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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other AURKA 203
TK ABL1 261
TK ABL2 288
TK ALK 1116
Other AURKB 77
Other AURKC 43
TK BLK 241
TK BMX 422
TK BTK 402
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK4 6
TK CSK 195
CAMK DAPK2 23
TK EGFR 712
TK EPHA3 621
TK EPHB1 619
TK FER 563
TK FGFR1 478
TK FGFR2 481
TK FGFR3 472
TK LCK 245
CMGC MAPK10 64
CMGC MAPK8 26
CAMK MAPKAPK5 22
Other PLK4 12
TK PTK2B 425
CAMK SIK1 27
STE STK10 36
CAMK STK17A 61
CAMK STK17B 33
TK TEC 370
TK TEK 824
TK TIE1 839
TK TNK1 116
---FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVL---FKAQLEKA---GV--EHQLRR----EVEIQSHL--R---HPNILRLYGYFH-D----------ATRVYLILEYAPLGTVYRELQ---KLS-----------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGS---AGEL----KIADFGWSV------HAPSSRR-TT---LCGTLDYLPPEMIE------------------GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN-----TYQETYKRISRVEFTFPDFVT---------------------------------------EGARD-LISRLLKHNPSQRPMLREVLEHPWI--
---ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTL---K-ED-TM----EV--EEFL-K----EAAVMKEI--K---HPNLVQLLGVCT-R----------EPPFYIITEFMTYGNLLDYLR----EC--------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGE---NHLV----KVADFGLSRLM----T--GDTY-TAHAGAKFPIKWTAPESLA------------------YNKFSIKSDVWAFGVLLWEIATYGMSPYPGI--DLSQVYELLEKDYRMERPEGCP-----------------------------------------EKVYE-LMRACWQWNPSDRPSFAEIHQA--F--
---ITMKHKLGGGQYGEVYVGVWK-------KYSLTVAVKTL---K-ED-TM----EV--EEFL-K----EAAVMKEI--K---HPNLVQLLGVCT-L----------EPPFYIVTEYMPYGNLLDYLR----EC--------------NREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGE---NHVV----KVADFGLSRLM----T--GDTY-TAHAGAKFPIKWTAPESLA------------------YNTFSIKSDVWAFGVLLWEIATYGMSPYPGI--DLSQVYDLLEKGYRMEQPEGCP-----------------------------------------PKVYE-LMRACWKWSPADRPSFAETHQA--F--
--I-TLIRGLGHGAFGEVYEGQVSG--MPNDPSPLQVAVKTL---P-EV-CS----EQDELDFL-M----EALIISKF--N---HQNIVRCIGVSL-Q----------SLPRFILLELMAGGDLKSFLR----ETRP---------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVA----KIGDFGMARDI---YR--ASYY-RKGGCAMLPVKWMPPEAFM------------------EGIFTSKTDTWSFGVLLWEIFSLGYMPYPSK--SNQEVLEFVTSGGRMDPPKNCP-----------------------------------------GPVYR-IMTQCWQHQPEDRPNFAIILER--I--
---FEIGRPLGKGKFGNVYLAREK-------KSHFIVALKVL---FKSQ-IEK---EG--VEHQLR---REIEIQAHL--H---HPNILRLYNYFY-D----------RRRIYLILEYAPRGELYKELQ---KSC-----------------TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGL---KGEL----KIADFGWSV------HAPSLRR-KT---MCGTLDYLPPEMIE------------------GRMHNEKVDLWCIGVLCYELLV-GNPPFESA-----SHNETYRRIVKVDLKFPASVP---------------------------------------MGAQD-LISKLLRHNPSERLPLAQVSAHPWV--
---FEIGRPLGKGKFGNVYLARLK-------ESHFIVALKVL---FKSQ-IEK---EG--LEHQLR---REIEIQAHL--Q---HPNILRLYNYFH-D----------ARRVYLILEYAPRGELYKELQ---KSE-----------------KLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGF---RGEV----KIADFGWSV------HTPSLRR-KT---MCGTLDYLPPEMIE------------------GRTYDEKVDLWCIGVLCYELLV-GYPPFESA-----SHSETYRRILKVDVRFPLSMP---------------------------------------LGARD-LISRLLRYQPLERLPLAQILKHPWV--
