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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
TK ABL1 261
Other CAMKK2 165
CMGC CDC2 4
CMGC CDK3 4
CMGC CDK4 6
CMGC CDK5 4
CMGC CDK6 13
CMGC CDK7 2.7.11.23
CMGC CDK9 2.7.11.23
CMGC CLK1 161
CMGC CLK2 163
CMGC CLK4 159
CAMK DAPK3 13
CMGC DYRK1A 150
CMGC DYRK1B 111
TK FGR 263
TK FYN 271
TK HCK 241
TK JAK3 822
CMGC MAPK14 24
CMGC MAPK3 42
TK MUSK 575
TK NTRK2 538
TK NTRK3 538
STE PAK4 321
STE PAK7 449
CMGC PCTK1 165
Other PLK1 53
Other PLK3 62
STE SLK 34
TK SRC 270
TK TNK2 150
Other TTK 525
TK YES1 277
----FQKVEKIGEGTYGVVYKARNK-----L-T-GE-VVALKKIRLD--TETE---GV--PSTAIR-------------------------EISLLKEL-N-----HPN-----IVKLLDVIH--T--------ENKLYLVFEFLHQ-DLKKFMDA-SALT-------------------------GI---PLPLIKSYLFQLLQGLAFCHS--HRVLHRDLKPQNLLIN--TEGAI-------------------KLADFGLARAF------GVPVRTY--------------TH---EVVTLWYRAPEILL----------GCKY--YSTAVDIWSLGCIFAEMVT-RRAL-------------FPGD-SEIDQLFRI-FRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-----------------------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF-
----ITMKHKLGGGQYGEVYEGVWK-----K-Y-SL-TVAVKTLK-E--DTM----EV--EEFL-K-------------------------EAAVMKEI-K-----HPN-----LVQLLGVCT--R--------EPPFYIITEFMTYGNLLDYLR----EC----------------------NRQEV---NAVVLLYMATQISSAMEYLEK--KNFIHRDLAARNCLVG--ENHLV-------------------KVADFGLSRLM------T--GDTY--------------TAHAGAKFPIKWTAPESLA-----------YNK--FSIKSDVWAFGVLLWEIATYGMSP-------------YPGI-DLSQVYELL-EKDYRMERPEGCP---------------------------------------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F-
----YTLKDEIGKGSYGVVKLAYNE-----N-D-NT-YYAMKVLSKK--KLIR---QA--GFPR-RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKL-D-----HPN-----VVKLVEVLD--DP------NEDHLYMVFELVNQGPVMEVPT----LK-------------------------PL---SEDQARFYFQDLIKGIEYLHY--QKIIHRDIKPSNLLVG--EDGHI-------------------KIADFGVSNEF------KGSDALL--------------SN---TVGTPAFMAPESLS----------ETRKIFSGKALDVWAMGVTLYCFVF-GQCP-------------FMDE----RIMCLH-SKIKSQALEFPDQPDIA-----------------------------------------------------------EDLKDLITRMLDKNPESRIVVPEIKLHPWV-
----YTKIEKIGEGTYGVVYKGRHK-----T-T-GQ-VVAMKKIRLE--SEEE---GV--PSTAIR-------------------------EISLLKEL-R-----HPN-----IVSLQDVLM--Q--------DSRLYLIFEFLSM-DLKKYLDSIPPGQ-------------------------YM---DSSLVKSYLYQILQGIVFCHS--RRVLHRDLKPQNLLID--DKGTI-------------------KLADFGLARAF------GIPIRVY--------------TH---EVVTLWYRSPEVLL----------GSAR--YSTPVDIWSIGTIFAELAT-KKPL-------------FHGD-SEIDQLFRI-FRALGTPNNEVWPEVESLQDYKNTFPKWKP-----------------------------------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF-
----FQKVEKIGEGTYGVVYKAKNR-----E-T-GQ-LVALKKIRLD--LEME---GV--PSTAIR-------------------------EISLLKEL-K-----HPN-----IVRLLDVVH--N--------ERKLYLVFEFLSQ-DLKKYMDS-TPGS-------------------------EL---PLHLIKSYLFQLLQGVSFCHS--HRVIHRDLKPQNLLIN--ELGAI-------------------KLADFGLARAF------GVPLRTY--------------TH---EVVTLWYRAPEILL----------GSKF--YTTAVDIWSIGCIFAEMVT-RKAL-------------FPGD-SEIDQLFRI-FRMLGTPSEDTWPGVTQLPDYKGSFPKWTR-----------------------------------KGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYF-
