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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC ADRBK1 203
AGC ADRBK2 191
AGC AKT1 150
AGC GRK1 190
AGC GRK4 187
AGC GRK5 186
AGC GRK6 186
AGC GRK7 191
AGC PKN2 657
AGC PRKACA 44
AGC PRKCD 349
AGC PRKCZ 252
AGC PRKG1 375
AGC ROCK2 92
---F-SVHRIIGRGGFGEVYGCRKA-DTGKMYAMKCLDKKRIKMKQGETLAL-NERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLS----QHGVFSEADMRFYAAEIILGLEHMHN-RFVVYRDLKPANILLDEHGHVRISDLGLAC---DFSKKKPHASVGTHGYMAPEVLQ---KGVAYDSSADWFSLGCMLFKLLRGHSPFRQH----KTKDKHEIDRMTLTMAVELPDSFS----PELRSLLEGLLQRDVNR--RLGCL-GRGAQEVKESPFF------------
---F-SVHRIIGRGGFGEVYGCRKA-DTGKMYAMKCLDKKRIKMKQGETLAL-NERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLS----QHGVFSEKEMRFYATEIILGLEHMHN-RFVVYRDLKPANILLDEHGHARISDLGLAC---DFSKKKPHASVGTHGYMAPEVLQ---KGTAYDSSADWFSLGCMLFKLLRGHSPFRQH----KTKDKHEIDRMTLTVNVELPDTFS----PELKSLLEGLLQRDVSK--RLGCH-GGGSQEVKEHSFF------------
---F-EYLKLLGKGTFGKVILVKEK-ATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNS-R---HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS----RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEG-IKDGATMKTFCGTPEYLAPEVLE----DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQ-------DHEKLFELILMEEIRFPRTLG----PEAKSLLSGLLKKDPKQ--RLGGG-SEDAKEIMQHRFF------------
FLDF----RVLGKGGFGEVSACQMK-ATGKLYACKKLNKKRLKKRKGYQGAMVEKKILMKV-H---SRFIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALFYTAQIICGLEHLHQ-RRIVYRDLKPENVLLDNDGNVRISDLGLAVEL-LDGQSKTKGYAGTPGFMAPELLQ----GEEYDFSVDYFALGVTLYEMIAARGPFRAR---GEKVENKELKHRIISEPVKYPDKFS----QASKDFCEALLEKDPEK--RLG------FRD-------ETCDKLRAHPLF
--FR--HYRVLGKGGFGEVCACQVR-ATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKV-Q---SRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYN--LGNPGFDEQRAVFYAAELCCGLEDLQR-ERIVYRDLKPENILLDDRGHIRISDLGLATE--IPEGQRVRGRVGTVGYMAPEVVN----NEKYTFSPDWWGLGCLIYEMIQGHSPFKKY----KEKVKWEEVDQRIKNDTEEYSE---KFSEDAKSICRMLLTKNPSK--RLGCR-GEGAAGVKQHPV-F-----------
---F-RQYRVLGKGGFGEVCACQVR-ATGKMYACKRLEKKRIKKRKGESMALNEKQILEKV-N---SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYN--MGNPGFEEERALFYAAEILCGLEDLHR-ENTVYRDLKPENILLDDYGHIRISDLGLAVK--IPEGDLIRGRVGTVGYMAPEVLN----NQRYGLSPDYWGLGCLIYEMIEGQSPFRGR-------KEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQ--RLGCQ-EEGAAEVKRHPFF------------
---F-RQYRVLGKGGFGEVCACQVR-ATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV-N---SRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYH--MGQAGFPEARAVFYAAEICCGLEDLHR-ERIVYRDLKPENILLDDHGHIRISDLGLAVH--VPEGQTIKGRVGTVGYMAPEVVK----NERYTFSPDWWALGCLLYEMIAGQSPFQQR----KKKIKREEVERLVK-EVPEEYSER--FSPQARSLCSQLLCKDPAE--RLGCR-GGSAREVKEHPLF------------
---F-TEFRVLGKGGFGEVCAVQVK-NTGKMYACKKLDKKRLKKKGGEKMALLEKEILEKV-S---SPFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYN--VGTRGLDMSRVIFYSAQIACGMLHLHE-LGIVYRDMKPENVLLDDLGNCRLSDLGLAVE--MKGGKPITQRAGTNGYMAPEILM---EKVSYSYPVDWFAMGCSIYEMVAGRTPFKDY---KEKVSKEDLKQRTLQDEVKFQHDNF---TEEAKDICRLFLAKKPEQ--RLG------SRE-------KSDDPR------
--FR--CCAVLGRGHFGKVLLAEYK-NTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETV-NSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIH-----TDVFSEPRAVFYAACVVLGLQYLHE-HKIVYRDLKLDNLLLDTEGFVKIADFGLCKEG-MGYGDRTSTFCGTPEFLAPEVLT----ETSYTRAVDWWGLGVLIYEMLVGESPFPGD-------DEEEVFDSIVNDEVRYPRFLS----TEAISIMRRLLRRNPER--RLGAS-EKDAEDVKKHPFF------------
---F-ERIKTLGTGSFGRVMLVKHK-ETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAV-N---FPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLR----RIGRFSEPHARFYAAQIVLTFEYLHS-LDLIYRDLKPENLLIDQQGYIQVTDFGFAK----RVKGRTWTLCGTPEYLAPEIIL----SKGYNKAVDWWALGVLIYEMAAGYPPFFAD-------QPIQIYEKIVSGKVRFPSHFS----SDLKDLLRNLLQVDLTK--RFGNL-KNGVNDIKNHKWF------------
--FI--FHKVLGKGSFGKVLLGELK-GRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAE---NPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQ----DKGRFELYRATFYAAEIMCGLQFLHS-KGIIYRDLKLDNVLLDRDGHIKIADFGMCKEN-IFGESRASTFCGTPDYIAPEILQ----GLKYTFSVDWWSFGVLLYEMLIGQSPFHGD-------DEDELFESIRVDTPHYPRWIT----KESKDILEKLFEREPTK--RLG-----VTGNIKIHPFF------------
---F-DLIRVIGRGSYAKVLLVRLK-KNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASS---NPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQ----RQRKLPEEHARFYAAEICIALNFLHE-RGIIYRDLKLDNVLLDADGHIKLTDYGMCKEG-LGPGDTTSTFCGTPNYIAPEILR----GEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLS----VKASHVLKGFLNKDPKE--RLGCRPQTGF---------SDIKSHAFF---
---F-NIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGA-H---SDFIVRLYRTFKDSKYLYMLMEACLGGELWTILR----DRGSFEDSTTRFYTACVVEAFAYLHS-KGIIYRDLKPENLILDHRGYAKLVDFGFAKK--IGFGKKTWTFCGTPEYVAPEIIL----NKGHDISADYWSLGILMYELLTGSPPFSGP-------DPMKTYNIILRGIDMIEFPKKIA--KNAANLIKKLCRDNPSE--RLGNL-KNGVKDIQKHKWF------------
----YDVVKVIGRGAFGEVQLVRHK-ASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFA-N---SPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMS-----NYDVPEKWAKFYTAEVVLALDAIHS-MGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYAD-------SLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNG------VEEIRQHPFF------------
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