGSLDSFLR----QN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLADM--------NYVHRDLAARNILVN--SNLVC----KVSDFGLSRFLE-DDT--S--DPTY-TSALGGKIPIRWTAPEAIQ------YRKFTSASDVWSYGIVMWEVMSYGE----------RP---------------YWDM-----TNQDV-INAI-EQDYRLPPPMDCP-------------------------------SALHQ-LMLDCWQKDRNHRPK-------FGQIVNTL----------------
----V-KIEEVIGAGEFGEVCRGRLK----APGKKESCVAIKTL---K-G--GYT-ERQ-RRE-FL-S----EASIMGQF--E---HPNIIRLEGVVT--N----------SMPVMILTEFMENGALDSFLR----LN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIASGMRYLAEM--------SYVHRDLAARNILVN--SNLVC----KVSDFGLSRFLE-ENS--S--DPTY-TSSLGGKIPIRWTAPEAIA------FRKFTSASDAWSYGIVMWEVMSFGE----------RP---------------YWDM-----SNQDV-INAI-EQDYRLPPPPDCP-------------------------------TSLHQ-LMLDCWQKDRNARPR-------FPQVVSAL----------------
-----IKIEEVIGTGSFGEVRQGRLQ----PRGRREQTVAIQAL---W-A--GGA-ESL-QMT-FL-G----RAAVLGQF--Q---HPNILRLEGVVT--K----------SRPLMVLTEFMELGPLDSFLR----QR--------------------------------------------------------------------------------------------------EGQFSSLQLVAMQRGVAAAMQYLSSF--------AFVHRSLSAHSVLVN--SHLVC----KVARLGHSPQG--------------------PSCLLRWAAPEVIA------HGKHTTSSDVWSFGILMWEVMSYGE----------RP---------------YWDM-----SEQEV-LNAI-EQEFRLPPPPGCP-------------------------------PGLHL-LMLDTWQKDRARRPH-------FDQLVA---AF-------------
----L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKML---K-S--DAT-EKD-LSD-LI-S----EMEMMKMIG-K---HKNIINLLGACT--Q----------DGPLYVIVEYASKGNLREYLQ----ARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASK--------KCIHRDLAARNVLVT--EDNVM----KIADFGLARDI----H--H--IDYY-KKTTNGRLPVKWMAPEALF------DRIYTHQSDVWSFGVLLWEIFTLGG----------SP---------------YPGV-----PVEEL-FKLL-KEGHRMDKPSNCT-------------------------------NELYM-MMRDCWHAVPSQRPT-------FKQLVEDL----------------
-----LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKML---K-D--DAT-EKD-LSD-LV-S----EMEMMKMIG-K---HKNIINLLGACT--Q----------DGPLYVIVEYASKGNLREYLR----ARRPPGMEY-----------------------------------------------------------------------------------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQ--------KCIHRDLAARNVLVT--ENNVM----KIADFGLARDI----N--N--IDYY-KKTTNGRLPVKWMAPEALF------DRVYTHQSDVWSFGVLMWEIFTLGG----------SP---------------YPGI-----PVEEL-FKLL-KEGHRMDKPANCT-------------------------------NELYM-MMRDCWHAVPSQRPT-------FKQLVEDL----------------
-----LTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKML---K-D--DAT-DKD-LSD-LV-S----EMEMMKMIG-K---HKNIINLLGACT--Q----------GGPLYVLVEYAAKGNLREFLR----ARRPPGLDY-----------------------------------------------------------------------------------SFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQ--------KCIHRDLAARNVLVT--EDNVM----KIADFGLARDV----H--N--LDYY-KKTTNGRLPVKWMAPEALF------DRVYTHQSDVWSFGVLLWEIFTLGG----------SP---------------YPGI-----PVEEL-FKLL-KEGHRMDKPANCT-------------------------------HDLYM-IMRECWHAAPSQRPT-------FKQLVEDL----------------