---Y-EPVAEIGVGAYGTVYKARDP-----H-S-GH-FVALKSVRVP--NGGGGGGGL--PISTVR-------------------------EVALLRRL-EA--FEHPN-----VVRLMDVCA--TSR---TDREIKVTLVFEHVDQ-DLRTYLDK-APPP-------------------------GL---PAETIKDLMRQFLRGLDFLHA--NCIVHRDLKPENILVT--SGGTV-------------------KLADFGLARI-------YSYQMAL--------------TP---VVVTLWYRAPEVLL-----------QST--YATPVDMWSVGCIFAEMFR-RKPL-------------FCGN-SEADQLGKI-FDLIGLPPEDDWPRDVSLPRGAFPPRGPR-------------------------------------PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL-
----YEKLEKIGEGTYGTVFKAKNR-----E-T-HE-IVALKRVRLD--DDDE---GV--PSSALR-------------------------EICLLKEL-K-----HKN-----IVRLHDVLH--S--------DKKLTLVFEFCDQ-DLKKYFD--SCNG-------------------------DL---DPEIVKSFLFQLLKGLGFCHS--RNVLHRDLKPQNLLIN--RNGEL-------------------KLADFGLARAF------GIPVRCY--------------SA---EVVTLWYRPPDVLF----------GAKL--YSTSIDMWSAGCIFAELANAGRPL-------------FPGN-DVDDQLKRI-FRLLGTPTEEQWPSMTKLPDYKPYPMYPAT-----------------------------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF-
----YECVAEIGEGAYGKVFKARDL-----K-N-GGRFVALKRVRVQ--TGEE---GM--PLSTIR-------------------------EVAVLRHL-ET--FEHPN-----VVRLFDVCT--VSR---TDRETKLTLVFEHVDQ-DLTTYLDK-VPEP-------------------------GV---PTETIKDMMFQLLRGLDFLHS--HRVVHRDLKPQNILVT--SSGQI-------------------KLADFGLARI-------YSFQMAL--------------TS---VVVTLWYRAPEVLL-----------QSS--YATPVDLWSVGCIFAEMFR-RKPL-------------FRGS-SDVDQLGKI-LDVIGLPGEEDWPRDVALPRQAFHSKSAQ-------------------------------------PIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF-
----YEKLDFLGEGQFATVYKARDK-----N-T-NQ-IVAIKKIKLG--HRSE---AK--DGINRTA----------------------LREIKLLQEL-S-----HPN-----IIGLLDAFG--H--------KSNISLVFDFMET-DLEVIIK--DNSL-------------------------VL---TPSHIKAYMLMTLQGLEYLHQ--HWILHRDLKPNNLLLD--ENGVL-------------------KLADFGLAKSF------GSPNRAY--------------TH---QVVTRWYRAPELLF----------GARM--YGVGVDMWAVGCILAELLL-RVPF-------------LPGD-SDLDQLTRI-FETLGTPTEEQWPDMCSLPDYVTFKSFPG------------------------------------IPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF-
----YEKLAKIGQGTFGEVFKARHR-----K-T-GQ-KVALKKVLME--NEKE---GF--PITALR-------------------------EIKILQLL-K-----HEN-----VVNLIEICR--TKASPYNRCKGSIYLVFDFCEH-DLAGLLS--NVLV-------------------------KF---TLSEIKRVMQMLLNGLYYIHR--NKILHRDMKAANVLIT--RDGVL-------------------KLADFGLARAFSL--AKNSQPNRY--------------TN---RVVTLWYRPPELLL----------GERD--YGPPIDLWGAGCIMAEMWT-RSPI-------------MQGN-TEQHQLALI-SQLCGSITPEVWPNVDNYELYEKLELVKGQK--------------------------------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF-
----YEIVDTLGEGAFGKVVECIDH-----K-AGGR-HVAVKIVKNV--DRYC---EA--ARS----------------------------EIQVLEHL-NT---TDPNST-FRCVQMLEWFE--H--------HGHICIVFELLGL-STYDFIK---ENG-------------------------FLP-FRLDHIRKMAYQICKSVNFLHS--NKLTHTDLKPENILFV--QSDYTEAYNPKIKRDERTLINPDIKVVDFGSA---------TYDDEHH--------------ST---LVSTRHYRAPEVIL-----------ALG--WSQPCDVWSIGCILIEYYL-GFTV-------------FPTH-DSKEHLAMM-ERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRY--------------------VSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFF-
