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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other AAK1 203
TK ABL1 261
TK ABL2 288
TK ALK 1116
Other AURKA 133
Other AURKB 77
Other AURKC 43
TK BLK 241
Other BMP2K 51
TK BTK 402
CAMK CAMK2A 13
Other CAMKK1 128
Other CAMKK2 165
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK4 6
CMGC CDK5 4
CMGC CDKL2 4
CAMK CHEK1 9
CMGC CSNK2A1 39
CMGC CSNK2A2 40
CAMK DAPK2 23
CAMK DAPK3 13
TK EGFR 712
TK EPHA3 621
TK EPHB1 619
TK FER 563
TK FES 561
TK FGFR1 478
TK FGFR2 481
TK FGFR3 472
TK FGFR4 467
AGC GRK1 190
AGC GRK4 187
AGC GRK7 191
CMGC GSK3A 119
CMGC GSK3B 56
CMGC ICK 4
TKL IRAK4 186
TK ITK 363
TK JAK1 875
TK JAK2 849
TK JAK3 822
TK LCK 245
TKL LIMK2 331
STE MAP2K4 102
STE MAP4K1 17
STE MAP4K2 16
CMGC MAPK10 64
CMGC MAPK8 26
CAMK MARK2 53
CAMK MARK4 59
CAMK MELK 11
CAMK MYLK 1464
CAMK MYLK2 301
CAMK MYLK3 594
CAMK MYLK4 106
TK NTRK1 510
TK NTRK2 538
TK NTRK3 538
CAMK NUAK1 55
CAMK NUAK2 97
STE OXSR1 17
STE PAK4 321
AGC PDPK1 82
CAMK PHKG1 20
CAMK PHKG2 24
AGC PKN2 657
Other PLK1 53
Other PLK4 12
CAMK PRKAA1 18
CAMK PRKAA2 16
AGC PRKCD 349
AGC PRKCQ 380
AGC PRKCZ 252
CAMK PRKD1 583
CAMK PRKD2 551
CAMK PRKD3 576
AGC PRKG1 375
CMGC PRPF4B 687
TK PTK2 422
TK PTK2B 425
TKL RAF1 349
TK RET 724
TKL RIPK1 17
AGC RPS6KB1 91
Other SBK1 53
CAMK SIK1 27
CAMK SIK2 20
STE SLK 34
STE STK10 36
CAMK STK17A 61
CAMK STK17B 33
STE STK24 24
STE STK3 27
STE STK39 63
STE STK4 30
TK TEK 824
TK TIE1 839
TK TNK1 116
TK TNK2 150
CAMK TSSK1B 12
Other TTK 525
TK TXK 271
Other ULK1 16
Other ULK2 9
TK ZAP70 338
----V-TVDEVLAEGGFAIVFLVRT---S-------N-GM--KCAL-KRM---FVN--N-EHD---LQ--V-C-K--R-------------------------EIQIMRDL-SG------HKNIVGYIDSSI--NNVSSGDVWE--VL---ILMDFCRGG--QVVNLMNQ------RLQT-------------------------GFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLH--D---R--GHY---------VLCDFGSATNKFQNP-----------QTEGVNAVEDE--------------IK---KYTTLSYRAPEM--VNL--------YSGKI----ITTKADIWALGCLLYKLCY-FTLP---------------FG-ES----------QVAI-CDGNF----TI---PD-----NSRYS-----------------------------------------------------QDMHC-LIRYMLEPDPDKRPD------IY-QV------SYFSF-------
-----ITMKHKLGGGQYGEVYEGVW---K-------K-YSL-TVAV-KTL---K-E--D-TM----EV--E-E-FL-K-------------------------EAAVMKEI--K------HPNLVQLLGVCT--R------EPP--FY---IITEFMTYG--NLLDYLR---------EC----------------------NRQEVNAVVLLYMATQISSAMEYLEKK--NFIHRDLAARNCLVG--E---N--HLV---------KVADFGLSRLM-------------------T--GDTY--------------TAHAGAKFPIKWTAPES--LA-----------YNK----FSIKSDVWAFGVLLWEIATYGMSP---------------YP-GI----DLSQV-YELL-EKDYR----ME---RPEGCP-----------------------------------------------------------EKVYE-LMRACWQWNPSDRPS------FA-EIHQA--F------------
-----ITMKHKLGGGQYGEVYVGVW---K-------K-YSL-TVAV-KTL---K-E--D-TM----EV--E-E-FL-K-------------------------EAAVMKEI--K------HPNLVQLLGVCT--L------EPP--FY---IVTEYMPYG--NLLDYLR---------EC----------------------NREEVTAVVLLYMATQISSAMEYLEKK--NFIHRDLAARNCLVG--E---N--HVV---------KVADFGLSRLM-------------------T--GDTY--------------TAHAGAKFPIKWTAPES--LA-----------YNT----FSIKSDVWAFGVLLWEIATYGMSP---------------YP-GI----DLSQV-YDLL-EKGYR----ME---QPEGCP-----------------------------------------------------------PKVYE-LMRACWKWSPADRPS------FA-ETHQA--F------------
----I-TLIRGLGHGAFGEVYEGQV---SG--MPNDP-SPL-QVAV-KTL---P-E--V-CS----EQDEL-D-FL-M-------------------------EALIISKF--N------HQNIVRCIGVSL--Q------SLP--RF---ILLELMAGG--DLKSFLR---------ETRP-----------------RPSQPSSLAMLDLLHVARDIACGCQYLEEN--HFIHRDIAARNCLLT--CPGPG--RVA---------KIGDFGMARDI-------------Y-----R--ASYY--------------RKGGCAMLPVKWMPPEA--FM-----------EGI----FTSKTDTWSFGVLLWEIFSLGYMP---------------YP-SK----SNQEV-LEFV-TSGGR----MD---PPKNCP-----------------------------------------------------------GPVYR-IMTQCWQHQPEDRPN------FA-IILER--I------------
-----FEIGRPLGKGKFGNVYLARE---K-------Q-SKF-ILAL-KVL---FKA--QLEKA---GV--E-H-QLRR-------------------------EVEIQSHL--R------HPNILRLYGYFH--D------ATR--VY---LILEYAPLG--TVYRELQ--------KLS-------------------------KFDEQRTATYITELANALSYCHSK--RVIHRDIKPENLLLG--S---A--GEL---------KIADFGWSV---------------------HAPSSRR--------------TT---LCGTLDYLPPEM--IE-----------GRM----HDEKVDLWSLGVLCYEFLV-GKPP---------------FE-AN-------TY-QETY-KRISR----VE---FTFPDFVT---------------------------------------------------------EGARD-LISRLLKHNPSQRPM------LR-EVLEHPWI------------
-----FEIGRPLGKGKFGNVYLARE---K-------K-SHF-IVAL-KVL---FKS--Q-IEK---EG--V-E-HQLR------------------------REIEIQAHL--H------HPNILRLYNYFY--D------RRR--IY---LILEYAPRG--ELYKELQ--------KSC-------------------------TFDEQRTATIMEELADALMYCHGK--KVIHRDIKPENLLLG--L---K--GEL---------KIADFGWSV---------------------HAPSLRR--------------KT---MCGTLDYLPPEM--IE-----------GRM----HNEKVDLWCIGVLCYELLV-GNPP---------------FE-SA-------SH-NETY-RRIVK----VD---LKFPASVP---------------------------------------------------------MGAQD-LISKLLRHNPSERLP------LA-QVSAHPWV------------
-----FEIGRPLGKGKFGNVYLARL---K-------E-SHF-IVAL-KVL---FKS--Q-IEK---EG--L-E-HQLR------------------------REIEIQAHL--Q------HPNILRLYNYFH--D------ARR--VY---LILEYAPRG--ELYKELQ--------KSE-------------------------KLDEQRTATIIEELADALTYCHDK--KVIHRDIKPENLLLG--F---R--GEV---------KIADFGWSV---------------------HTPSLRR--------------KT---MCGTLDYLPPEM--IE-----------GRT----YDEKVDLWCIGVLCYELLV-GYPP---------------FE-SA-------SH-SETY-RRILK----VD---VRFPLSMP---------------------------------------------------------LGARD-LISRLLRYQPLERLP------LA-QILKHPWV------------
----L-RLVRKLGSGQFGEVWMGYY---K---------NNM-KVAI-KTL---K-E--G-TM----SP--E-A-FL-G-------------------------EANVMKAL--Q------HERLVRLYAVVT---------KEP--IY---IVTEYMARG--CLLDFLK---------TD----------------------EGSRLSLPRLIDMSAQIAEGMAYIERM--NSIHRDLRAANILVS--E---A--LCC---------KIADFGLARII----------------------DSEY--------------TAQEGAKFPIKWTAPEA--IH-----------FGV----FTIKADVWSFGVLLMEVVTYGRVP---------------YP-GM----SNPEV-IRNL-ERGYR----MP---RPDTCP-----------------------------------------------------------PELYRGVIAECWRSRPEERPT------FE-FLQSV--L------------
----V-TLEESLAEGGFSTVFLVRT---H-------G-GI--RCAL-KRM---YVN--N-MPD---LN--V-C---KR-------------------------EITIMKEL-SG------HKNIVGYLDCAV--NS----ISDN--VWEVLILMEYCRAG--QVVNQMNK------KLQT-------------------------GFTEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLN--D---G--GNY---------VLCDFGSATNKFLNP----------QKDGVN-VVEEE--------------IK---KYTTLSYRAPEM--INL--------YGGKP----ITTKADIWALGCLLYKLCF-FTLP---------------FG-ES----------QVAI-CDGNF----TI---PDNS-----RYS-----------------------------------------------------RNIHC-LIRFMLEPDPEHRPD------IF-QV------SYFAF-------
-----LTFLKELGTGQFGVVKYGKW---R---------GQY-DVAI-KMI---K-E--G-SM----SE--D-E-FI-E-------------------------EAKVMMNL--S------HEKLVQLYGVCT--K------QRP--IF---IITEYMANG--CLLNYLR---------EM-----------------------RHRFQTQQLLEMCKDVCEAMEYLESK--QFLHRDLAARNCLVN--D---Q--GVV---------KVSDFGLSRYV-------------------L--DDEY--------------TSSVGSKFPVRWSPPEV--LM-----------YSK----FSSKSDIWAFGVLMWEIYSLGKMP---------------YE-RF----TNSET-AEHI-AQGLR----LY---RPHLAS-----------------------------------------------------------EKVYT-IMYSCWHEKADERPT------FK-ILLSN--I------------
-----YQLFEELGKGAFSVVRRCVK---V-------L-AGQ-EYAA-KII---NTK--K-LSA---RD--H-Q-KLER-------------------------EARICRLL--K------HPNIVRLHDSIS--E------EGH--HY---LIFDLVTGG--ELFEDIV--------ARE-------------------------YYSEADASHCIQQILEAVLHCHQM--GVVHRDLKPENLLLA--S---K--LKGA------AVKLADFGLAIEV-------------------EGEQQAW--------------FG---FAGTPGYLSPEV--LR-----------KDP----YGKPVDLWACGVILYILLV-GYPP---------------FW-DE-------DQ-HRLY-QQIKA----GA---YDFPSPEWDTVT-----------------------------------------------------PEAKD-LINKMLTINPSKRIT------AA-EALKHPWI------------
