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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK ALK 203
TK ABL1 261
TK ABL2 288
Other AURKA 133
Other AURKB 77
Other AURKC 43
TK AXL 527
TK BLK 241
TK BMX 422
TK BTK 402
TK CSF1R 582
TK CSK 195
TK DDR1 572
TK DDR2 563
TK EGFR 712
TK EPHA2 613
TK EPHB1 619
TK EPHB2 621
TK EPHB3 633
TK EPHB4 615
TK EPHB6 670
TK ERBB4 718
TK FER 563
TK FES 561
TK FGFR1 478
TK FGFR2 481
TK FGFR3 472
TK FGFR4 467
TK FGR 263
TK FLT4 845
TK FYN 271
TK HCK 241
TK IGF1R 999
TK INSR 1023
TK INSRR 979
TK ITK 363
TK JAK1 875
TK JAK2 849
TK JAK3 822
TK KDR 834
TK LTK 510
STE MAP3K1 1242
STE MAP3K6 645
TKL MAP3K7 36
TK MATK 235
TK MERTK 587
TK MET 1078
TK MST1R 1082
TK MUSK 575
Other NEK3 4
TK NTRK1 510
TK NTRK2 538
TK PTK2 422
TK PTK6 191
TK RET 724
TK ROS1 1945
STE SLK 34
TK SRC 270
TK SRMS 230
STE STK24 24
TK SYK 371
TK TEC 370
TK TNK1 116
TK TNK2 150
TKL TNNI3K 463
TK TXK 271
TK TYK2 589
TK TYRO3 518
TK YES1 277
STE YSK4 1162
TK ZAP70 338
---I-TLIRGLGHGAFGEVYEGQVSG-----------MPNDPSPLQVAVKTL---P-E--V-CS-EQD-ELDFL-M----EALIISKF-NHQNIVRCIGVSL--QSLP------RFILLELMAGGDLKSFLR---ETRP--------------------------------------------------------------RPSQP-SSL--AMLDLLHVARDIACGCQYLEE--NH---FIHRDIAARNCLLT-CP--GPGR-VA-KIGDFGMARDI-----Y---R--ASYY--RKGGCAMLPVKWMPPEAFM-----EGI-FTSKTDTWSFGVLLWEIFSLGY-MP---------------YPSK--SNQEVLEFV----TS----GGR---MDPPKNCP----GPVYR-IMTQCWQHQPEDRPNFAIILER--I----
----ITMKHKLGGGQYGEVYEGVWK----------------KYSLTVAVKTL---K-E--D-TM-EV---EEFL-K----EAAVMKEI-KHPNLVQLLGVCT--REPP------FYIITEFMTYGNLLDYLR---EC-------------------------------------------------------------------NR-QEV--NAVVLLYMATQISSAMEYLEK--KN---FIHRDLAARNCLVG-E-----NH-LV-KVADFGLSRLM---------T--GDTY--TAHAGAKFPIKWTAPESLA-----YNK-FSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI--DLSQVYELL----EK----DYR---MERPEGCP----EKVYE-LMRACWQWNPSDRPSFAEIHQA--F----
----ITMKHKLGGGQYGEVYVGVWK----------------KYSLTVAVKTL---K-E--D-TM-EV---EEFL-K----EAAVMKEI-KHPNLVQLLGVCT--LEPP------FYIVTEYMPYGNLLDYLR---EC-------------------------------------------------------------------NR-EEV--TAVVLLYMATQISSAMEYLEK--KN---FIHRDLAARNCLVG-E-----NH-VV-KVADFGLSRLM---------T--GDTY--TAHAGAKFPIKWTAPESLA-----YNT-FSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI--DLSQVYDLL----EK----GYR---MEQPEGCP----PKVYE-LMRACWKWSPADRPSFAETHQA--F----
----FEIGRPLGKGKFGNVYLAREK----------------QSKFILALKVL---FKA--QLEKAGV---EHQLRR----EVEIQSHL-RHPNILRLYGYFH--DATR------VYLILEYAPLGTVYRELQ--KLS-----------------------------------------------------------------------KF--DEQRTATYITELANALSYCHS--KR---VIHRDIKPENLLLG-S-----AG-EL-KIADFGWSV-----------HAPSSRR--TT---LCGTLDYLPPEMIE-----GRM-HDEKVDLWSLGVLCYEFLV-GK-PP---------------FEAN-----TYQETY----KR----ISR---VEFTFPDFVT--EGARD-LISRLLKHNPSQRPMLREVLEHPWI----
----FEIGRPLGKGKFGNVYLAREK----------------KSHFIVALKVL---FKS--Q-IEKEG---VEHQLR---REIEIQAHL-HHPNILRLYNYFY--DRRR------IYLILEYAPRGELYKELQ--KSC-----------------------------------------------------------------------TF--DEQRTATIMEELADALMYCHG--KK---VIHRDIKPENLLLG-L-----KG-EL-KIADFGWSV-----------HAPSLRR--KT---MCGTLDYLPPEMIE-----GRM-HNEKVDLWCIGVLCYELLV-GN-PP---------------FESA-----SHNETY----RR----IVK---VDLKFPASVP--MGAQD-LISKLLRHNPSERLPLAQVSAHPWV----
----FEIGRPLGKGKFGNVYLARLK----------------ESHFIVALKVL---FKS--Q-IEKEG---LEHQLR---REIEIQAHL-QHPNILRLYNYFH--DARR------VYLILEYAPRGELYKELQ--KSE-----------------------------------------------------------------------KL--DEQRTATIIEELADALTYCHD--KK---VIHRDIKPENLLLG-F-----RG-EV-KIADFGWSV-----------HTPSLRR--KT---MCGTLDYLPPEMIE-----GRT-YDEKVDLWCIGVLCYELLV-GY-PP---------------FESA-----SHSETY----RR----ILK---VDVRFPLSMP--LGARD-LISRLLRYQPLERLPLAQILKHPWV----
---V-ALGKTLGEGEFGAVMEGQLN--------------QDDSILKVAVKTM---K-I-AI-CT-RSE-LEDFL-S----EAVCMKEF-DHPNVMRLIGVCF--QGSERESFPAPVVILPFMKHGDLHSFLL---YSRL---------------------------------------------------------------GDQP-VYL--PTQMLVKFMADIASGMEYLST--KR---FIHRDLAARNCMLN-E-----NM-SV-CVADFGLSKKI-----Y---N--GDYY--RQGRIAKMPVKWIAIESLA-----DRV-YTSKSDVWSFGVTMWEIATRGQ-TP---------------YPGV--ENSEIYDYL----RQ----GNR---LKQPADCL----DGLYA-LMSRCWELNPQDRPSFTELREDL------
