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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
TK ABL1 261
Other AURKA 133
CAMK CASK 12
CMGC CDK9 2.7.11.23
CAMK CHEK2 220
CMGC CSNK2A1 39
CAMK DAPK1 13
Other EIF2AK2 267
TK FGFR1 478
TK FGFR2 481
AGC GRK6 186
CMGC GSK3B 56
TK HCK 241
TKL IRAK4 186
TK LCK 245
STE MAP2K1 68
CMGC MAPK10 64
CMGC MAPK12 27
TK MET 1078
Other NEK2 8
AGC PDPK1 82
CAMK PIM1 38
Other PLK1 53
AGC ROCK1 76
AGC RPS6KA1 62
AGC RPS6KA5 49
AGC SGK1 98
TK SRC 270
STE STK24 24
TK TNK2 150
Other TTK 525
TK ZAP70 338
----FQKVEKIGEGTYGVV---YKARN---K-------LTGEVVALKKIRLD--T-ETEGV--P-S-TAIR------EISLL-KEL--N-HPN--IVKLLDVIH-T-----------------------------ENKLY--LVFEFLHQ---DLK-KFMDA--SALT-----------------GIPLPLIKSYLFQLLQGLAFCHS-H-----RVLHRDLKPQNLLIN-TEGAI----KLADFGLARAF------GVPVRTY--TH---EVVTLWYRAPEILL----------GCKYYSTAVDIWSLGCIFAEMVT-RR-ALFP-GD-SEIDQLFRI-FRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---------------QDFSKVVPPLDEDGRSLLSQMLHYDPNK--RIS-----AKAALAHPFF-----------
----ITMKHKLGGGQYGEV---YEGVW---K-------KYSLTVAVKTLK-E--D-TM-EV--E-E-FL-K------EAAVM-KEI--K-HPN--LVQLLGVCT-R-----------------------------EPPFY--IITEFMTYG--NLL-DYLR-----EC--------------NRQEVNAVVLLYMATQISSAMEYLEK-K-----NFIHRDLAARNCLVG-ENHLV----KVADFGLSRLM------T--GDTY--TAHAGAKFPIKWTAPESLA-----------YNKFSIKSDVWAFGVLLWEIATYGM-SPYP-GI-DLSQVYELL-EKDYRMERPEGCP-------------------------------------------EKVYELMRACWQWNPSD--RPS-----FAEIHQA--F-----------
----FEIGRPLGKGKFGNV---YLARE---K-------QSKFILALKVLFKA--QLEKAGV--E-H-QLRR------EVEIQ-SHL--R-HPN--ILRLYGYFH-D-----------------------------ATRVY--LILEYAPLG--TVY-RELQ----KLS-----------------KFDEQRTATYITELANALSYCHS-K-----RVIHRDIKPENLLLG-SAGEL----KIADFGWSV--------HAPSSRR--TT---LCGTLDYLPPEMIE-----------GRMHDEKVDLWSLGVLCYEFLV-GK-PPFE-AN----TYQETY-KRISRVEFTFPDFVT-----------------------------------------EGARDLISRLLKHNPSQ--RPM-----LREVLEHPWI-----------
----YELCEVIGKGPFSVV---RRCIN---R-------ETGQQFAVKIVDVA--K-FTSSP--G-L-STEDL---KREASIC-HML--K-HPH--IVELLETYS-S-----------------------------DGMLY--MVFEFMDGA--DLCFEIVKR-ADAGF-----------------VYSEAVASHYMRQILEALRYCHD-N-----NIIHRDVKPHCVLLA-SKENSA-PVKLGGFGVAIQL------GESGLVA--GG---RVGTPHFMAPEVVK-----------REPYGKPVDVWGCGVILFILLS-GC-LPFY-GT-----KERLF-EGIIKGKYKMNPRQWSHIS-------------------------------------ESAKDLVRRMLMLDPAE--RIT-----VYEALNHPWL-----------