----YEIVSTLGEGTFGRVVQCVDH-----R-R-GGARVALKIIKNV--EKYK---EA--AR---L-------------------------EINVLEKI-NEKDPDNKN----LCVQMFDWFD--Y--------HGHMCISFELLGL-STFDFLK---DNN-------------------------YLP-YPIHQVRHMAFQLCQAVKFLHD--NKLTHTDLKPENILFV--NSDYELTYNLEKKRDERSVKSTAVRVVDFGSAT---------FDHEHH--------------ST---IVSTRHYRAPEVIL-----------ELG--WSQPCDVWSIGCIIFEYYV-GFTL-------------FQTH-DNREHLAMM-ERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRY--------------------VRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFF-
----YEIVDTLGEGAFGKVVECIDH-----GMD-GM-HVAVKIVKNV--GRYR---EA--ARS----------------------------EIQVLEHL-NS---TDPNSV-FRCVQMLEWFD--H--------HGHVCIVFELLGL-STYDFIK---ENS-------------------------FLP-FQIDHIRQMAYQICQSINFLHH--NKLTHTDLKPENILFV--KSDYVVKYNSKMKRDERTLKNTDIKVVDFGSA---------TYDDEHH--------------ST---LVSTRHYRAPEVIL-----------ALG--WSQPCDVWSIGCILIEYYL-GFTV-------------FQTH-DSKEHLAMM-ERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRY--------------------VRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFF-
----YEMGEELGSGQFAIVRKCRQK-----G-T-GK-EYAAKFIKKR--RLSS---SR--RGVSREEI---------------------EREVNILREI-R-----HPN-----IITLHDIFE--N--------KTDVVLILELVSGGELFDFLA---EKE-------------------------SL---TEDEATQFLKQILDGVHYLHS--KRIAHFDLKPENIMLL--DKNVPNP---------------RIKLIDFGIAHK-------IEAGNEF--------------KN---IFGTPEFVAPEIVN-----------YEP--LGLEADMWSIGVITYILLS-GASP-------------FLGE----TKQETL-TNISAVNYDFDEEYFSNTS---------------------------------------------------------ELAKDFIRRLLVKDPKRRMTIAQSLEHSWI-
----YEIDSLIGKGSFGQVVKAYDR-----V-E-QE-WVAIKIIKNK--KAFL---NQ--AQI----------------------------EVRLLELMNK-----HDTEMKYYIVHLKRHFM--F--------RNHLCLVFEMLSY-NLYDLLR----NT-------------------------NFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAI-------------------KIVDFGSSCQ---------LGQRI--------------YQ---YIQSRFYRSPEVLL-----------GMP--YDLAIDMWSLGCILVEMHT-GEPL-------------FSGA-NEVDQMNKI-VEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF-
----YEIDSLIGKGSFGQVVKAYDH-----Q-T-QE-LVAIKIIKNK--KAFL---NQ--AQI----------------------------ELRLLELMNQ-----HDTEMKYYIVHLKRHFM--F--------RNHLCLVFELLSY-NLYDLLR----NT-------------------------HFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAI-------------------KIVDFGSSCQ---------LGQRI--------------YQ---YIQSRFYRSPEVLL-----------GTP--YDLAIDMWSLGCILVEMHT-GEPL-------------FSGS-NEVDQMNRI-VEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFF-
----ITLERRLGTGCFGDVWLGTWN-------G-ST-KVAVKTLK-P--GTM----SP--KAFL-E-------------------------EAQVMKLL-R-----HDK-----LVQLYAVVS-----------EEPIYIVTEFMCHGSLLDFLK----NP----------------------EGQDL---RLPQLVDMAAQVAEGMAYMER--MNYIHRDLRAANILVG--ERLAC-------------------KIADFGLARLI------K--DDEY--------------NPCQGSKFPIKWTAPEAAL-----------FGR--FTIKSDVWSFGILLTELITKGRIP-------------YPGM-NKREVLEQV-EQGYHMPCPPGCP---------------------------------------------------------------ASLYEAMEQTWRLDPEERPTFEYLQSFL---