---L-RLVRKLGSGQFGEVWMGYYK-----------------NNMKVAIKTL---K-E--G-TM-SP---EAFL-G----EANVMKAL-QHERLVRLYAVVT---KEP------IYIVTEYMARGCLLDFLK---TD-------------------------------------------------------------------EG-SRL--SLPRLIDMSAQIAEGMAYIER--MN---SIHRDLRAANILVS-E-----AL-CC-KIADFGLARII------------DSEY--TAQEGAKFPIKWTAPEAIH-----FGV-FTIKADVWSFGVLLMEVVTYGR-VP---------------YPGM--SNPEVIRNL----ER----GYR---MPRPDTCP----PELYRGVIAECWRSRPEERPTFEFLQSV--L----
----ITLLKELGSGQFGVVQLGKWK-----------------GQYDVAVKMI---K-E--G-SM-SE---DEFF-Q----EAQTMMKL-SHPKLVKFYGVCS--KEYP------IYIVTEYISNGCLLNYLR---SH--------------------------------------------------------------------G-KGL--EPSQLLEMCYDVCEGMAFLES--HQ---FIHRDLAARNCLVD-R-----DL-CV-KVSDFGMTRYV---------L--DDQY--VSSVGTKFPVKWSAPEVFH-----YFK-YSSKSDVWAFGILMWEVFSLGK-QP---------------YDLY--DNSQVVLKV----SQ----GHR---LYRPHLAS----DTIYQ-IMYSCWHELPEKRPTFQQLLSS--I----
----LTFLKELGTGQFGVVKYGKWR-----------------GQYDVAIKMI---K-E--G-SM-SE---DEFI-E----EAKVMMNL-SHEKLVQLYGVCT--KQRP------IFIITEYMANGCLLNYLR---EM--------------------------------------------------------------------R-HRF--QTQQLLEMCKDVCEAMEYLES--KQ---FLHRDLAARNCLVN-D-----QG-VV-KVSDFGLSRYV---------L--DDEY--TSSVGSKFPVRWSPPEVLM-----YSK-FSSKSDIWAFGVLMWEIYSLGK-MP---------------YERF--TNSETAEHI----AQ----GLR---LYRPHLAS----EKVYT-IMYSCWHEKADERPTFKILLSN--I----
----LQFGKTLGAGAFGKVVEATAFG-----------LGKEDAVLKVAVKML---K-S--T-AH-ADE-KEALM-S----ELKIMSHLGQHENIVNLLGACT--HGGP------VLVITEYCCYGDLLNFLR---RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDG-RPL--ELRDLLHFSSQVAQGMAFLAS--KN---CIHRDVAARNVLLT-N-----GH-VA-KIGDFGLARDI-----M---N--DSNY--IVKGNARLPVKWMAPESIF-----DCV-YTVQSDVWSYGILLWEIFSLGL-NP---------------YPGI-LVNSKFYKLV----KD----GYQ---MAQPAFAP----KNIYS-IMQACWALEPTHRPTFQQICSFL------
----LKLLQTIGKGEFGDVMLGDYR------------------GNKVAVKCI---K-N--D-AT-AQ----AFL-A----EASVMTQL-RHSNLVQLLGVIV-EEKGG------LYIVTEYMAKGSLVDYLR---SR-------------------------------------------------------------------GR-SVL--GGDCLLKFSLDVCEAMEYLEG--NN---FVHRDLAARNVLVS-E-----DN-VA-KVSDFGLTKEA---------------S--STQDTGKLPVKWTAPEALR-----EKK-FSTKSDVWSFGILLWEIYSFGR-VP---------------YPRI--PLKDVVPRV----EK----GYK---MDAPDGCP----PAVYE-VMKNCWHLDAAMRPSFLQLREQL------
----LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKIL---R-P--D-AT-KNA-RNDFL-K----EVKIMSRL-KDPNIIRLLGVCV--QDDP------LCMITDYMENGDLNQFLS---AHQLEDKAAE--------------------------------------------------GAPGDGQAAQG-PTI--SYPMLLHVAAQIASGMRYLAT--LN---FVHRDLATRNCLVG-E-----NF-TI-KIADFGMSRNL-----Y---A--GDYY--RVQGRAVLPIRWMAWECIL-----MGK-FTTASDVWAFGVTLWEVLMLCRAQP---------------FGQL--TDEQVIENAGEFFRD----QGRQVYLSRPPACP----QGLYE-LMLRCWSRESEQRPPFSQLHRFL------
----LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKML---R-A--D-AN-KNA-RNDFL-K----EIKIMSRL-KDPNIIHLLAVCI--TDDP------LCMITEYMENGDLNQFLS---RHEPPN-----------------------------------------------------------SSSSDV-RTV--SYTNLKFMATQIASGMKYLSS--LN---FVHRDLATRNCLVG-K-----NY-TI-KIADFGMSRNL-----Y---S--GDYY--RIQGRAVLPIRWMSWESIL-----LGK-FTTASDVWAFGVTLWETFTFCQEQP---------------YSQL--SDEQVIENT----GEFFRDQGRQTYLPQPAICP----DSVYK-LMLSCWRRDTKNRPSFQEIHL---LL---
---F-KKIKVLGSGAFGTVYKGLWIP------------EGEKVKIPVAIKEL---R-E--A-TS-PKA-NKEIL-D----EAYVMASV-DNPHVCRLLGICL---TST------VQLITQLMPFGCLLDYVR---EH--------------------------------------------------------------------K-DNI--GSQYLLNWCVQIAKGMNYLED--RR---LVHRDLAARNVLVK-T-----PQ-HV-KITDFGLAKLL-----G---A--EEKE--YHAEGGKVPIKWMALESIL-----HRI-YTHQSDVWSYGVTVWELMTFGS-KP---------------YDGI--PASEISSIL----EK----GER---LPQPPICT----IDVYM-IMVKCWMIDADSRPKFRELI----IEF--
---V-TRQKVIGAGEFGEVYKGMLKT------------SSGKKEVPVAIKTL---K-A--G-YT-EKQ-RVDFL-G----EAGIMGQF-SHHNIIRLEGVIS--KYKP------MMIITEYMENGALDKFLR---EK--------------------------------------------------------------------D-GEF--SVLQLVGMLRGIAAGMKYLAN--MN---YVHRDLAARNILVN-S-----NL-VC-KVSDFGLSRVL-----E---D--DPEA-TYTTSGGKIPIRWTAPEAIS-----YRK-FTSASDVWSFGIVMWEVMTYGE-RP---------------YWEL--SNHEVMKAI----ND----GFR---LPTPMDCP----SAIYQ-LMMQCWQQERARRPKFADIVSIL------
