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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK BTK 203
TK ABL1 261
TK BLK 241
TK CSF1R 582
TK CSK 195
TK EGFR 712
TK EPHB4 615
TK FGFR2 481
TK FGFR3 472
TK FYN 271
TK HCK 241
TK KDR 834
TK KIT 589
TK LCK 245
TK LYN 247
TK PDGFRB 600
TK RET 724
TK SRC 270
TK YES1 277
-LTFLKELGTGQFGVVKYGKWR--------GQYDVAIKMIKEGSMSE--DEFIEEAKVMMNL-SHEKLVQLYGVCT-KQRPIFIITEYMANGCLLNYLREM--------------------------------------------------------------------------------------------------RHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYV----LDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERF-TNSETAEHIAQGLRLYRPHLASEKVYT-IMYSCWHEKADERPTFKILLSN-I--
-ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLKEDTMEV--EEFLKEAAVMKEI-KHPNLVQLLGVCT-REPPFYIITEFMTYGNLLDYLREC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM----TGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGI-DLSQVYELLEKDYRMERPEGCPEKVYE-LMRACWQWNPSDRPSFAEIHQA-F--
L-RLVRKLGSGQFGEVWMGYYK--------NNMKVAIKTLKEGTMSP--EAFLGEANVMKAL-QHERLVRLYAVVT--KEPIYIVTEYMARGCLLDFLKTD-------------------------------------------------------------------------------------------------EGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARII-----DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGM-SNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEERPTFEFLQSV-L--
-LQFGKTLGAGAFGKVVEATAFG--LGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACT-HGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDI---MNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYS-IMQACWALEPTHRPTFQQICSFL---
-LKLLQTIGKGEFGDVMLGDYR---------GNKVAVKCIKNDATAQ---AFLAEASVMTQL-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSR-------------------------------------------------------------------------------------------------GRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEA--------SSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRI-PLKDVVPRVEKGYKMDAPDGCPPAVYE-VMKNCWHLDAAMRPSFLQLREQL---
F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKELREATSPKANKEILDEAYVMASV-DNPHVCRLLGICL--TSTVQLITQLMPFGCLLDYVREH--------------------------------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLL---GAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGI-PASEISSILEKGERLPQPPICTIDVYM-IMVKCWMIDADSRPKFRELI---IEF
V-KIEEVIGAGEFGEVCRGRLK----APGKKESCVAIKTLKGGYTERQRREFLSEASIMGQF-EHPNIIRLEGVVT-NSMPVMILTEFMENGALDSFLRLN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDM-SNQDVINAIEQDYRLPPPPDCPTSLHQ-LMLDCWQKDRNARPRFPQVVSAL---
-LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACT-QDGPLYVIVEYASKGNLREYLRARRPPGMEY-----------------------------------------------------------------------------------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDI---NNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGI-PVEELFKLLKEGHRMDKPANCTNELYM-MMRDCWHAVPSQRPTFKQLVEDL---
-LTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACT-QGGPLYVLVEYAAKGNLREFLRARRPPGLDY-----------------------------------------------------------------------------------SFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDV---HNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGI-PVEELFKLLKEGHRMDKPANCTHDLYM-IMRECWHAAPSQRPTFKQLVEDL---
-LQLIKRLGNGQFGEVWMGTWN--------GNTKVAIKTLKPGTMSP--ESFLEEAQIMKKL-KHDKLVQLYAVVS--EEPIYIVTEYMNKGSLLDFLKDG-------------------------------------------------------------------------------------------------EGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLI----EDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGM-NNREVLEQVERGYRMPCPQDCPISLHE-LMIHCWKKDPEERPTFEYLQSFL---
-LKLEKKLGAGQFGEVWMATYN--------KHTKVAVKTMKPGSMSV--EAFLAEANVMKTL-QHDKLVKLHAVVT--KEPIYIITEFMAKGSLLDFLKSD-------------------------------------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVI----EDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGM-SNPEVIRALERGYRMPRPENCPEELYN-IMMRCWKNRPEERPTFEYIQSV-L--
-LKLGKPLGRGAFGQVIEADAFG--IDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---------------------------------DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDI---YKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQ-TMLDCWHGEPSQRPTFSELVEHL---
-LSFGKTLGAGAFGKVVEATAYG--LIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACT-IGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDI---KNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYD-IMKTCWDADPLKRPTFKQIVQL-I--
-LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLKQGSMSP--DAFLAEANLMKQL-QHQRLVRLYAVVT--QEPIYIITEYMENGSLVDFLKTP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI----EDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGM-TNPEVIQNLERGYRMVRPDNCPEELYQ-LMRLCWKERPEDRPTFDYLRSV-L--
-IKLVKRLGAGQFGEVWMGYYN--------NSTKVAVKTLKPGTMSV--QAFLEEANLMKTL-QHDKLVRLYAVVT-REEPIYIITEYMAKGSLLDFLKSD-------------------------------------------------------------------------------------------------EGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVI----EDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGR-TNADVMTALSQGYRMPRVENCPDELYD-IMKMCWKEKAEERPTFDYLQSV-L--
L-VLGRTLGSGAFGQVVEATAHG--LSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACT-KGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDI---MRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYE-IMQKCWEEKFEIRPPFSQLVL--LL-
L-VLGKTLGEGEFGKVVKATAFH--LKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQV-NHPHVIKLYGACS-QDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSG---------------------------------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDV---YEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI-PPERLFNLLKTGHRMERPDNCSEEMYR-LMLQCWKQEPDKRPVFADISKDL---
L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLKPGTMSP--EAFLQEAQVMKKL-RHEKLVQLYAVVS--EEPIYIVTEYMSKGSLLDFLKGE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI----EDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGM-VNREVLDQVERGYRMPCPPECPESLHD-LMCQCWRKEPEERPTFEYLQAF-L--
L-RLEVKLGQGCFGEVWMGTWN--------GTTKVAIKTLKPGTMMP--EAFLQEAQIMKKL-RHDKLVPLYAVVS--EEPIYIVTEFMSKGSLLDFLKEG-------------------------------------------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLI----EDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGM-VNREVLEQVERGYRMPCPQGCPESLHE-LMNLCWKKDPDERPTFEYIQSFL---
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