--L-RLVRKLGSGQFGEVWMGYYK--------NNMKVAIKTL---K-EG-TM----SP--EAFL-G----EANVMKAL--Q---HERLVRLYAVVT------------KEPIYIVTEYMARGCLLDFLK----TD--------------EGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSE---ALCC----KIADFGLARII-------DSEY-TAQEGAKFPIKWTAPEAIH------------------FGVFTIKADVWSFGVLLMEVVTYGRVPYPGM--SNPEVIRNLERGYRMPRPDTCP-----------------------------------------PELYRGVIAECWRSRPEERPTFEFLQSV--L--
---ITLLKELGSGQFGVVQLGKWK--------GQYDVAVKMI---K-EG-SM----SE--DEFF-Q----EAQTMMKL--S---HPKLVKFYGVCS-K----------EYPIYIVTEYISNGCLLNYLR----SH---------------GKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDR---DLCV----KVSDFGMTRYV----L--DDQY-VSSVGTKFPVKWSAPEVFH------------------YFKYSSKSDVWAFGILMWEVFSLGKQPYDLY--DNSQVVLKVSQGHRLYRPHLAS-----------------------------------------DTIYQ-IMYSCWHELPEKRPTFQQLLSS--I--
---LTFLKELGTGQFGVVKYGKWR--------GQYDVAIKMI---K-EG-SM----SE--DEFI-E----EAKVMMNL--S---HEKLVQLYGVCT-K----------QRPIFIITEYMANGCLLNYLR----EM---------------RHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVND---QGVV----KVSDFGLSRYV----L--DDEY-TSSVGSKFPVRWSPPEVLM------------------YSKFSSKSDIWAFGVLMWEIYSLGKMPYERF--TNSETAEHIAQGLRLYRPHLAS-----------------------------------------EKVYT-IMYSCWHEKADERPTFKILLSN--I--
---YTKIEKIGEGTYGVVYKGRHK-------TTGQVVAMKKI---RLES-EEE---GV--PSTAIR----EISLLKEL--R---HPNIVSLQDVLM-Q----------DSRLYLIFEFLSM-DLKKYLDSIPPGQ-----------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDD---KGTI----KLADFGLARAF----GIPIRVY-TH---EVVTLWYRSPEVLL-----------------GSARYSTPVDIWSIGTIFAELAT-KKPLFHGD--SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------GSLASHVKNLDENGLD-LLSKMLIYDPAKRISGKMALNHPYF--
---FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKI---RLDT-ETE---GV--PSTAIR----EISLLKEL--N---HPNIVKLLDVIH-T----------ENKLYLVFEFLHQ-DLKKFMDA-SALT-----------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINT---EGAI----KLADFGLARAF----GVPVRTY-TH---EVVTLWYRAPEILL-----------------GCKYYSTAVDIWSLGCIFAEMVT-RRALFPGD--SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRS-LLSQMLHYDPNKRISAKAALAHPFF--
--Y-EPVAEIGVGAYGTVYKARDP-------HSGHFVALKSV---RVPN-GGGGGGGL--PISTVR----EVALLRRL--EAFEHPNVVRLMDVCA-TSR-----TDREIKVTLVFEHVDQ-DLRTYLDK-APPP-----------------GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTS---GGTV----KLADFGLARI-----YSYQMAL-TP---VVVTLWYRAPEVLL------------------QSTYATPVDMWSVGCIFAEMFR-RKPLFCGN--SEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR---------------PVQSVVPEMEESGAQ-LLLEMLTFNPHKRISAFRALQHSYL--
---LKLLQTIGKGEFGDVMLGDYR---------GNKVAVKCI---K-ND-AT----AQ---AFL-A----EASVMTQL--R---HSNLVQLLGVIVEE----------KGGLYIVTEYMAKGSLVDYLR----SR--------------GRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSE---DNVA----KVSDFGLTKEA----------S-STQDTGKLPVKWTAPEALR------------------EKKFSTKSDVWSFGILLWEIYSFGRVPYPRI--PLKDVVPRVEKGYKMDAPDGCP-----------------------------------------PAVYE-VMKNCWHLDAAMRPSFLQLREQL----