----LQLIKRLGNGQFGEVWMGTWN-------G-NT-KVAIKTLK-P--GTM----SP--ESFL-E-------------------------EAQIMKKL-K-----HDK-----LVQLYAVVS-----------EEPIYIVTEYMNKGSLLDFLK----DG----------------------EGRAL---KLPNLVDMAAQVAAGMAYIER--MNYIHRDLRSANILVG--NGLIC-------------------KIADFGLARLI------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----------YGR--FTIKSDVWSFGILLTELVTKGRVP-------------YPGM-NNREVLEQV-ERGYRMPCPQDCP---------------------------------------------------------------ISLHELMIHCWKKDPEERPTFEYLQSFL---
----LKLEKKLGAGQFGEVWMATYN-------K-HT-KVAVKTMK-P--GSM----SV--EAFL-A-------------------------EANVMKTL-Q-----HDK-----LVKLHAVVT-----------KEPIYIITEFMAKGSLLDFLK----SD----------------------EGSKQ---PLPKLIDFSAQIAEGMAFIEQ--RNYIHRDLRAANILVS--ASLVC-------------------KIADFGLARVI------E--DNEY--------------TAREGAKFPIKWTAPEAIN-----------FGS--FTIKSDVWSFGILLMEIVTYGRIP-------------YPGM-SNPEVIRAL-ERGYRMPRPENCP---------------------------------------------------------------EELYNIMMRCWKNRPEERPTFEYIQSV--L-
---L-KYISQLGKGNFGSVELCRYDP-LGDN-T-GA-LVAVKQLQ-H--SGP----DQ-QRDFQ-R-------------------------EIQILKAL-H-----SDF-----IVKYRGVSYGPG--------RQSLRLVMEYLPSGCLRDFLQ----RH-----------------------RARL---DASRLLLYSSQICKGMEYLGS--RRCVHRDLAARNILVE--SEAHV-------------------KIADFGLAKLL--PL--D--KDYY--------------VVREPGQSPIFWYAPESLS-----------DNI--FSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELL-EEGQRLPAPPACP---------------------------------------------------------------AEVHELMKLCWAPSPQDRPSFSALGP---QL
----YQNLSPVGSGAYGSVCAAFDT-----K-T-GL-RVAVKKLSRP--FQSI---IH--AKRTYR-------------------------ELRLLKHM-K-----HEN-----VIGLLDVFT--PARS--LEEFNDVYLVTHLMGA-DLNNIVK----CQ-------------------------KL---TDDHVQFLIYQILRGLKYIHS--ADIIHRDLKPSNLAVN--EDCEL-------------------KILDFGLAR---------HTDDEM--------------TG---YVATRWYRAPEIML----------NWMH--YNQTVDIWSVGCIMAELLT-GRTL-------------FPGT-DHIDQLKLI-LRLVGTPGAELLKKISSESARNYIQSLTQMP---------------------------------KMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF-
----YTQLQYIGEGAYGMVSSAYDH-----V-R-KT-RVAIKKISPF--EHQT---YC--QRT-LR-------------------------EIQILLRF-R-----HEN-----VIGIRDILR--AST---LEAMRDVYIVQDLMET-DLYKLLK----SQ-------------------------QL---SNDHICYFLYQILRGLKYIHS--ANVLHRDLKPSNLLIN--TTCDL-------------------KICDFGLARIAD---PEHDHTGFL--------------TE---YVATRWYRAPEIML----------NSKG--YTKSIDIWSVGCILAEMLS-NRPI-------------FPGK-HYLDQLNHI-LGILGSPSQEDLNCIINMKARNYLQSLPSKT---------------------------------KVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL-
---I-EYVRDIGEGAFGRVFQARAPGLLPYE-P-FT-MVAVKMLK-E--EAS----ADMQADFQ-R-------------------------EAALMAEF-D-----NPN-----IVKLLGVCA--V--------GKPMCLLFEYMAYGDLNEFLR----SMSPHTVCSLSHSDLSMRAQVSSPGPPPL---SCAEQLCIARQVAAGMAYLSE--RKFVHRDLATRNCLVG--ENMVV-------------------KIADFGLSRNI---Y--S--ADYY--------------KANENDAIPIRWMPPESIF-----------YNR--YTTESDVWAYGVVLWEIFSYGLQP-------------YYGM-AHEEVIYYV-RDGNILSCPENCP---------------------------------------------------------------VELYNLMRLCWSKLPADRPSFTSIHRIL---
