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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDC2 203
CMGC CDK2 4
CMGC CDK3 4
CMGC CDK5 4
CMGC CDK6 13
CMGC CDKL1 5
CMGC CDKL2 4
CMGC CDKL3 4
CMGC CDKL5 13
AGC GRK1 190
AGC GRK5 186
AGC GRK6 186
AGC GRK7 191
CMGC ICK 4
CMGC MAK 4
STE MAP2K3 64
STE MAP2K6 53
STE MAP3K1 1242
STE MAP3K15 649
STE MAP3K2 356
STE MAP3K3 362
STE MAP3K4 1342
STE MAP3K5 677
STE MAP3K6 645
Other SBK1 53
CAMK STK17A 61
STE STK24 24
STE YSK4 1162
----YTKIEKIGEGTYGVVYKGRHKTTGQ-VVAMKKIRLESEEEGVPSTAIR----EISLLKEL-R---HPNIVSLQDVLMQ-----DSRLYLIFEFLSM----DLKKYLDS-IPPGQYM--DSSLVKSYLYQILQGIVFCHSR-RVLHRDLKPQNLLID--DKGTI---KLADFGLARAF------GIPIRVYTHEVVTLWYRSPEVLL----GSARYSTPVDIWSIGTIFAELAT-KKPLFHGD-SEIDQ-LFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP---GSLASHVKNLDENGLDLLSKMLIYDPAKRIS-----GKMALNHPYF------------
----FQKVEKIGEGTYGVVYKARNKLTGE-VVALKKIRLDTETEGVPSTAIR----EISLLKEL-N---HPNIVKLLDVIHT-----ENKLYLVFEFLHQ----DLKKFMDA--SALTGI--PLPLIKSYLFQLLQGLAFCHSH-RVLHRDLKPQNLLIN--TEGAI---KLADFGLARAF------GVPVRTYTHEVVTLWYRAPEILL----GCKYYSTAVDIWSLGCIFAEMVT-RRALFPGD-SEIDQ-LFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF------------
----FQKVEKIGEGTYGVVYKAKNRETGQ-LVALKKIRLDLEMEGVPSTAIR----EISLLKEL-K---HPNIVRLLDVVHN-----ERKLYLVFEFLSQ----DLKKYMDS--TPGSEL--PLHLIKSYLFQLLQGVSFCHSH-RVIHRDLKPQNLLIN--ELGAI---KLADFGLARAF------GVPLRTYTHEVVTLWYRAPEILL----GSKFYTTAVDIWSIGCIFAEMVT-RKALFPGD-SEIDQ-LFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTR---KGLEEIVPNLEPEGRDLLMQLLQYDPSQRIT-----AKTALAHPYF------------
----YEKLEKIGEGTYGTVFKAKNRETHE-IVALKRVRLDDDDEGVPSSALR----EICLLKEL-K---HKNIVRLHDVLHS-----DKKLTLVFEFCDQ----DLKKYFD---SCNGDL--DPEIVKSFLFQLLKGLGFCHSR-NVLHRDLKPQNLLIN--RNGEL---KLADFGLARAF------GIPVRCYSAEVVTLWYRPPDVLF----GAKLYSTSIDMWSAGCIFAELANAGRPLFPGN-DVDDQ-LKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT---TSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AEEALQHPYF------------
----YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR----EVAVLRHL-ETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ----DLTTYLDK--VPEPGV--PTETIKDMMFQLLRGLDFLHSH-RVVHRDLKPQNILVT--SSGQI---KLADFGLARI-------YSFQMALTSVVVTLWYRAPEVLL-----QSSYATPVDLWSVGCIFAEMFR-RKPLFRGS-SDVDQ-LGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ-----PIEKFVTDIDELGKDLLLKCLTFNPAKRIS-----AYSALSHPYF------------
----YEKIGKIGEGSYGVVFKCRNRDTGQ-IVAIKKFLESEDDPVIKKIALR----EIRMLKQL-K---HPNLVNLLEVFRR-----KRRLHLVFEYCDHT---VLHELDR----YQRGV--PEHLVKSITWQTLQAVNFCHKH-NCIHRDVKPENILIT--KHSVI---KLCDFGFARLL------AGPSDYYTDYVATRWYRSPELLV----GDTQYGPPVDVWAIGCVFAELLS-GVPLWPGK-SDVDQ-LYLIRKTLGDLIPRHQQVFSTNQYFSGVKIPDPED-MEPLELKFPNISYPALGLLKGCLHMDPTQRLT-----CEQLLHHPYF------------
----YENLGLVGEGSYGMVMKCRNKDTGR-IVAIKKFLESDDDKMVKKIAMR----EIKLLKQL-R---HENLVNLLEVCKK-----KKRWYLVFEFVDHT---ILDDLEL----FPNGL--DYQVVQKYLFQIINGIGFCHSH-NIIHRDIKPENILVS--QSGVV---KLCDFGFARTL------AAPGEVYTDYVATRWYRAPELLV----GDVKYGKAVDVWAIGCLVTEMFM-GEPLFPGD-SDIDQ-LYHIMMCLGNLIPRHQELFNKNPVFAGVRLPEIKE-REPLERRYPKLSEVVIDLAKKCLHIDPDKRPF-----CAELLHHDFF------------
----YETLGKVGEGSYGTVMKCKHKNTGQ-IVAIKIFYERPEQSVNK-IAMR----EIKFLKQF-H---HENLVNLIEVFRQ-----KKKIHLVFEFIDHT---VLDELQH----YCHGL--ESKRLRKYLFQILRAIDYLHSN-NIIHRDIKPENILVS--QSGIT---KLCDFGFARTL------AAPGDIYTDYVATRWYRAPELVL----KDTSYGKPVDIWALGCMIIEMAT-GNPYLPSS-SDLDL-LHKIVLKVGN-LSPHLQNIFSKSPIFAGVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRIS-----SSDLLHHEYF------------
----FEILGVVGEGAYGVVLKCRHKETHE-IVAIKKFKDSEENEEVKETTLR----ELKMLRTL-K---QENIVELKEAFRR-----RGKLYLVFEYVEK----NMLELLE---EMPNGV--PPEKVKSYIYQLIKAIHWCHKN-DIVHRDIKPENLLIS--HNDVL---KLCDFGFARNL-----SEGNNANYTEYVATRWYRSPELLL-----GAPYGKSVDMWSVGCILGELSD-GQPLFPGE-SEIDQ-LFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYL-----TEQCLNHPTF------------
FLDF----RVLGKGGFGEVSACQMKATGK-LYACKKLNKKRLKKRKGYQGAM---VEKKILMKV-H---SRFIVSLAYAFET-----KADLCLVMTIMNGG---DIRYHIYNVNEENPGF--PEPRALFYTAQIICGLEHLHQR-RIVYRDLKPENVLLD--NDGNV---RISDLGLAVEL------LDGQSKTKGYAGTPGFMAPELLQ-----GEEYDFSVDYFALGVTLYEMIA-ARGPFRARGEKVEN-KELKHRIISEPVKYPDKFS-----------------------------QASKDFCEALLEKDPEKRLG-----FRD-------ETCDKLRAHPLF