-----YKLQSEIGKGAYGVVRLAYN---E-------S-EDR-HYAM-KVL---SKK--K-LLK---QY--G-F-PR-RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKL--D------HVNVVKLIEVLD--DP----AEDN--LY---LVFDLLRKG--PVMEVPC---------DK-------------------------PFSEEQARLYLRDVILGLEYLHCQ--KIVHRDIKPSNLLLG--D---D--GHV---------KIADFGVSNQF-------------------EGNDAQL--------------SS---TAGTPAFMAPEA--ISD--------SGQSF----SGKALDVWATGVTLYCFVY-GKCP---------------FI-DD-------FI-LALH-RKIKN----EP---VVFPEEPEIS-------------------------------------------------------EELKD-LILKMLDKNPETRIG------VP-DIKLHPWV------------
-----YTLKDEIGKGSYGVVKLAYN---E-------N-DNT-YYAM-KVL---SKK--K-LIR---QA--G-F-PR-RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKL--D------HPNVVKLVEVLD--DP----NEDH--LY---MVFELVNQG--PVMEVPT---------LK-------------------------PLSEDQARFYFQDLIKGIEYLHYQ--KIIHRDIKPSNLLVG--E---D--GHI---------KIADFGVSNEF-------------------KGSDALL--------------SN---TVGTPAFMAPES--LS----------ETRKIF--SGKALDVWAMGVTLYCFVF-GQCP---------------FM-DE-------RI-MCLH-SKIKS----QA---LEFPDQPDIA-------------------------------------------------------EDLKD-LITRMLDKNPESRIV------VP-EIKLHPWV------------
-----YTKIEKIGEGTYGVVYKGRH---K-------T-TGQ-VVAM-KKI---RLE--S-EEE---GV--P-S-TAIR-------------------------EISLLKEL--R------HPNIVSLQDVLM--Q------DSR--LY---LIFEFLSM---DLKKYLDS-----IPPGQ-------------------------YMDSSLVKSYLYQILQGIVFCHSR--RVLHRDLKPQNLLID--D---K--GTI---------KLADFGLARAF-------------------GIPIRVY--------------TH---EVVTLWYRSPEV--LL----------GSAR----YSTPVDIWSIGTIFAELAT-KKPL---------------FH-GD----SEIDQ-LFRI-FRALG----TP---NNEVWPEVESLQDYKNTFPKWKP-------------------------------GSLASHVKNLDENGLD-LLSKMLIYDPAKRIS------GK-MALNHPYF------------
-----FQKVEKIGEGTYGVVYKARN---K-------L-TGE-VVAL-KKI---RLD--T-ETE---GV--P-S-TAIR-------------------------EISLLKEL--N------HPNIVKLLDVIH--T------ENK--LY---LVFEFLHQ---DLKKFMDA------SALT-------------------------GIPLPLIKSYLFQLLQGLAFCHSH--RVLHRDLKPQNLLIN--T---E--GAI---------KLADFGLARAF-------------------GVPVRTY--------------TH---EVVTLWYRAPEI--LL----------GCKY----YSTAVDIWSLGCIFAEMVT-RRAL---------------FP-GD----SEIDQ-LFRI-FRTLG----TP---DEVVWPGVTSMPDYKPSFPKWAR-------------------------------QDFSKVVPPLDEDGRS-LLSQMLHYDPNKRIS------AK-AALAHPFF------------
----Y-EPVAEIGVGAYGTVYKARD---P-------H-SGH-FVAL-KSV---RVP--N-GGGGGGGL--P-I-STVR-------------------------EVALLRRL--EA---FEHPNVVRLMDVCA--TSR-TDREIK--VT---LVFEHVDQ---DLRTYLDK------APPP-------------------------GLPAETIKDLMRQFLRGLDFLHAN--CIVHRDLKPENILVT--S---G--GTV---------KLADFGLARI--------------------YSYQMAL--------------TP---VVVTLWYRAPEV--LL-----------QST----YATPVDMWSVGCIFAEMFR-RKPL---------------FC-GN----SEADQ-LGKI-FDLIG----LP---PEDDWPRDVSLPRGAFPPRGPR---------------------------------PVQSVVPEMEESGAQ-LLLEMLTFNPHKRIS------AF-RALQHSYL------------
-----YEKLEKIGEGTYGTVFKAKN---R-------E-THE-IVAL-KRV---RLD--D-DDE---GV--P-S-SALR-------------------------EICLLKEL--K------HKNIVRLHDVLH--S------DKK--LT---LVFEFCDQ---DLKKYFD-------SCNG-------------------------DLDPEIVKSFLFQLLKGLGFCHSR--NVLHRDLKPQNLLIN--R---N--GEL---------KLADFGLARAF-------------------GIPVRCY--------------SA---EVVTLWYRPPDV--LF----------GAKL----YSTSIDMWSAGCIFAELANAGRPL---------------FP-GN----DVDDQ-LKRI-FRLLG----TP---TEEQWPSMTKLPDYKPYPMYPAT-------------------------------TSLVNVVPKLNATGRD-LLQNLLKCNPVQRIS------AE-EALQHPYF------------
-----YENLGLVGEGSYGMVMKCRN---K-------D-TGR-IVAI-KKF---LES--D-DDK---MV--K-K-IAMR-------------------------EIKLLKQL--R------HENLVNLLEVCK--K------KKR--WY---LVFEFVDHT--ILDDLEL--------FPN-------------------------GLDYQVVQKYLFQIINGIGFCHSH--NIIHRDIKPENILVS--Q---S--GVV---------KLCDFGFARTL-------------------AAPGEVY--------------TD---YVATRWYRAPEL--LV----------GDVK----YGKAVDVWAIGCLVTEMFM-GEPL---------------FP-GD----SDIDQ-LYHI-MMCLG----NL---IPRHQELFNKNPVFAGVRLPEIKE-----------------------------REPLERRYPKLSEVVID-LAKKCLHIDPDKRPF------CA-ELLHHDFF------------
----W-DLVQTLGEGAYGEVQLAVN---R-------V-TEE-AVAV-KIV---DMK--R-AVD---CP--E-N-I-KK-------------------------EICINKML--N------HENVVKFYGHRR--E------GNI--QY---LFLEYCSGG--ELFDRIE--------PDI-------------------------GMPEPDAQRFFHQLMAGVVYLHGI--GITHRDIKPENLLLD--E---R--DNL---------KISDFGLATVFR-----------------YNNRERLL--------------NK---MCGTLPYVAPEL--LK----------RREF----HAEPVDVWSCGIVLTAMLA-GELP---------------WD-QP------SDS-CQEY-SDWKE----KK---TYLNPWKKI--D-----------------------------------------------------SAPLA-LLHKILVENPSARIT------IP-DIKKDRW-Y-----------
-----YQLVRKLGRGKYSEVFEAIN---I-------T-NNE-KVVV-KIL---KPV--K-KKK---IK--R--------------------------------EIKILENL-RG------GPNIITLADIVK--DP----VSRT--PA---LVFEHVNNT--DFKQLY-----------Q-------------------------TLTDYDIRFYMYEILKALDYCHSM--GIMHRDVKPHNVMID-HE---H--RKL---------RLIDWGLAEF--------------------YHPGQEY--------------NV---RVASRYFKGPEL--LV----------DYQM----YDYSLDMWSLGCMLASMIF-RKEP---------------FFHGH----DNYDQ-LVRI-AKVLG----TE---DLYDYIDKYNIELDPRFNDILGRHSRK-----------------------RWERFVHSENQHLVSPEALD-FLDKLLRYDHQSRLT------AR-EAMEHPYF------------
-----YQLVRKLGRGKYSEVFEAIN---I-------T-NNE-RVVV-KIL---KPV--K-KKK---IK--R--------------------------------EVKILENL-RG------GTNIIKLIDTVK--DP----VSKT--PA---LVFEYINNT--DFKQLY-----------Q-------------------------ILTDFDIRFYMYELLKALDYCHSK--GIMHRDVKPHNVMID-HQ---Q--KKL---------RLIDWGLAEF--------------------YHPAQEY--------------NV---RVASRYFKGPEL--LV----------DYQM----YDYSLDMWSLGCMLASMIF-RREP---------------FFHGQ----DNYDQ-LVRI-AKVLG----TE---ELYGYLKKYHIDLDPHFNDILGQHSRK-----------------------RWENFIHSENRHLVSPEALD-LLDKLLRYDHQQRLT------AK-EAMEHPYF------------
-----YDIGEELGSGQFAIVKKCRE---K-------S-TGL-EYAA-KFI---KKR--Q-SRA---SR--R-G-VSREEI---------------------EREVSILRQV--L------HHNVITLHDVYE--N------RTD--VV---LILELVSGG--ELFDFLA--------QKE-------------------------SLSEEEATSFIKQILDGVNYLHTK--KIAHFDLKPENIMLL--D---K--NIPIP-----HIKLIDFGLAHE--------------------IEDGVEF--------------KN---IFGTPEFVAPEI--VN-----------YEP----LGLEADMWSIGVITYILLS-GASP---------------FL-GD-------TK-QETL-ANITA----VS---YDFDEEFFSQTS-----------------------------------------------------ELAKD-FIRKLLVKETRKRLT------IQ-EALRHPWI------------
-----YEMGEELGSGQFAIVRKCRQ---K-------G-TGK-EYAA-KFI---KKR--R-LSS---SR--R-G-VSREEI---------------------EREVNILREI--R------HPNIITLHDIFE--N------KTD--VV---LILELVSGG--ELFDFLA--------EKE-------------------------SLTEDEATQFLKQILDGVHYLHSK--RIAHFDLKPENIMLL--D---K--NVPNP-----RIKLIDFGIAHK--------------------IEAGNEF--------------KN---IFGTPEFVAPEI--VN-----------YEP----LGLEADMWSIGVITYILLS-GASP---------------FL-GE-------TK-QETL-TNISA----VN---YDFDEEYFSNTS-----------------------------------------------------ELAKD-FIRRLLVKDPKRRMT------IA-QSLEHSWI------------
----F-KKIKVLGSGAFGTVYKGLW---IP---EGEK-VKI-PVAI-KEL---R-E--A-TS----PKANK-E-IL-D-------------------------EAYVMASV--D------NPHVCRLLGICL---------TST--VQ---LITQLMPFG--CLLDYVR---------EH-----------------------KDNIGSQYLLNWCVQIAKGMNYLEDR--RLVHRDLAARNVLVK--T---P--QHV---------KITDFGLAKLL-------------G-----A--EEKE--------------YHAEGGKVPIKWMALES--IL-----------HRI----YTHQSDVWSYGVTVWELMTFGSKP---------------YD-GI----PASEI-SSIL-EKGER----LP---QPPICT-----------------------------------------------------------IDVYM-IMVKCWMIDADSRPK------FR-ELI----IEF----------
----I-SIDKVVGAGEFGEVCSGRL---K----LPSK-KEI-SVAI-KTL---K-V--G-YT----EKQRR-D-FL-G-------------------------EASIMGQF--D------HPNIIRLEGVVT--K------SKP--VM---IVTEYMENG--SLDSFLR---------KH-----------------------DAQFTVIQLVGMLRGIASGMKYLSDM--GYVHRDLAARNILIN--S---N--LVC---------KVSDFGLSRVL-------------E-----D--DPEA-------------AYTTRGGKIPIRWTSPEA--IA-----------YRK----FTSASDVWSYGIVLWEVMSYGERP---------------YW-EM----SNQDV-IKAV-DEGYR----LP---PPMDCP-----------------------------------------------------------AALYQ-LMLDCWQKDRNNRPK------FE-QIVSIL--------------