----YEKLAKIGQGTFGEV---FKARH---R-------KTGQKVALKKVLME--N-EKEGF--P-I-TALR------EIKIL-QLL--K-HEN--VVNLIEICR-TKASP---------------------YNRCKGSIY--LVFDFCEH---DLA-GLLS---NVLV-----------------KFTLSEIKRVMQMLLNGLYYIHR-N-----KILHRDMKAANVLIT-RDGVL----KLADFGLARAFSL--AKNSQPNRY--TN---RVVTLWYRPPELLL----------GERDYGPPIDLWGAGCIMAEMWT-RS-PIMQ-GN-TEQHQLALI-SQLCGSITPEVWPNVDNYELYEKLELVKGQK------------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQ--RID-----SDDALNHDFF-----------
--YI--MSKTLGSGACGEV---KLAFE---R-------KTCKKVAIKIISKR--K-FAIGS--A-R-EADPALNVETEIEIL-KKL--N-HPC--IIKIKNFF--D-----------------------------AEDYY--IVLELMEGG--ELF-DKVV----GNK-----------------RLKEATCKLYFYQMLLAVQYLHE-N-----GIIHRDLKPENVLLS-SQEEDC-LIKITDFGHSKI-------LGETSLM--RT---LCGTPTYLAPEVLVS--------VGTAGYNRAVDCWSLGVILFICLS-GY-PPFS-EH---RTQVSLK-DQITSGKYNFIPEVWAEVS-------------------------------------EKALDLVKKLLVVDPKA--RFT-----TEEALRHPWL-----------
----YQLVRKLGRGKYSEV---FEAIN---I-------TNNEKVVVKILKPV--K-KKKIK--R-------------EIKIL-ENL-RG-GPN--IITLADIVK-DP---------------------------VSRTPA--LVFEHVNNT--DFK-QLY-------Q-----------------TLTDYDIRFYMYEILKALDYCHS-M-----GIMHRDVKPHNVMIDHEHRKL----RLIDWGLAEF-------YHPGQEY--NV---RVASRYFKGPELLV----------DYQMYDYSLDMWSLGCMLASMIF-RK-EPFFHGH-DNYDQLVRI-AKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK-------RWERFVHSENQHLVSPEALDFLDKLLRYDHQS--RLT-----AREAMEHPYF-----------
----YDTGEELGSGQFAVV---KKCRE---K-------STGLQYAAKFIKKR--R-TKSSR--R-G-VSREDI--EREVSIL-KEI--Q-HPN--VITLHEVYE-N-----------------------------KTDVI--LILELVAGG--ELF-DFLA----EKE-----------------SLTEEEATEFLKQILNGVYYLHS-L-----QIAHFDLKPENIMLL-DRNVPKPRIKIIDFGLAHK-------IDFGNEF--KN---IFGTPEFVAPEIVN-----------YEPLGLEADMWSIGVITYILLS-GA-SPFL-GD----TKQETL-ANVSAVNYEFEDEYFSNTS-------------------------------------ALAKDFIRRLLVKDPKK--RMT-----IQDSLQHPWI-----------
---F-KEIELIGSGGFGQV---FKAKH---R-------IDGKTYVIKRVKYN--N-EKAER----------------EVKAL-AKL--D-HVN--IVHYNGCWD-GFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLF--IQMEFCDKG--TLE-QWIEK--RRGE-----------------KLDKVLALELFEQITKGVDYIHS-K-----KLIHRDLKPSNIFLV-DTKQV----KIGDFGLVTS-------LKNDGKR--TR---SKGTLRYMSPEQIS-----------SQDYGKEVDLYALGLILAELLH-VCDTAFE-T--------SKF-FTDLRDGIISDIFDK------------------------------------------KEKTLLQKLLSKKPED--RPN-----TSEILR----TLT--------
---L-VLGKPLGEGCFGQV---VLAEA---IGLDKDKPNRVTKVAVKMLK-S--D-AT-EKDLS-D-LI-S------EMEMM-KMIG-K-HKN--IINLLGACT-Q-----------------------------DGPLY--VIVEYASKG--NLR-EYLQ-----ARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLAS-K-----KCIHRDLAARNVLVT-EDNVM----KIADFGLARDI---H--H--IDYY--KKTTNGRLPVKWMAPEALF-----------DRIYTHQSDVWSFGVLLWEIFTLGG-SPYP-GV-PVEELFKLL-KEGHRMDKPSNCT-------------------------------------------NELYMMMRDCWHAVPSQ--RPT-----FKQLVEDL-------------