---V-KIEEVIGAGEFGEVYKGRLK-------------LPGKREIYVAIKTL---K-A--G-YS-EKQ-RRDFL-S----EASIMGQF-DHPNIIRLEGVVT--KSRP------VMIITEFMENGALDSFLR---QN--------------------------------------------------------------------D-GQF--TVIQLVGMLRGIAAGMKYLAE--MN---YVHRDLAARNILVN-S-----NL-VC-KVSDFGLSRYLQ--DDT---S--DPTY--TSSLGGKIPVRWTAPEAIA-----YRK-FTSASDVWSYGIVMWEVMSFGE-RP---------------YWDM--SNQDVINAI----EQ----DYR---LPPPMDCP----AALHQ-LMLDCWQKDRNSRPRFAEIVNTL------
---V-KIEQVIGAGEFGEVCSGHLK-------------LPGKREIFVAIKTL---K-S--G-YT-EKQ-RRDFL-S----EASIMGQF-DHPNVIHLEGVVT--KSTP------VMIITEFMENGSLDSFLR---QN--------------------------------------------------------------------D-GQF--TVIQLVGMLRGIAAGMKYLAD--MN---YVHRDLAARNILVN-S-----NL-VC-KVSDFGLSRFLE--DDT---S--DPTY--TSALGGKIPIRWTAPEAIQ-----YRK-FTSASDVWSYGIVMWEVMSYGE-RP---------------YWDM--TNQDVINAI----EQ----DYR---LPPPMDCP----SALHQ-LMLDCWQKDRNHRPKFGQIVNTL------
---V-KIEEVIGAGEFGEVCRGRLK-------------QPGRREVFVAIKTL---K-V--G-YT-ERQ-RRDFL-S----EASIMGQF-DHPNIIRLEGVVT--KSRP------VMILTEFMENCALDSFLR---LN--------------------------------------------------------------------D-GQF--TVIQLVGMLRGIAAGMKYLSE--MN---YVHRDLAARNILVN-S-----NL-VC-KVSDFGLSRFLE--DDP---S--DPTY--TSSLGGKIPIRWTAPEAIA-----YRK-FTSASDVWSYGIVMWEVMSYGE-RP---------------YWDM--SNQDVINAV----EQ----DYR---LPPPMDCP----TALHQ-LMLDCWVRDRNLRPKFSQIVNTL------
---V-KIEEVIGAGEFGEVCRGRLK-------------APGKKESCVAIKTL---K-G--G-YT-ERQ-RREFL-S----EASIMGQF-EHPNIIRLEGVVT--NSMP------VMILTEFMENGALDSFLR---LN--------------------------------------------------------------------D-GQF--TVIQLVGMLRGIASGMRYLAE--MS---YVHRDLAARNILVN-S-----NL-VC-KVSDFGLSRFLE--ENS---S--DPTY--TSSLGGKIPIRWTAPEAIA-----FRK-FTSASDAWSYGIVMWEVMSFGE-RP---------------YWDM--SNQDVINAI----EQ----DYR---LPPPPDCP----TSLHQ-LMLDCWQKDRNARPRFPQVVSAL------
----IKIEEVIGTGSFGEVRQGRLQ-------------PRGRREQTVAIQAL---W-A--G-GA-ESL-QMTFL-G----RAAVLGQF-QHPNILRLEGVVT--KSRP------LMVLTEFMELGPLDSFLR---QR--------------------------------------------------------------------E-GQF--SSLQLVAMQRGVAAAMQYLSS--FA---FVHRSLSAHSVLVN-S-----HL-VC-KVARLGHSPQG-----------------------PSCLLRWAAPEVIA-----HGK-HTTSSDVWSFGILMWEVMSYGE-RP---------------YWDM--SEQEVLNAI----EQ----EFR---LPPPPGCP----PGLHL-LMLDTWQKDRARRPHFDQLVA---AF---
---L-KRVKVLGSGAFGTVYKGIWVP------------EGETVKIPVAIKIL---N-E--T-TG-PKA-NVEFM-D----EALIMASM-DHPHLVRLLGVCL---SPT------IQLVTQLMPHGCLLEYVH---EH--------------------------------------------------------------------K-DNI--GSQLLLNWCVQIAKGMMYLEE--RR---LVHRDLAARNVLVK-S-----PN-HV-KITDFGLARLL-----E---G--DEKE--YNADGGKMPIKWMALECIH-----YRK-FTHQSDVWSYGVTIWELMTFGG-KP---------------YDGI--PTREIPDLL----EK----GER---LPQPPICT----IDVYM-VMVKCWMIDADSRPKFKELAAE--F----
--VI--LGELLGKGNFGEVYKGTLK-----------------DKTSVAVKTC---K-E--D-LP-QEL-KIKFL-Q----EAKILKQY-DHPNIVKLIGVCT--QRQP------VYIIMELVSGGDFLTFLR---RK--------------------------------------------------------------------K-DEL--KLKQLVKFSLDAAAGMLYLES--KN---CIHRDLAARNCLVG-E-----NN-VL-KISDFGMSRQE---------D--GGVY--SSSGLKQIPIKWTAPEALN-----YGR-YSSESDVWSFGILLWETFSLGV-CP---------------YPGM--TNQQAREQV----ER----GYR---MSAPQHCP----EDISK-IMMKCWDYKPENRPKFSELQKEL------
---L-VLGEQIGRGNFGEVFSGRLR----------------ADNTLVAVKSC---R-E--T-LP-PDL-KAKFL-Q----EARILKQY-SHPNIVRLIGVCT--QKQP------IYIVMELVQGGDFLTFLR---TE--------------------------------------------------------------------G-ARL--RVKTLLQMVGDAAAGMEYLES--KC---CIHRDLAARNCLVT-E-----KN-VL-KISDFGMSREE-----A---D--GVYA--ASGGLRQVPVKWTAPEALN-----YGR-YSSESDVWSFGILLWETFSLGA-SP---------------YPNL--SNQQTREFV----EK----GGR---LPCPELCP----DAVFR-LMEQCWAYEPGQRPSFSTIYQEL------
---L-VLGKPLGEGCFGQVVLAEAIGL---------DKDKPNRVTKVAVKML---K-S--D-AT-EKD-LSDLI-S----EMEMMKMIGKHKNIINLLGACT--QDGP------LYVIVEYASKGNLREYLQ---ARRPPGLEY-----------------------------------------------------CYNPSHNPE-EQL--SSKDLVSCAYQVARGMEYLAS--KK---CIHRDLAARNVLVT-E-----DN-VM-KIADFGLARDI-----H---H--IDYY--KKTTNGRLPVKWMAPEALF-----DRI-YTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGV--PVEELFKLL----KE----GHR---MDKPSNCT----NELYM-MMRDCWHAVPSQRPTFKQLVEDL------