----V-KIEEVIGAGEFGEVYKGRL---K----LPGK-REI-YVAI-KTL---K-A--G-YS----EKQRR-D-FL-S-------------------------EASIMGQF--D------HPNIIRLEGVVT--K------SRP--VM---IITEFMENG--ALDSFLR---------QN-----------------------DGQFTVIQLVGMLRGIAAGMKYLAEM--NYVHRDLAARNILVN--S---N--LVC---------KVSDFGLSRYLQ----------DDT-----S--DPTY--------------TSSLGGKIPVRWTAPEA--IA-----------YRK----FTSASDVWSYGIVMWEVMSFGERP---------------YW-DM----SNQDV-INAI-EQDYR----LP---PPMDCP-----------------------------------------------------------AALHQ-LMLDCWQKDRNSRPR------FA-EIVNTL--------------
---VI--LGELLGKGNFGEVYKGTL---K---------DKT-SVAV-KTC---K-E--D-LP----QELKI-K-FL-Q-------------------------EAKILKQY--D------HPNIVKLIGVCT--Q------RQP--VY---IIMELVSGG--DFLTFLR---------RK-----------------------KDELKLKQLVKFSLDAAAGMLYLESK--NCIHRDLAARNCLVG--E---N--NVL---------KISDFGMSRQE-------------------D--GGVY--------------SSSGLKQIPIKWTAPEA--LN-----------YGR----YSSESDVWSFGILLWETFSLGVCP---------------YP-GM----TNQQA-REQV-ERGYR----MS---APQHCP-----------------------------------------------------------EDISK-IMMKCWDYKPENRPK------FS-ELQKEL--------------
----L-VLGEQIGRGNFGEVFSGRL---R-------A-DNT-LVAV-KSC---R-E--T-LP----PDLKA-K-FL-Q-------------------------EARILKQY--S------HPNIVRLIGVCT--Q------KQP--IY---IVMELVQGG--DFLTFLR---------TE-----------------------GARLRVKTLLQMVGDAAAGMEYLESK--CCIHRDLAARNCLVT--E---K--NVL---------KISDFGMSREE-------------A-----D--GVYA--------------ASGGLRQVPVKWTAPEA--LN-----------YGR----YSSESDVWSFGILLWETFSLGASP---------------YP-NL----SNQQT-REFV-EKGGR----LP---CPELCP-----------------------------------------------------------DAVFR-LMEQCWAYEPGQRPS------FS-TIYQEL--------------
----L-VLGKPLGEGCFGQVVLAEA---IGLDKDKPN-RVT-KVAV-KML---K-S--D-AT----EKDLS-D-LI-S-------------------------EMEMMKMIG-K------HKNIINLLGACT--Q------DGP--LY---VIVEYASKG--NLREYLQ---------ARRPPGLEY--------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASK--KCIHRDLAARNVLVT--E---D--NVM---------KIADFGLARDI-------------H-----H--IDYY--------------KKTTNGRLPVKWMAPEA--LF-----------DRI----YTHQSDVWSFGVLLWEIFTLGGSP---------------YP-GV----PVEEL-FKLL-KEGHR----MD---KPSNCT-----------------------------------------------------------NELYM-MMRDCWHAVPSQRPT------FK-QLVEDL--------------
-----LTLGKPLGEGCFGQVVMAEA---VGIDKDKPK-EAV-TVAV-KML---K-D--D-AT----EKDLS-D-LV-S-------------------------EMEMMKMIG-K------HKNIINLLGACT--Q------DGP--LY---VIVEYASKG--NLREYLR---------ARRPPGMEY--------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQ--KCIHRDLAARNVLVT--E---N--NVM---------KIADFGLARDI-------------N-----N--IDYY--------------KKTTNGRLPVKWMAPEA--LF-----------DRV----YTHQSDVWSFGVLMWEIFTLGGSP---------------YP-GI----PVEEL-FKLL-KEGHR----MD---KPANCT-----------------------------------------------------------NELYM-MMRDCWHAVPSQRPT------FK-QLVEDL--------------
-----LTLGKPLGEGCFGQVVMAEA---IGIDKDRAA-KPV-TVAV-KML---K-D--D-AT----DKDLS-D-LV-S-------------------------EMEMMKMIG-K------HKNIINLLGACT--Q------GGP--LY---VLVEYAAKG--NLREFLR---------ARRPPGLDY--------SFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQ--KCIHRDLAARNVLVT--E---D--NVM---------KIADFGLARDV-------------H-----N--LDYY--------------KKTTNGRLPVKWMAPEA--LF-----------DRV----YTHQSDVWSFGVLLWEIFTLGGSP---------------YP-GI----PVEEL-FKLL-KEGHR----MD---KPANCT-----------------------------------------------------------HDLYM-IMRECWHAAPSQRPT------FK-QLVEDL--------------
----L-VLGKPLGEGCFGQVVRAEA---FGMDPARPD-QAS-TVAV-KML---K-D--N-AS----DKDLA-D-LV-S-------------------------EMEVMKLIG-R------HKNIINLLGVCT--Q------EGP--LY---VIVECAAKG--NLREFLR---------ARRPPGPDL--------SPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESR--KCIHRDLAARNVLVT--E---D--NVM---------KIADFGLARGV-------------H-----H--IDYY--------------KKTSNGRLPVKWMAPEA--LF-----------DRV----YTHQSDVWSFGILLWEIFTLGGSP---------------YP-GI----PVEEL-FSLL-REGHR----MD---RPPHCP-----------------------------------------------------------PELYG-LMRECWHAAPSQRPT------FK-QLVEAL--------------
-FLDF----RVLGKGGFGEVSACQM---K-------A-TGK-LYAC-KKL---NKK--R-LKK---RK--G-Y-QGAM------------------------VEKKILMKV--H------SRFIVSLAYAFE--T------KAD--LC---LVMTIMNGG--DIRYHIYNV----NEENP-------------------------GFPEPRALFYTAQIICGLEHLHQR--RIVYRDLKPENVLLD--N---D--GNV---------RISDLGLAVEL-------------------LDGQSKT--------------KG---YAGTPGFMAPEL--LQ-----------GEE----YDFSVDYFALGVTLYEMIA-ARGP---------------FR-AR---GEKVEN-KELK-HRIIS----EP---VKYPDKFS---------------------------------------------------------QASKD-FCEALLEKDPEKRLG------FR-D-------ETCDKLRAHPLF
---FR--HYRVLGKGGFGEVCACQV---R-------A-TGK-MYAC-KKL---QKK--R-IKK---RK--G-E-AMAL------------------------NEKRILEKV--Q------SRFVVSLAYAYE--T------KDA--LC---LVLTIMNGG--DLKFHIYN------LGNP-------------------------GFDEQRAVFYAAELCCGLEDLQRE--RIVYRDLKPENILLD--D---R--GHI---------RISDLGLATE--------------------IPEGQRV--------------RG---RVGTVGYMAPEV--VN-----------NEK----YTFSPDWWGLGCLIYEMIQ-GHSP---------------FK-KY----KEKVK-WEEV-DQRIK----ND---TEEYSE---KFS-----------------------------------------------------EDAKS-ICRMLLTKNPSKRLGCR-GEGAA-GVKQHPV-F-----------
----F-TEFRVLGKGGFGEVCAVQV---K-------N-TGK-MYAC-KKL---DKK--R-LKK---KG--G-E-KMAL------------------------LEKEILEKV--S------SPFIVSLAYAFE--S------KTH--LC---LVMSLMNGG--DLKFHIYN------VGTR-------------------------GLDMSRVIFYSAQIACGMLHLHEL--GIVYRDMKPENVLLD--D---L--GNC---------RLSDLGLAVE--------------------MKGGKPI--------------TQ---RAGTNGYMAPEI--LM----------EKVS----YSYPVDWFAMGCSIYEMVA-GRTP---------------FK-DY---KEKVSK-EDLK-QRTLQ----DE---VKFQHDNF---T-----------------------------------------------------EEAKD-ICRLFLAKKPEQRLG------SR-E-------KSDDPR------
-----YTDIKVIGNGSFGVVYQARL---A-------E-TRE-LVAI-KKV---LQD--K-RFK---NR-----------------------------------ELQIMRKL--D------HCNIVRLRYFFY--SSG--EKKDE--LYL-NLVLEYVPETVYRVARHFT-------KAKL-------------------------TIPILYVKVYMYQLFRSLAYIHSQ--GVCHRDIKPQNLLVD-PD---T--AVL---------KLCDFGSAKQ--------------------LVRGEPN--------------VS---YICSRYYRAPEL--IF----------GATD----YTSSIDVWSAGCVLAELLL-GQPI---------------FP-GD----SGVDQ-LVEI-IKVLG----TP---TREQIREMNPNYTEFKFPQIKAH-------------------------------PWTKVFKSRTPPEAIA-LCSSLLEYTPSSRLS------PL-EACAHSFF------------
-----YTDTKVIGNGSFGVVYQAKL---C-------D-SGE-LVAI-KKV---LQD--K-RFK---NR-----------------------------------ELQIMRKL--D------HCNIVRLRYFFY--SSG--EKKDE--VYL-NLVLDYVPETVYRVA---RHY----SRAKQ-------------------------TLPVIYVKLYMYQLFRSLAYIHSF--GICHRDIKPQNLLLD-PD---T--AVL---------KLCDFGSAKQ--------------------LVRGEPN--------------VS---YICSRYYRAPEL--IF----------GATD----YTSSIDVWSAGCVLAELLL-GQPI---------------FP-GD----SGVDQ-LVEI-IKVLG----TP---TREQIREMNPNYTEFKFPQIKAH-------------------------------PWTKVFRPRTPPEAIA-LCSRLLEYTPTARLT------PL-EACAHSFF------------
-----YTTIRQLGDGTYGSVLLGRS---I-------E-SGE-LIAI-KKM---KRK--F-YSW---EE--C---MNLR-------------------------EVKSLKKL--N------HANVVKLKEVIR--E------NDH--LY---FIFEYMKE---NLYQLIK-------ERNK-------------------------LFPESAIRNIMYQILQGLAFIHKH--GFFHRDLKPENLLCM--G---P--ELV---------KIADFGLARE--------------------IRSKPPY--------------TD---YVSTRWYRAPEV--LL----------RSTN----YSSPIDVWAVGCIMAEVYT-LRPL---------------FP-GA----SEIDT-IFKI-CQVLG----TP---KKTDWPEGYQLSSAMNFRWPQCV------------------------------PNNLKTLIPNASSEAVQ-LLRDMLQWDPKKRPT------AS-QALRYPYF------------
