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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TKL BRAF 203
TK ABL1 261
TK INSR 1023
TK KDR 834
TK KIT 589
TK LCK 245
TK TEK 824
ITVGQRIGSGSFGTVYKGKWH--------GDVAVKMLNVTAPTPQQLQAFKNEVGVLRKT-RHVNILLFMGYST--KPQLAIVTQWCEGSSLYHHLHII---------------------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILA--SI
ITMKHKLGGGQYGEVYEGVWK-----KYSLTVAVKTLKE-DTMEV--EEFLKEAAVMKEI-KHPNLVQLLGVCT-REPPFYIITEFMTYGNLLDYLREC--------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM-TGDTYTAHAGAKFPIKWTAPESLAYNK---FSIKSDVWAFGVLLWEIATYGMSPYPGI-DLSQVYELLEKDYR----MERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQA-F-
ITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNE-SASLRERIEFLNEASVMKGF-TCHHVVRLLGVVS-KGQPTLVVMELMAHGDLKSYLRSLRPEA------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGV---FTTSSDMWSFGVVLWEITSLAEQPYQGL-SNEQVLKFVMDGGY----LDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLL--
LKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKE-GATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL----------DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRV---YTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTR----MRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHL--
LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKP-SAHLTEREALMSELKVLSYLGNHMNIVNLLGACT-IGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCV---YTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFR----MLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQL-I-
LKLVERLGAGQFGEVWMGYYN------GHTKVAVKSLKQ-GSMSP--DAFLAEANLMKQL-QHQRLVRLYAVVT--QEPIYIITEYMENGSLVDFLKTP--------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI-EDNEYTAREGAKFPIKWTAPEAINYGT---FTIKSDVWSFGILLTEIVTHGRIPYPGM-TNPEVIQNLERGYR----MVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSV-L-
IKFQDVIGEGNFGQVLKARIK---KDGLRMDAAIKRMKE-YASKDDHRDFAGELEVLCKLGHHPNIINLLGACE-HRGYLYLAIEYAPHGNLLDFLRKSRVLETDP------------------------------------------------------------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ---EVYVKKTMGRLPVRWMAIESLNYSV---YTTNSDVWSYGVLLWEIVSLGGTPYCGM-TCAELYEKLPQGYR----LEKPLNCDDEVYDLMRQCWREKPYERPSFAQILV--SL
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