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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC AKT2 203
AGC AKT1 150
AGC AKT3 148
CMGC CDC2 4
CAMK MAPKAPK2 64
CAMK PIM1 38
AGC PRKCA 339
AGC ROCK1 76
AGC ROCK2 92
--F-EYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTL---TENRVLQNS-RHPF--LTALKYSFQT----HDRLCFVMEYANGG-ELFFHLS---RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD-KDGHI---KITDFGLCKEG-IKDGATMKTFCGTPEYLAPEVLE----DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQ----DHEKLFELILMEEIRFPRTLG--------------------------PEAKSLLSGLLKKDPKQ--RLGGGSEDAKEIMQHRFF--------------
-FD--YLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTL---TESRVLKNT-RHPF--LTSLKYSFQT----KDRLCFVMEYVNGG-ELFFHLS---RERVFSEDRTRFYGAEIVSALDYLHS-GKIVYRDLKLENLMLD-KDGHI---KITDFGLCKEG-ITDAATMKTFCGTPEYLAPEVLE----DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQ----DHEKLFELILMEDIKFPRTLS--------------------------SDAKSLLSGLLIKDPNK--RLGGGPDDAKEIMRHSFF--------------
---YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIR----EISLLKEL-RHPN--IVSLQDVLMQ----DSRLYLIFEFLSM--DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS-RRVLHRDLKPQNLLID-DKGTI---KLADFGLARAF-GIPIRVYTHEVVTLWYRSPEVLL---GSARYSTPVDIWSIGTIFAELATKKPLFHGD-SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAK--RIS-----GKMALNHPYF--------------
KVT---SQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR-------R----EVELHWRASQCPH--IVRIVDVYENLYAGRKCLLIVMECLDGG-ELFSRIQD-RGDQAFTEREASEIMKSIGEAIQYLHS-INIAHRDVKPENLLYT-SKRPNAILKLTDFGFAKE--TTSHNSLTTPCYTPYYVAPEVLG----PEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS----------------------EEVKMLIRNLLKTEPTQ--RMT-----ITEFMNHPWI--------------
---YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV-SSGFSGVIRLLDWFER----PDSFVLILERPEPVQDLFDFIT---ERGALQEELARSFFWQVLEAVRHCHN-CGVLHRDIKDENILIDLNRGEL---KLIDFGSGA---LLKDTVYTDFDGTRVYSPPEWIR---YHRYHGRSAAVWSLGILLYDMVCGDIPFEHD----------EEIIRGQVFFRQRVS--------------------------SECQHLIRWCLALRPSD--RPT-----FEEIQNHPWM--------------
--F-NFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTM---VEKRVLALLDKPPF--LTQLHSCFQT----VDRLYFVMEYVNGG-DLMYHIQ---QVGKFKEPQAVFYAAEISIGLFFLHK-RGIIYRDLKLDNVMLD-SEGHI---KIADFGMCKEH-MMDGVTTRTFCGTPDYIAPEIIA----YQPYGKSVDWWAYGVLLYEMLAGQPPFDGE----DEDELFQSIMEHNVSYPKSLS--------------------------KEAVSVCKGLMTKHPAK--RLG-----C---------GPEGERDVREHAFF
---YEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFW---EERDIMAFA-NSPW--VVQLFYAFQD----DRYLYMVMEYMPGG-DLVNLMS----NYDVPEKWARFYTAEVVLALDAIHS-MGFIHRDVKPDNMLLD-KSGHL---KLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYAD----SLVGTYSKIMNHKNSLTFPDDNDIS----------------------KEAKNLICAFLTDREVRLGRNG-----VEEIKRHLFF--------------
---YDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFW---EERDIMAFA-NSPW--VVQLFYAFQD----DRYLYMVMEYMPGG-DLVNLMS----NYDVPEKWAKFYTAEVVLALDAIHS-MGLIHRDVKPDNMLLD-KHGHL---KLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYAD----SLVGTYSKIMDHKNSLCFPEDAEIS----------------------KHAKNLICAFLTDREVRLGRNG-----VEEIRQHPFF--------------
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