----LTLGKPLGEGCFGQVVMAEAVGI---------DKDKPKEAVTVAVKML---K-D--D-AT-EKD-LSDLV-S----EMEMMKMIGKHKNIINLLGACT--QDGP------LYVIVEYASKGNLREYLR---ARRPPGMEY-----------------------------------------------------SYDINRVPE-EQM--TFKDLVSCTYQLARGMEYLAS--QK---CIHRDLAARNVLVT-E-----NN-VM-KIADFGLARDI-----N---N--IDYY--KKTTNGRLPVKWMAPEALF-----DRV-YTHQSDVWSFGVLMWEIFTLGG-SP---------------YPGI--PVEELFKLL----KE----GHR---MDKPANCT----NELYM-MMRDCWHAVPSQRPTFKQLVEDL------
----LTLGKPLGEGCFGQVVMAEAIGI---------DKDRAAKPVTVAVKML---K-D--D-AT-DKD-LSDLV-S----EMEMMKMIGKHKNIINLLGACT--QGGP------LYVLVEYAAKGNLREFLR---ARRPPGLDY-----------------------------------------------------SFDTCKPPE-EQL--TFKDLVSCAYQVARGMEYLAS--QK---CIHRDLAARNVLVT-E-----DN-VM-KIADFGLARDV-----H---N--LDYY--KKTTNGRLPVKWMAPEALF-----DRV-YTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGI--PVEELFKLL----KE----GHR---MDKPANCT----HDLYM-IMRECWHAAPSQRPTFKQLVEDL------
---L-VLGKPLGEGCFGQVVRAEAFGM---------DPARPDQASTVAVKML---K-D--N-AS-DKD-LADLV-S----EMEVMKLIGRHKNIINLLGVCT--QEGP------LYVIVECAAKGNLREFLR---ARRPPGPDL-----------------------------------------------------SPDGPRSSE-GPL--SFPVLVSCAYQVARGMQYLES--RK---CIHRDLAARNVLVT-E-----DN-VM-KIADFGLARGV-----H---H--IDYY--KKTSNGRLPVKWMAPEALF-----DRV-YTHQSDVWSFGILLWEIFTLGG-SP---------------YPGI--PVEELFSLL----RE----GHR---MDRPPHCP----PELYG-LMRECWHAAPSQRPTFKQLVEAL------
----ITLERRLGTGCFGDVWLGTWN-----------------GSTKVAVKTL---K-P--G-TM-SP---KAFL-E----EAQVMKLL-RHDKLVQLYAVVS---EEP------IYIVTEFMCHGSLLDFLK---NP-------------------------------------------------------------------EG-QDL--RLPQLVDMAAQVAEGMAYMER--MN---YIHRDLRAANILVG-E-----RL-AC-KIADFGLARLI---------K--DDEY--NPCQGSKFPIKWTAPEAAL-----FGR-FTIKSDVWSFGILLTELITKGR-IP---------------YPGM--NKREVLEQV----EQ----GYH---MPCPPGCP----ASLYE-AMEQTWRLDPEERPTFEYLQSFL------
----LHLGRVLGYGAFGKVVEASAFG-----------IHKGSSCDTVAVKML---K-E--G-AT-ASE-HRALM-S----ELKILIHIGNHLNVVNLLGACT-KPQGP------LMVIVEFCKYGNLSNFLR---AKRDAFSPCAEKSPEQRGRFRAMVELARLDRRR-----PGSSDRVLFARFSKTEGGARRASPDQEAEDLWL-SPL--TMEDLVCYSFQVARGMEFLAS--RK---CIHRDLAARNILLS-E-----SD-VV-KICDFGLARDI-----Y---K--DPDY--VRKGSARLPLKWMAPESIF-----DKV-YTTQSDVWSFGVLLWEIFSLGA-SP---------------YPGV-QINEEFCQRL----RD----GTR---MRAPELAT----PAIRR-IMLNCWSGDPKARPAFSELVEIL------
----LQLIKRLGNGQFGEVWMGTWN-----------------GNTKVAIKTL---K-P--G-TM-SP---ESFL-E----EAQIMKKL-KHDKLVQLYAVVS---EEP------IYIVTEYMNKGSLLDFLK---DG-------------------------------------------------------------------EG-RAL--KLPNLVDMAAQVAAGMAYIER--MN---YIHRDLRSANILVG-N-----GL-IC-KIADFGLARLI---------E--DNEY--TARQGAKFPIKWTAPEAAL-----YGR-FTIKSDVWSFGILLTELVTKGR-VP---------------YPGM--NNREVLEQV----ER----GYR---MPCPQDCP----ISLHE-LMIHCWKKDPEERPTFEYLQSFL------
----LKLEKKLGAGQFGEVWMATYN-----------------KHTKVAVKTM---K-P--G-SM-SV---EAFL-A----EANVMKTL-QHDKLVKLHAVVT---KEP------IYIITEFMAKGSLLDFLK---SD-------------------------------------------------------------------EG-SKQ--PLPKLIDFSAQIAEGMAFIEQ--RN---YIHRDLRAANILVS-A-----SL-VC-KIADFGLARVI---------E--DNEY--TAREGAKFPIKWTAPEAIN-----FGS-FTIKSDVWSFGILLMEIVTYGR-IP---------------YPGM--SNPEVIRAL----ER----GYR---MPRPENCP----EELYN-IMMRCWKNRPEERPTFEYIQSV--L----
----ITMSRELGQGSFGMVYEGVAKG-----------VVKDEPETRVAIKTV---N-E--A-AS-MRE-RIEFL-N----EASVMKEF-NCHHVVRLLGVVS--QGQP------TLVIMELMTRGDLKSYLR---SLRPEM-----------------------------------------------------------ENNPVL-APP--SLSKMIQMAGEIADGMAYLNA--NK---FVHRDLAARNCMVA-E-----DF-TV-KIGDFGMTRDI-----Y---E--TDYY--RKGGKGLLPVRWMSPESLK-----DGV-FTTYSDVWSFGVVLWEIATLAE-QP---------------YQGL--SNEQVLRFV----ME----GGL---LDKPDNCP----DMLFE-LMRMCWQYNPKMRPSFLEIISS--I----
----ITLLRELGQGSFGMVYEGNARD-----------IIKGEAETRVAVKTV---N-E--S-AS-LRE-RIEFL-N----EASVMKGF-TCHHVVRLLGVVS--KGQP------TLVVMELMAHGDLKSYLR---SLRPEA-----------------------------------------------------------ENNPGR-PPP--TLQEMIQMAAEIADGMAYLNA--KK---FVHRDLAARNCMVA-H-----DF-TV-KIGDFGMTRDI-----Y---E--TDYY--RKGGKGLLPVRWMAPESLK-----DGV-FTTSSDMWSFGVVLWEITSLAE-QP---------------YQGL--SNEQVLKFV----MD----GGY---LDQPDNCP----ERVTD-LMRMCWQFNPKMRPTFLEIVNLL------