--VGG----NKMGEGGFGVVYKGYV---N-------N-TT---VAV-KKL---AAM--V-DIT---TE--ELK-QQFD------------------------QEIKVMAKC--Q------HENLVELLGFSS--D------GDD--LC---LVYVYMPNG--SLLDRLSC-----LDGTP-------------------------PLSWHMRCKIAQGAANGINFLHEN--HHIHRDIKSANILLD--E---A--FTA---------KISDFGLARASE-----------------KFAQTVMT--------------SR---IVGTTAYMAPEA--LR------------GE----ITPKSDIYSFGVVLLEIIT-GLPA---------------VD-EH----REPQL-LLDI-KEEIE----DE---EKTIEDYIDKKMNDAD---------------------------------------------STSVEAMYS-VASQCLHEKKNKRPD------IK-KVQQ----LLQ---------
-----LTFVQEIGSGQFGLVHLGYW---L---------NKD-KVAI-KTI---R-E--G-AM----SE--E-D-FI-E-------------------------EAEVMMKL--S------HPKLVQLYGVCL--E------QAP--IC---LVFEFMEHG--CLSDYLR---------TQ-----------------------RGLFAAETLLGMCLDVCEGMAYLEEA--CVIHRDLAARNCLVG--E---N--QVI---------KVSDFGMTRFV-------------------L--DDQY--------------TSSTGTKFPVKWASPEV--FS-----------FSR----YSSKSDVWSFGVLMWEVFSEGKIP---------------YE-NR----SNSEV-VEDI-STGFR----LY---KPRLAS-----------------------------------------------------------THVYQ-IMNHCWKERPEDRPA------FS-RLLRQL--------------
----L-KRIRDLGEGHFGKVELCRY---DP---EGDN-TGE-QVAV-KSL---K-P--E-SG----GNHIA-D-LK-K-------------------------EIEILRNL--Y------HENIVKYKGICT-ED-------GGNGIK---LIMEFLPSG--SLKEYLP---------KN-----------------------KNKINLKQQLKYAVQICKGMDYLGSR--QYVHRDLAARNVLVE--S---E--HQV---------KIGDFGLTKAI------------ET-----D--KEYY--------------TVKDDRDSPVFWYAPEC--LM-----------QSK----FYIASDVWSFGVTLHELLTYCDSDSSPMALF-LKMIGPTHG-QM----TVTRL-VNTL-KEGKR----LP---CPPNCP-----------------------------------------------------------DEVYQ-LMRKCWEFQPSNRTS------FQ-NLIE---GF-----------
-----LKFLQQLGKGNFGSVEMCRY---DP---LQDN-TGE-VVAV-KKL---Q-H--S-TE-----EHLR-D-FE-R-------------------------EIEILKSL--Q------HDNIVKYKGVCYSAG------RRN--LK---LIMEYLPYG--SLRDYLQ---------KH-----------------------KERIDHIKLLQYTSQICKGMEYLGTK--RYIHRDLATRNILVE--N---E--NRV---------KIGDFGLTKVL------------PQ-----D--KEYY--------------KVKEPGESPIFWYAPES--LT-----------ESK----FSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQG-QM----IVFHL-IELL-KNNGR----LP---RPDGCP-----------------------------------------------------------DEIYM-IMTECWNNNVNQRPS------FR-DLA----LRV----------
----L-KYISQLGKGNFGSVELCRY---DP---LGDN-TGA-LVAV-KQL---Q-H--S-GP----DQ-QR-D-FQ-R-------------------------EIQILKAL--H------SDFIVKYRGVSYGPG------RQS--LR---LVMEYLPSG--CLRDFLQ---------RH-----------------------RARLDASRLLLYSSQICKGMEYLGSR--RCVHRDLAARNILVE--S---E--AHV---------KIADFGLAKLL------------PL-----D--KDYY--------------VVREPGQSPIFWYAPES--LS-----------DNI----FSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCER-DV-P--ALCRL-LELL-EEGQR----LP---APPACP-----------------------------------------------------------AEVHE-LMKLCWAPSPQDRPS------FS-ALGP---QL-----------
-----LKLVERLGAGQFGEVWMGYY---N---------GHT-KVAV-KSL---K-Q--G-SM----SP--D-A-FL-A-------------------------EANLMKQL--Q------HQRLVRLYAVVT---------QEP--IY---IITEYMENG--SLVDFLK---------TP----------------------SGIKLTINKLLDMAAQIAEGMAFIEER--NYIHRDLRAANILVS--D---T--LSC---------KIADFGLARLI-------------------E--DNEY--------------TAREGAKFPIKWTAPEA--IN-----------YGT----FTIKSDVWSFGILLTEIVTHGRIP---------------YP-GM----TNPEV-IQNL-ERGYR----MV---RPDNCP-----------------------------------------------------------EELYQ-LMRLCWKERPEDRPT------FD-YLRSV--L------------
---LI--HGEVLGKGFFGQAIKVTH---K---------ATG-KVMVMKEL-----I--R-CD----EETQK-T-FL-T-------------------------EVKVMRSL--D------HPNVLKFIGVLY--K------DKK--LN---LLTEYIEGG--TLKDFLR---------SM------------------------DPFPWQQKVRFAKGIASGMAYLHSM--CIIHRDLNSHNCLIK--L---D--KTV---------VVADFGLSRLIVEERKRAPMEKATT-----------KKRTL-----RKNDRKKRYTVVGNPYWMAPEM--LN-----------GKS----YDETVDIFSFGIVLCEIIGQVYAD---------------PD-CL-P--RTLDF-GLNV-KLFWE----KF---VPTDCP-----------------------------------------------------------PAFFP-LAAICCRLEPESRPA------FS-KLED---SF-----------
---LK--DLGEIGRGAYGSVNKMVH---K-------P-SGQ-IMAV-KRI---RST--V-DEK---EQ--K-Q-L-LM-------------------------DLDVVMRS-SD------CPYIVQFYGALF--R------EGD--CW---ICMELMSTSFDKFYKYVYS------VLDD-------------------------VIPEEILGKITLATVKALNHLKEN-LKIIHRDIKPSNILLD--R---S--GNI---------KLCDFGISGQ--------------------LVDSIAK--------------TR---DAGCRPYMAPER--IDP-------SASRQG----YDVRSDVWSLGITLYELAT-GRFP---------------YP-KW-----NSVF-DQLT-QVVKG----DP---PQLSNSEEREFS-----------------------------------------------------PSFIN-FVNLCLTKDESKRPK------YK-ELLKHPFI------------
-----YDLLQRLGGGTYGEVFKARD---K-------V-SGD-LVAL-KMV---KME--P-DDD---VS--T----LQK-------------------------EILILKTC--R------HANIVAYHGSYL--W------LQK--LW---ICMEFCGAG--SLQDIYQ--------VTG-------------------------SLSELQISYVCREVLQGLAYLHSQ--KKIHRDIKGANILIN--D---A--GEV---------RLADFGISAQI-------------------GATLARR--------------LS---FIGTPYWMAPEVAAVA----------LKGG----YNELCDIWSLGITAIELAE-LQPP---------------LF-DV----HPLRV-LFLM-TKSGY----QP---PRLKEKGKWS-------------------------------------------------------AAFHN-FIKVTLTKSPKKRPS------AT-KMLSHQL-V-----------
-----FELLQRVGAGTYGDVYKARD---T-------V-TSE-LAAV-KIV---KLD--P-GDD---IS--S-L---QQ-------------------------EITILREC--R------HPNVVAYIGSYL--R------NDR--LW---ICMEFCGGG--SLQEIYH--------ATG-------------------------PLEERQIAYVCREALKGLHHLHSQ--GKIHRDIKGANLLLT--L---Q--GDV---------KLADFGVSGEL-------------------TASVAKR--------------RS---FIGTPYWMAPEVAAVE----------RKGG----YNELCDVWALGITAIELGE-LQPP---------------LF-HL----HPMRA-LMLM-SKSSF----QP---PKLRDKTR--WT-----------------------------------------------------QNFHH-FLKLALTKNPKKRPT------AE-KLLQHPF-T-----------
-----YQNLKPIGSGAQGIVCAAYD---A-------V-LDR-NVAI-KKL---SRP--F-QNQ---TH--A-K-RAYR-------------------------ELVLMKCV--N------HKNIISLLNVFT--PQKTLEEFQD--VY---LVMELMDA---NLCQVIQ----------M-------------------------ELDHERMSYLLYQMLCGIKHLHSA--GIIHRDLKPSNIVVK--S---D--CTL---------KILDFGLART--------------------AGTSFMM--------------TP---YVVTRYYRAPEV--IL-----------GMG----YKENVDIWSVGCIMGEMVR-HKIL---------------FP-GR----DYIDQ-WNKV-IEQLG----TP---CPEFMKKLQPTVRNYVENRPKYAGLTFPK------------------LFPDSLFPADSEHNKLKASQARD-LLSKMLVIDPAKRIS------VD-DALQHPYI------------
-----YQNLKPIGSGAQGIVCAAYD---A-------I-LER-NVAI-KKL---SRP--F-QNQ---TH--A-K-RAYR-------------------------ELVLMKCV--N------HKNIIGLLNVFT--PQKSLEEFQD--VY---IVMELMDA---NLCQVIQ----------M-------------------------ELDHERMSYLLYQMLCGIKHLHSA--GIIHRDLKPSNIVVK--S---D--CTL---------KILDFGLART--------------------AGTSFMM--------------TP---YVVTRYYRAPEV--IL-----------GMG----YKENVDLWSVGCIMGEMVC-HKIL---------------FP-GR----DYIDQ-WNKV-IEQLG----TP---CPEFMKKLQPTVRTYVENRPKYAGYSFEK------------------LFPDVLFPADSEHNKLKASQARD-LLSKMLVIDASKRIS------VD-EALQHPYI------------
-----YRLLKTIGKGNFAKVKLARH---I-------L-TGK-EVAV-KII---DKT--Q-LNS---SS--L-Q-KLFR-------------------------EVRIMKVL--N------HPNIVKLFEVIE--T------EKT--LY---LVMEYASGG--EVFDYLV--------AHG-------------------------RMKEKEARAKFRQIVSAVQYCHQK--FIVHRDLKAENLLLD--A---D--MNI---------KIADFGFSNE--------------------FTFGNKL--------------DT---FCGSPPYAAPEL--FQ----------GKKY----DGPEVDVWSLGVILYTLVS-GSLP---------------FD-GQ-------NL-KELR-ERVLR----GK---YRIPFYMS---------------------------------------------------------TDCEN-LLKKFLILNPSKRGT------LE-QIMKDRWM------------
-----YRLLRTIGKGNFAKVKLARH---I-------L-TGR-EVAI-KII---DKT--Q-LNP---SS--L-Q-KLFR-------------------------EVRIMKGL--N------HPNIVKLFEVIE--T------EKT--LY---LVMEYASAG--EVFDYLV--------SHG-------------------------RMKEKEARAKFRQIVSAVHYCHQK--NIVHRDLKAENLLLD--A---E--ANI---------KIADFGFSNE--------------------FTLGSKL--------------DT---FCGSPPYAAPEL--FQ----------GKKY----DGPEVDIWSLGVILYTLVS-GSLP---------------FD-GH-------NL-KELR-ERVLR----GK---YRVPFYMS---------------------------------------------------------TDCES-ILRRFLVLNPAKRCT------LE-QIMKDKWI------------