----LTLGKPLGEGCFGQV---VMAEA---VGIDKDKPKEAVTVAVKMLK-D--D-AT-EKDLS-D-LV-S------EMEMM-KMIG-K-HKN--IINLLGACT-Q-----------------------------DGPLY--VIVEYASKG--NLR-EYLR-----ARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLAS-Q-----KCIHRDLAARNVLVT-ENNVM----KIADFGLARDI---N--N--IDYY--KKTTNGRLPVKWMAPEALF-----------DRVYTHQSDVWSFGVLMWEIFTLGG-SPYP-GI-PVEELFKLL-KEGHRMDKPANCT-------------------------------------------NELYMMMRDCWHAVPSQ--RPT-----FKQLVEDL-------------
---F-RQYRVLGKGGFGEV---CACQV---R-------ATGKMYACKKLEKK--R-IKKRK--G-E-AMAL-----NEKQIL-EKV--N-SRF--VVSLAYAYE-T-----------------------------KDALC--LVLTLMNGG--DLK-FHIYH--MGQA-----------------GFPEARAVFYAAEICCGLEDLHR-E-----RIVYRDLKPENILLD-DHGHI----RISDLGLAVH-------VPEGQTI--KG---RVGTVGYMAPEVVK-----------NERYTFSPDWWALGCLLYEMIA-GQ-SPFQ-QR-KKKIKREEV-ERLVK-EVPEEYSER--FS-------------------------------------PQARSLCSQLLCKDPAE--RLGCRGGSAREVKEHPLF-----------
----YTDTKVIGNGSFGVV---YQAKL---C-------DSGELVAIKKVLQD--K-RFKNR----------------ELQIM-RKL--D-HCN--IVRLRYFFY-SSG-------------------------EKKDEVYLNLVLDYVPETVYRVA----RHYSRAKQ-----------------TLPVIYVKLYMYQLFRSLAYIHS-F-----GICHRDIKPQNLLLDPDTAVL----KLCDFGSAKQ-------LVRGEPN--VS---YICSRYYRAPELIF----------GATDYTSSIDVWSAGCVLAELLL-GQ-PIFP-GD-SGVDQLVEI-IKVLGTPTREQIREMNPNYTEFKFPQIKAH---------------PWTKVFRPRTPPEAIALCSRLLEYTPTA--RLT-----PLEACAHSFF-----------
----LKLEKKLGAGQFGEV---WMATY---N--------KHTKVAVKTMK-P--G-SM-SV--E-A-FL-A------EANVM-KTL--Q-HDK--LVKLHAVVT-------------------------------KEPIY--IITEFMAKG--SLL-DFLK-----SD--------------EGSKQPLPKLIDFSAQIAEGMAFIEQ-R-----NYIHRDLRAANILVS-ASLVC----KIADFGLARVI------E--DNEY--TAREGAKFPIKWTAPEAIN-----------FGSFTIKSDVWSFGILLMEIVTYGR-IPYP-GM-SNPEVIRAL-ERGYRMPRPENCP-------------------------------------------EELYNIMMRCWKNRPEE--RPT-----FEYIQSV--L-----------
-VGG----NKMGEGGFGVV---YKGYV---N-------NTT--VAVKKLAAM--V-DITTE--ELK-QQFD-----QEIKVM-AKC--Q-HEN--LVELLGFSS-D-----------------------------GDDLC--LVYVYMPNG--SLL-DRLSC-LDGTP-----------------PLSWHMRCKIAQGAANGINFLHE-N-----HHIHRDIKSANILLD-EAFTA----KISDFGLARASE----KFAQTVMT--SR---IVGTTAYMAPEALR------------GEITPKSDIYSFGVVLLEIIT-GL-PAVD-EH-REPQLLLDI-KEEIEDEEKTIEDYIDKKMNDAD-----------------------------STSVEAMYSVASQCLHEKKNK--RPD-----IKKVQQ----LLQ--------
----LKLVERLGAGQFGEV---WMGYY---N--------GHTKVAVKSLK-Q--G-SM-SP--D-A-FL-A------EANLM-KQL--Q-HQR--LVRLYAVVT-------------------------------QEPIY--IITEYMENG--SLV-DFLK-----TP--------------SGIKLTINKLLDMAAQIAEGMAFIEE-R-----NYIHRDLRAANILVS-DTLSC----KIADFGLARLI------E--DNEY--TAREGAKFPIKWTAPEAIN-----------YGTFTIKSDVWSFGILLTEIVTHGR-IPYP-GM-TNPEVIQNL-ERGYRMVRPDNCP-------------------------------------------EELYQLMRLCWKERPED--RPT-----FDYLRSV--L-----------