---YDIGEELGSGQFAIVKKCREK-------STGLEYAAKFI---KKRQ-SRA---SR--RGVSREEIEREVSILRQV--L---HHNVITLHDVYE-N----------RTDVVLILELVSGGELFDFLA---QKE-----------------SLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLD---KNIPIPHIKLIDFGLAHE-----IEDGVEF-KN---IFGTPEFVAPEIVN------------------YEPLGLEADMWSIGVITYILLS-GASPFLGD-----TKQETLANITAVSYDFDEEFFSQTS-----------------------------------ELAKD-FIRKLLVKETRKRLTIQEALRHPWI--
--F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKEL---R-EA-TS----PKANKEIL-D----EAYVMASV--D---NPHVCRLLGICL------------TSTVQLITQLMPFGCLLDYVR----EH---------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT---PQHV----KITDFGLAKLL---GA--EEKE-YHAEGGKVPIKWMALESIL------------------HRIYTHQSDVWSYGVTVWELMTFGSKPYDGI--PASEISSILEKGERLPQPPICT-----------------------------------------IDVYM-IMVKCWMIDADSRPKFRELI----IEF
--I-SIDKVVGAGEFGEVCSGRLK----LPSKKEISVAIKTL---K-VG-YT----EKQRRDFL-G----EASIMGQF--D---HPNIIRLEGVVT-K----------SKPVMIVTEYMENGSLDSFLR----KH---------------DAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINS---NLVC----KVSDFGLSRVL---ED--DPEAAYTTRGGKIPIRWTSPEAIA------------------YRKFTSASDVWSYGIVLWEVMSYGERPYWEM--SNQDVIKAVDEGYRLPPPMDCP-----------------------------------------AALYQ-LMLDCWQKDRNNRPKFEQIVSIL----
--V-KIEEVIGAGEFGEVYKGRLK----LPGKREIYVAIKTL---K-AG-YS----EKQRRDFL-S----EASIMGQF--D---HPNIIRLEGVVT-K----------SRPVMIITEFMENGALDSFLR----QN---------------DGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNS---NLVC----KVSDFGLSRYLQDDTS--DPTY-TSSLGGKIPVRWTAPEAIA------------------YRKFTSASDVWSYGIVMWEVMSFGERPYWDM--SNQDVINAIEQDYRLPPPMDCP-----------------------------------------AALHQ-LMLDCWQKDRNSRPRFAEIVNTL----
-VI--LGELLGKGNFGEVYKGTLK--------DKTSVAVKTC---K-ED-LP----QELKIKFL-Q----EAKILKQY--D---HPNIVKLIGVCT-Q----------RQPVYIIMELVSGGDFLTFLR----RK---------------KDELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGE---NNVL----KISDFGMSRQE----D--GGVY-SSSGLKQIPIKWTAPEALN------------------YGRYSSESDVWSFGILLWETFSLGVCPYPGM--TNQQAREQVERGYRMSAPQHCP-----------------------------------------EDISK-IMMKCWDYKPENRPKFSELQKEL----
--L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKML---K-SD-AT----EKDLSDLI-S----EMEMMKMIG-K---HKNIINLLGACT-Q----------DGPLYVIVEYASKGNLREYLQ----ARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTE---DNVM----KIADFGLARDI---HH--IDYY-KKTTNGRLPVKWMAPEALF------------------DRIYTHQSDVWSFGVLLWEIFTLGGSPYPGV--PVEELFKLLKEGHRMDKPSNCT-----------------------------------------NELYM-MMRDCWHAVPSQRPTFKQLVEDL----
---LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKML---K-DD-AT----EKDLSDLV-S----EMEMMKMIG-K---HKNIINLLGACT-Q----------DGPLYVIVEYASKGNLREYLR----ARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTE---NNVM----KIADFGLARDI---NN--IDYY-KKTTNGRLPVKWMAPEALF------------------DRVYTHQSDVWSFGVLMWEIFTLGGSPYPGI--PVEELFKLLKEGHRMDKPANCT-----------------------------------------NELYM-MMRDCWHAVPSQRPTFKQLVEDL----
---LTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKML---K-DD-AT----DKDLSDLV-S----EMEMMKMIG-K---HKNIINLLGACT-Q----------GGPLYVLVEYAAKGNLREFLR----ARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTE---DNVM----KIADFGLARDV---HN--LDYY-KKTTNGRLPVKWMAPEALF------------------DRVYTHQSDVWSFGVLLWEIFTLGGSPYPGI--PVEELFKLLKEGHRMDKPANCT-----------------------------------------HDLYM-IMRECWHAAPSQRPTFKQLVEDL----
---LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSL---K-QG-SM----SP--DAFL-A----EANLMKQL--Q---HQRLVRLYAVVT------------QEPIYIITEYMENGSLVDFLK----TP--------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSD---TLSC----KIADFGLARLI----E--DNEY-TAREGAKFPIKWTAPEAIN------------------YGTFTIKSDVWSFGILLTEIVTHGRIPYPGM--TNPEVIQNLERGYRMVRPDNCP-----------------------------------------EELYQ-LMRLCWKERPEDRPTFDYLRSV--L--
---YQNLKPIGSGAQGIVCAAYDA-------VLDRNVAIKKL---SRPF-QNQ---TH--AKRAYR----ELVLMKCV--N---HKNIISLLNVFT-PQKT----LEEFQDVYLVMELMDA-NLCQVIQ-----M-----------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS---DCTL----KILDFGLART-----AGTSFMM-TP---YVVTRYYRAPEVIL------------------GMGYKENVDIWSVGCIMGEMVR-HKILFPGR--DYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARD-LLSKMLVIDPAKRISVDDALQHPYI--
---YQNLKPIGSGAQGIVCAAYDA-------ILERNVAIKKL---SRPF-QNQ---TH--AKRAYR----ELVLMKCV--N---HKNIIGLLNVFT-PQKS----LEEFQDVYIVMELMDA-NLCQVIQ-----M-----------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKS---DCTL----KILDFGLART-----AGTSFMM-TP---YVVTRYYRAPEVIL------------------GMGYKENVDLWSVGCIMGEMVC-HKILFPGR--DYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARD-LLSKMLVIDASKRISVDEALQHPYI--
INW---TQKLGAGISGPVRVCVKK-------STQERFALKIL---LDRP-KAR------------N----EVRLHMMC-AT---HPNIVQIIEVFA-NSVQFPHESSPRARLLIVMEMMEGGELFHRIS---QHR-----------------HFTEKQASQVTKQIALALRHCHLLNIAHRDLKPENLLFKD---NS-LDAPVKLCDFGFAK-------IDQGDL-MT---PQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLC-GYPPFYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQIS-----------------------------------EMAKD-VVRKLLKVKPEERLTIEGVLDHPWL--
--F-KVGNLLGKGSFAGVYRAESI-------HTGLEVAIKMI---DKKA-MYK---AG--MVQRVQ---NEVKIHCQL--K---HPSILELYNYFE-D----------SNYVYLVLEMCHNGEMNRYLK--NRVK-----------------PFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTR---NMNI----KIADFGLATQL----KMPHEKH-YT---LCGTPNYISPEIAT------------------RSAHGLESDVWSLGCMFYTLLI-GRPPFDTD-----TVKNTLNKVVLADYEMPSFLS---------------------------------------IEAKD-LIHQLLRRNPADRLSLSSVLDHPFM--
--V-VLNRILGEGFFGEVYEGVYT----NHKGEKINVAVKTC---K-KD-CT----LDNKEKFM-S----EAVIMKNL--D---HPHIVKLIGIIE------------EEPTWIIMELYPYGELGHYLE----RN---------------KNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVAS---PECV----KLGDFGLSRYI----E--DEDY-YKASVTRLPIKWMSPESIN------------------FRRFTTASDVWMFAVCMWEILSFGKQPFFWL--ENKDVIGVLEKGDRLPKPDLCP-----------------------------------------PVLYT-LMTRCWDYDPSDRPRFTELVCS--L--
---YDIERTLGKGNFAVVKLARHR-------VTKTQVAIKII---DKTR-LDS---SN--LEKIYR----EVQLMKLL--N---HPHIIKLYQVME-T----------KDMLYIVTEFAKNGEMFDYLT---SNG-----------------HLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDG---NMDI----KLADFGFGNF-----YKSGEPL-ST---WCGSPPYAAPEVFE-----------------GKEYEGPQLDIWSLGVVLYVLVC-GSLPFDGP-----NLPTLRQRVLEGRFRIPFFMS---------------------------------------QDCES-LIRRMLVVDPARRITIAQIRQHRWM--