---I-SIIRELGQGSFGMVYEGLARG-----------LEAGEESTPVALKTV---N-E--L-AS-PRE-CIEFL-K----EASVMKAF-KCHHVVRLLGVVS--QGQP------TLVIMELMTRGDLKSHLR---SLRPEA-----------------------------------------------------------ENNPGL-PQP--ALGEMIQMAGEIADGMAYLAA--NK---FVHRDLAARNCMVS-Q-----DF-TV-KIGDFGMTRDV-----Y---E--TDYY--RKGGKGLLPVRWMAPESLK-----DGI-FTTHSDVWSFGVVLWEIVTLAE-QP---------------YQGL--SNEQVLKFV----MD----GGV---LEELEGCP----LQLQE-LMSRCWQPNPRLRPSFTHILD---SI---
----LTFVQEIGSGQFGLVHLGYWL-----------------NKDKVAIKTI---R-E--G-AM-SE---EDFI-E----EAEVMMKL-SHPKLVQLYGVCL--EQAP------ICLVFEFMEHGCLSDYLR---TQ--------------------------------------------------------------------R-GLF--AAETLLGMCLDVCEGMAYLEE--AC---VIHRDLAARNCLVG-E-----NQ-VI-KVSDFGMTRFV---------L--DDQY--TSSTGTKFPVKWASPEVFS-----FSR-YSSKSDVWSFGVLMWEVFSEGK-IP---------------YENR--SNSEVVEDI----ST----GFR---LYKPRLAS----THVYQ-IMNHCWKERPEDRPAFSRLLRQL------
---L-KRIRDLGEGHFGKVELCRYDP------------EGDNTGEQVAVKSL---K-P--E-SG-GNH-IADLK-K----EIEILRNL-YHENIVKYKGICT-ED-GGN----GIKLIMEFLPSGSLKEYLP---KN--------------------------------------------------------------------K-NKI--NLKQQLKYAVQICKGMDYLGS--RQ---YVHRDLAARNVLVE-S-----EH-QV-KIGDFGLTKAI----ET---D--KEYY--TVKDDRDSPVFWYAPECLM-----QSK-FYIASDVWSFGVTLHELLTYCD-SDSSPMALF-LKMIGPTHGQM--TVTRLVNTL----KE----GKR---LPCPPNCP----DEVYQ-LMRKCWEFQPSNRTSFQNLIE---GF---
----LKFLQQLGKGNFGSVEMCRYDP------------LQDNTGEVVAVKKL---Q-H--S-TE--EH-LRDFE-R----EIEILKSL-QHDNIVKYKGVCYSAGRRN------LKLIMEYLPYGSLRDYLQ---KH--------------------------------------------------------------------K-ERI--DHIKLLQYTSQICKGMEYLGT--KR---YIHRDLATRNILVE-N-----EN-RV-KIGDFGLTKVL----PQ---D--KEYY--KVKEPGESPIFWYAPESLT-----ESK-FSVASDVWSFGVVLYELFTYIE-KSKSPPAEFMRMIGNDKQGQM--IVFHLIELL----KN----NGR---LPRPDGCP----DEIYM-IMTECWNNNVNQRPSFRDLA----LRV--
---L-KYISQLGKGNFGSVELCRYDP------------LGDNTGALVAVKQL---Q-H--S-GP-DQ--QRDFQ-R----EIQILKAL-HSDFIVKYRGVSYGPGRQS------LRLVMEYLPSGCLRDFLQ---RH--------------------------------------------------------------------R-ARL--DASRLLLYSSQICKGMEYLGS--RR---CVHRDLAARNILVE-S-----EA-HV-KIADFGLAKLL----PL---D--KDYY--VVREPGQSPIFWYAPESLS-----DNI-FSRQSDVWSFGVVLYELFTYCD-KSCSPSAE--FLRMMGCERDV-PALCRLLELL----EE----GQR---LPAPPACP----AEVHE-LMKLCWAPSPQDRPSFSALGP---QL---
----LKLGKPLGRGAFGQVIEADAFG-----------IDKTATCRTVAVKML---K-E--G-AT-HSE-HRALM-S----ELKILIHIGHHLNVVNLLGACT-KPGGP------LMVIVEFCKFGNLSTYLR---SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYK-DFL--TLEHLICYSFQVAKGMEFLAS--RK---CIHRDLAARNILLS-E-----KN-VV-KICDFGLARDI-----Y---K--DPDY--VRKGDARLPLKWMAPETIF-----DRV-YTIQSDVWSFGVLLWEIFSLGA-SP---------------YPGV-KIDEEFCRRL----KE----GTR---MRAPDYTT----PEMYQ-TMLDCWHGEPSQRPTFSELVEHL------
---V-TLLRALGHGAFGEVYEGLVIG-----------LPGDSSPLQVAIKTL---P-E--L-CS-PQD-ELDFL-M----EALIISKF-RHQNIVRCVGLSL--RATP------RLILLELMSGGDMKSFLR---HSRP--------------------------------------------------------------HLGQP-SPL--VMRDLLQLAQDIAQGCHYLEE--NH---FIHRDIAARNCLLS-CA--GPSR-VA-KIGDFGMARDI-----Y---R--ASYY--RRGDRALLPVKWMPPEAFL-----EGI-FTSKTDSWSFGVLLWEIFSLGY-MP---------------YPGR--TNQEVLDFV----VG----GGR---MDPPRGCP----GPVYR-IMTQCWQHEPELRPSFASILERL------
--WL--KGQQIGLGAFSSCYQAQDV----------------GTGTLMAVKQV---TYV--R-NTSSE---QEEVVEALREEIRMMSHL-NHPNIIRMLGATC--EKSN------YNLFIEWMAGGSVAHLLS--KYG-----------------------------------------------------------------------AF--KESVVINYTEQLLRGLSYLHE--NQ---IIHRDVKGANLLID-S-----TG-QRLRIADFGAAARLAS-----KGTGAGEFQ--GQ---LLGTIAFMAPEVLR-----GQQ-YGRSCDVWSVGCAIIEMAC-AK-PP---------------WNAE--KHSNHLALI----FK----IAS---ATTAPSIPSHLSPGLRD-VALRCLELQPQDRPPSRELLKHPVF----
-ERL-----VLGKGTYGVVYAGRDR----------------HTRVRIAIKEI---PER--D-SRFSQ---PLH--E----EIALHRRL-RHKNIVRYLGSAS--QGGY------LKIFMEEVPGGSLSSLLR-SVWG-----------------------------------------------------------------------PLKDNESTISFYTRQILQGLGYLHD--NH---IVHRDIKGDNVLINTF-----SG-LL-KISDFGTSKRL---------AGITPCT--ET---FTGTLQYMAPEIID---QGPRG-YGKAADIWSLGCTVIEMAT-GR-PP---------------FHEL----GSPQAAM----FQ----VGM---YKVHPPMPSSLSAEAQA-FLLRTFEPDPRLRASAQTLLGDPFL----
----IEVEEVVGRGAFGVVCKAKWR------------------AKDVAIKQI---E-------S-ESE-RKAFI-V----ELRQLSRV-NHPNIVKLYGACL----NP------VCLVMEYAEGGSLYNVLH---GA-------------------------------------------------------------------EPLPYY--TAAHAMSWCLQCSQGVAYLHS--MQPKALIHRDLKPPNLLLV-A-----GGTVL-KICDFGTACDI---------------Q--THMTNNKGSAAWMAPEVFE-----GSN-YSEKCDVFSWGIILWEVITR-R-KP---------------FDEIGGPAFRIMWAV----HN----GTR---PPLIKNLP----KPIES-LMTRCWSKDPSQRPSMEEIVKI--M----