----FEKISELGAGNGGVV---FKVSH---K-------PSGL-VMARKLIHL--E-IKPAI--R-N-QIIR------ELQVL-HEC--N-SPY--IVGFYGAFY-S-----------------------------DGEIS--ICMEHMDGG--SLD-QVLK----KAG-----------------RIPEQILGKVSIAVIKGLTYLREKH-----KIMHRDVKPSNILVN-SRGEI----KLCDFGVSG--------QLIDSMA--NS---FVGTRSYMSPERLQ-----------GTHYSVQSDIWSMGLSLVEMAV-GR-YPIP-PP-DAKELELMF-GCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAE--RAD-----LKQLMVHAFI-----------
----YQNLKPIGSGAQGIV---CAAYD---A-------VLDRNVAIKKLSRP--F-QNQTH--A-K-RAYR------ELVLM-KCV--N-HKN--IISLLNVFT-PQKT-----------------------LEEFQDVY--LVMELMDA---NLC-QVIQ------M-----------------ELDHERMSYLLYQMLCGIKHLHS-A-----GIIHRDLKPSNIVVK-SDCTL----KILDFGLART-------AGTSFMM--TP---YVVTRYYRAPEVIL-----------GMGYKENVDIWSVGCIMGEMVR-HK-ILFP-GR-DYIDQWNKV-IEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPK--LFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAK--RIS-----VDDALQHPYI-----------
----YRDLQPVGSGAYGAV---CSAVD---G-------RTGAKVAIKKLYRP--F-QSELF--A-K-RAYR------ELRLL-KHM--R-HEN--VIGLLDVFT-PDET-----------------------LDDFTDFY--LVMPFMGT---DLG-KLMK-----HE-----------------KLGEDRIQFLVYQMLKGLRYIHA-A-----GIIHRDLKPGNLAVN-EDCEL----KILDFGLAR---------QADSEM--TG---YVVTRWYRAPEVIL----------NWMRYTQTVDIWSVGCIMAEMIT-GK-TLFK-GS-DHLDQLKEI-MKVTGTPPAEFVQRLQSDEAKNYMKGLPELE-------------KKDFASILTNASPLAVNLLEKMLVLDAEQ--RVT-----AGEALAHPYF-----------
----VHFNEVIGRGHFGCV---YHGTL---L----DNDGKKIHCAVKSLN-R--I-TD-IGEVS-Q-FL-T------EGIIM-KDF--S-HPN--VLSLLGICLRS-----------------------------EGSPL--VVLPYMKHG--DLR-NFIR-----NE---------------THNPTVKDLIGFGLQVAKGMKYLAS-K-----KFVHRDLAARNCMLD-EKFTV----KVADFGLARDM---Y--D--KEYYSVHNKTGAKLPVKWMALESLQ-----------TQKFTTKSDVWSFGVLLWELMTRGA-PPYP-DV-NTFDITVYL-LQGRRLLQPEYCP-------------------------------------------DPLYEVMLKCWHPKAEM--RPS-----FSELVSR--I-----------
----YEVLYTIGTGSYGRC---QKIRR---K-------SDGKILVWKELDYG--S-MTEAE--K-Q-MLVS------EVNLL-REL--K-HPN--IVRYYDRII-DR---------------------------TNTTLY--IVMEYCEGG--DLA-SVITKGTKERQ-----------------YLDEEFVLRVMTQLTLALKECHR-RSDGGHTVLHRDLKPANVFLD-GKQNV----KLGDFGLARIL------NHDTSFA--KT---FVGTPYYMSPEQMN-----------RMSYNEKSDIWSLGCLLYELCA-LM-PPFT-AF----SQKELA-GKIREGKFRRIPYRY---S-------------------------------------DELNEIITRMLNLKDYH--RPS-----VEEILENPL-I----------