---F-RQYRVLGKGGFGEVCACQVRATGK-MYACKRLEKKRIKKRKGESMAL---NEKQILEKV-N---SQFVVNLAYAYET-----KDALCLVLTIMNGG---DLKFHIYN--MGNPGF--EEERALFYAAEILCGLEDLHRE-NTVYRDLKPENILLD--DYGHI---RISDLGLAVK-------IPEGDLIRGRVGTVGYMAPEVLN-----NQRYGLSPDYWGLGCLIYEMIE-GQSPFRGR----KE-KVKREEVDRRVLETEEVYSHKFS-------------------------EEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFF------------
---F-RQYRVLGKGGFGEVCACQVRATGK-MYACKKLEKKRIKKRKGEAMAL---NEKQILEKV-N---SRFVVSLAYAYET-----KDALCLVLTLMNGG---DLKFHIYH--MGQAGF--PEARAVFYAAEICCGLEDLHRE-RIVYRDLKPENILLD--DHGHI---RISDLGLAVH-------VPEGQTIKGRVGTVGYMAPEVVK-----NERYTFSPDWWALGCLLYEMIA-GQSPFQQR-KKKIK-REEVERLVK-EVPEEYSER--FS-------------------------PQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF------------
---F-TEFRVLGKGGFGEVCAVQVKNTGK-MYACKKLDKKRLKKKGGEKMAL---LEKEILEKV-S---SPFIVSLAYAFES-----KTHLCLVMSLMNGG---DLKFHIYN--VGTRGL--DMSRVIFYSAQIACGMLHLHEL-GIVYRDMKPENVLLD--DLGNC---RLSDLGLAVE-------MKGGKPITQRAGTNGYMAPEILM----EKVSYSYPVDWFAMGCSIYEMVA-GRTPFKDYKEKVSK-EDLKQRTLQDEVKFQHDNF---T-------------------------EEAKDICRLFLAKKPEQRLG-----SRE-------KSDDPR------
----YTTIRQLGDGTYGSVLLGRSIESGE-LIAIKKMKRKFYSWEEC-MNLR----EVKSLKKL-N---HANVVKLKEVIRE-----NDHLYFIFEYMKE----NLYQLIK---ERNKLF--PESAIRNIMYQILQGLAFIHKH-GFFHRDLKPENLLCM--GPELV---KIADFGLARE-------IRSKPPYTDYVSTRWYRAPEVLL----RSTNYSSPIDVWAVGCIMAEVYT-LRPLFPGA-SEIDT-IFKICQVLGTPKKTDWPEGYQLSSAMNFRWPQCV--PNNLKTLIPNASSEAVQLLRDMLQWDPKKRPT-----ASQALRYPYF------------
----YTTMRQLGDGTYGSVLMGKSNESGE-LVAIKRMKRKFYSWDECM-NLR----EVKSLKKL-N---HANVIKLKEVIRE-----NDHLYFIFEYMKE----NLYQLMK---DRNKLF--PESVIRNIMYQILQGLAFIHKH-GFFHRDMKPENLLCM--GPELV---KIADFGLARE-------LRSQPPYTDYVSTRWYRAPEVLL----RSSVYSSPIDVWAVGSIMAELYM-LRPLFPGT-SEVDE-IFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCV--PINLKTLIPNASNEAIQLMTEMLNWDPKKRPT-----ASQALKHPYF------------
--LV--TISELGRGAYGVVEKVRHAQSGT-IMAVKRIRATVNSQEQKRL-LM----DLDINMRTVD---CFYTVTFYGALFR-----EGDVWICMELMDTS----LDKFYRKVLDKNMTI--PEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLIN--KEGHV---KMCDFGISGY-------LVDSVAKTMDAGCKPYMAPERINP-ELNQKGYNVKSDVWSLGITMIEMAI-LRFPYESWGTPFQQ-LKQVVEEPSPQLPADRF-----S-------------------------PEFVDFTAQCLRKNPAERMS-----YLELMEHPFF------------
