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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC AKT1 203
TK BTK 402
CMGC CDC2 4
CMGC CDK2 4
CAMK CHEK2 220
STE MAP4K2 16
AGC ROCK2 92
-F-EYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTL-----TENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS---RER--VFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHI---KITDFGLCKEG-IKDGATMKT---FCGTPEYLAPEV--LE----DNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQ---DHEKLFELILMEEIRFPRTLG--------------------------PEAKSLLSGLLKKDPKQ--RLGGGSEDAKEIMQHRFF-
--LTFLKELGTGQFGVVKYGKWR-GQYDVAIKMIK-EGSM-SEDEFI-E------EAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLR----EMRHRFQTQQLLEMCKDVCEAMEYLES-KQFLHRDLAARNCLVNDQGVV---KVSDFGLSRYV-L--DDEYTSSVGSKFPVRWSPPEV--LM----YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLAS----------------------------EKVYTIMYSCWHEKADE--RPT-----FKILLSN--I-
--YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIR------EISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQ--YMDSSLVKSYLYQILQGIVFCHS-RRVLHRDLKPQNLLIDDKGTI---KLADFGLARAF-GIPIRVYTH---EVVTLWYRSPEV--LL---GSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAK--RIS-----GKMALNHPYF-
--FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIR------EISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDA-SALT--GIPLPLIKSYLFQLLQGLAFCHS-HRVLHRDLKPQNLLINTEGAI---KLADFGLARAF-GVPVRTYTH---EVVTLWYRAPEI--LL---GCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNK--RIS-----AKAALAHPFF-
YI--MSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFF-DAEDYYIVLELMEGGELFDKVV---GNK--RLKEATCKLYFYQMLLAVQYLHE-NGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKI--LGETSLMRT---LCGTPTYLAPEV--LVS-VGTAGYNRAVDCWSLGVILFICLS-GYPPFSEH--RTQVSLKDQITSGKYNFIPEVWAEVS----------------------EKALDLVKKLLVVDPKA--RFT-----TEEALRHPWL-
--FELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSL--QQ------EITILRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYH---ATG--PLEERQIAYVCREALKGLHHLHS-QGKIHRDIKGANLLLTLQGDV---KLADFGVSGEL-TASVAKRRS---FIGTPYWMAPEVAAVE---RKGGYNELCDVWALGITAIELGE-LQPPLFHLHPMRALMLMSKSSFQPPKLRDKTR--WT----------------------QNFHHFLKLALTKNPKK--RPT-----AEKLLQHPF-T
--YDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFW-----EERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMS----NY--DVPEKWAKFYTAEVVLALDAIHS-MGLIHRDVKPDNMLLDKHGHL---KLADFGTCMKMDETGMVHCDT---AVGTPDYISPEV--LKSQGGDGFYGRECDWWSVGVFLYEMLV-GDTPFYAD---SLVGTYSKIMDHKNSLCFPEDAEIS----------------------KHAKNLICAFLTDREVRLGRNG-----VEEIRQHPFF-
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