----L-VLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKML---K-D--NAS-DKD-LAD-LV-S----EMEVMKLIG-R---HKNIINLLGVCT--Q----------EGPLYVIVECAAKGNLREFLR----ARRPPGPDL-----------------------------------------------------------------------------------SPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESR--------KCIHRDLAARNVLVT--EDNVM----KIADFGLARGV----H--H--IDYY-KKTSNGRLPVKWMAPEALF------DRVYTHQSDVWSFGILLWEIFTLGG----------SP---------------YPGI-----PVEEL-FSLL-REGHRMDRPPHCP-------------------------------PELYG-LMRECWHAAPSQRPT-------FKQLVEAL----------------
-----ITLERRLGTGCFGDVWLGTWN--------GSTKVAVKTL---K-P--GTM-SP---KA-FL-E----EAQVMKLL--R---HDKLVQLYAVVS-------------EEPIYIVTEFMCHGSLLDFLK----NP-------------------------------------------------------------------------------------------------EGQDLRLPQLVDMAAQVAEGMAYMERM--------NYIHRDLRAANILVG--ERLAC----KIADFGLARLI-------K--DDEY-NPCQGSKFPIKWTAPEAAL------FGRFTIKSDVWSFGILLTELITKGR----------IP---------------YPGM-----NKREV-LEQV-EQGYHMPCPPGCP-------------------------------ASLYE-AMEQTWRLDPEERPT-------FEYLQSFL----------------
-----IQLLKRLGSGQFGEVWEGLWN--------NTTPVAVKTL---K-P--GSM-DP---ND-FL-R----EAQIMKNL--R---HPKLIQLYAVCT--L----------EDPIYIITELMRHGSLQEYLQ----ND-------------------------------------------------------------------------------------------------TGSKIHLTQQVDMAAQVASGMAYLESR--------NYIHRDLAARNVLVG--EHNIY----KVADFGLARVFK--VD--N--EDIY-ESRHEIKLPVKWTAPEAIR------SNKFSIKSDVWSFGILLYEIITYGK----------MP---------------YSGM-----TGAQV-IQML-AQNYRLPQPSNCP-------------------------------QQFYN-IMLECWNAEPKERPT-------FETLRWK--L--------------
-----LQLIKRLGNGQFGEVWMGTWN--------GNTKVAIKTL---K-P--GTM-SP---ES-FL-E----EAQIMKKL--K---HDKLVQLYAVVS-------------EEPIYIVTEYMNKGSLLDFLK----DG-------------------------------------------------------------------------------------------------EGRALKLPNLVDMAAQVAAGMAYIERM--------NYIHRDLRSANILVG--NGLIC----KIADFGLARLI-------E--DNEY-TARQGAKFPIKWTAPEAAL------YGRFTIKSDVWSFGILLTELVTKGR----------VP---------------YPGM-----NNREV-LEQV-ERGYRMPCPQDCP-------------------------------ISLHE-LMIHCWKKDPEERPT-------FEYLQSFL----------------
-----LKLEKKLGAGQFGEVWMATYN--------KHTKVAVKTM---K-P--GSM-SV---EA-FL-A----EANVMKTL--Q---HDKLVKLHAVVT-------------KEPIYIITEFMAKGSLLDFLK----SD-------------------------------------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQR--------NYIHRDLRAANILVS--ASLVC----KIADFGLARVI-------E--DNEY-TAREGAKFPIKWTAPEAIN------FGSFTIKSDVWSFGILLMEIVTYGR----------IP---------------YPGM-----SNPEV-IRAL-ERGYRMPRPENCP-------------------------------EELYN-IMMRCWKNRPEERPT-------FEYIQSV--L--------------
-----YTTIRQLGDGTYGSVLLGRSI-------ESGELIAIKKM---KRK--FYSWEE---C--MNLR----EVKSLKKL--N---HANVVKLKEVIR--E----------NDHLYFIFEYMKE-NLYQLIK--ERNK----------------------------------------------------------------------------------------------------LFPESAIRNIMYQILQGLAFIHKH--------GFFHRDLKPENLLCM--GPELV----KIADFGLARE--------IRSKPPY-TD---YVSTRWYRAPEVLL-----RSTNYSSPIDVWAVGCIMAEVYT-LR----------PL---------------FPGA-----SEIDT-IFKI-CQVLGTPKKTDWPEGYQLSSAMNFRWPQCV--PNNLKTLIPNASSEAVQ-LLRDMLQWDPKKRPT-------ASQALRYPYF--------------
-----LKFLQQLGKGNFGSVEMCRYDP---LQDNTGEVVAVKKL---Q-H--STE--EH-LRD-FE-R----EIEILKSL--Q---HDNIVKYKGVCYSAG----------RRNLKLIMEYLPYGSLRDYLQ----KH--------------------------------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTK--------RYIHRDLATRNILVE--NENRV----KIGDFGLTKVL---PQ--D--KEYY-KVKEPGESPIFWYAPESLT------ESKFSVASDVWSFGVVLYELFTYIE----------KSKSPPAEFMRMIGNDKQGQM-----IVFHL-IELL-KNNGRLPRPDGCP-------------------------------DEIYM-IMTECWNNNVNQRPS-------FRDLA----LRV------------
