|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TKL ACVR1 203
TK ABL1 261
TK ABL2 288
TKL ACVR2A 192
TKL ACVRL1 202
TKL BRAF 456
TK CSK 195
TK EPHB4 615
TK FYN 271
TK LCK 245
TKL MAP3K7 36
TKL RAF1 349
TK SRC 270
TKL TGFBR1 205
TKL TGFBR2 269
-I-TLLECVGKGRYGEVWRGSWQ---GEN------VAVKIFSSR-DEKSWF--RET--ELYNTVMLRHENILGFIASDM-TSRHSSTQLWLITHYHEMGSLYDYLQLT----TLDTVSCLRIVLSIASGLAHLHIEIFGT--QGKPA---IAHRDLKSKNILVKKNG-QCCIADLGLAVMHSQ---STNQLDVGNNP---RVGTKRYMAPEV----LDETIQVDCFD---SYKRVDIWAFGLVLWEVAR-RMVSNGI-VEDYKPPFYDVVPNDPSFEDMRKVVCVDQQ----RPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKK---TL--
--ITMKHKLGGGQYGEVYEGVWK---KYSL----TVAVKTLK-E-DTM-EV--EEFLKEAAVMKEIKHPNLVQLLGVCT-R----EPPFYIITEFMTYGNLLDYLRECNR-QEVNAVVLLYMATQISSAMEYLEKK----------N---FIHRDLAARNCLVGENH-LVKVADFGLSRLM-------T--GDTYTAHAGAKFPIKWTAPES----LA------YNK---FSIKSDVWAFGVLLWEIATYGM-----------SPYPGI-----DLSQVYELLEKDYR----MERPEGCP------EKVYELMRACWQWNPSDRPSFAEIHQA-F----
--ITMKHKLGGGQYGEVYVGVWK---KYSL----TVAVKTLK-E-DTM-EV--EEFLKEAAVMKEIKHPNLVQLLGVCT-L----EPPFYIVTEYMPYGNLLDYLRECNR-EEVTAVVLLYMATQISSAMEYLEKK----------N---FIHRDLAARNCLVGENH-VVKVADFGLSRLM-------T--GDTYTAHAGAKFPIKWTAPES----LA------YNT---FSIKSDVWAFGVLLWEIATYGM-----------SPYPGI-----DLSQVYDLLEKGYR----MEQPEGCP------PKVYELMRACWKWSPADRPSFAETHQA-F----
-L-QLLEVKARGRFGCVWKAQLL---NEY------VAVKIFPIQ-DKQSWQ--NEY--EVYSLPGMKHENILQFIGAEK-RGTSVDVDLWLITAFHEKGSLSDFLKAN----VVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPA---ISHRDIKSKNVLLKNNL-TACIADFGLALKFE-----AGKSAGDTHG---QVGTRRYMAPEVLEGAIN-----FQRD---AFLRIDMYAMGLVLWELAS-RCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKK----RPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCV-----GERI
VA--LVECVGKGRYGEVWRGLWH---GES------VAVKIFSSR-DEQSWF--RET--EIYNTVLLRHDNILGFIASDM-TSRNSSTQLWLITHYHEHGSLYDFLQRQ----TLEPHLALRLAVSAACGLAHLHVEIFGT--QGKPA---IAHRDFKSRNVLVKSNL-QCCIADLGLAVMHSQ---GSDYLDIGNNP---RVGTKRYMAPEV----LDEQIRTDCFE---SYKWTDIWAFGLVLWEIAR-RTIVNGI-VEDYRPPFYDVVPNDPSFEDMKKVVCVDQQ----TPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKK---TLQ-
--ITVGQRIGSGSFGTVYKGKWH------G----DVAVKMLN-VTAPT-PQQLQAFKNEVGVLRKTRHVNILLFMGYST------KPQLAIVTQWCEGSSLYHHLHII-E-TKFEMIKLIDIARQTAQGMDYLHAK----------S---IIHRDLKSNNIFLHEDL-TVKIGDFGLATVK----S--R--WSGSHQFEQLSGSILWMAPEV----IR------MQDKNPYSFQSDVYAFGIVLYELMT-GQ-----------LPYSNI-N---NRDQIIFMVGRGYLSPDLSKVRSNCP------KAMKRLMAECLKKKRDERPLFPQILA--SI---
--LKLLQTIGKGEFGDVMLGDYR-----GN----KVAVKCIK-N-DAT-AQ---AFLAEASVMTQLRHSNLVQLLGVIVEE----KGGLYIVTEYMAKGSLVDYLRSRGR-SVLGGDCLLKFSLDVCEAMEYLEGN----------N---FVHRDLAARNVLVSEDN-VAKVSDFGLTKEA-------------SSTQDTGKLPVKWTAPEA----LR------EKK---FSTKSDVWSFGILLWEIYSFGR-----------VPYPRI-----PLKDVVPRVEKGYK----MDAPDGCP------PAVYEVMKNCWHLDAAMRPSFLQLREQL-----