---I-VLKRELGEGAFGKVFLAECYNLCPEQ-D-KI-LVAVKTLK-D--ASD----NA-RKDFH-R-------------------------EAELLTNL-Q-----HEH-----IVKFYGVCV--E--------GDPLIMVFEYMKHGDLNKFLR----AHGPDAV-----------LMAEGNPPTEL---TQSQMLHIAQQIAAGMVYLAS--QHFVHRDLATRNCLVG--ENLLV-------------------KIGDFGMSRDV---Y--S--TDYY--------------RVGGHTMLPIRWMPPESIM-----------YRK--FTTESDVWSLGVVLWEIFTYGKQP-------------WYQL-SNNEVIECI-TQGRVLQRPRTCP---------------------------------------------------------------QEVYELMLGCWQREPHMRKNIKGIHTL--L-
---I-VLKRELGEGAFGKVFLAECYNLSPTK-D-KM-LVAVKALK-D--PTL----AA-RKDFQ-R-------------------------EAELLTNL-Q-----HEH-----IVKFYGVCG--D--------GDPLIMVFEYMKHGDLNKFLR----AHGPDAMIL--------VDGQPRQAKGEL---GLSQMLHIASQIASGMVYLAS--QHFVHRDLATRNCLVG--ANLLV-------------------KIGDFGMSRDV---Y--S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM-----------YRK--FTTESDVWSFGVILWEIFTYGKQP-------------WFQL-SNTEVIECI-TQGRVLERPRVCP---------------------------------------------------------------KEVYDVMLGCWQREPQQRLNIKEIYKIL---
DNFI-----KIGEGSTGIVCIATVR-----S-S-GK-LVAVKKMDLR--KQQR---RE--L--LFN-------------------------EVVIMRDY-Q-----HEN-----VVEMYNSYL--V--------GDELWVVMEFLEGGALTDIVT----HT-------------------------RM---NEEQIAAVCLAVLQALSVLHA--QGVIHRDIKSDSILLT--HDGRV-------------------KLSDFGFCAQV------SKEVPRR--------------KS---LVGTPYWMAPELIS-----------RLP--YGPEVDIWSLGIMVIEMVD-GEPP-------------YFNE-PPLKAMKMI-RDNLPPRLKNLHKVS-------------------------------------------------------------PSLKGFLDRLLVRDPAQRATAAELLKHPFL-
ANFI-----KIGEGSTGIVCIATEK-----H-T-GK-QVAVKKMDLR--KQQR---RE--L--LFN-------------------------EVVIMRDY-H-----HDN-----VVDMYSSYL--V--------GDELWVVMEFLEGGALTDIVT----HT-------------------------RM---NEEQIATVCLSVLRALSYLHN--QGVIHRDIKSDSILLT--SDGRI-------------------KLSDFGFCAQV------SKEVPKR--------------KS---LVGTPYWMAPEVIS-----------RLP--YGTEVDIWSLGIMVIEMID-GEPP-------------YFNE-PPLQAMRRI-RDSLPPRVKDLHK----VS---------------------------------------------------------SVLRGFLDLMLVREPSQRATAQELLGHPFL-
---Y-IKLDKLGEGTYATVYKGKSK-----L-T-DN-LVALKEIRLE--HEEG---AP--C-TAIR-------------------------EVSLLKDL-K-----HAN-----IVTLHDIIH--T--------EKSLTLVFEYLDK-DLKQYLD--DCGN-------------------------II---NMHNVKLFLFQLLRGLAYCHR--QKVLHRDLKPQNLLIN--ERGEL-------------------KLADFGLARAK------SIPTKTY--------------SN---EVVTLWYRPPDILL----------GSTD--YSTQIDMWGVGCIFYEMAT-GRPL-------------FPGS-TVEEQLHFI-FRILGTPTEETWPGILSNEEFKTYNYPKYR----------------------------------AEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF-
--YV--RGRFLGKGGFAKCFEISDA-----D-T-KE-VFAGKIVPKS--LLLK---PH--QREKMS------------------------MEISIHRSL-A-----HQH-----VVGFHGFFE--D--------NDFVFVVLELCRRRSLLELHK---RRK-------------------------AL---TEPEARYYLRQIVLGCQYLHR--NRVIHRDLKLGNLFLN--EDLEV-------------------KIGDFGLATKV------EYDGERK--------------KT---LCGTPNYIAPEVLS-----------KKG--HSFEVDVWSIGCIMYTLLV-GKPP-------------FETS----CLKETY-LRIKKNEYSIPKHIN-------------------------------------------------------------PVAASLIQKMLQTDPTARPTINELLNDEFF-
