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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TKL ACVR1 203
TK ABL1 261
TKL BRAF 456
TK EPHB4 615
TK JAK2 849
TK LCK 245
TK SRC 270
I-TLLECVGKGRYGEVWRGSWQ----GEN--VAVKIFSSR-DEKSWF--RET--ELYNTVMLRHENILGFIASDM--TSRHSSTQLWLITHYHEMGSLYDYLQLT---TLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQ---STNQLDVGNNP---RVGTKRYMAPEVLDETIQVDCFD---SYKRVDIWAFGLVLWEVAR-RMVSNGIVEDYKPP---------------FYDVVPNDPSFEDMRKVVCVDQQ----RPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKK---TL
-ITMKHKLGGGQYGEVYEGVWK----KYSLTVAVKTLK-E-DTM-EV--EEFLKEAAVMKEIKHPNLVQLLGVCT--R----EPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK--------NFIHRDLAARNCLVGENHLVKVADFGLSRLM-------T--GDTYTAHAGAKFPIKWTAPESLA------YNK---FSIKSDVWAFGVLLWEIATYGM----------SP---------------YPGI-----DLSQVYELLEKDYR----MERPEGCP------EKVYELMRACWQWNPSDRPSFAEIHQA-F--
-ITVGQRIGSGSFGTVYKGKWH-------GDVAVKMLN-VTAPT-PQQLQAFKNEVGVLRKTRHVNILLFMGYST-------KPQLAIVTQWCEGSSLYHHLHII-ETKFEMIKLIDIARQTAQGMDYLHAK--------SIIHRDLKSNNIFLHEDLTVKIGDFGLATVK----S--R--WSGSHQFEQLSGSILWMAPEVIR------MQDKNPYSFQSDVYAFGIVLYELMT-GQ----------LP---------------YSNI-N---NRDQIIFMVGRGYLSPDLSKVRSNCP------KAMKRLMAECLKKKRDERPLFPQILA--SI-
V-KIEEVIGAGEFGEVCRGRLK-APGKKESCVAIKTLK-G-GYT-ERQRREFLSEASIMGQFEHPNIIRLEGVVT--N----SMPVMILTEFMENGALDSFLRLN-DGQFTVIQLVGMLRGIASGMRYLAEM--------SYVHRDLAARNILVNSNLVCKVSDFGLSRFLE-ENS--S--DPTYTSSLGGKIPIRWTAPEAIA------FRK---FTSASDAWSYGIVMWEVMSFGE----------RP---------------YWDM-----SNQDVINAIEQDYR----LPPPPDCP------TSLHQLMLDCWQKDRNARPRFPQVVSAL---
-LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQ-H-STE--EHLRDFEREIEILKSLQHDNIVKYKGVCYSAG----RRNLKLIMEYLPYGSLRDYLQKH-KERIDHIKLLQYTSQICKGMEYLGTK--------RYIHRDLATRNILVENENRVKIGDFGLTKVL---PQ--D--KEYYKVKEPGESPIFWYAPESLT------ESK---FSVASDVWSFGVVLYELFTYIE----------KSKSPPAEFMRMIGNDKQGQM-----IVFHLIELLKNNGR----LPRPDGCP------DEIYMIMTECWNNNVNQRPSFRDLA---LRV
-LKLVERLGAGQFGEVWMGYYN-----GHTKVAVKSLK-Q-GSM-SP--DAFLAEANLMKQLQHQRLVRLYAVVT-------QEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEER--------NYIHRDLRAANILVSDTLSCKIADFGLARLI-------E--DNEYTAREGAKFPIKWTAPEAIN------YGT---FTIKSDVWSFGILLTEIVTHGR----------IP---------------YPGM-----TNPEVIQNLERGYR----MVRPDNCP------EELYQLMRLCWKERPEDRPTFDYLRSV-L--
L-RLEVKLGQGCFGEVWMGTWN-----GTTRVAIKTLK-P-GTM-SP--EAFLQEAQVMKKLRHEKLVQLYAVVS-------EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM--------NYVHRDLRAANILVGENLVCKVADFGLARLI-------E--DNEYTARQGAKFPIKWTAPEAAL------YGR---FTIKSDVWSFGILLTELTTKGR----------VP---------------YPGM-----VNREVLDQVERGYR----MPCPPECP------ESLHDLMCQCWRKEPEERPTFEYLQAF-L--
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