-----YELHETIGTGGFAKVKLACH---I-------L-TGE-MVAI-KIM---DKN--T-LGS---DL--P-R-IKT--------------------------EIEALKNL--R------HQHICQLYHVLE--T------ANK--IF---MVLEYCPGG--ELFDYII--------SQD-------------------------RLSEEETRVVFRQIVSAVAYVHSQ--GYAHRDLKPENLLFD--E---Y--HKL---------KLIDFGLCAKP------------------KGNKDYHL--------------QT---CCGSLAYAAPEL--IQ----------GKSY----LGSEADVWSMGILLYVLMC-GFLP---------------FD-DD-------NV-MALY-KKIMR----GK---YDVPKWLS---------------------------------------------------------PSSIL-LLQQMLQVDPKKRIS------MK-NLLNHPWI------------
-----YDIEERLGSGKFGQVFRLVE---K-------K-TRK-VWAG-KFF---KAY--S-AKE---KE--N-I-R--Q-------------------------EISIMNCL--H------HPKLVQCVDAFE--E------KAN--IV---MVLEIVSGG--ELFERII-------DEDF-------------------------ELTERECIKYMRQISEGVEYIHKQ--GIVHLDLKPENIMCV--N---K--TGTR-------IKLIDFGLARR--------------------LENAGSL--------------KV---LFGTPEFVAPEV--IN-----------YEP----IGYATDMWSIGVICYILVS-GLSP---------------FM-GD-------ND-NETL-ANVTS----AT---WDFDDEAFDEIS-----------------------------------------------------DDAKD-FISNLLKKDMKNRLD------CT-QCLQHPWL------------
---MN--SKEALGGGKFGAVCTCME---K-------A-TGL-KLAA-KVI---KKQ--T-PKD---KE--M----VLL-------------------------EIEVMNQL--N------HRNLIQLYAAIE--T------PHE--IV---LFMEYIEGG--ELFERIV-------DEDY-------------------------HLTEVDTMVFVRQICDGILFMHKM--RVLHLDLKPENILCV-NT---T--GHL--------VKIIDFGLARR--------------------YNPNEKL--------------KV---NFGTPEFLSPEV--VN-----------YDQ----ISDKTDMWSMGVITYMLLS-GLSP---------------FL-GD-------DD-TETL-NNVLS----GN---WYFDEETFEAVS-----------------------------------------------------DEAKD-FVSNLIVKDQRARMN------AA-QCLAHPWL------------
---VC--QHEVLGGGRFGQVHRCTE---K-------S-TGL-PLAA-KII---KVK--S-AKD---RE--D-V-K--N-------------------------EINIMNQL--S------HVNLIQLYDAFE--S------KHS--CT---LVMEYVDGG--ELFDRIT-------DEKY-------------------------HLTELDVVLFTRQICEGVHYLHQH--YILHLDLKPENILCV--N---QTGHQI---------KIIDFGLARR--------------------YKPREKL--------------KV---NFGTPEFLAPEV--VN-----------YEF----VSFPTDMWSVGVITYMLLS-GLSP---------------FL-GE-------TD-AETM-NFIVN----CS---WDFDADTFEGLS-----------------------------------------------------EEAKD-FVSRLLVKEKSCRMS------AT-QCLKHEWL------------
---VS--KTEILGGGRFGQVHKCEE---T-------A-TGL-KLAA-KII---KTR--G-MKD---KE--E-V-K--N-------------------------EISVMNQL--D------HANLIQLYDAFE--S------KND--IV---LVMEYVDGG--ELFDRII-------DESY-------------------------NLTELDTILFMKQICEGIRHMHQM--YILHLDLKPENILCVNRD---A--KQI---------KIIDFGLARR--------------------YKPREKL--------------KV---NFGTPEFLAPEV--VN-----------YDF----VSFPTDMWSVGVIAYMLLS-GLSP---------------FL-GD-------ND-AETL-NNILA----CR---WDLEDEEFQDIS-----------------------------------------------------EEAKE-FISKLLIKEKSWRIS------AS-EALKHPWL------------
---IV--LKWELGEGAFGKVFLAEC---HN--LLPEQ-DKM-LVAV-KAL---K-E--A-SE----SA-RQ-D-FQ-R-------------------------EAELLTML--Q------HQHIVRFFGVCT--E------GRP--LL---MVFEYMRHG--DLNRFLR---------SHGPDAKL---------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGL--HFVHRDLATRNCLVG--Q---G--LVV---------KIGDFGMSRDI-------------Y-----S--TDYY--------------RVGGRTMLPIRWMPPES--IL-----------YRK----FTTESDVWSFGVVLWEIFTYGKQP---------------WY-QL----SNTEA-IDCI-TQGRE----LE---RPRACP-----------------------------------------------------------PEVYA-IMRGCWQREPQQRHS------IK-DVHARL--------------
----I-VLKRELGEGAFGKVFLAEC---YN--LCPEQ-DKI-LVAV-KTL---K-D--A-SD----NA-RK-D-FH-R-------------------------EAELLTNL--Q------HEHIVKFYGVCV--E------GDP--LI---MVFEYMKHG--DLNKFLR---------AHGPDAV-----------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQ--HFVHRDLATRNCLVG--E---N--LLV---------KIGDFGMSRDV-------------Y-----S--TDYY--------------RVGGHTMLPIRWMPPES--IM-----------YRK----FTTESDVWSLGVVLWEIFTYGKQP---------------WY-QL----SNNEV-IECI-TQGRV----LQ---RPRTCP-----------------------------------------------------------QEVYE-LMLGCWQREPHMRKN------IK-GIHTL--L------------
----I-VLKRELGEGAFGKVFLAEC---YN--LSPTK-DKM-LVAV-KAL---K-D--P-TL----AA-RK-D-FQ-R-------------------------EAELLTNL--Q------HEHIVKFYGVCG--D------GDP--LI---MVFEYMKHG--DLNKFLR---------AHGPDAMIL--------VDGQPRQAKGELGLSQMLHIASQIASGMVYLASQ--HFVHRDLATRNCLVG--A---N--LLV---------KIGDFGMSRDV-------------Y-----S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPES--IM-----------YRK----FTTESDVWSFGVILWEIFTYGKQP---------------WF-QL----SNTEV-IECI-TQGRV----LE---RPRVCP-----------------------------------------------------------KEVYD-VMLGCWQREPQQRLN------IK-EIYKIL--------------
-----YELQETLGKGTYGKVKRATE---R-------F-SGR-VVAI-KSI---RKD--K-IKD---EQ--D-M-VHIR------------------------REIEIMSSL--N------HPHIISIYEVFE--N------KDK--IV---IIMEYASKG--ELYDYIS--------ERR-------------------------RLSERETRHFFRQIVSAVHYCHKN--GVVHRDLKLENILLD--D---N--CNI---------KIADFGLSNL--------------------YQKDKFL--------------QT---FCGSPLYASPEI--VN----------GRPY----RGPEVDSWALGVLLYTLVY-GTMP---------------FD-GF-------DH-KNLI-RQISS----GE---YREPTQP----------------------------------------------------------SDARG-LIRWMLMVNPDRRAT------IE-DIANHWW-V-----------
-----YEFLETLGKGTYGKVKKARE---S-------S-GR--LVAI-KSI---RKD--K-IKD---EQ--D-L-MHIR------------------------REIEIMSSL--N------HPHIIAIHEVFE--N------SSK--IV---IVMEYASRG--DLYDYIS--------ERQ-------------------------QLSEREARHFFRQIVSAVHYCHQN--RVVHRDLKLENILLD--A---N--GNI---------KIADFGLSNL--------------------YHQGKFL--------------QT---FCGSPLYASPEI--VN----------GKPY----TGPEVDSWSLGVLLYILVH-GTMP---------------FD-GH-------DH-KILV-KQISN----GA---YREPPK-----P-----------------------------------------------------SDACG-LIRWLLMVNPTRRAT------LE-DVASHWW-V-----------
-----YELQEVIGSGATAVVQAAYC---A-------P-KKE-KVAI-KRI---NLE--K-CQT---SM--D-E--LLK-------------------------EIQAMSQC--H------HPNIVSYYTSFV--V------KDE--LW---LVMKLLSGG--SVLDIIKHIVAKGEHKSG-------------------------VLDESTIATILREVLEGLEYLHKN--GQIHRDVKAGNILLG--E---D--GSV---------QIADFGVSAFLAT--------------GGDITRNKVR--------------KT---FVGTPCWMAPEV--ME----------QVRG----YDFKADIWSFGITAIELAT-GAAP---------------YH-KY----PPMKV-LMLT-LQNDP----PS---LETGVQDKE--MLK------------------------------------------------KYGKSFRK-MISLCLQKDPEKRPT------AA-ELLRHKFF------------
-DNFI-----KIGEGSTGIVCIATV---R-------S-SGK-LVAV-KKM---DLR--K-QQR---RE--L----LFN-------------------------EVVIMRDY--Q------HENVVEMYNSYL--V------GDE--LW---VVMEFLEGG--ALTDIVT---------HT-------------------------RMNEEQIAAVCLAVLQALSVLHAQ--GVIHRDIKSDSILLT--H---D--GRV---------KLSDFGFCAQV-------------------SKEVPRR--------------KS---LVGTPYWMAPEL--IS-----------RLP----YGPEVDIWSLGIMVIEMVD-GEPP---------------YF-NE----PPLKA-MKMI-RDNLP----PR---LKNLHKVS---------------------------------------------------------PSLKG-FLDRLLVRDPAQRAT------AA-ELLKHPFL------------
----F-KFGKILGEGSFSTVVLARE---L-------A-TSR-EYAI-KIL---EKR--H-IIK---EN--K-VPYVTR-------------------------ERDVMSRL--D------HPFFVKLYFTFQ--D------DEK--LY---FGLSYAKNG--ELLKYIR--------KIG-------------------------SFDETCTRFYTAEIVSALEYLHGK--GIIHRDLKPENILLN--E---D--MHI---------QITDFGTAKVLS-----------------PESKQARA--------------NS---FVGTAQYVSPEL--LT-----------EKS----ACKSSDLWALGCIIYQLVA-GLPP---------------FR-AG-------NE-YLIF-QKIIK----LE---YDFPEKFF---------------------------------------------------------PKARD-LVEKLLVLDATKRLG------CE-EM------EGYGPLKAHPF-
-----YEPKEILGRGVSSVVRRCIH---K-------P-TSQ-EYAV-KVI---DVT--G-GGS---FS--P-E-EVRELRE------------------ATLKEVDILRKV-SG------HPNIIQLKDTYE--T------NTF--FF---LVFDLMKRG--ELFDYLT--------EKV-------------------------TLSEKETRKIMRALLEVICTLHKL--NIVHRDLKPENILLD--D---N--MNI---------KLTDFGFSCQ--------------------LEPGERL--------------RE---VCGTPSYLAPEI--IECS-----MNEDHPG----YGKEVDMWSTGVIMYTLLA-GSPP---------------FW-HR-------KQ-MLML-RMIMS----GN---YQFGSPEWDDYS-----------------------------------------------------DTVKD-LVSRFLVVQPQNRYT------AE-EALAHPFF------------