-----YEIDRTIGKGNFAVVKRATHL-------VTKAKVAIKII---DKT--QLDEEN---LK-KIFR----EVQIMKML--C---HPHIIRLYQVME--T----------ERMIYLVTEYASGGEIFDHLV---AHG----------------------------------------------------------------------------------------------------RMAEKEARRKFKQIVTAVYFCHCR--------NIVHRDLKAENLLLD--ANLNI----KIADFGFSNL--------FTPGQLL-KT---WCGSPPYAAPELFE-----GKEYDGPKVDIWSLGVVLYVLVC-GA----------LP---------------FDGS--------TL-QNLR-ARVLSGKFRIPFFMS-----------------------------TECEH-LIRHMLVLDPNKRLS-------MEQICKHKWM--------------
-----LSFGKTLGAGAFGKVVEATAYG--LIKSDAAMTVAVKML---K-P--SAH-LTE-REA-LM-S----ELKVLSYLG-N---HMNIVNLLGACT--I----------GGPTLVITEYCCYGDLLNFLR----RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASK--------NCIHRDLAARNILLT--HGRIT----KICDFGLARDI----K--N--DSNY-VVKGNARLPVKWMAPESIF------NCVYTFESDVWSYGIFLWELFSLGS----------SP---------------YPGM-P---VDSKF-YKMI-KEGFRMLSPEHAP-------------------------------AEMYD-IMKTCWDADPLKRPT-------FKQIVQL--I--------------
-----LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSL---K-Q--GSM-SP---DA-FL-A----EANLMKQL--Q---HQRLVRLYAVVT-------------QEPIYIITEYMENGSLVDFLK----TP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEER--------NYIHRDLRAANILVS--DTLSC----KIADFGLARLI-------E--DNEY-TAREGAKFPIKWTAPEAIN------YGTFTIKSDVWSFGILLTEIVTHGR----------IP---------------YPGM-----TNPEV-IQNL-ERGYRMVRPDNCP-------------------------------EELYQ-LMRLCWKERPEDRPT-------FDYLRSV--L--------------
-----IKLVKRLGAGQFGEVWMGYYN--------NSTKVAVKTL---K-P--GTM-SV---QA-FL-E----EANLMKTL--Q---HDKLVRLYAVVT--R----------EEPIYIITEYMAKGSLLDFLK----SD-------------------------------------------------------------------------------------------------EGGKVLLPKLIDFSAQIAEGMAYIERK--------NYIHRDLRAANVLVS--ESLMC----KIADFGLARVI-------E--DNEY-TAREGAKFPIKWTAPEAIN------FGCFTIKSDVWSFGILLYEIVTYGK----------IP---------------YPGR-----TNADV-MTAL-SQGYRMPRVENCP-------------------------------DELYD-IMKMCWKEKAEERPT-------FDYLQSV--L--------------
-----YTTMRQLGDGTYGSVLMGKSN-------ESGELVAIKRM---KRK--FYSWDE---CM--NLR----EVKSLKKL--N---HANVIKLKEVIR--E----------NDHLYFIFEYMKE-NLYQLMK--DRNK----------------------------------------------------------------------------------------------------LFPESVIRNIMYQILQGLAFIHKH--------GFFHRDMKPENLLCM--GPELV----KIADFGLARE--------LRSQPPY-TD---YVSTRWYRAPEVLL-----RSSVYSSPIDVWAVGSIMAELYM-LR----------PL---------------FPGT-----SEVDE-IFKI-CQVLGTPKKSDWPEGYQLASSMNFRFPQCV--PINLKTLIPNASNEAIQ-LMTEMLNWDPKKRPT-------ASQALKHPYF--------------
-----YQNLSPVGSGAYGSVCAAFDT-------KTGLRVAVKKL---SRP--FQSIIH---AK-RTYR----ELRLLKHM--K---HENVIGLLDVFT--PARS----LEEFNDVYLVTHLMGA-DLNNIVK----CQ----------------------------------------------------------------------------------------------------KLTDDHVQFLIYQILRGLKYIHSA--------DIIHRDLKPSNLAVN--EDCEL----KILDFGLAR----------HTDDEM-TG---YVATRWYRAPEIML-----NWMHYNQTVDIWSVGCIMAELLT-GR----------TL---------------FPGT-----DHIDQ-LKLI-LRLVGTPGAELLKKISSESARNYIQSLTQMP-KMNFANVFIGANPLAVD-LLEKMLVLDSDKRIT-------AAQALAHAYF--------------