---F-KFGKILGEGSFSTV---VLARE---L-------ATSREYAIKILEKR--H-IIKEN--K-VPYVTR------ERDVM-SRL--D-HPF--FVKLYFTFQ-D-----------------------------DEKLY--FGLSYAKNG--ELL-KYIR----KIG-----------------SFDETCTRFYTAEIVSALEYLHG-K-----GIIHRDLKPENILLN-EDMHI----QITDFGTAKVLS----PESKQARA--NS---FVGTAQYVSPELLT-----------EKSACKSSDLWALGCIIYQLVA-GL-PPFR-AG----NEYLIF-QKIIKLEYDFPEKFF-----------------------------------------PKARDLVEKLLVLDATK--RLG-----CEEM------EGYGPLKAHPF
----YQVGPLLGSGGFGSV---YSGIR---V-------SDNLPVAIKHVEKD--R-ISDWG--E-L-PNGTRV--PMEVVLL-KKV--S-SGFSGVIRLLDWFE-R-----------------------------PDSFV--LILERPEPV-QDLF-DFIT----ERG-----------------ALQEELARSFFWQVLEAVRHCHN-C-----GVLHRDIKDENILIDLNRGEL----KLIDFGSGA--------LLKDTVY--TD---FDGTRVYSPPEWIR----------YHRYHGRSAAVWSLGILLYDMVC-GD-IPFE-HD-----------EEIIRGQVFFRQRVS-----------------------------------------SECQHLIRWCLALRPSD--RPT-----FEEIQNHPWM-----------
--YV--RGRFLGKGGFAKC---FEISD---A-------DTKEVFAGKIVPKS--L-LLKPH--Q-R-EKMS-----MEISIH-RSL--A-HQH--VVGFHGFFE-D-----------------------------NDFVF--VVLELCRRR--SLL-ELHK----RRK-----------------ALTEPEARYYLRQIVLGCQYLHR-N-----RVIHRDLKLGNLFLN-EDLEV----KIGDFGLATKV------EYDGERK--KT---LCGTPNYIAPEVLS-----------KKGHSFEVDVWSIGCIMYTLLV-GK-PPFE-TS----CLKETY-LRIKKNEYSIPKHIN-----------------------------------------PVAASLIQKMLQTDPTA--RPT-----INELLNDEFF-----------
----YEVVKVIGRGAFGEV---QLVRH---K-------STRKVYAMKLLSKF--E-MIKRS--D-S-AFFW-----EERDIM-AFA--N-SPW--VVQLFYAFQ-D-----------------------------DRYLY--MVMEYMPGG--DLV-NLMS-----NY-----------------DVPEKWARFYTAEVVLALDAIHS-M-----GFIHRDVKPDNMLLD-KSGHL----KLADFGTCMKM-----NKEGMVRC--DT---AVGTPDYISPEVLKS-------QGGDGYYGRECDWWSVGVFLYEMLV-GD-TPFY-AD----SLVGTY-SKIMNHKNSLTFPDDNDIS-------------------------------------KEAKNLICAFLTDREVRLGRNG-----VEEIKRHLFF-----------
----FELLKVLGQGSFGKVFLVRKVTR---P-------DSGHLYAMKVLKKA--T-LKVRD--R-V-RTKM------ERDIL-ADV--N-HPF--VVKLHYAFQ-T-----------------------------EGKLY--LILDFLRGG--DLF-TRLS----KEV-----------------MFTEEDVKFYLAELALGLDHLHS-L-----GIIYRDLKPENILLD-EEGHI----KLTDFGLSKEA------IDHEKKA--YS---FCGTVEYMAPEVVN-----------RQGHSHSADWWSYGVLMFEMLT-GS-LPFQ-GK----DRKETM-TLILKAKLGMPQFLS-----------------------------------------TEAQSLLRALFKRNPAN--RLGSGPDGAEEIKRHV--FY---------
----FELLKVLGTGAYGKV---FLVRKISGH-------DTGKLYAMKVLKKA--T-IVQKA--K-T-TEHTR----TERQVL-EHI-RQ-SPF--LVTLHYAFQ-T-----------------------------ETKLH--LILDYINGG--ELF-THLS----QRE-----------------RFTEHEVQIYVGEIVLALEHLHK-L-----GIIYRDIKLENILLD-SNGHV----VLTDFGLSKEF-----VADETERA--YS---FCGTIEYMAPDIVR---------GGDSGHDKAVDWWSLGVLMYELLT-GA-SPFT-VDGEKNSQAEIS-RRILKSEPPYPQEMS-----------------------------------------ALAKDLIQRLLMKDPKK--RLGCGPRDADEIKEHLFF-----------