--YDP---KDVIGRGVSSVVRRCVH---R-------A-TGH-EFAV-KIM---EVT--A-ERL---SP--E-Q-LEEVREA-------------------TRRETHILRQV-AG------HPHIITLIDSYE--S------SSF--MF---LVFDLMRKG--ELFDYLT--------EKV-------------------------ALSEKETRSIMRSLLEAVSFLHAN--NIVHRDLKPENILLD--D---N--MQI---------RLSDFGFSCH--------------------LEPGEKL--------------RE---LCGTPGYLAPEI--LKCS-----MDETHPG----YGKEVDLWACGVILFTLLA-GSPP---------------FW-HR-------RQ-ILML-RMIME----GQ---YQFSSPEWDDRS-----------------------------------------------------STVKD-LISRLLQVDPEARLT------AE-QALQHPFF------------
---FR--CCAVLGRGHFGKVLLAEY---K-------N-TNE-MFAI-KAL---KKG--D-IVA---RD--E-V-DSLM------------------------CEKRIFETV--NS---VRHPFLVNLFACFQ--T------KEH--VC---FVMEYAAGG--DLMMHIH---------TD-------------------------VFSEPRAVFYAACVVLGLQYLHEH--KIVYRDLKLDNLLLD--T---E--GFV---------KIADFGLCKEG-------------------MGYGDRT--------------ST---FCGTPEFLAPEV--LT-----------ETS----YTRAVDWWGLGVLIYEMLV-GESP---------------FP-GD-------DE-EEVF-DSIVN----DE---VRYPRFLS---------------------------------------------------------TEAIS-IMRRLLRRNPERRLGAS-EKDAE-DVKKHPFF------------
---YV--RGRFLGKGGFAKCFEISD---A-------D-TKE-VFAG-KIV---PKS--L-LLK---PH--Q-R-EKMS------------------------MEISIHRSL--A------HQHVVGFHGFFE--D------NDF--VF---VVLELCRRR--SLLELHK--------RRK-------------------------ALTEPEARYYLRQIVLGCQYLHRN--RVIHRDLKLGNLFLN--E---D--LEV---------KIGDFGLATKV-------------------EYDGERK--------------KT---LCGTPNYIAPEV--LS-----------KKG----HSFEVDVWSIGCIMYTLLV-GKPP---------------FE-TS-------CL-KETY-LRIKK----NE---YSIPKHIN---------------------------------------------------------PVAAS-LIQKMLQTDPTARPT------IN-ELLNDEFF------------
----F-KVGNLLGKGSFAGVYRAES---I-------H-TGL-EVAI-KMI---DKK--A-MYK---AG--M-V-QRVQ------------------------NEVKIHCQL--K------HPSILELYNYFE--D------SNY--VY---LVLEMCHNG--EMNRYLK-------NRVK-------------------------PFSENEARHFMHQIITGMLYLHSH--GILHRDLTLSNLLLT--R---N--MNI---------KIADFGLATQL-------------------KMPHEKH--------------YT---LCGTPNYISPEI--AT-----------RSA----HGLESDVWSLGCMFYTLLI-GRPP---------------FD-TD-------TV-KNTL-NKVVL----AD---YEMPSFLS---------------------------------------------------------IEAKD-LIHQLLRRNPADRLS------LS-SVLDHPFM------------
----Y-ILGDTLGVGTFGKVKVGKH---E-------L-TGH-KVAV-KIL---NRQ--K-IRS---LD--V-V-GKIR------------------------REIQNLKLF--R------HPHIIKLYQVIS--T------PSD--IF---MVMEYVSGG--ELFDYIC--------KNG-------------------------RLDEKESRRLFQQILSGVDYCHRH--MVVHRDLKPENVLLD--A---H--MNA---------KIADFGLSNM--------------------MSDGEFL--------------RT---SCGSPNYAAPEV--IS----------GRLY----AGPEVDIWSSGVILYALLC-GTLP---------------FD-DD-------HV-PTLF-KKICD----GI---FYTPQYLN---------------------------------------------------------PSVIS-LLKHMLQVDPMKRAT------IK-DIREHEWF------------
-----YVLGDTLGVGTFGKVKIGEH---Q-------L-TGH-KVAV-KIL---NRQ--K-IRS---LD--V-V-GKIK------------------------REIQNLKLF--R------HPHIIKLYQVIS--T------PTD--FF---MVMEYVSGG--ELFDYIC--------KHG-------------------------RVEEMEARRLFQQILSAVDYCHRH--MVVHRDLKPENVLLD--A---H--MNA---------KIADFGLSNM--------------------MSDGEFL--------------RT---SCGSPNYAAPEV--IS----------GRLY----AGPEVDIWSCGVILYALLC-GTLP---------------FD-DE-------HV-PTLF-KKIRG----GV---FYIPEYLN---------------------------------------------------------RSVAT-LLMHMLQVDPLKRAT------IK-DIREHEWF------------
---FI--FHKVLGKGSFGKVLLGEL---K-------G-RGE-YFAI-KAL---KKD--V-VLI---DD--D-V-ECTM------------------------VEKRVLTLA-AE------NPFLTHLICTFQ--T------KDH--LF---FVMEFLNGG--DLMYHIQ--------DKG-------------------------RFELYRATFYAAEIMCGLQFLHSK--GIIYRDLKLDNVLLD--R---D--GHI---------KIADFGMCKEN-------------------IFGESRA--------------ST---FCGTPDYIAPEI--LQ-----------GLK----YTFSVDWWSFGVLLYEMLI-GQSP---------------FH-GD-------DE-DELF-ESIRV----DT---PHYPRWIT---------------------------------------------------------KESKD-ILEKLFEREPTKRLG-----VTG-NIKIHPFF------------
---FI--LHKMLGKGSFGKVFLAEF---K-------K-TNQ-FFAI-KAL---KKD--V-VLM---DD--D-V-ECTM------------------------VEKRVLSLA-WE------HPFLTHMFCTFQ--T------KEN--LF---FVMEYLNGG--DLMYHIQ--------SCH-------------------------KFDLSRATFYAAEIILGLQFLHSK--GIVYRDLKLDNILLD--K---D--GHI---------KIADFGMCKEN-------------------MLGDAKT--------------NT---FCGTPDYIAPEI--LL-----------GQK----YNHSVDWWSFGVLLYEMLI-GQSP---------------FH-GQ-------DE-EELF-HSIRM----DN---PFYPRWLE---------------------------------------------------------KEAKD-LLVKLFVREPEKRLG------VRGDIRQHPLF------------
----F-DLIRVIGRGSYAKVLLVRL---K-------K-NDQ-IYAM-KVV---KKE--L-VHD---DE--D-I-DWVQ------------------------TEKHVFEQA-SS------NPFLVGLHSCFQ--T------TSR--LF---LVIEYVNGG--DLMFHMQ--------RQR-------------------------KLPEEHARFYAAEICIALNFLHER--GIIYRDLKLDNVLLD--A---D--GHI---------KLTDYGMCKEG-------------------LGPGDTT--------------ST---FCGTPNYIAPEI--LR-----------GEE----YGFSVDWWALGVLMFEMMA-GRSP---------------FD-IITDNPDMNTE-DYLF-QVILE----KP---IRIPRFLS---------------------------------------------------------VKASH-VLKGFLNKDPKERLGCRPQTGF----------SDIKSHAFF---
---PD----EVLGSGQFGIVYGGKH---R-------K-TGR-DVAI-KII---DKL--R-FPT---KQ--E-S-QLRN-------------------------EVAILQNL--H------HPGVVNLECMFE--T------PER--VF---VVMEKLHGD--MLEMILS-------SEKG-------------------------RLPEHITKFLITQILVALRHLHFK--NIVHCDLKPENVLLA--S---A--DPFP------QVKLCDFGFARI--------------------IGEKSFR--------------RS---VVGTPAYLAPEV--LR-----------NKG----YNRSLDMWSVGVIIYVSLS-GTFP---------------FN-ED----------EDIH-DQIQN----AA---FMYPPNPWKEIS-----------------------------------------------------HEAID-LINNLLQVKMRKRYS------VD-KTLSHPWL------------
---PD----EVLGSGQFGVVYGGKH---R-------K-TGR-DVAV-KVI---DKL--R-FPT---KQ--E-S-QLRN-------------------------EVAILQSL--R------HPGIVNLECMFE--T------PEK--VF---VVMEKLHGD--MLEMILS-------SEKG-------------------------RLPERLTKFLITQILVALRHLHFK--NIVHCDLKPENVLLA--S---A--DPFP------QVKLCDFGFARI--------------------IGEKSFR--------------RS---VVGTPAYLAPEV--LL-----------NQG----YNRSLDMWSVGVIMYVSLS-GTFP---------------FN-ED----------EDIN-DQIQN----AA---FMYPASPWSHIS-----------------------------------------------------AGAID-LINNLLQVKMRKRYS------VD-KSLSHPWL------------
--FAD----EVLGSGQFGIVYGGKH---R-------K-TGR-DVAI-KVI---DKM--R-FPT---KQ--E-S-QLRN-------------------------EVAILQNL--H------HPGIVNLECMFE--T------PER--VF---VVMEKLHGD--MLEMILS-------SEKS-------------------------RLPERITKFMVTQILVALRNLHFK--NIVHCDLKPENVLLA--S---A--EPFP------QVKLCDFGFARI--------------------IGEKSFR--------------RS---VVGTPAYLAPEV--LR-----------SKG----YNRSLDMWSVGVIIYVSLS-GTFP---------------FN-ED----------EDIN-DQIQN----AA---FMYPPNPWREIS-----------------------------------------------------GEAID-LINNLLQVKMRKRYS------VD-KSLSHPWL------------
----F-NIIDTLGVGGFGRVELVQL---KS------E-ESK-TFAM-KIL---KKR--H-IVD---TR--Q-Q-EHIR------------------------SEKQIMQGA--H------SDFIVRLYRTFK--D------SKY--LY---MLMEACLGG--ELWTILR--------DRG-------------------------SFEDSTTRFYTACVVEAFAYLHSK--GIIYRDLKPENLILD--H---R--GYA---------KLVDFGFAKK--------------------IGFGKKT--------------WT---FCGTPEYVAPEI--IL-----------NKG----HDISADYWSLGILMYELLT-GSPP---------------FS-GP-------DP-MKTY-NIILR----GI---DMIEFPKKIA-------------------------------------------------------KNAAN-LIKKLCRDNPSERLGNL-KNGVK-DIQKHKWF------------
-YNVY----GYTGQGVFSNVVRARD---N-------ARANQ-EVAV-KII---RNN--E-LMQ---KT--G-----LK-------------------------ELEFLKKL--NDADPDDKFHCLRLFRHFY--H------KQH--LC---LVFEPLSM---NLREVLKK-----YGKDV-------------------------GLHIKAVRSYSQQLFLALKLLKRC--NILHADIKPDNILVN--E---S--KTI--------LKLCDFGSAS---------------------HVADNDI--------------TP---YLVSRFYRAPEI--II-----------GKS----YDYGIDMWSVGCTLYELYT-GKIL---------------FP-GK----TNNHM-LKLA-MDLKG----KM---PNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQLKD-LLDQILMLDPAKRIS------IN-QALQHAFI------------