-----YRLLKTIGKGNFAKVKLARHI-------LTGKEVAVKII---DKT--QLNSSS---LQ-KLFR----EVRIMKVL--N---HPNIVKLFEVIE--T----------EKTLYLVMEYASGGEVFDYLV---AHG----------------------------------------------------------------------------------------------------RMKEKEARAKFRQIVSAVQYCHQK--------FIVHRDLKAENLLLD--ADMNI----KIADFGFSNE--------FTFGNKL-DT---FCGSPPYAAPELFQ-----GKKYDGPEVDVWSLGVILYTLVS-GS----------LP---------------FDGQ--------NL-KELR-ERVLRGKYRIPFYMS-----------------------------TDCEN-LLKKFLILNPSKRGT-------LEQIMKDRWM--------------
-----YRLLRTIGKGNFAKVKLARHI-------LTGREVAIKII---DKT--QLNPSS---LQ-KLFR----EVRIMKGL--N---HPNIVKLFEVIE--T----------EKTLYLVMEYASAGEVFDYLV---SHG----------------------------------------------------------------------------------------------------RMKEKEARAKFRQIVSAVHYCHQK--------NIVHRDLKAENLLLD--AEANI----KIADFGFSNE--------FTLGSKL-DT---FCGSPPYAAPELFQ-----GKKYDGPEVDIWSLGVILYTLVS-GS----------LP---------------FDGH--------NL-KELR-ERVLRGKYRVPFYMS-----------------------------TDCES-ILRRFLVLNPAKRCT-------LEQIMKDKWI--------------
-----LTLGAQIGEGEFGAVLQGEYL---------GQKVAVKNI---K-C--DVT-AQ----A-FL-D----ETAVMTKM--Q---HENLVRLLGVIL-------------HQGLYIVMEHVSKGNLVNFLR----TR-------------------------------------------------------------------------------------------------GRALVNTAQLLQFSLHVAEGMEYLESK--------KLVHRDLAARNILVS--EDLVA----KVSDFGLAKAE-------------R-KGLDSSRLPVKWTAPEALK------HGKFTSKSDVWSFGVLLWEVFSYGR----------AP---------------YPKM-----SLKEV-SEAV-EKGYRMEPPEGCP-------------------------------GPVHV-LMSSCWEAEPARRPP-------FRKLAEKL----------------
-----YRIRGEIGSGNFSQVKLGIHS-------LTKEKVAIKIL---DKT--KLDQKT---QR-LLSR----EISSMEKL--H---HPNIIRLYEVVE--T----------LSKLHLVMEYAGGGELFGKIS---TEG----------------------------------------------------------------------------------------------------KLSEPESKLIFSQIVSAVKHMHEN--------QIIHRDLKAENVFYT--SNTCV----KVGDFGFSTV--------SKKGEML-NT---FCGSPPYAAPELFR-----DEHYIGIYVDIWALGVLLYFMVT-GT----------MP---------------FRAE--------TV-AKLK-KSILEGTYSVPPHV----S-------------------------EPCHR-LIRGVLQQIPTERYG-------IDCIMNDEWM--------------
-----YELQETLGKGTYGKVKRATER-------FSGRVVAIKSI---RKD--KIKDEQ---DM-VHIR---REIEIMSSL--N---HPHIISIYEVFE--N----------KDKIVIIMEYASKGELYDYIS---ERR----------------------------------------------------------------------------------------------------RLSERETRHFFRQIVSAVHYCHKN--------GVVHRDLKLENILLD--DNCNI----KIADFGLSNL--------YQKDKFL-QT---FCGSPLYASPEIVN-----GRPYRGPEVDSWALGVLLYTLVY-GT----------MP---------------FDGF--------DH-KNLI-RQISSGEYREPTQP------------------------------SDARG-LIRWMLMVNPDRRAT-------IEDIANHWW-V-------------
-----YEFLETLGKGTYGKVKKARES-------SGR-LVAIKSI---RKD--KIKDEQ---DL-MHIR---REIEIMSSL--N---HPHIIAIHEVFE--N----------SSKIVIVMEYASRGDLYDYIS---ERQ----------------------------------------------------------------------------------------------------QLSEREARHFFRQIVSAVHYCHQN--------RVVHRDLKLENILLD--ANGNI----KIADFGLSNL--------YHQGKFL-QT---FCGSPLYASPEIVN-----GKPYTGPEVDSWSLGVLLYILVH-GT----------MP---------------FDGH--------DH-KILV-KQISNGAYREPPK-----P-------------------------SDACG-LIRWLLMVNPTRRAT-------LEDVASHWW-V-------------
