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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TKL BMPR1B 203
TK ABL1 261
TKL ACVR1 208
TKL ACVRL1 202
TKL BRAF 456
TK FYN 271
TK HCK 241
TK JAK2 849
TK LCK 245
TK PTK6 191
TK SRC 270
TKL TGFBR1 205
-I-QMVKQIGKGRYGEVWMGKWR----GEK--VAVKVFFTT-EEASWF--RET--EIYQTVLMRHENILGFIAADI--KGTGSWTQLYLITDYHENGSLYDYLKST---TLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFIS--DTNEVDIPPNT---RVGTKRYMPPEVLDESLNRNHFQ---SYIMADMYSFGLILWEVAR-RCVSGGIVEEYQLPYHD-------------------LVPSDPSYEDMREIVCIKKL----RPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKK---TL-
--ITMKHKLGGGQYGEVYEGVWK----KYSLTVAVKTLK-E-DTM-EV--EEFLKEAAVMKEIKHPNLVQLLGVCT--R----EPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK--------NFIHRDLAARNCLVGENHLVKVADFGLSRLM------T--GDTYTAHAGAKFPIKWTAPESLA------YNK---FSIKSDVWAFGVLLWEIATYGM--------------SP---------------YPGI-----DLSQVYELLEKDYR----MERPEGCP------EKVYELMRACWQWNPSDRPSFAEIHQA-F---
-I-TLLECVGKGRYGEVWRGSWQ----GEN--VAVKIFSSR-DEKSWF--RET--ELYNTVMLRHENILGFIASDM--TSRHSSTQLWLITHYHEMGSLYDYLQLT---TLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQ--STNQLDVGNNP---RVGTKRYMAPEVLDETIQVDCFD---SYKRVDIWAFGLVLWEVAR-RMVSNGI----VEDYKPP---------------FYDVVPNDPSFEDMRKVVCVDQQ----RPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKK---TL-
VA--LVECVGKGRYGEVWRGLWH----GES--VAVKIFSSR-DEQSWF--RET--EIYNTVLLRHDNILGFIASDM--TSRNSSTQLWLITHYHEHGSLYDFLQRQ---TLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQ--GSDYLDIGNNP---RVGTKRYMAPEVLDEQIRTDCFE---SYKWTDIWAFGLVLWEIAR-RTIVNGI----VEDYRPP---------------FYDVVPNDPSFEDMKKVVCVDQQ----TPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKK---TLQ
--ITVGQRIGSGSFGTVYKGKWH-------GDVAVKMLN-VTAPT-PQQLQAFKNEVGVLRKTRHVNILLFMGYST-------KPQLAIVTQWCEGSSLYHHLHII-ETKFEMIKLIDIARQTAQGMDYLHAK--------SIIHRDLKSNNIFLHEDLTVKIGDFGLATVK---S--R--WSGSHQFEQLSGSILWMAPEVIR------MQDKNPYSFQSDVYAFGIVLYELMT-GQ--------------LP---------------YSNI-N---NRDQIIFMVGRGYLSPDLSKVRSNCP------KAMKRLMAECLKKKRDERPLFPQILA--SI--
--LQLIKRLGNGQFGEVWMGTWN-----GNTKVAIKTLK-P-GTM-SP--ESFLEEAQIMKKLKHDKLVQLYAVVS-------EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERM--------NYIHRDLRSANILVGNGLICKIADFGLARLI------E--DNEYTARQGAKFPIKWTAPEAAL------YGR---FTIKSDVWSFGILLTELVTKGR--------------VP---------------YPGM-----NNREVLEQVERGYR----MPCPQDCP------ISLHELMIHCWKKDPEERPTFEYLQSFL----
--LKLEKKLGAGQFGEVWMATYN-----KHTKVAVKTMK-P-GSM-SV--EAFLAEANVMKTLQHDKLVKLHAVVT-------KEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQR--------NYIHRDLRAANILVSASLVCKIADFGLARVI------E--DNEYTAREGAKFPIKWTAPEAIN------FGS---FTIKSDVWSFGILLMEIVTYGR--------------IP---------------YPGM-----SNPEVIRALERGYR----MPRPENCP------EELYNIMMRCWKNRPEERPTFEYIQSV-L---
--LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQ-H-STE--EHLRDFEREIEILKSLQHDNIVKYKGVCYSAG----RRNLKLIMEYLPYGSLRDYLQKH-KERIDHIKLLQYTSQICKGMEYLGTK--------RYIHRDLATRNILVENENRVKIGDFGLTKVL--PQ--D--KEYYKVKEPGESPIFWYAPESLT------ESK---FSVASDVWSFGVVLYELFTYIE--------------KSKSPPAEFMRMIGNDKQGQM-----IVFHLIELLKNNGR----LPRPDGCP------DEIYMIMTECWNNNVNQRPSFRDLA---LRV-
--LKLVERLGAGQFGEVWMGYYN-----GHTKVAVKSLK-Q-GSM-SP--DAFLAEANLMKQLQHQRLVRLYAVVT-------QEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEER--------NYIHRDLRAANILVSDTLSCKIADFGLARLI------E--DNEYTAREGAKFPIKWTAPEAIN------YGT---FTIKSDVWSFGILLTEIVTHGR--------------IP---------------YPGM-----TNPEVIQNLERGYR----MVRPDNCP------EELYQLMRLCWKERPEDRPTFDYLRSV-L---
-F-TLCRKLGSGYFGEVFEGLWK-----DRVQVAIKVIS-R-DNL-LH-QQMLQSEIQAMKKLRHKHILALYAVVS--V----GDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQ--------NYIHRDLAARNILVGENTLCKVGDFGLARLI---------KEDVYLSHDHNIPYKWTAPEALS------RGH---YSTKSDVWSFGILLHEMFSRGQ--------------VP---------------YPGM-----SNHEAFLRVDAGYR----MPCPLECP------PSVHKLMLTCWCRDPEQRPCFKALRERL----
-L-RLEVKLGQGCFGEVWMGTWN-----GTTRVAIKTLK-P-GTM-SP--EAFLQEAQVMKKLRHEKLVQLYAVVS-------EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM--------NYVHRDLRAANILVGENLVCKVADFGLARLI------E--DNEYTARQGAKFPIKWTAPEAAL------YGR---FTIKSDVWSFGILLTELTTKGR--------------VP---------------YPGM-----VNREVLDQVERGYR----MPCPPECP------ESLHDLMCQCWRKEPEERPTFEYLQAF-L---
IV--LQESIGKGRFGEVWRGKWR----GEE--VAVKIFSSR-EERSWF--REA--EIYQTVMLRHENILGFIAADN--KDNGTWTQLWLVSDYHEHGSLFDYLNRY---TVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS--ATDTIDIAPNH---RVGTKRYMAPEVLDDSINMKHFE---SFKRADIYAMGLVFWEIAR-RCSIGGI----HEDYQLP---------------YYDLVPSDPSVEEMRKVVCEQKL----RPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKK---TL-
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