-V-KIEEVIGAGEFGEVCRGRLKAPGKKES----CVAIKTLK-G-GYT-ERQRREFLSEASIMGQFEHPNIIRLEGVVT-N----SMPVMILTEFMENGALDSFLRLN-D-GQFTVIQLVGMLRGIASGMRYLAEM----------S---YVHRDLAARNILVNSNL-VCKVSDFGLSRFLE-ENS--S--DPTYTSSLGGKIPIRWTAPEA----IA------FRK---FTSASDAWSYGIVMWEVMSFGE-----------RPYWDM-----SNQDVINAIEQDYR----LPPPPDCP------TSLHQLMLDCWQKDRNARPRFPQVVSAL-----
--LQLIKRLGNGQFGEVWMGTWN----GNT----KVAIKTLK-P-GTM-SP--ESFLEEAQIMKKLKHDKLVQLYAVVS------EEPIYIVTEYMNKGSLLDFLKDGEG-RALKLPNLVDMAAQVAAGMAYIERM----------N---YIHRDLRSANILVGNGL-ICKIADFGLARLI-------E--DNEYTARQGAKFPIKWTAPEA----AL------YGR---FTIKSDVWSFGILLTELVTKGR-----------VPYPGM-----NNREVLEQVERGYR----MPCPQDCP------ISLHELMIHCWKKDPEERPTFEYLQSFL-----
--LKLVERLGAGQFGEVWMGYYN----GHT----KVAVKSLK-Q-GSM-SP--DAFLAEANLMKQLQHQRLVRLYAVVT------QEPIYIITEYMENGSLVDFLKTPSG-IKLTINKLLDMAAQIAEGMAFIEER----------N---YIHRDLRAANILVSDTL-SCKIADFGLARLI-------E--DNEYTAREGAKFPIKWTAPEA----IN------YGT---FTIKSDVWSFGILLTEIVTHGR-----------IPYPGM-----TNPEVIQNLERGYR----MVRPDNCP------EELYQLMRLCWKERPEDRPTFDYLRSV-L----
--IEVEEVVGRGAFGVVCKAKWR-----AK----DVAIKQIE-----S-ESERKAFIVELRQLSRVNHPNIVKLYGACL-------NPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSM----------QPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDI-------------QTHMTNNKGSAAWMAPEV----FE------GSN---YSEKCDVFSWGIILWEVITR-R-----------KPFDEIGG---PAFRIMWAVHNGTR----PPLIKNLP------KPIESLMTRCWSKDPSQRPSMEEIVKI-M----
VM--LSTRIGSGSFGTVYKGKWH------G----DVAVKILK-VVDPT-PEQFQAFRNEVAVLRKTRHVNILLFMGYMT------KDNLAIVTQWCEGSSLYKHLHVQ-E-TKFQMFQLIDIARQTAQGMDYLHAK----------N---IIHRDMKSNNIFLHEGL-TVKIGDFGLATVK----S--R--WSGSQQVEQPTGSVLWMAPEV----IR------MQDNNPFSFQSDVYSYGIVLYELMT-GE-----------LPYSHI-N---NRDQIIFMVGRGYASPDLSKLYKNCP------KAMKRLVADCVKKVKEERPLFPQILSS-I----
-L-RLEVKLGQGCFGEVWMGTWN----GTT----RVAIKTLK-P-GTM-SP--EAFLQEAQVMKKLRHEKLVQLYAVVS------EEPIYIVTEYMSKGSLLDFLKGETG-KYLRLPQLVDMAAQIASGMAYVERM----------N---YVHRDLRAANILVGENL-VCKVADFGLARLI-------E--DNEYTARQGAKFPIKWTAPEA----AL------YGR---FTIKSDVWSFGILLTELTTKGR-----------VPYPGM-----VNREVLDQVERGYR----MPCPPECP------ESLHDLMCQCWRKEPEERPTFEYLQAF-L----
IV--LQESIGKGRFGEVWRGKWR---GEE------VAVKIFSSR-EERSWF--REA--EIYQTVMLRHENILGFIAADN-KDNGTWTQLWLVSDYHEHGSLFDYLNRY----TVTVEGMIKLALSTASGLAHLHMEIVGT--QGKPA---IAHRDLKSKNILVKKNG-TCCIADLGLAVRHDS---ATDTIDIAPNH---RVGTKRYMAPEV----LDDSINMKHFE---SFKRADIYAMGLVFWEIAR-RCSIGGI-HEDYQLPYYDLVPSDPSVEEMRKVVCEQKL----RPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKK---TL--
-I-ELDTLVGKGRFAEVYKAKLK---QNTSEQFETVAVKIFPYE-EYASWK--TEK--DIFSDINLKHENILQFLTAEE-RKTELGKQYWLITAFHAKGNLQEYLTRH----VISWEDLRKLGSSLARGIAHLHSDHTPC-GRPKMP---IVHRDLKSSNILVKNDL-TCCLCDFGLSLRLDP---TLSVDDLANSG---QVGTARYMAPEV----LESRMNLENVE---SFKQTDVYSMALVLWEMTS-RCNAVGE-VKDYEPPFGSKVREHPCVESMKDNVLRDRG----RPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAE---RF--
|