----L-VLGRVLGSGAFGKVVEGTAYG--LSRSQPVMKVAVKML---K-P--TAR-SSE-KQA-LM-S----ELKIMTHLG-P---HLNIVNLLGACT--K----------SGPIYIITEYCFYGDLVNYLH----KNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASK--------NCVHRDLAARNVLLA--QGKIV----KICDFGLARDI----M--H--DSNY-VSKGSTFLPVKWMAPESIF------DNLYTTLSDVWSYGILLWEIFSLGG----------TP---------------YPGM-M---VDSTF-YNKI-KSGYRMAKPDHAT-------------------------------SEVYE-IMVKCWNSEPEKRPS-------FYHLSE---IV-------------
----L-VLGRTLGSGAFGQVVEATAHG--LSHSQATMKVAVKML---K-S--TAR-SSE-KQA-LM-S----ELKIMSHLG-P---HLNVVNLLGACT--K----------GGPIYIITEYCRYGDLVDYLH----RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASK--------NCVHRDLAARNVLIC--EGKLV----KICDFGLARDI----M--R--DSNY-ISKGSTFLPLKWMAPESIF------NSLYTTLSDVWSFGILLWEIFTLGG----------TP---------------YPEL-P---MNEQF-YNAI-KRGYRMAQPAHAS-------------------------------DEIYE-IMQKCWEEKFEIRPP-------FSQLVL---LL-------------
----F-KFGKILGEGSFSTVVLAREL-------ATSREYAIKIL---EKR--HIIKEN---KVPYVTR----ERDVMSRL--D---HPFFVKLYFTFQ--D----------DEKLYFGLSYAKNGELLKYIR---KIG----------------------------------------------------------------------------------------------------SFDETCTRFYTAEIVSALEYLHGK--------GIIHRDLKPENILLN--EDMHI----QITDFGTAKVLS-----PESKQARA-NS---FVGTAQYVSPELLT------EKSACKSSDLWALGCIIYQLVA-GL----------PP---------------FRAG--------NE-YLIF-QKIIKLEYDFPEKFF-----------------------------PKARD-LVEKLLVLDATKRLG-------CEEM------EGYGPLKAHPF---
----F-KFLAVLGRGHFGKVLLSEFR-------PSGELFAIKAL---KKG--DIVARD---EV-ESLM---CEKRILAAV--TSAGHPFLVNLFGCFQ--T----------PEHVCFVMEYSAGGDLMLHIH----SD----------------------------------------------------------------------------------------------------VFSEPRAIFYSACVVLGLQFLHEH--------KIVYRDLKLDNLLLD--TEGYV----KIADFGLCKEG-------MGYGDRT-ST---FCGTPEFLAPEVLT------DTSYTRAVDWWGLGVLLYEMLV-GE----------SP---------------FPGD--------DE-EEVF-DSIVNDEVRYPRFLS-----------------------------AEAIG-IMRRLLRRNPERRLGSS--ERDAEDVKKQPFF--------------
----F-NFLMVLGKGSFGKVMLADRK-------GTEELYAIKIL---KKD--VVIQDD---DV-ECTM---VEKRVLALL-DK---PPFLTQLHSCFQ--T----------VDRLYFVMEYVNGGDLMYHIQ---QVG----------------------------------------------------------------------------------------------------KFKEPQAVFYAAEISIGLFFLHKR--------GIIYRDLKLDNVMLD--SEGHI----KIADFGMCKEH-------MMDGVTT-RT---FCGTPDYIAPEIIA------YQPYGKSVDWWAYGVLLYEMLA-GQ----------PP---------------FDGE--------DE-DELF-QSIMEHNVSYPKSLS-----------------------------KEAVS-VCKGLMTKHPAKRLG-------C---------GPEGERDVREHAFF
----F-NFIKVLGKGSFGKVMLAELK-------GKDEVYAVKVL---KKD--VILQDD---DV-DCTM---TEKRILALA-RK---HPYLTQLYCCFQ--T----------KDRLFFVMEYVNGGDLMFQIQ---RSR----------------------------------------------------------------------------------------------------KFDEPRSRFYAAEVTSALMFLHQH--------GVIYRDLKLDNILLD--AEGHC----KLADFGMCKEG-------ILNGVTT-TT---FCGTPDYIAPEILQ------ELEYGPSVDWWALGVLMYEMMA-GQ----------PP---------------FEAD--------NE-DDLF-ESILHDDVLYPVWLS-----------------------------KEAVS-ILKAFMTKNPHKRLGCVASQNGEDAIKQHP--FF------------
---PD----EVLGSGQFGIVYGGKHR-------KTGRDVAIKII---DKL--RFPTKQ---ES-QLRN----EVAILQNL--H---HPGVVNLECMFE--T----------PERVFVVMEKLHGDMLEMILS--SEKG----------------------------------------------------------------------------------------------------RLPEHITKFLITQILVALRHLHFK--------NIVHCDLKPENVLLA--SADPFP-QVKLCDFGFARI--------IGEKSFR-RS---VVGTPAYLAPEVLR------NKGYNRSLDMWSVGVIIYVSLS-GT----------FP---------------FNED-----------EDIH-DQIQNAAFMYPPNPWKEIS-------------------------HEAID-LINNLLQVKMRKRYS-------VDKTLSHPWL--------------
