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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other AURKA 203
Other AURKB 77
CAMK CHEK1 9
TKL IRAK4 186
TK LCK 245
TK TNK2 150
---FEIGRPLGKGKFGNVYLAREK---QSKFILALKVLFKA--QLEKAGV--E-HQLRR-EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQ---KLS---KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSV------HAPSSRRTT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN---TYQETY-KRISRVEFTFPDFVT------------EGARDLISRLLKHNPSQRPMLREVLEHPWI---
---FEIGRPLGKGKFGNVYLAREK---KSHFIVALKVLFKS--Q-IEKEG--V-EHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQ---KSC---TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSV------HAPSLRRKT---MCGTLDYLPPEMIE-GRMHNEKVDLWCIGVLCYELLV-GNPPFESA---SHNETY-RRIVKVDLKFPASVP------------MGAQDLISKLLRHNPSERLPLAQVSAHPWV---
--W-DLVQTLGEGAYGEVQLAVNR---VTEEAVAVKIVDMK--R-AVDCP--E-NI-KK-EICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIE---PDI---GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFR--YNNRERLLNK---MCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLA-GELPWDQP--SDSCQEY-SDWKEKKTYLNPWKKI--D--------SAPLALLHKILVENPSARITIPDIKKDRW-Y--
VGG----NKMGEGGFGVVYKGYVN---NTT--VAVKKLAAM--V-DITTE--ELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTP---PLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASE--KFAQTVMTSR---IVGTTAYMAPEALR--GEITPKSDIYSFGVVLLEIIT-GLPAVDEHREPQLLLDI-KEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQ----LLQ
---LKLVERLGAGQFGEVWMGYYN----GHTKVAVKSLK-Q--G-SM-SP--D-AFL-A-EANLMKQLQHQRLVRLYAVVT-QEPIYIITEYMENGSLVDFLK----TPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI----E--DNEYTAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNL-ERGYRMVRPDNCP--------------EELYQLMRLCWKERPEDRPTFDYLRSV--L---
--L-RLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLK-PDVL-SQ-PEAMD-DFI-R-EVNAMHSLDHRNLIRLYGVVL-TPPMKMVTELAPLGSLLDRLR----KH-QGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRAL-PQ-N--DDHYVMQEHRKVPFAWCAPESLK-TRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCP--------------QDIYNVMVQCWAHKPEDRPTFVALRDF--L---
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