LEPI----MELGRGAYGVVEKMRHVPSGQ-IMAVKRIRATVNSQEQKRL-LM----DLDISMRTVD---CPFTVTFYGALFR-----EGDVWICMELMDTSLDKFYKQVID----KGQTI--PEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLIN--ALGQV---KMCDFGISGY-------LVDSVAKTIDAGCKPYMAPERINP-ELNQKGYSVKSDIWSLGITMIELAI-LRFPYDSWGTPFQQ-LKQVVEEPSPQLPADKF-----S-------------------------AEFVDFTSQCLKKNSKERPT-----YPELMQHPFF------------
--WL--KGQQIGLGAFSSCYQAQDVGTGT-LMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHL-N---HPNIIRMLGATCE-----KSNYNLFIEWMAGG---SVAHLLS----KYGAF--KESVVINYTEQLLRGLSYLHEN-QIIHRDVKGANLLID--STGQR--LRIADFGAAARLAS--KGTGAGEFQGQLLGTIAFMAPEVLR-----GQQYGRSCDVWSVGCAIIEMAC-AKPPWNAE-KHSNH-LALIFKIASATTAPSIPSHLS---------------------------PGLRDVALRCLELQPQDRPP-----SRELLKHPVF------------
-ERV-----VLGKGTYGIVYAGRDLSNQV-RIAIKEIPERDSRYSQPLH--E----EIALHKYL-K---HRNIVQYLGSVSE-----NGYIKIFMEQVPGG---SLSALLR---SKWGPM--KEPTIKFYTKQILEGLKYLHEN-QIVHRDIKGDNVLVN-TYSGVV---KISDFGTSKRL------AGVNPCTETFTGTLQYMAPEIID---QGPRGYGAPADIWSLGCTIIEMAT-SKPPFHEL---GEP-QAAMFKVGMFKIHPEIPEALS---------------------------AEARAFILSCFEPDPHKRAT-----TAELLREGF-L-----------
----WRLGKLLGQGAFGRVYLCYDVDTGR-ELAVKQVQFDPDSPETSKEVNAL-ECEIQLLKNL-L---HERIVQYYGCLRDP---QEKTLSIFMEYMPGG---SIKDQLK----AYGAL--TENVTRKYTRQILEGVHYLHSN-MIVHRDIKGANILRD--STGNV---KLGDFGASKRLQ---TICLSGTGMKSVTGTPYWMSPEVIS-----GEGYGRKADIWSVACTVVEMLT-EKPPWAEF----EA-MAAIFKIATQPTNPKLPPHVS---------------------------DYTRDFLKRIFV-EAKLRPS-----ADELLRHMF-V-----------
---W-RRGKLLGQGAFGRVYLCYDVDTGR-ELASKQVQFDPDSPETSKEVSAL-ECEIQLLKNL-Q---HERIVQYYGCLRDR---AEKTLTIFMEYMPGG---SVKDQLK----AYGAL--TESVTRKYTRQILEGMSYLHSN-MIVHRDIKGANILRD--SAGNV---KLGDFGASKRLQ---TICMSGTGMRSVTGTPYWMSPEVIS-----GEGYGRKADVWSLGCTVVEMLT-EKPPWAEY----EA-MAAIFKIATQPTNPQLPSHIS---------------------------EHGRDFLRRIFV-EARQRPS-----AEELLTHHF-A-----------
---W-QRGNKIGEGQYGKVYTCISVDTGE-LMAMKEIRFQPNDHKTIKETAD----ELKIFEGI-K---HPNLVRYFGVELH-----REEMYIFMEYCDEG---TLEEVS------RLGL--QEHVIRLYSKQITIAINVLHEH-GIVHRDIKGANIFLT--SSGLI---KLGDFGCSVKLKN--NAQTMPGEVNSTLGTAAYMAPEVITR--AKGEGHGRAADIWSLGCVVIEMVT-GKRPWHEY--EHNF-QIMYKVGMGHKPPIPERLS-----------------------------PEGKDFLSHCLESDPKMRWT-----ASQLLDHSFV------------
