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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TKL ACVR2A 203
TKL ACVR1 208
TKL ACVRL1 202
TKL RAF1 349
TKL TGFBR1 205
TKL TGFBR2 269
-LQLLEVKARGRFGCVWKAQLLNEY------VAVKIFPIQ-DKQSWQ--NEY--EVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKAN--VVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFE---AGKSAGDTHG---QVGTRRYMAPEVLEGAIN-----FQRD---AFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKK----RPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCV----GERI
-ITLLECVGKGRYGEVWRGSWQGEN------VAVKIFSSR-DEKSWF--RET--ELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLT--TLDTVSCLRIVLSIASGLAHLHIEIFGT--QGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQ-STNQLDVGNNP---RVGTKRYMAPEV----LDETIQVDCFD---SYKRVDIWAFGLVLWEVARRMVSNGI-VEDYKPPFYDVVPNDPSFEDMRKVVCVDQQ----RPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKK--TL--
VA-LVECVGKGRYGEVWRGLWHGES------VAVKIFSSR-DEQSWF--RET--EIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQ--TLEPHLALRLAVSAACGLAHLHVEIFGT--QGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQ-GSDYLDIGNNP---RVGTKRYMAPEV----LDEQIRTDCFE---SYKWTDIWAFGLVLWEIARRTIVNGI-VEDYRPPFYDVVPNDPSFEDMKKVVCVDQQ----TPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKK--TLQ-
VM-LSTRIGSGSFGTVYKGKWH---G----DVAVKILK-VVDPT-PEQFQAFRNEVAVLRKTRHVNILLFMGYMT-----KDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAK----------NIIHRDMKSNNIFLHEGLTVKIGDFGLATVK--S--R--WSGSQQVEQPTGSVLWMAPEV----IR------MQDNNPFSFQSDVYSYGIVLYELMTGE-----------LPYSHI-N---NRDQIIFMVGRGYASPDLSKLYKNCP------KAMKRLVADCVKKVKEERPLFPQILSSI----
IV-LQESIGKGRFGEVWRGKWRGEE------VAVKIFSSR-EERSWF--REA--EIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRY--TVTVEGMIKLALSTASGLAHLHMEIVGT--QGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS-ATDTIDIAPNH---RVGTKRYMAPEV----LDDSINMKHFE---SFKRADIYAMGLVFWEIARRCSIGGI-HEDYQLPYYDLVPSDPSVEEMRKVVCEQKL----RPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKK--TL--
-IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYE-EYASWK--TEK--DIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRH--VISWEDLRKLGSSLARGIAHLHSDHTPC-GRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDP-TLSVDDLANSG---QVGTARYMAPEV----LESRMNLENVE---SFKQTDVYSMALVLWEMTSRCNAVGE-VKDYEPPFGSKVREHPCVESMKDNVLRDRG----RPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAE--RF--
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