---PD----EVLGSGQFGVVYGGKHR-------KTGRDVAVKVI---DKL--RFPTKQ---ES-QLRN----EVAILQSL--R---HPGIVNLECMFE--T----------PEKVFVVMEKLHGDMLEMILS--SEKG----------------------------------------------------------------------------------------------------RLPERLTKFLITQILVALRHLHFK--------NIVHCDLKPENVLLA--SADPFP-QVKLCDFGFARI--------IGEKSFR-RS---VVGTPAYLAPEVLL------NQGYNRSLDMWSVGVIMYVSLS-GT----------FP---------------FNED-----------EDIN-DQIQNAAFMYPASPWSHIS-------------------------AGAID-LINNLLQVKMRKRYS-------VDKSLSHPWL--------------
--FAD----EVLGSGQFGIVYGGKHR-------KTGRDVAIKVI---DKM--RFPTKQ---ES-QLRN----EVAILQNL--H---HPGIVNLECMFE--T----------PERVFVVMEKLHGDMLEMILS--SEKS----------------------------------------------------------------------------------------------------RLPERITKFMVTQILVALRNLHFK--------NIVHCDLKPENVLLA--SAEPFP-QVKLCDFGFARI--------IGEKSFR-RS---VVGTPAYLAPEVLR------SKGYNRSLDMWSVGVIIYVSLS-GT----------FP---------------FNED-----------EDIN-DQIQNAAFMYPPNPWREIS-------------------------GEAID-LINNLLQVKMRKRYS-------VDKSLSHPWL--------------
-----IELGRCIGEGQFGDVHQGIYM----SPENPALAVAIKTC---K-N--CTS-DSV-REK-FL-Q----EALTMRQF--D---HPHIVKLIGVIT-------------ENPVWIIMELCTLGELRSFLQ----VR--------------------------------------------------------------------------------------------------KYSLDLASLILYAYQLSTALAYLESK--------RFVHRDIAARNVLVS--SNDCV----KLGDFGLSRYM-------E--DSTY-YKASKGKLPIKWMAPESIN------FRRFTSASDVWMFGVCMWEILMHGV----------KP---------------FQGV-----KNNDV-IGRI-ENGERLPMPPNCP-------------------------------PTLYS-LMTKCWAYDPSRRPR-------FTELKAQL----------------
----F-TLCRKLGSGYFGEVFEGLWK--------DRVQVAIKVI---S-R--DNL-LH--QQM-LQ-S----EIQAMKKL--R---HKHILALYAVVS--V----------GDPVYIITELMAKGSLLELLR----DS-------------------------------------------------------------------------------------------------DEKVLPVSELLDIAWQVAEGMCYLESQ--------NYIHRDLAARNILVG--ENTLC----KVGDFGLARLI----------KEDV-YLSHDHNIPYKWTAPEALS------RGHYSTKSDVWSFGILLHEMFSRGQ----------VP---------------YPGM-----SNHEA-FLRV-DAGYRMPCPLECP-------------------------------PSVHK-LMLTCWCRDPEQRPC-------FKALRERL----------------
-----YELVRELGKGTYGKVDLVVYK-------GTGTKMALKFV---NKS--KTKLKN---F----LR----EVSITNSL-SS---SPFIIKVFDVVF--E---------TEDCYVFAQEYAPAGDLFDIIP---PQV----------------------------------------------------------------------------------------------------GLPEDTVKRCVQQLGLALDFMHGR--------QLVHRDIKPENVLLFDRECRRV----KLADFGMTR----------RVGCRV-KR---VSGTIPYTAPEVCQAG-RADGLAVDTGVDVWAFGVLIFCVLT-GN----------FP---------------WEAA-----SGADAFFEEF-VRWQRGRLPGLPSQWRRFT-------------------------EPALR-MFQRLLALEPERRGP-------AKEVF-----RFLKH---------
-----YDIERTLGKGNFAVVKLARHR-------VTKTQVAIKII---DKT--RLDSSN---LE-KIYR----EVQLMKLL--N---HPHIIKLYQVME--T----------KDMLYIVTEFAKNGEMFDYLT---SNG----------------------------------------------------------------------------------------------------HLSENEARKKFWQILSAVEYCHDH--------HIVHRDLKTENLLLD--GNMDI----KLADFGFGNF--------YKSGEPL-ST---WCGSPPYAAPEVFE-----GKEYEGPQLDIWSLGVVLYVLVC-GS----------LP---------------FDGP--------NL-PTLR-QRVLEGRFRIPFFMS-----------------------------QDCES-LIRRMLVVDPARRIT-------IAQIRQHRWM--------------
