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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other AURKA 203
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK5 4
TK ITK 363
CMGC MAPK8 26
CMGC MAPK9 26
TK PTK2 422
TK PTK2B 425
Other TTK 525
-FEIGRPLGKGKFGNVYLAREK---QSKFILALKVLFKAQLEKAGV--EHQLRREVEIQSHL-R-HPNILRLYGYFHD------ATRVYLILEYAPLGTVYRELQ---KLS--KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSV----HAPSSRRTT---LCGTLDYLPPEMIE-----------GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN---TYQETYKRISRVEFTFPDFVT---------------------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI
-YTKIEKIGEGTYGVVYKGRHK---TTGQVVAMKKIRLES-EEEGV--PSTAIREISLLKEL-R-HPNIVSLQDVLMQ------DSRLYLIFEFLSM-DLKKYLDSIPPGQ--YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF--GIPIRVYTH---EVVTLWYRSPEVLL----------GSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF
-FQKVEKIGEGTYGVVYKARNK---LTGEVVALKKIRLDT-ETEGV--PSTAIREISLLKEL-N-HPNIVKLLDVIHT------ENKLYLVFEFLHQ-DLKKFMDA-SALT--GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTYTH---EVVTLWYRAPEILL----------GCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
-YEKLEKIGEGTYGTVFKAKNR---ETHEIVALKRVRLDD-DDEGV--PSSALREICLLKEL-K-HKNIVRLHDVLHS------DKKLTLVFEFCDQ-DLKKYFD--SCNG--DLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF--GIPVRCYSA---EVVTLWYRPPDVLF----------GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT-------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF
-LTFVQEIGSGQFGLVHLGYWL----NKDKVAIKTIR-EG-AM-SE--EDFI-EEAEVMMKL-S-HPKLVQLYGVCLE------QAPICLVFEFMEHGCLSDYLR----TQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFV--L--DDQYTSSTGTKFPVKWASPEVFS-----------FSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLAS-----------------------------------------THVYQIMNHCWKERPEDRPAFSRLLRQL--
-YQNLKPIGSGAQGIVCAAYDA---ILERNVAIKKLSRPF-QNQTH--AKRAYRELVLMKCV-N-HKNIIGLLNVFTPQKSLEEFQDVYIVMELMDA-NLCQVIQ-----M--ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART---AGTSFMMTP---YVVTRYYRAPEVIL-----------GMGYKENVDLWSVGCIMGEMVC-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYI
-YQQLKPIGSGAQGIVCAAFDT---VLGINVAVKKLSRPF-QNQTH--AKRAYRELVLLKCV-N-HKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIH-----M--ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART---ACTNFMMTP---YVVTRYYRAPEVIL-----------GMGYKENVDIWSVGCIMGELVK-GCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYI
-IELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCK-NC-TS-DSVREKFL-QEALTMRQF-D-HPHIVKLIGVIT-------ENPVWIIMELCTLGELRSFLQ----VRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYM--E--DSTYYKASKGKLPIKWMAPESIN-----------FRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCP-----------------------------------------PTLYSLMTKCWAYDPSRRPRFTELKAQL--
V-VLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCK-KD-CT-LDNKEKFM-SEAVIMKNL-D-HPHIVKLIGIIE-------EEPTWIIMELYPYGELGHYLE----RNKNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYI--E--DEDYYKASVTRLPIKWMSPESIN-----------FRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCP-----------------------------------------PVLYTLMTRCWDYDPSDRPRFTELVCS--L
-YSILKQIGSGGSSKVFQVLNE---KKQ-IYAIKYVNLEE-ADNQT--LDSYRNEIAYLNKLQQHSDKIIRLYDYEIT------DQYIYMVMECGNI-DLNSWLK---KKK--SIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDS---QVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTY-GKTPFQQI--INQISKLHAIIDPNHEIEFPDIPE-------------------------------------KDLQDVLKCCLKRDPKQRISIPELLAHPYV
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