-DRV-----VLGKGTYGIVYAGRDLSNQV-RIAIKEIPERDSRYSQPLH--E----EIALHKHL-K---HKNIVQYLGSFSE-----NGFIKIFMEQVPGG---SLSALLR---SKWGPLKDNEQTIGFYTKQILEGLKYLHDN-QIVHRDIKGDNVLIN-TYSGVL---KISDFGTSKRL------AGINPCTETFTGTLQYMAPEIID---KGPRGYGKAADIWSLGCTIIEMAT-GKPPFYEL---GEP-QAAMFKVGMFKVHPEIPESMS---------------------------AEAKAFILKCFEPDPDKRAC-----ANDLLVDEF-L-----------
-ERL-----VLGKGTYGVVYAGRDRHTRV-RIAIKEIPERDSRFSQPLH--E----EIALHRRL-R---HKNIVRYLGSASQ-----GGYLKIFMEEVPGG---SLSSLLR---SVWGPLKDNESTISFYTRQILQGLGYLHDN-HIVHRDIKGDNVLIN-TFSGLL---KISDFGTSKRL------AGITPCTETFTGTLQYMAPEIID---QGPRGYGKAADIWSLGCTVIEMAT-GRPPFHEL---GSP-QAAMFQVGMYKVHPPMPSSLS---------------------------AEAQAFLLRTFEPDPRLRAS-----AQTLLGDPFL------------
----YELVRELGKGTYGKVDLVVYKGTGT-KMALKFVNKSKTKLKNF---LR----EVSITNSLSS---SPFIIKVFDVVFE----TEDCYVFAQEYAPAG---DLFDIIP----PQVGL--PEDTVKRCVQQLGLALDFMHGR-QLVHRDIKPENVLLFDRECRRV---KLADFGMTR---------RVGCRVKRVSGTIPYTAPEVCQAGRADGLAVDTGVDVWAFGVLIFCVLT-GNFPWEAA-SGADAFFEEFVRWQRGRLPGLPSQWRRFT-------------------------EPALRMFQRLLALEPERRGP-----AKEVF-----RFLKH-------
-LCP---GRELGRGKFAVVRKCIKKDSGK-EFAAKFMRKRRKGQDCRMEIIH----EIAVLELAQD---NPWVINLHEVYET-----ASEMILVLEYAAGG---EIFDQCVA--DREEAF--KEKDVQRLMRQILEGVHFLHTR-DVVHLDLKPQNILLT--SESPLGDIKIVDFGLSRI-------LKNSEELREIMGTPEYVAPEILS-----YDPISMATDMWSIGVLTYVMLT-GISPFLGN----DK-QETFLNISQMNLSYSEEEFDVLS-------------------------ESAVDFIRTLLVKKPEDRAT-----AEECLKHPWL------------
----FTKLEKIGKGSFGEVFKGIDNRTQK-VVAIKIIDLEEAEDEIEDIQ-Q----EITVLSQC-D---SPYVTKYYGSYLK-----DTKLWIIMEYLGGG---SALDLLE-----PGPL--DETQIATILREILKGLDYLHSE-KKIHRDIKAANVLLS--EHGEV---KLADFGVAGQL------TDTQIKRNTFVGTPFWMAPEVIK-----QSAYDSKADIWSLGITAIELAR-GEPPHSEL-HPMKV-LFLIPKNNPPTLEGNYS-------------------------------KPLKEFVEACLNKEPSFRPT-----AKELLKHKFI------------
----WTKGEILGKGAYGTVYCGLTSQGQ--LIAVKQVALDTSNKLAAEKEYRKLQEEVDLLKAL-K---HVNIVAYLGTCLQ-----ENTVSIFMEFVPGG---SISSIIN----RFGPL--PEMVFCKYTKQILQGVAYLHEN-CVVHRDIKGNNVMLM--PTGII---KLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVIN-----ESGYGRKSDIWSIGCTVFEMAT-GKPPLASM---DRM-AAMFYIGAHRGLMPPLPDHFS---------------------------ENAADFVRMCLTRDQHERPS-----ALQLLKHSFL------------
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