-----YDIEGTLGKGNFAVVKLGRHR-------ITKTEVAIKII---DKS--QLDAVN---LE-KIYR----EVQIMKML--D---HPHIIKLYQVME--T----------KSMLYLVTEYAKNGEIFDYLA---NHG----------------------------------------------------------------------------------------------------RLNESEARRKFWQILSAVDYCHGR--------KIVHRDLKAENLLLD--NNMNI----KIADFGFGNF--------FKSGELL-AT---WCGSPPYAAPEVFE-----GQQYEGPQLDIWSMGVVLYVLVC-GA----------LP---------------FDGP--------TL-PILR-QRVLEGRFRIPYFMS-----------------------------EDCEH-LIRRMLVLDPSKRLT-------IAQIKEHKWM--------------
-----YDLDKTLGRGHFAVVKLARHV-------FTGEKVAVKVI---DKT--KLDTLA---TG-HLFQ----EVRCMKLV--Q---HPNIVRLYEVID--T----------QTKLYLILELGDGGDMFDYIM--KHEE----------------------------------------------------------------------------------------------------GLNEDLAKKYFAQIVHAISYCHKL--------HVVHRDLKPENVVFF-EKQGLV----KLTDFGFSNK--------FQPGKKL-TT---SCGSLAYSAPEILL-----GDEYDAPAVDIWSLGVILFMLVC-GQ----------PP---------------FQEA--------ND-SETL-TMIMDCKYTVPSHVS-----------------------------KECKD-LITRMLQRDPKRRAS-------LEEIENHPWL--------------
----L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTL---K-P--GTM-SP---EA-FL-Q----EAQVMKKL--R---HEKLVQLYAVVS-------------EEPIYIVTEYMSKGSLLDFLK----GE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERM--------NYVHRDLRAANILVG--ENLVC----KVADFGLARLI-------E--DNEY-TARQGAKFPIKWTAPEAAL------YGRFTIKSDVWSFGILLTELTTKGR----------VP---------------YPGM-----VNREV-LDQV-ERGYRMPCPPECP-------------------------------ESLHD-LMCQCWRKEPEERPT-------FEYLQAF--L--------------
---FA--LGRKLGEGYFGEVWEGLWL--------GSLPVAIKVI---K-S--ANM-K---LTD-LA-K----EIQTLKGL--R---HERLIRLHAVCS--G----------GEPVYIVTELMRKGNLQAFLG----TP-------------------------------------------------------------------------------------------------EGRALRLPPLLGFACQVAEGMSYLEEQ--------RVVHRDLAARNVLVD--DGLAC----KVADFGLARLL-------K--DDIY-SPSSSSKIPVKWTAPEAAN------YRVFSQKSDVWSFGVLLHEVFTYGQ----------CP---------------YEGM-----TNHET-LQQI-MRGYRLPRPAACP-------------------------------AEVYV-LMLECWRSSPEERPS-------FATLREKL----------------
--LCP---GRELGRGKFAVVRKCIKK-------DSGKEFAAKFM---RKR--RKGQDC---RM-EIIH----EIAVLELA-QD---NPWVINLHEVYE--T----------ASEMILVLEYAAGGEIFDQCVA-DREE----------------------------------------------------------------------------------------------------AFKEKDVQRLMRQILEGVHFLHTR--------DVVHLDLKPQNILLT--SESPLG-DIKIVDFGLSRI--------LKNSEEL-RE---IMGTPEYVAPEILS------YDPISMATDMWSIGVLTYVMLT-GI----------SP---------------FLGN--------DK-QETF-LNISQMNLSYSEEEFDVLS-------------------------ESAVD-FIRTLLVKKPEDRAT-------AEECLKHPWL--------------
--ILT---SKELGRGKFAVVRQCISK-------STGQEYAAKFL---KKR--RRGQDC---RA-EILH----EIAVLELA-KS---CPRVINLHEVYE--N----------TSEIILILEYAAGGEIFSLCLP-ELAE----------------------------------------------------------------------------------------------------MVSENDVIRLIKQILEGVYYLHQN--------NIVHLDLKPQNILLS--SIYPLG-DIKIVDFGMSRK--------IGHACEL-RE---IMGTPEYLAPEILN------YDPITTATDMWNIGIIAYMLLT-HT----------SP---------------FVGE--------DN-QETY-LNISQVNVDYSEETFSSVS-------------------------QLATD-FIQSLLVKNPEKRPT-------AEICLSHSWL--------------
