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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC AKT2 203
CMGC CDK2 4
CAMK CHEK2 220
AGC GRK6 186
CAMK MAPKAPK2 64
Other NEK2 8
CAMK PASK 999
AGC PDPK1 82
AGC PRKCI 245
TK RET 724
AGC ROCK1 76
---FQKVEKIGEGTYGVVYKARNK-----LTGEVVALKKIRLDTETEGV--PS-TAIR------EISLLKEL-NHPNIVKLLDVIHT----ENKLYLVFEFLHQ--DLKKFMDA--SALT-------------------------GIPLPLIKSYLFQLLQGLAFCHSH-----RVLHRDLKPQNLLINTEGAI---KLADFGLARAF---GVPVRTYTH---EVVTLWYRAPEILL---GCKYYSTAVDIWSLGCIFAEMVT-RRALFPGD------SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNK--RIS------AKAALAHPFF-----------
-YI--MSKTLGSGACGEVKLAFER-----KTCKKVAIKIISKRKFAIGS--AR-EADPALNVETEIEILKKL-NHPCIIKIKNFF-D----AEDYYIVLELMEGG-ELFDKVV----GNK-------------------------RLKEATCKLYFYQMLLAVQYLHEN-----GIIHRDLKPENVLLSSQEEDCLIKITDFGHSKI----LGETSLMRT---LCGTPTYLAPEVLVS-VGTAGYNRAVDCWSLGVILFICLS-GYPPFSEH--------RTQVSLKDQITSGKYNFIPEVWAEVS----------------------EKALDLVKKLLVVDPKA--RFT------TEEALRHPWL-----------
--F-RQYRVLGKGGFGEVCACQVR-----ATGKMYACKKLEKKRIKKRK--GE-AMAL-----NEKQILEKV-NSRFVVSLAYAYET----KDALCLVLTLMNGG-DLKFHIYH--MGQA-------------------------GFPEARAVFYAAEICCGLEDLHRE-----RIVYRDLKPENILLDDHGHI---RISDLGLAVH----VPEGQTIKG---RVGTVGYMAPEVVK----NERYTFSPDWWALGCLLYEMIA-GQSPFQQR------KKKIKREEVERLVK-EVPEEYSER--FS----------------------PQARSLCSQLLCKDPAE--RLGCR-GGSAREVKEHPLF-----------
KVT---SQVLGLGINGKVLQIFNK-----RTQEKFALKMLQDCPKAR----------R------EVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGG-ELFSRIQD--RGDQ-------------------------AFTEREASEIMKSIGEAIQYLHSI-----NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE----TTSHNSLTT---PCYTPYYVAPEVLG----PEKYDKSCDMWSLGVIMYILLC-GYPPFYSN-----HGLAISPGMKTRIRMGQYEFPNPEWSEVS----------------------EEVKMLIRNLLKTEPTQ--RMT------ITEFMNHPWI-----------
---YEVLYTIGTGSYGRCQKIRRK-----SDGKILVWKELDYGSMTEAE--KQ-MLVS------EVNLLREL-KHPNIVRYYDRIIDR--TNTTLYIVMEYCEGG-DLASVITKGTKERQ-------------------------YLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNV---KLGDFGLARIL---NHDTSFAKT---FVGTPYYMSPEQMN----RMSYNEKSDIWSLGCLLYELCA-LMPPFTAF---------SQKELAGKIREGKFRRIPYRY---S----------------------DELNEIITRMLNLKDYH--RPS------VEEILENPL-I----------
---YSTMSPLGSGAFGFVWTAVDK-----EKNKEVVVKFIKKEKVLEDC--WI-EDPKLGKVTLEIAILSRV-EHANIIKVLDIFEN----QGFFQLVMEKHGSGLDLFAFID----RHP-------------------------RLDEPLASYIFRQLVSAVGYLRLK-----DIIHRDIKDENIVIAEDFTI---KLIDFGSAAY----LERGKLFYT---FCGTIEYCAPEVLM---GNPYRGPELEMWSLGVTLYTLVF-EENPFCEL-----------EETVEAAIHPPYLVS------------------------------KELMSLVSGLLQPVPER--RTT------LEKLVTDPWV-----------
--F-KFGKILGEGSFSTVVLAREL-----ATSREYAIKILEKRHIIKEN--KVPYVTR------ERDVMSRL-DHPFFVKLYFTFQD----DEKLYFGLSYAKNG-ELLKYIR----KIG-------------------------SFDETCTRFYTAEIVSALEYLHGK-----GIIHRDLKPENILLNEDMHI---QITDFGTAKVLS-PESKQARANS---FVGTAQYVSPELLT----EKSACKSSDLWALGCIIYQLVA-GLPPFRAG---------NEYLIFQKIIKLEYDFPEKFF--------------------------PKARDLVEKLLVLDATK--RLG------CEEM------EGYGPLKAHPF
--F-DLLRVIGRGSYAKVLLVRLK-----KTDRIYAMKVVKKELVNDDE--DI-DWVQ-----TEKHVFEQASNHPFLVGLHSCFQT----ESRLFFVIEYVNGG-DLMFHMQ----RQR-------------------------KLPEEHARFYSAEISLALNYLHER-----GIIYRDLKLDNVLLDSEGHI---KLTDYGMCKEG---LRPGDTTST---FCGTPNYIAPEILR----GEDYGFSVDWWALGVLMFEMMA-GRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLS--------------------------VKAASVLKSFLNKDPKE--RLGCHPQTGFADIQGHPF-F----------
--L-VLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK-ENAS-PSELRD-LL-S------EFNVLKQV-NHPHVIKLYGACSQ----DGPLLLIVEYAKYG-SLRGFLR-----ESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEM-----KLVHRDLAARNILVAEGRKM---KISDFGLSRDV-Y-E--EDSYVKRSQGRIPVKWMAIESLF----DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI------PPERLFNLLKTGHRMERPDNCS----------------------------EEMYRLMLQCWKQEPDK--RPV------FADISKDL-------------
---YEVVKVIGRGAFGEVQLVRHK-----STRKVYAMKLLSKFEMIKRS--DS-AFFW-----EERDIMAFA-NSPWVVQLFYAFQD----DRYLYMVMEYMPGG-DLVNLMS-----NY-------------------------DVPEKWARFYTAEVVLALDAIHSM-----GFIHRDVKPDNMLLDKSGHL---KLADFGTCMKM--NKEGMVRCDT---AVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLV-GDTPFYAD---------SLVGTYSKIMNHKNSLTFPDDNDIS----------------------KEAKNLICAFLTDREVRLGRNG------VEEIKRHLFF-----------
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