----LTLGAQIGEGEFGAVLQGEYL------------------GQKVAVKNI---K-C--D-VT-AQ----AFL-D----ETAVMTKM-QHENLVRLLGVIL---HQG------LYIVMEHVSKGNLVNFLR---TR-------------------------------------------------------------------GR-ALV--NTAQLLQFSLHVAEGMEYLES--KK---LVHRDLAARNILVS-E-----DL-VA-KVSDFGLAKAE---------------R--KGLDSSRLPVKWTAPEALK-----HGK-FTSKSDVWSFGVLLWEVFSYGR-AP---------------YPKM--SLKEVSEAV----EK----GYR---MEPPEGCP----GPVHV-LMSSCWEAEPARRPPFRKLAEKL------
---L-ILGKILGEGEFGSVMEGNLK-------------QEDGTSLKVAVKTM---KLD--N-SS-QRE-IEEFL-S----EAACMKDF-SHPNVIRLLGVCI--EMSSQG-IPKPMVILPFMKYGDLHTYLL---YSRL---------------------------------------------------------------ETGP-KHI--PLQTLLKFMVDIALGMEYLSN--RN---FLHRDLAARNCMLR-D-----DM-TV-CVADFGLSKKI-----Y---S--GDYY--RQGRIAKMPVKWIAIESLA-----DRV-YTSKSDVWAFGVTMWEIATRGM-TP---------------YPGV--QNHEMYDYL----LH----GHR---LKQPEDCL----DELYE-IMYSCWRTDPLDRPTFSVLRLQ--L----
----VHFNEVIGRGHFGCVYHGTLL-------------DNDGKKIHCAVKSL---N-R--I-TD-IGE-VSQFL-T----EGIIMKDF-SHPNVLSLLGICL-RSEGS------PLVVLPYMKHGDLRNFIR---NE--------------------------------------------------------------------T-HNP--TVKDLIGFGLQVAKGMKYLAS--KK---FVHRDLAARNCMLD-E-----KF-TV-KVADFGLARDM-----Y---D--KEYYSVHNKTGAKLPVKWMALESLQ-----TQK-FTTKSDVWSFGVLLWELMTRGA-PP---------------YPDV--NTFDITVYL----LQ----GRR---LLQPEYCP----DPLYE-VMLKCWHPKAEMRPSFSELVSR--I----
-THS---DRVIGKGHFGVVYHGEYI-------------DQAQNRIQCAIKSL---S-R--I-TE-MQQ-VEAFL-R----EGLLMRGL-NHPNVLALIGIML-PPEGL------PHVLLPYMCHGDLLQFIR---SP--------------------------------------------------------------------Q-RNP--TVKDLISFGLQVARSMEYLAE--QK---FVHRDLAARNCMLD-E-----SF-TV-KVADFGLARDI-----L---D--REYYSVQQHRHARLPVKWMALESLQ-----TYR-FTTKSDVWSFGVLLWELLTRGA-PP---------------YRHI--DPFDLTHFL----AQ----GRR---LPQPEYCP----DSLYQ-VMQQCWEADPAVRPTFRVLV----GEV--
---I-EYVRDIGEGAFGRVFQARAPG-----------LLPYEPFTMVAVKML---K-E--E-AS-ADM-QADFQ-R----EAALMAEF-DNPNIVKLLGVCA--VGKP------MCLLFEYMAYGDLNEFLR---SMSPHTVCSLSHS---------------------------------------------DLSMRAQVSSPGP-PPL--SCAEQLCIARQVAAGMAYLSE--RK---FVHRDLATRNCLVG-E-----NM-VV-KIADFGLSRNI-----Y---S--ADYY--KANENDAIPIRWMPPESIF-----YNR-YTTESDVWAYGVVLWEIFSYGL-QP---------------YYGM--AHEEVIYYV----RD----GNI---LSCPENCP----VELYN-LMRLCWSKLPADRPSFTSIHRIL------
---Y-MVLRMIGEGSFGRALLVQHE----------------SSNQMFAMKEI---RLP--K-SFSNT---QN-SRK----EAVLLAKM-KHPNIVAFKESFE--AEGH------LYIVMEYCDGGDLMQKIKQQKGK-----------------------------------------------------------------------LF--PEDMILNWFTQMCLGVNHIHK--KR---VLHRDIKSKNIFLT-Q-----NG-KV-KLGDFGSARLL---------SNPMAFA--CT---YVGTPYYVPPEIWE-----NLP-YNNKSDIWSLGCILYELCT-LK-HP---------------FQAN--SWKNLILKV----CQ----GCI---SPLPSHYS----YELQF-LVKQMFKRNPSHRPSATTLLS----RGIV
--IV--LKWELGEGAFGKVFLAECHN-----------LLPEQDKMLVAVKAL---K-E--A-SE-SA--RQDFQ-R----EAELLTML-QHQHIVRFFGVCT--EGRP------LLMVFEYMRHGDLNRFLR---SHGPDAKL------------------------------------------------------LAGGEDVAP-GPL--GLGQLLAVASQVAAGMVYLAG--LH---FVHRDLATRNCLVG-Q-----GL-VV-KIGDFGMSRDI-----Y---S--TDYY--RVGGRTMLPIRWMPPESIL-----YRK-FTTESDVWSFGVVLWEIFTYGK-QP---------------WYQL--SNTEAIDCI----TQ----GRE---LERPRACP----PEVYA-IMRGCWQREPQQRHSIKDVHARL------
---I-VLKRELGEGAFGKVFLAECYN-----------LCPEQDKILVAVKTL---K-D--A-SD-NA--RKDFH-R----EAELLTNL-QHEHIVKFYGVCV--EGDP------LIMVFEYMKHGDLNKFLR---AHGPDAV--------------------------------------------------------LMAEGNPP-TEL--TQSQMLHIAQQIAAGMVYLAS--QH---FVHRDLATRNCLVG-E-----NL-LV-KIGDFGMSRDV-----Y---S--TDYY--RVGGHTMLPIRWMPPESIM-----YRK-FTTESDVWSLGVVLWEIFTYGK-QP---------------WYQL--SNNEVIECI----TQ----GRV---LQRPRTCP----QEVYE-LMLGCWQREPHMRKNIKGIHTL--L----
----IELGRCIGEGQFGDVHQGIYM-------------SPENPALAVAIKTC---K-N--C-TS-DSV-REKFL-Q----EALTMRQF-DHPHIVKLIGVIT---ENP------VWIIMELCTLGELRSFLQ---VR--------------------------------------------------------------------K-YSL--DLASLILYAYQLSTALAYLES--KR---FVHRDIAARNVLVS-S-----ND-CV-KLGDFGLSRYM---------E--DSTY--YKASKGKLPIKWMAPESIN-----FRR-FTSASDVWMFGVCMWEILMHGV-KP---------------FQGV--KNNDVIGRI----EN----GER---LPMPPNCP----PTLYS-LMTKCWAYDPSRRPRFTELKAQL------