-----IELGRCIGEGQFGDVHQGIY---M----SPEN-PAL-AVAI-KTC---K-N--C-TS----DSVRE-K-FL-Q-------------------------EALTMRQF--D------HPHIVKLIGVIT---------ENP--VW---IIMELCTLG--ELRSFLQ---------VR-----------------------KYSLDLASLILYAYQLSTALAYLESK--RFVHRDIAARNVLVS--S---N--DCV---------KLGDFGLSRYM-------------------E--DSTY--------------YKASKGKLPIKWMAPES--IN-----------FRR----FTSASDVWMFGVCMWEILMHGVKP---------------FQ-GV----KNNDV-IGRI-ENGER----LP---MPPNCP-----------------------------------------------------------PTLYS-LMTKCWAYDPSRRPR------FT-ELKAQL--------------
----V-VLNRILGEGFFGEVYEGVY---T----NHKG-EKI-NVAV-KTC---K-K--D-CT----LDNKE-K-FM-S-------------------------EAVIMKNL--D------HPHIVKLIGIIE---------EEP--TW---IIMELYPYG--ELGHYLE---------RN-----------------------KNSLKVLTLVLYSLQICKAMAYLESI--NCVHRDIAVRNILVA--S---P--ECV---------KLGDFGLSRYI-------------------E--DEDY--------------YKASVTRLPIKWMSPES--IN-----------FRR----FTTASDVWMFAVCMWEILSFGKQP---------------FF-WL----ENKDV-IGVL-EKGDR----LP---KPDLCP-----------------------------------------------------------PVLYT-LMTRCWDYDPSDRPR------FT-ELVCS--L------------
---VM--LSTRIGSGSFGTVYKGKW---H-----------G-DVAV-KIL---K-V-VD-PT----PEQFQ-A-FR-N-------------------------EVAVLRKT--R------HVNILLFMGYMT---------KDN--LA---IVTQWCEGS--SLYKHLH---------VQ-----------------------ETKFQMFQLIDIARQTAQGMDYLHAK--NIIHRDMKSNNIFLH--E---G--LTV---------KIGDFGLATVK-------------S-----R--WSGS--------------QQVEQPTGSVLWMAPEV--IR-----------MQDN-NPFSFQSDVYSYGIVLYELMT-GELP---------------YS-HI-N--NRDQI-IFMV-GRGYASPDLSK---LYKNCP-----------------------------------------------------------KAMKR-LVADCVKKVKEERPL------FP-QILSS--I------------
----L-VLGKTLGEGEFGKVVKATA---FH--LKGRA-GYT-TVAV-KML---K-E--N-AS----PSELR-D-LL-S-------------------------EFNVLKQV--N------HPHVIKLYGACS--Q------DGP--LL---LIVEYAKYG--SLRGFLR---------ESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEM--KLVHRDLAARNILVA--E---G--RKM---------KISDFGLSRDV-------------Y-----E--EDSY--------------VKRSQGRIPVKWMAIES--LF-----------DHI----YTTQSDVWSFGVLLWEIVTLGGNP---------------YP-GI----PPERL-FNLL-KTGHR----ME---RPDNCS-----------------------------------------------------------EEMYR-LMLQCWKQEPDKRPV------FA-DISKDL--------------
--LES----AELDSGGFGKVSLCFH---R---------TQG-LMIM-KTV--YK-G--P-NC----IEHNE-A-LL-E-------------------------EAKMMNRL--R------HSRVVKLLGVII--E------EGK--YS---LVMEYMEKG--NLMHVLK---------AE------------------------MSTPLSVKGRIILEIIEGMCYLHGK--GVIHKDLKPENILVD--N---D--FHI---------KIADLGLASFKMWS------KLNNE---------EHNELR--------EVDGTAKKNGGTLYYMAPEH--LN-----------DVNA--KPTEKSDVYSFAVVLWAIFA-NKEP---------------YE-NA-I--CEQQL-IMCI-KSGNR----PDVDDITEYCP-----------------------------------------------------------REIIS-LMKLCWEANPEARPT------FP-GIEEK--F------------
-----FELLRVLGKGGYGKVFQVRKVTGA-------N-TGK-IFAM-KVL---KKA--M-IVR---NA--K-D-TAHTK-----------------------AERNILEEV--K------HPFIVDLIYAFQ--T------GGK--LY---LILEYLSGG--ELFMQLE--------REG-------------------------IFMEDTACFYLAEISMALGHLHQK--GIIYRDLKPENIMLN--H---Q--GHV---------KLTDFGLCKES-------------------IHDGTVT--------------HT---FCGTIEYMAPEI--LM-----------RSG----HNRAVDWWSLGALMYDMLT-GAPP---------------FT-GE-------NR-KKTI-DKILK----CK---LNLPPYLT---------------------------------------------------------QEARD-LLKKLLKRNAASRLGAG-PGDAG-EVQAHPFF------------
-----YELVRELGKGTYGKVDLVVY---K-------G-TGT-KMAL-KFV---NKS--K-TKL---KN--F-----LR-------------------------EVSITNSL-SS------SPFIIKVFDVVF--E-----TEDC--YV---FAQEYAPAG--DLFDIIP--------PQV-------------------------GLPEDTVKRCVQQLGLALDFMHGR--QLVHRDIKPENVLLFDRE---C--RRV---------KLADFGMTR----------------------RVGCRV--------------KR---VSGTIPYTAPEV--CQAG------RADGLA----VDTGVDVWAFGVLIFCVLT-GNFP---------------WE-AA----SGADAFFEEF-VRWQR----GR---LPGLPSQWRRFT-----------------------------------------------------EPALR-MFQRLLALEPERRGP------AK-EVF-----RFLKH-------
-----YDIERTLGKGNFAVVKLARH---R-------V-TKT-QVAI-KII---DKT--R-LDS---SN--L-E-KIYR-------------------------EVQLMKLL--N------HPHIIKLYQVME--T------KDM--LY---IVTEFAKNG--EMFDYLT--------SNG-------------------------HLSENEARKKFWQILSAVEYCHDH--HIVHRDLKTENLLLD--G---N--MDI---------KLADFGFGNF--------------------YKSGEPL--------------ST---WCGSPPYAAPEV--FE----------GKEY----EGPQLDIWSLGVVLYVLVC-GSLP---------------FD-GP-------NL-PTLR-QRVLE----GR---FRIPFFMS---------------------------------------------------------QDCES-LIRRMLVVDPARRIT------IA-QIRQHRWM------------
-----YDIEGTLGKGNFAVVKLGRH---R-------I-TKT-EVAI-KII---DKS--Q-LDA---VN--L-E-KIYR-------------------------EVQIMKML--D------HPHIIKLYQVME--T------KSM--LY---LVTEYAKNG--EIFDYLA--------NHG-------------------------RLNESEARRKFWQILSAVDYCHGR--KIVHRDLKAENLLLD--N---N--MNI---------KIADFGFGNF--------------------FKSGELL--------------AT---WCGSPPYAAPEV--FE----------GQQY----EGPQLDIWSMGVVLYVLVC-GALP---------------FD-GP-------TL-PILR-QRVLE----GR---FRIPYFMS---------------------------------------------------------EDCEH-LIRRMLVLDPSKRLT------IA-QIKEHKWM------------
-----WEIIGELGDGAFGKVYKAQN---K-------E-TSV-LAAA-KVI---DTK--S-EEE---LE--D-Y-M--V-------------------------EIDILASC--D------HPNIVKLLDAFY--Y------ENN--LW---ILIEFCAGG--AVDAVML-------ELER-------------------------PLTESQIQVVCKQTLDALNYLHDN--KIIHRDLKAGNILFT--L---D--GDI---------KLADFGVSAKN-------------------TRTIQRR--------------DS---FIGTPYWMAPEV--VMCE------TSKDRP----YDYKADVWSLGITLIEMAE-IEPP---------------HH-EL----NPMRV-LLKI-AKSEP----PT---LAQPSRWS---------------------------------------------------------SNFKD-FLKKCLEKNVDARWT------TS-QLLQHPFV------------
-----WEIVGELGDGAFGKVYKAKN---K-------E-TGA-LAAA-KVI---ETK--S-EEE---LE--D-Y-I--V-------------------------EIEILATC--D------HPYIVKLLGAYY--H------DGK--LW---IMIEFCPGG--AVDAIML-------ELDR-------------------------GLTEPQIQVVCRQMLEALNFLHSK--RIIHRDLKAGNVLMT--L---E--GDI---------RLADFGVSAKN-------------------LKTLQKR--------------DS---FIGTPYWMAPEV--VMCE------TMKDTP----YDYKADIWSLGITLIEMAQ-IEPP---------------HH-EL----NPMRV-LLKI-AKSDP----PT---LLTPSKWS---------------------------------------------------------VEFRD-FLKIALDKNPETRPS------AA-QLLEHPFV------------
--LCP---GRELGRGKFAVVRKCIK---K-------D-SGK-EFAA-KFM---RKR--R-KGQ---DC--R-M-EIIH-------------------------EIAVLELA-QD------NPWVINLHEVYE--T------ASE--MI---LVLEYAAGG--EIFDQCVA------DREE-------------------------AFKEKDVQRLMRQILEGVHFLHTR--DVVHLDLKPQNILLT--S---E--SPLG------DIKIVDFGLSRI--------------------LKNSEEL--------------RE---IMGTPEYVAPEI--LS-----------YDP----ISMATDMWSIGVLTYVMLT-GISP---------------FL-GN-------DK-QETF-LNISQ----MN---LSYSEEEFDVLS-----------------------------------------------------ESAVD-FIRTLLVKKPEDRAT------AE-ECLKHPWL------------
--ILT---SKELGRGKFAVVRQCIS---K-------S-TGQ-EYAA-KFL---KKR--R-RGQ---DC--R-A-EILH-------------------------EIAVLELA-KS------CPRVINLHEVYE--N------TSE--II---LILEYAAGG--EIFSLCLP------ELAE-------------------------MVSENDVIRLIKQILEGVYYLHQN--NIVHLDLKPQNILLS--S---I--YPLG------DIKIVDFGMSRK--------------------IGHACEL--------------RE---IMGTPEYLAPEI--LN-----------YDP----ITTATDMWNIGIIAYMLLT-HTSP---------------FV-GE-------DN-QETY-LNISQ----VN---VDYSEETFSSVS-----------------------------------------------------QLATD-FIQSLLVKNPEKRPT------AE-ICLSHSWL------------
