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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other AURKA 203
TK ABL1 261
TKL BRAF 456
CMGC CSNK2A1 39
TK EGFR 712
TK FGFR1 478
TK JAK2 849
TK LCK 245
TKL LIMK1 339
CMGC MAPK10 64
CMGC MAPK8 26
CAMK MAPKAPK2 64
TK PTK2 422
TK PTK2B 425
---FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKA-QLEKAGV--EHQLRREVEIQSHL--RHPNILRLYGYFH--D------ATRVYLILEYAPLGTVYRELQ--KLS-----------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGEL---KIADFGWSV----HAPSSRR------------TT---LCGTLDYLPPEMIE-GRM---HDEKVDLWSLGVLCYEFLV-GKPP---------------FE-AN-----TYQETYKRISR----VEFTFPDFVT---------------------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI--
---ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-E-D-TM-EV--EEFL-KEAAVMKEI--KHPNLVQLLGVCT--R------EPPFYIITEFMTYGNLLDYLR---EC--------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG-ENHLV---KVADFGLSRLM--T--GDTY------------TAHAGAKFPIKWTAPESLA-YNK---FSIKSDVWAFGVLLWEIATYGMSP---------------YP-GI--DLSQVYELLEKDYR----MERPEGCP-----------------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F--
---ITVGQRIGSGSFGTVYKGKWH----------GDVAVKMLN-VTA-PT-PQQLQAFK-NEVGVLRKT--RHVNILLFMGYST---------KPQLAIVTQWCEGSSLYHHLH---II---------------ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLH-EDLTV---KIGDFGLATVK-SR--WSGS------------HQFEQLSGSILWMAPEVIR-MQDKNPYSFQSDVYAFGIVLYELMT-GQLP---------------YS-NIN-NRDQIIFMVGRGYLSPDLSKVRSNCP-----------------------------------------KAMKRLMAECLKKKRDERPLFPQILA---SI-
---YQLVRKLGRGKYSEVFEAINI-------TNNEKVVVKILKPV-K-KKKIK--R-----EIKILENL-RGGPNIITLADIVK--DP----VSRTPALVFEHVNNTDFKQLY-----Q-----------------TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKL---RLIDWGLAEF---YHPGQEY------------NV---RVASRYFKGPELLVDYQM---YDYSLDMWSLGCMLASMIF-RKEP---------------FFHGH--DNYDQLVRIAKVLG----TEDLYDYIDKYNIELDPRFNDILGRHSRK-----RWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF--
--F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKELR-E-A-TS-PKANKEIL-DEAYVMASV--DNPHVCRLLGICL---------TSTVQLITQLMPFGCLLDYVR---EH---------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVK-TPQHV---KITDFGLAKLL-GA--EEKE------------YHAEGGKVPIKWMALESIL-HRI---YTHQSDVWSYGVTVWELMTFGSKP---------------YD-GI--PASEISSILEKGER----LPQPPICT-----------------------------------------IDVYMIMVKCWMIDADSRPKFRELI----IEF
--L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-S-D-AT-EKDLSDLI-SEMEMMKMIG-KHKNIINLLGACT--Q------DGPLYVIVEYASKGNLREYLQ---ARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT-EDNVM---KIADFGLARDI-HH--IDYY------------KKTTNGRLPVKWMAPEALF-DRI---YTHQSDVWSFGVLLWEIFTLGGSP---------------YP-GV--PVEELFKLLKEGHR----MDKPSNCT-----------------------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL----
---LKFLQQLGKGNFGSVEMCRYDP---LQDNTGEVVAVKKLQ-H-S-TE--EHLRDFE-REIEILKSL--QHDNIVKYKGVCYSAG------RRNLKLIMEYLPYGSLRDYLQ---KH---------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVE-NENRV---KIGDFGLTKVLPQD--KEYY------------KVKEPGESPIFWYAPESLT-ESK---FSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQG-QM--IVFHLIELLKNNGR----LPRPDGCP-----------------------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV
---LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-Q-G-SM-SP--DAFL-AEANLMKQL--QHQRLVRLYAVVT---------QEPIYIITEYMENGSLVDFLK---TP--------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSC---KIADFGLARLI--E--DNEY------------TAREGAKFPIKWTAPEAIN-YGT---FTIKSDVWSFGILLTEIVTHGRIP---------------YP-GM--TNPEVIQNLERGYR----MVRPDNCP-----------------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L--
-LI--HGEVLGKGCFGQAIKVTHR-------ETGEVMVMKELI---R-FD-EETQRTFL-KEVKVMRCL--EHPNVLKFIGVLY--K------DKRLNFITEYIKGGTLRGIIK---SM---------------DSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVR-ENKNV---VVADFGLARLM-VD--EKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMIN-GRS---YDEKVDVFSFGIVLCEIIGRVNAD---------------PD-YLP-RTMDFGLNVRGFLD----RYCPPNCP-----------------------------------------PSFFPITVRCCDLDPEKRPSFVKLEH---WL-
---YQNLKPIGSGAQGIVCAAYDA-------VLDRNVAIKKLSRP-F-QNQTH--AKRAYRELVLMKCV--NHKNIISLLNVFT--PQKTLEEFQDVYLVMELMDA-NLCQVIQ----M-----------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL---KILDFGLART---AGTSFMM------------TP---YVVTRYYRAPEVIL-GMG---YKENVDIWSVGCIMGEMVR-HKIL---------------FP-GR--DYIDQWNKVIEQLG----TPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI--
---YQNLKPIGSGAQGIVCAAYDA-------ILERNVAIKKLSRP-F-QNQTH--AKRAYRELVLMKCV--NHKNIIGLLNVFT--PQKSLEEFQDVYIVMELMDA-NLCQVIQ----M-----------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL---KILDFGLART---AGTSFMM------------TP---YVVTRYYRAPEVIL-GMG---YKENVDLWSVGCIMGEMVC-HKIL---------------FP-GR--DYIDQWNKVIEQLG----TPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYI--
KVT---SQVLGLGINGKVLQIFNK-------RTQEKFALKMLQDC-P-KAR---------REVELHWRA-SQCPHIVRIVDVYE--NLY--AGRKCLLIVMECLDGGELFSRIQDRGDQ-----------------AFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYT-SKRPNAILKLTDFGFAKE---TTSHNSL------------TT---PCYTPYYVAPEVLG-PEK---YDKSCDMWSLGVIMYILLC-GYPP---------------FY-SN-HGLAISPGMKTRIRM----GQYEFPNPEWSEVS-----------------------------------EEVKMLIRNLLKTEPTQRMTITEFMNHPWI--
---IELGRCIGEGQFGDVHQGIYM----SPENPALAVAIKTCK-N-C-TS-DSVREKFL-QEALTMRQF--DHPHIVKLIGVIT---------ENPVWIIMELCTLGELRSFLQ---VR---------------KYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVS-SNDCV---KLGDFGLSRYM--E--DSTY------------YKASKGKLPIKWMAPESIN-FRR---FTSASDVWMFGVCMWEILMHGVKP---------------FQ-GV--KNNDVIGRIENGER----LPMPPNCP-----------------------------------------PTLYSLMTKCWAYDPSRRPRFTELKAQL----
--V-VLNRILGEGFFGEVYEGVYT----NHKGEKINVAVKTCK-K-D-CT-LDNKEKFM-SEAVIMKNL--DHPHIVKLIGIIE---------EEPTWIIMELYPYGELGHYLE---RN---------------KNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVA-SPECV---KLGDFGLSRYI--E--DEDY------------YKASVTRLPIKWMSPESIN-FRR---FTTASDVWMFAVCMWEILSFGKQP---------------FF-WL--ENKDVIGVLEKGDR----LPKPDLCP-----------------------------------------PVLYTLMTRCWDYDPSDRPRFTELVCS--L--
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