---WEIVGELGDGAFGKVYKAKNK-------ETGALAAAKVI---ETKS-EEE---LE--DYI--V----EIEILATC--D---HPYIVKLLGAYY-H----------DGKLWIMIEFCPGGAVDAIML--ELDR-----------------GLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTL---EGDI----RLADFGVSAKN----LKTLQKR-DS---FIGTPYWMAPEVVMCE-------------TMKDTPYDYKADIWSLGITLIEMAQ-IEPPHHEL--NPMRVLLKIAKSDPPTLLTPSKWS---------------------------------------VEFRD-FLKIALDKNPETRPSAAQLLEHPFV--
LCP---GRELGRGKFAVVRKCIKK-------DSGKEFAAKFM---RKRR-KGQ---DC--RMEIIH----EIAVLELA-QD---NPWVINLHEVYE-T----------ASEMILVLEYAAGGEIFDQCVA-DREE-----------------AFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLTS---ESPLG-DIKIVDFGLSRI-----LKNSEEL-RE---IMGTPEYVAPEILS------------------YDPISMATDMWSIGVLTYVMLT-GISPFLGN-----DKQETFLNISQMNLSYSEEEFDVLS-----------------------------------ESAVD-FIRTLLVKKPEDRATAEECLKHPWL--
ILT---SKELGRGKFAVVRQCISK-------STGQEYAAKFL---KKRR-RGQ---DC--RAEILH----EIAVLELA-KS---CPRVINLHEVYE-N----------TSEIILILEYAAGGEIFSLCLP-ELAE-----------------MVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSS---IYPLG-DIKIVDFGMSRK-----IGHACEL-RE---IMGTPEYLAPEILN------------------YDPITTATDMWNIGIIAYMLLT-HTSPFVGE-----DNQETYLNISQVNVDYSEETFSSVS-----------------------------------QLATD-FIQSLLVKNPEKRPTAEICLSHSWL--
---LTFMRELGSGLFGVVRLGKWR--------AQYKVAIKAI---R-EG-AM----CE--EDFI-E----EAKVMMKL--T---HPKLVQLYGVCT-Q----------QKPIYIVTEFMERGCLLNFLR----QR---------------QGHFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSE---AGVV----KVSDFGMARYV----L--DDQY-TSSSGAKFPVKWCPPEVFN------------------YSRFSSKSDVWSFGVLMWEVFTEGRMPFEKY--TNYEVVTMVTRGHRLYQPKLAS-----------------------------------------NYVYE-VMLRCWQEKPEGRPSFEDLLRT--I--
---IKFQDVIGEGNFGQVLKARIK-----KDGLRMDAAIKRM---K-EY-AS----KDDHRDFA-G----ELEVLCKLG-H---HPNIINLLGACE-H----------RGYLYLAIEYAPHGNLLDFLR----KSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGE---NYVA----KIADFGLSRGQ--------EVY-VKKTMGRLPVRWMAIESLN------------------YSVYTTNSDVWSYGVLLWEIVSLGGTPYCGM--TCAELYEKLPQGYRLEKPLNCD-----------------------------------------DEVYD-LMRQCWREKPYERPSFAQILV---SL-
---ITFEDLIGEGNFGQVIRAMIK-----KDGLKMNAAIKML---K-EY-AS----ENDHRDFA-G----ELEVLCKLG-H---HPNIINLLGACK-N----------RGYLYIAIEYAPYGNLLDFLR----KSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGE---NLAS----KIADFGLSRGE--------EVY-VKKTMGRLPVRWMAIESLN------------------YSVYTTKSDVWSFGVLLWEIVSLGGTPYCGM--TCAELYEKLPQGYRMEQPRNCD-----------------------------------------DEVYE-LMRQCWRDRPYERPPFAQIALQ--L--
VCR---GELLGSGCFGVVHRGLWT----LPSGKSVPVAVKSLRVGP-EG-PM----GTELGDFL-R----EVSVMMNL--E---HPHVLRLHGLVL------------GQPLQMVMELAPLGSLHARLT----AP-------------APTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLAS---PRTI----KVADFGLVRPL--GGA--RGRY-VMGGPRPIPYAWCAPESLR------------------HGAFSSASDVWMFGVTLWEMFSGGEEPWAGV--PPYLILQRLEDRARLPRPPLCS-----------------------------------------RALYS-LALRCWAPHPADRPSFSHLE----GLL
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