-----FTKLEKIGKGSFGEVFKGID---N-------R-TQK-VVAI-KII---DLE--E-AED---EI--E-D-IQ-Q-------------------------EITVLSQC--D------SPYVTKYYGSYL--K------DTK--LW---IIMEYLGGG--SALDLLE---------PG-------------------------PLDETQIATILREILKGLDYLHSE--KKIHRDIKAANVLLS--E---H--GEV---------KLADFGVAGQL-------------------TDTQIKR--------------NT---FVGTPFWMAPEV--IK-----------QSA----YDSKADIWSLGITAIELAR-GEPP---------------HS-EL----HPMKV-LFLI-PKNNP----PT---LEGNYS-----------------------------------------------------------KPLKE-FVEACLNKEPSFRPT------AK-ELLKHKFI------------
----F-DVLEKLGEGSYGSVFKAIH---K-------E-SGQ-VVAI-KQV---PVE--S-DLQ---EI--------IK-------------------------EISIMQQC--D------SPYVVKYYGSYF--K------NTD--LW---IVMEYCGAG--SVSDIIR-------LRNK-------------------------TLIEDEIATILKSTLKGLEYLHFM--RKIHRDIKAGNILLN--T---E--GHA---------KLADFGVAGQL-------------------TDTMAKR--------------NT---VIGTPFWMAPEV--IQ-----------EIG----YNCVADIWSLGITSIEMAE-GKPP---------------YA-DI----HPMRA-IFMI-PTNPP----PT---FRKPELWS---------------------------------------------------------DDFTD-FVKKCLVKNPEQRAT------AT-QLLQHPFI------------
-----YELQEVIGSGATAVVQAALC---K-------P-RQE-RVAI-KRI---NLE--K-CQT---SM--D-E--LLK-------------------------EIQAMSQC--S------HPNVVTYYTSFV--V------KDE--LW---LVMKLLSGG--SMLDIIKYIVNRGEHKNG-------------------------VLEEAIIATILKEVLEGLDYLHRN--GQIHRDLKAGNILLG--E---D--GSV---------QIADFGVSAFLAT--------------GGDVTRNKVR--------------KT---FVGTPCWMAPEV--ME----------QVRG----YDFKADMWSFGITAIELAT-GAAP---------------YH-KY----PPMKV-LMLT-LQNDP----PT---LETGVEDKE--MMK------------------------------------------------KYGKSFRK-LLSLCLQKDPSKRPT------AA-ELLKCKFF------------
----F-DVLEKLGEGSYGSVYKAIH---K-------E-TGQ-IVAI-KQV---PVE--S-DLQ---EI--------IK-------------------------EISIMQQC--D------SPHVVKYYGSYF--K------NTD--LW---IVMEYCGAG--SVSDIIR-------LRNK-------------------------TLTEDEIATILQSTLKGLEYLHFM--RKIHRDIKAGNILLN--T---E--GHA---------KLADFGVAGQL-------------------TDTMAKR--------------NT---VIGTPFWMAPEV--IQ-----------EIG----YNCVADIWSLGITAIEMAE-GKPP---------------YA-DI----HPMRA-IFMI-PTNPP----PT---FRKPELWS---------------------------------------------------------DNFTD-FVKQCLVKSPEQRAT------AT-QLLQHPFV------------
-----IKFQDVIGEGNFGQVLKARI---K-----KDG-LRM-DAAI-KRM---K-E--Y-AS----KDDHR-D-FA-G-------------------------ELEVLCKLG-H------HPNIINLLGACE--H------RGY--LY---LAIEYAPHG--NLLDFLR---------KSRVLETDP--------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQK--QFIHRDLAARNILVG--E---N--YVA---------KIADFGLSRGQ-----------------------EVY--------------VKKTMGRLPVRWMAIES--LN-----------YSV----YTTNSDVWSYGVLLWEIVSLGGTP---------------YC-GM----TCAEL-YEKL-PQGYR----LE---KPLNCD-----------------------------------------------------------DEVYD-LMRQCWREKPYERPS------FA-QILV---SL-----------
-----ITFEDLIGEGNFGQVIRAMI---K-----KDG-LKM-NAAI-KML---K-E--Y-AS----ENDHR-D-FA-G-------------------------ELEVLCKLG-H------HPNIINLLGACK--N------RGY--LY---IAIEYAPYG--NLLDFLR---------KSRVLETDP--------AFAREHGTASTLSSRQLLRFASDAANGMQYLSEK--QFIHRDLAARNVLVG--E---N--LAS---------KIADFGLSRGE-----------------------EVY--------------VKKTMGRLPVRWMAIES--LN-----------YSV----YTTKSDVWSFGVLLWEIVSLGGTP---------------YC-GM----TCAEL-YEKL-PQGYR----ME---QPRNCD-----------------------------------------------------------DEVYE-LMRQCWRDRPYERPP------FA-QIALQ--L------------
--VCR---GELLGSGCFGVVHRGLW---T----LPSG-KSV-PVAV-KSLRVGP-E--G-PM----GTELG-D-FL-R-------------------------EVSVMMNL--E------HPHVLRLHGLVL---------GQP--LQ---MVMELAPLG--SLHARLT---------AP---------------------APTPPLLVALLCLFLRQLAGAMAYLGAR--GLVHRDLATRNLLLA--S---P--RTI---------KVADFGLVRPL------------GG-----A--RGRY--------------VMGGPRPIPYAWCAPES--LR-----------HGA----FSSASDVWMFGVTLWEMFSGGEEP---------------WA-GV----PPYLI-LQRL-EDRAR----LP---RPPLCS-----------------------------------------------------------RALYS-LALRCWAPHPADRPS------FS-HLE----GLL----------
----L-RLLEKLGDGSFGVVRRGEW---D----APSG-KTV-SVAV-KCL---K-PDVL-SQ----PEAMD-D-FI-R-------------------------EVNAMHSL--D------HRNLIRLYGVVL---------TPP--MK---MVTELAPLG--SLLDRLR---------KH-----------------------QGHFLLGTLSRYAVQVAEGMGYLESK--RFIHRDLAARNLLLA--T---R--DLV---------KIGDFGLMRAL------------PQ-----N--DDHY--------------VMQEHRKVPFAWCAPES--LK-----------TRT----FSHASDTWMFGVTLWEMFTYGQEP---------------WI-GL----NGSQI-LHKIDKEGER----LP---RPEDCP-----------------------------------------------------------QDIYN-VMVQCWAHKPEDRPT------FV-ALRDF--L------------
YLLGI-----NLGEGSYAKVKSAYS---E-------R-LKF-NVAI-KII---DRK--K-APA---DF--L-E-KFLP------------------------REIEILAML--N------HCSIIKTYEIFE--T-----SHGK--VY---IVMELAVQG--DLLELIK--------TRG-------------------------ALHEDEARKKFHQLSLAIKYCHDL--DVVHRDLKCDNLLLD--K---D--FNI---------KLSDFSFSKRCLR---------------DDSGRMALS--------------KT---FCGSPAYAAPEV--LQ----------GIPY----QPKVYDIWSLGVILYIMVC-GSMP---------------YD-DS-------NI-KKML-RIQKE----HR---VNFPRSKHLT-------------------------------------------------------GECKD-LIYHMLQPDVNRRLH------ID-EILSHCWM------------
-----YSILKQIGSGGSSKVFQVLN---E-------K-KQ--IYAI-KYV---NLE--E-ADN---QT--L-D-SYRN-------------------------EIAYLNKL-QQ-----HSDKIIRLYDYEI--T------DQY--IY---MVMECGNI---DLNSWLK--------KKK-------------------------SIDPWERKSYWKNMLEAVHTIHQH--GIVHSDLKPANFLIV------D--GML---------KLIDFGIANQMQ-----------------PDTTSVVK--------------DS---QVGTVNYMPPEA--IKDMSSSRENGKSKSK----ISPKSDVWSLGCILYYMTY-GKTP---------------FQ-QI------INQ-ISKL-HAIID----PN---HEIEFPDIPE-------------------------------------------------------KDLQD-VLKCCLKRDPKQRIS------IP-ELLAHPYV------------
----L-AFIKEIGSGQFGVVHLGEW---R---------SHI-QVAI-KAI---N-E--G-SM----SE--E-D-FI-E-------------------------EAKVMMKL--S------HSKLVQLYGVCI--Q------RKP--LY---IVTEFMENG--CLLNYLR---------EN-----------------------KGKLRKEMLLSVCQDICEGMEYLERN--GYIHRDLAARNCLVS--S---T--CIV---------KISDFGMTRYV-------------------L--DDEY--------------VSSFGAKFPIKWSPPEV--FL-----------FNK----YSSKSDVWSFGVLMWEVFTEGKMP---------------FE-NK----SNLQV-VEAI-SEGFR----LY---RPHLAP-----------------------------------------------------------MSIYE-VMYSCWHEKPEGRPT------FA-ELLR---AV-----------
---FS--RKDLIGHGAFAVVFKGRH---R-------E-KHDLEVAV-KCI---NKK--N-LAK---SQ--T---LLGK-------------------------EIKILKEL--K------HENIVALYDFQE--M------ANS--VY---LVMEYCNGG--DLADYLH--------AMR-------------------------TLSEDTIRLFLQQIAGAMRLLHSK--GIIHRDLKPQNILLS--N---P--AGRRANPNSIRVKIADFGFARY--------------------LQSNMMA--------------AT---LCGSPMYMAPEV--IM-----------SQH----YDGKADLWSIGTIVYQCLT-GKAP---------------FQ-AS----SPQDL-RLFY-EKNKT----LV---PTIPRETS---------------------------------------------------------APLRQ-LLLALLQRNHKDRMD------FD-EFFHHPFL------------
----Y-SKRDLVGHGAFAVVFRGRH---R-------Q-KTDWEVAI-KSI---NKK--N-LSK---SQ----I-LLGK-------------------------EIKILKEL--Q------HENIVALYDVQE--L------PNS--VF---LVMEYCNGG--DLADYLQ--------AKG-------------------------TLSEDTIRVFLHQIAAAMRILHSK--GIIHRDLKPQNILLS--Y---A--NRRKSSVSGIRIKIADFGFARY--------------------LHSNMMA--------------AT---LCGSPMYMAPEV--IM-----------SQH----YDAKADLWSIGTVIYQCLV-GKPP---------------FQ-AN----SPQDL-RMFY-EKNRS---------LMPSIPRETS-------------------------------------------------------PYLAN-LLLGLLQRNQKDRMD------FE-AFFSHPFL------------
-LIAD----IELGCGNFGSVRQGVY---R-----MRK-KQI-DVAI-KVL---K-Q--G-TE----KADTE-E-MM-R-------------------------EAQIMHQL--D------NPYIVRLIGVCQ---------AEA--LM---LVMEMAGGG--PLHKFLV---------GK-----------------------REEIPVSNVAELLHQVSMGMKYLEEK--NFVHRDLAARNVLLV--N---R--HYA---------KISDFGLSKAL------------GA-----D--DSYY--------------TARSAGKWPLKWYAPEC--IN-----------FRK----FSSRSDVWSYGVTMWEALSYGQKP---------------YK-KM----KGPEV-MAFI-EQGKR----ME---CPPECP-----------------------------------------------------------PELYA-LMSDCWIYKWEDRPD------FL-TVEQR--M------------
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