--TLE---DKELGSGNFGTVKKGYYQ-----MKKVVKTVAVKIL---K-N--EAN-DPALKDE-LL-A----EANVMQQL--D---NPYIVRMIGICE-------------AESWMLVMEMAELGPLNKYLQ----QN---------------------------------------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEES--------NFVHRDLAARNVLLV--TQHYA----KISDFGLSKAL----R--A--DENYYKAQTHGKWPVKWYAPECIN------YYKFSSKSDVWSFGVLMWEAFSYGQ----------KP---------------YRGM-----KGSEV-TAML-EKGERMGCPAGCP-------------------------------REMYD-LMNLCWTYDVENRPG-------FAAVE----LRL------------
--VCR---GELLGSGCFGVVHRGLWT----LPSGKSVPVAVKSLRVGP-E--GPM-GTE-LGD-FL-R----EVSVMMNL--E---HPHVLRLHGLVL-------------GQPLQMVMELAPLGSLHARLT----AP------------------------------------------------------------------------------------------------APTPPLLVALLCLFLRQLAGAMAYLGAR--------GLVHRDLATRNLLLA--SPRTI----KVADFGLVRPL---GG--A--RGRY-VMGGPRPIPYAWCAPESLR------HGAFSSASDVWMFGVTLWEMFSGGE----------EP---------------WAGV-----PPYLI-LQRL-EDRARLPRPPLCS-------------------------------RALYS-LALRCWAPHPADRPS-------FSHLE----GLL------------
----L-RLLEKLGDGSFGVVRRGEWD----APSGKTVSVAVKCL---K-PDVLSQ-PEA-MDD-FI-R----EVNAMHSL--D---HRNLIRLYGVVL-------------TPPMKMVTELAPLGSLLDRLR----KH--------------------------------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESK--------RFIHRDLAARNLLLA--TRDLV----KIGDFGLMRAL---PQ--N--DDHY-VMQEHRKVPFAWCAPESLK------TRTFSHASDTWMFGVTLWEMFTYGQ----------EP---------------WIGL-----NGSQI-LHKIDKEGERLPRPEDCP-------------------------------QDIYN-VMVQCWAHKPEDRPT-------FVALRDF--L--------------
YIVGI-----NLGKGSYAKVKSAYSE-------RLKFNVAVKII---DRK--KTPTDF---VE-RF-LP--REMDILATV--N---HGSIIKTYEIFE--T---------SDGRIYIIMELGVQGDLLEFIK---CQG----------------------------------------------------------------------------------------------------ALHEDVARKMFRQLSSAVKYCHDL--------DIVHRDLKCENLLLD--KDFNI----KLSDFGFSKRCLR---DSNGRIILS-KT---FCGSAAYAAPEVLQ-----SIPYQPKVYDIWSLGVILYIMVC-GS----------MP---------------YDDS--------DI-RKML-RIQKEHRVDFPRSKNLT---------------------------CECKD-LIYRMLQPDVSQRLH-------IDEILSHSWL--------------
----L-RLEVKLGQGCFGEVWMGTWN--------GTTKVAIKTL---K-P--GTM-MP---EA-FL-Q----EAQIMKKL--R---HDKLVPLYAVVS-------------EEPIYIVTEFMSKGSLLDFLK----EG-------------------------------------------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIERM--------NYIHRDLRAANILVG--ENLVC----KIADFGLARLI-------E--DNEY-TARQGAKFPIKWTAPEAAL------YGRFTIKSDVWSFGILQTELVTKGR----------VP---------------YPGM-----VNREV-LEQV-ERGYRMPCPQGCP-------------------------------ESLHE-LMNLCWKKDPDERPT-------FEYIQSFL----------------
-LIAD----IELGCGNFGSVRQGVYR-----MRKKQIDVAIKVL---K-Q--GTE-KAD-TEE-MM-R----EAQIMHQL--D---NPYIVRLIGVCQ-------------AEALMLVMEMAGGGPLHKFLV----GK--------------------------------------------------------------------------------------------------REEIPVSNVAELLHQVSMGMKYLEEK--------NFVHRDLAARNVLLV--NRHYA----KISDFGLSKAL---GA--D--DSYY-TARSAGKWPLKWYAPECIN------FRKFSSRSDVWSYGVTMWEALSYGQ----------KP---------------YKKM-----KGPEV-MAFI-EQGKRMECPPECP-------------------------------PELYA-LMSDCWIYKWEDRPD-------FLTVEQR--M--------------
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