---F-TLCRKLGSGYFGEVFEGLWK-----------------DRVQVAIKVI---S-R--D-NL-LH--QQMLQ-S----EIQAMKKL-RHKHILALYAVVS--VGDP------VYIITELMAKGSLLELLR---DS-------------------------------------------------------------------DE-KVL--PVSELLDIAWQVAEGMCYLES--QN---YIHRDLAARNILVG-E-----NT-LC-KVGDFGLARLI------------KEDV--YLSHDHNIPYKWTAPEALS-----RGH-YSTKSDVWSFGILLHEMFSRGQ-VP---------------YPGM--SNHEAFLRV----DA----GYR---MPCPLECP----PSVHK-LMLTCWCRDPEQRPCFKALRERL------
---L-VLGKTLGEGEFGKVVKATAFH-----------LKGRAGYTTVAVKML---K-E--N-AS-PSE-LRDLL-S----EFNVLKQV-NHPHVIKLYGACS--QDGP------LLLIVEYAKYGSLRGFLR---ESRKVGPGYLGSG---------------------------------------------GSRNSSSLDHPDE-RAL--TMGDLISFAWQISQGMQYLAE--MK---LVHRDLAARNILVA-E-----GR-KM-KISDFGLSRDV-----Y---E--EDSY--VKRSQGRIPVKWMAIESLF-----DHI-YTTQSDVWSFGVLLWEIVTLGG-NP---------------YPGI--PPERLFNLL----KT----GHR---MERPDNCS----EEMYR-LMLQCWKQEPDKRPVFADISKDL------
--LT--LRLLLGSGAFGEVYEGTAVDI----------LGVGSGEIKVAVKTL---K-K--G-ST-DQE-KIEFL-K----EAHLMSKF-NHPNILKQLGVCL--LNEP------QYIILELMEGGDLLTYLR---KARM--------------------------------------------------------------ATFYG-PLL--TLVDLVDLCVDISKGCVYLER--MH---FIHRDLAARNCLVS-VKDYTSPR-IV-KIGDFGLARDI-----Y---K--NDYY--RKRGEGLLPVRWMAPESLM-----DGI-FTTQSDVWSFGILIWEILTLGH-QP---------------YPAH--SNLDVLNYV----QT----GGR---LEPPRNCP----DDLWN-LMTQCWAQEPDQRPTFHRIQDQL------
----WEIIGELGDGAFGKVYKAQNK----------------ETSVLAAAKVI---DTK--S-EEELE---DYM--V----EIDILASC-DHPNIVKLLDAFY--YENN------LWILIEFCAGGAVDAVML-ELER-----------------------------------------------------------------------PL--TESQIQVVCKQTLDALNYLHD--NK---IIHRDLKAGNILFT-L-----DG-DI-KLADFGVSAKN---------TRTIQRR--DS---FIGTPYWMAPEVVMCETSKDRP-YDYKADVWSLGITLIEMAE-IE-PP---------------HHEL--NPMRVLLKI----AK----SEP---PTLAQPSRWS--SNFKD-FLKKCLEKNVDARWTTSQLLQHPFV----
---L-RLEVKLGQGCFGEVWMGTWN-----------------GTTRVAIKTL---K-P--G-TM-SP---EAFL-Q----EAQVMKKL-RHEKLVQLYAVVS---EEP------IYIVTEYMSKGSLLDFLK---GE-------------------------------------------------------------------TG-KYL--RLPQLVDMAAQIASGMAYVER--MN---YVHRDLRAANILVG-E-----NL-VC-KVADFGLARLI---------E--DNEY--TARQGAKFPIKWTAPEAAL-----YGR-FTIKSDVWSFGILLTELTTKGR-VP---------------YPGM--VNREVLDQV----ER----GYR---MPCPPECP----ESLHD-LMCQCWRKEPEERPTFEYLQAF--L----
--FA--LGRKLGEGYFGEVWEGLWL-----------------GSLPVAIKVI---K-S--A-NM-K---LTDLA-K----EIQTLKGL-RHERLIRLHAVCS--GGEP------VYIVTELMRKGNLQAFLG---TP-------------------------------------------------------------------EG-RAL--RLPPLLGFACQVAEGMSYLEE--QR---VVHRDLAARNVLVD-D-----GL-AC-KVADFGLARLL---------K--DDIY--SPSSSSKIPVKWTAPEAAN-----YRV-FSQKSDVWSFGVLLHEVFTYGQ-CP---------------YEGM--TNHETLQQI----MR----GYR---LPRPAACP----AEVYV-LMLECWRSSPEERPSFATLREKL------
----FTKLEKIGKGSFGEVFKGIDN----------------RTQKVVAIKII---DLE--E-AEDEI---EDIQ-Q----EITVLSQC-DSPYVTKYYGSYL--KDTK------LWIIMEYLGGGSALDLLE---PG-----------------------------------------------------------------------PL--DETQIATILREILKGLDYLHS--EK---KIHRDIKAANVLLS-E-----HG-EV-KLADFGVAGQL---------TDTQIKR--NT---FVGTPFWMAPEVIK-----QSA-YDSKADIWSLGITAIELAR-GE-PP---------------HSEL--HPMKVLFLI----PK----NNP---PTLEGNYS----KPLKE-FVEACLNKEPSFRPTAKELLKHKFI----
-TLE---DKELGSGNFGTVKKGYYQ--------------MKKVVKTVAVKIL---K-N--E-AN-DPALKDELL-A----EANVMQQL-DNPYIVRMIGICE---AES------WMLVMEMAELGPLNKYLQ---QN----------------------------------------------------------------------RHV--KDKNIIELVHQVSMGMKYLEE--SN---FVHRDLAARNVLLV-T-----QH-YA-KISDFGLSKAL-----R---A--DENY-YKAQTHGKWPVKWYAPECIN-----YYK-FSSKSDVWSFGVLMWEAFSYGQ-KP---------------YRGM--KGSEVTAML----EK----GER---MGCPAGCP----REMYD-LMNLCWTYDVENRPGFAAVE----LRL--
----LTFMRELGSGLFGVVRLGKWR-----------------AQYKVAIKAI---R-E--G-AM-CE---EDFI-E----EAKVMMKL-THPKLVQLYGVCT--QQKP------IYIVTEFMERGCLLNFLR---QR--------------------------------------------------------------------Q-GHF--SRDVLLSMCQDVCEGMEYLER--NS---FIHRDLAARNCLVS-E-----AG-VV-KVSDFGMARYV---------L--DDQY--TSSSGAKFPVKWCPPEVFN-----YSR-FSSKSDVWSFGVLMWEVFTEGR-MP---------------FEKY--TNYEVVTMV----TR----GHR---LYQPKLAS----NYVYE-VMLRCWQEKPEGRPSFEDLLRT--I----