--YL--KGRLLGKGGFARCYEATDT-----E-T-GS-AYAVKVIPQS--RVAK---PH--QREKIL------------------------NEIELHRDL-Q-----HRH-----IVRFSHHFE--D--------ADNIYIFLELCSRKSLAHIWK---ARH-------------------------TL---LEPEVRYYLRQILSGLKYLHQ--RGILHRDLKLGNFFIT--ENMEL-------------------KVGDFGLAARL------EPPEQRK--------------KT---ICGTPNYVAPEVLL-----------RQG--HGPEADVWSLGCVMYTLLC-GSPP-------------FETA----DLKETY-RCIKQVHYTLPASLS-------------------------------------------------------------LPARQLLAAILRASPRDRPSIDQILRHDFF-
----WEIIGELGDGAFGKVYKAQNK-----E-T-SV-LAAAKVIDTK--SEEE---LE--DYM--V-------------------------EIDILASC-D-----HPN-----IVKLLDAFY--Y--------ENNLWILIEFCAGGAVDAVML--ELER-------------------------PL---TESQIQVVCKQTLDALNYLHD--NKIIHRDLKAGNILFT--LDGDI-------------------KLADFGVSAKN------TRTIQRR--------------DS---FIGTPYWMAPEVVMCE------TSKDRP--YDYKADVWSLGITLIEMAE-IEPP-------------HHEL-NPMRVLLKI-AKSEPPTLAQPSRWS-------------------------------------------------------------SNFKDFLKKCLEKNVDARWTTSQLLQHPFV-
---L-RLEVKLGQGCFGEVWMGTWN-------G-TT-RVAIKTLK-P--GTM----SP--EAFL-Q-------------------------EAQVMKKL-R-----HEK-----LVQLYAVVS-----------EEPIYIVTEYMSKGSLLDFLK----GE----------------------TGKYL---RLPQLVDMAAQIASGMAYVER--MNYVHRDLRAANILVG--ENLVC-------------------KVADFGLARLI------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----------YGR--FTIKSDVWSFGILLTELTTKGRVP-------------YPGM-VNREVLDQV-ERGYRMPCPPECP---------------------------------------------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L-
---L-RLLEKLGDGSFGVVRRGEWD--APSG-K-TV-SVAVKCLK-PDVLSQ----PEAMDDFI-R-------------------------EVNAMHSL-D-----HRN-----LIRLYGVVL-----------TPPMKMVTELAPLGSLLDRLR----KH-----------------------QGHF---LLGTLSRYAVQVAEGMGYLES--KRFIHRDLAARNLLLA--TRDLV-------------------KIGDFGLMRAL--PQ--N--DDHY--------------VMQEHRKVPFAWCAPESLK-----------TRT--FSHASDTWMFGVTLWEMFTYGQEP-------------WIGL-NGSQILHKIDKEGERLPRPEDCP---------------------------------------------------------------QDIYNVMVQCWAHKPEDRPTFVALRDF--L-
----YSILKQIGSGGSSKVFQVLNE-----K-K-Q--IYAIKYVNLE--EADN---QT--LDSYRN-------------------------EIAYLNKLQQ----HSDK-----IIRLYDYEI--T--------DQYIYMVMECGNI-DLNSWLK---KKK-------------------------SI---DPWERKSYWKNMLEAVHTIHQ--HGIVHSDLKPANFLIV---DGML-------------------KLIDFGIANQMQ----PDTTSVVK--------------DS---QVGTVNYMPPEAIKDMSSSRENGKSKSK--ISPKSDVWSLGCILYYMTY-GKTP-------------FQQI---INQISKL-HAIIDPNHEIEFPDIPE-----------------------------------------------------------KDLQDVLKCCLKRDPKQRISIPELLAHPYV-
---L-RLEVKLGQGCFGEVWMGTWN-------G-TT-KVAIKTLK-P--GTM----MP--EAFL-Q-------------------------EAQIMKKL-R-----HDK-----LVPLYAVVS-----------EEPIYIVTEFMSKGSLLDFLK----EG----------------------DGKYL---KLPQLVDMAAQIADGMAYIER--MNYIHRDLRAANILVG--ENLVC-------------------KIADFGLARLI------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----------YGR--FTIKSDVWSFGILQTELVTKGRVP-------------YPGM-VNREVLEQV-ERGYRMPCPQGCP---------------------------------------------------------------ESLHELMNLCWKKDPDERPTFEYIQSFL---
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