-VCR---GELLGSGCFGVVHRGLWT-------------LPSGKSVPVAVKSLRVGP-E--G-PM-GTE-LGDFL-R----EVSVMMNL-EHPHVLRLHGLVL---GQP------LQMVMELAPLGSLHARLT---AP------------------------------------------------------------------APT-PPL--LVALLCLFLRQLAGAMAYLGA--RG---LVHRDLATRNLLLA-S-----PR-TI-KVADFGLVRPL----GG---A--RGRY--VMGGPRPIPYAWCAPESLR-----HGA-FSSASDVWMFGVTLWEMFSGGE-EP---------------WAGV--PPYLILQRL----ED----RAR---LPRPPLCS----RALYS-LALRCWAPHPADRPSFSHLE----GLL--
---L-RLLEKLGDGSFGVVRRGEWD-------------APSGKTVSVAVKCL---K-PDVL-SQ-PEA-MDDFI-R----EVNAMHSL-DHRNLIRLYGVVL---TPP------MKMVTELAPLGSLLDRLR---KH--------------------------------------------------------------------Q-GHF--LLGTLSRYAVQVAEGMGYLES--KR---FIHRDLAARNLLLA-T-----RD-LV-KIGDFGLMRAL----PQ---N--DDHY--VMQEHRKVPFAWCAPESLK-----TRT-FSHASDTWMFGVTLWEMFTYGQ-EP---------------WIGL--NGSQILHKI---DKE----GER---LPRPEDCP----QDIYN-VMVQCWAHKPEDRPTFVALRDF--L----
----IEFHEIIGSGSFGKVYKGRCR------------------NKIVAIKRY---R-ANTY-CS-KSD-VDMFC-R----EVSILCQL-NHPCVIQFVGACL-NDPSQ------FAIVTQYISGGSLFSLLH---EQ--------------------------------------------------------------------K-RIL--DLQSKLIIAVDVAKGMEYLHNLTQP---IIHRDLNSHNILLY-E-----DG-HA-VVADFGESRFL-----Q---S--LD-E--DNMTKQPGNLRWMAPEVFT-----QCTRYTIKADVFSYALCLWEILT-GE-IP---------------FAHL--KPAAAAADM---AYH----HIR---PPIGYSIP----KPISS-LLIRGWNACPEGRPEFSEVVMKL------
---L-AFIKEIGSGQFGVVHLGEWR-----------------SHIQVAIKAI---N-E--G-SM-SE---EDFI-E----EAKVMMKL-SHSKLVQLYGVCI--QRKP------LYIVTEFMENGCLLNYLR---EN--------------------------------------------------------------------K-GKL--RKEMLLSVCQDICEGMEYLER--NG---YIHRDLAARNCLVS-S-----TC-IV-KISDFGMTRYV---------L--DDEY--VSSFGAKFPIKWSPPEVFL-----FNK-YSSKSDVWSFGVLMWEVFTEGK-MP---------------FENK--SNLQVVEAI----SE----GFR---LYRPHLAP----MSIYE-VMYSCWHEKPEGRPTFAELLR---AV---
---L-KKIRDLGEGHFGKVSLYCYDP------------TNDGTGEMVAVKAL---K-A--D-CG-PQH-RSGWK-Q----EIDILRTL-YHEHIIKYKGCCEDQGEKS------LQLVMEYVPLGSLRDYLP---RH-----------------------------------------------------------------------SI--GLAQLLLFAQQICEGMAYLHA--QH---YIHRDLAARNVLLD-N-----DR-LV-KIGDFGLAKAV----PE---G--HEYY--RVREDGDSPVFWYAPECLK-----EYK-FYYASDVWSFGVTLYELLTHCD-SSQSPPTKF-LELIGIAQGQM--TVLRLTELL----ER----GER---LPRPDKCP----CEVYH-LMKNCWETEASFRPTFENLIP---IL---
---F-TLGRMLGKGEFGSVREAQLK-------------QEDGSFVKVAVKML---K-A-DI-IA-SSD-IEEFL-R----EAACMKEF-DHPHVAKLVGVSL--RSRAKGRLPIPMVILPFMKHGDLHAFLL---ASRI---------------------------------------------------------------GENP-FNL--PLQTLIRFMVDIACGMEYLSS--RN---FIHRDLAARNCMLA-E-----DM-TV-CVADFGLSRKI-----Y---S--GDYY--RQGCASKLPVKWLALESLA-----DNL-YTVQSDVWAFGVTMWEIMTRGQ-TP---------------YAGI--ENAEIYNYL----IG----GNR---LKQPPECM----EDVYD-LMYQCWSADPKQRPSFTCLRME--L----
---L-RLEVKLGQGCFGEVWMGTWN-----------------GTTKVAIKTL---K-P--G-TM-MP---EAFL-Q----EAQIMKKL-RHDKLVPLYAVVS---EEP------IYIVTEFMSKGSLLDFLK---EG-------------------------------------------------------------------DG-KYL--KLPQLVDMAAQIADGMAYIER--MN---YIHRDLRAANILVG-E-----NL-VC-KIADFGLARLI---------E--DNEY--TARQGAKFPIKWTAPEAAL-----YGR-FTIKSDVWSFGILQTELVTKGR-VP---------------YPGM--VNREVLEQV----ER----GYR---MPCPQGCP----ESLHE-LMNLCWKKDPDERPTFEYIQSFL------
----WTKGEILGKGAYGTVYCGLTS----------------QGQ-LIAVKQV---ALD--T-SNKLA---AEKEYRKLQEEVDLLKAL-KHVNIVAYLGTCL--QENT------VSIFMEFVPGGSISSIIN--RFG-----------------------------------------------------------------------PL--PEMVFCKYTKQILQGVAYLHE--NC---VVHRDIKGNNVMLM-P-----TG-II-KLIDFGCARRLAWA---GLNGTHSDML--KS---MHGTPYWMAPEVIN-----ESG-YGRKSDIWSIGCTVFEMAT-GK-PP---------------LASM----DRMAAMF----YI----GAH---RGLMPPLPDHFSENAAD-FVRMCLTRDQHERPSALQLLKHSFL----
LIAD----IELGCGNFGSVRQGVYR--------------MRKKQIDVAIKVL---K-Q--G-TE-KAD-TEEMM-R----EAQIMHQL-DNPYIVRLIGVCQ---AEA------LMLVMEMAGGGPLHKFLV---GK--------------------------------------------------------------------R-EEI--PVSNVAELLHQVSMGMKYLEE--KN---FVHRDLAARNVLLV-N-----RH-YA-KISDFGLSKAL----GA---D--DSYY--TARSAGKWPLKWYAPECIN-----FRK-FSSRSDVWSYGVTMWEALSYGQ-KP---------------YKKM--KGPEVMAFI----EQ----GKR---MECPPECP----PELYA-LMSDCWIYKWEDRPDFLTVEQR--M----
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