----FHFLKVIGKGSFGKV---LLARH---K-------AEEVFYAVKVLQKK--A-ILKKK--E-E-KHIM-----SERNVLLKNV--K-HPF--LVGLHFSFQ-T-----------------------------ADKLY--FVLDYINGG--ELF-YHLQ----RER-----------------CFLEPRARFYAAEIASALGYLHS-L-----NIVYRDLKPENILLD-SQGHI----VLTDFGLCKEN------IEHNSTT--ST---FCGTPEYLAPEVLH-----------KQPYDRTVDWWCLGAVLYEMLY-GL-PPFY-SR----NTAEMY-DNILNKPLQLKPNIT-----------------------------------------NSARHLLEGLLQKDRTK--RLGAK-DDFMEIKSHV--FF---------
---L-RLEVKLGQGCFGEV---WMGTW---N--------GTTRVAIKTLK-P--G-TM-SP--E-A-FL-Q------EAQVM-KKL--R-HEK--LVQLYAVVS-------------------------------EEPIY--IVTEYMSKG--SLL-DFLK-----GE--------------TGKYLRLPQLVDMAAQIASGMAYVER-M-----NYVHRDLRAANILVG-ENLVC----KVADFGLARLI------E--DNEY--TARQGAKFPIKWTAPEAAL-----------YGRFTIKSDVWSFGILLTELTTKGR-VPYP-GM-VNREVLDQV-ERGYRMPCPPECP-------------------------------------------ESLHDLMCQCWRKEPEE--RPT-----FEYLQAF--L-----------
----FTKLEKIGKGSFGEV---FKGID---N-------RTQKVVAIKIIDLE--E-AEDEI--E-D-IQ-Q------EITVL-SQC--D-SPY--VTKYYGSYL-K-----------------------------DTKLW--IIMEYLGGG--SAL-DLLE-----PG-----------------PLDETQIATILREILKGLDYLHS-E-----KKIHRDIKAANVLLS-EHGEV----KLADFGVAGQL------TDTQIKR--NT---FVGTPFWMAPEVIK-----------QSAYDSKADIWSLGITAIELAR-GE-PPHS-EL-HPMKVLFLI-PKNNPPTLEGNYS-------------------------------------------KPLKEFVEACLNKEPSF--RPT-----AKELLKHKFI-----------
---L-RLLEKLGDGSFGVV---RRGEW---D----APSGKTVSVAVKCLK-PDVL-SQ-PEAMD-D-FI-R------EVNAM-HSL--D-HRN--LIRLYGVVL-------------------------------TPPMK--MVTELAPLG--SLL-DRLR-----KH---------------QGHFLLGTLSRYAVQVAEGMGYLES-K-----RFIHRDLAARNLLLA-TRDLV----KIGDFGLMRAL--PQ--N--DDHY--VMQEHRKVPFAWCAPESLK-----------TRTFSHASDTWMFGVTLWEMFTYGQ-EPWI-GL-NGSQILHKIDKEGERLPRPEDCP-------------------------------------------QDIYNVMVQCWAHKPED--RPT-----FVALRDF--L-----------
----YSILKQIGSGGSSKV---FQVLN---E-------KKQ-IYAIKYVNLE--E-ADNQT--L-D-SYRN------EIAYL-NKL-QQHSDK--IIRLYDYEI-T-----------------------------DQYIY--MVMECGNI---DLN-SWLK----KKK-----------------SIDPWERKSYWKNMLEAVHTIHQ-H-----GIVHSDLKPANFLIV--DGML----KLIDFGIANQMQ----PDTTSVVK--DS---QVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTY-GK-TPFQ-QI---INQISKL-HAIIDPNHEIEFPDIPE---------------------------------------KDLQDVLKCCLKRDPKQ--RIS-----IPELLAHPYV-----------
LIAD----IELGCGNFGSV---RQGVY---R-----MRKKQIDVAIKVLK-Q--G-TE-KADTE-E-MM-R------EAQIM-HQL--D-NPY--IVRLIGVCQ-------------------------------AEALM--LVMEMAGGG--PLH-KFLV-----GK---------------REEIPVSNVAELLHQVSMGMKYLEE-K-----NFVHRDLAARNVLLV-NRHYA----KISDFGLSKAL--GA--D--DSYY--TARSAGKWPLKWYAPECIN-----------FRKFSSRSDVWSYGVTMWEALSYGQ-KPYK-KM-KGPEVMAFI-EQGKRMECPPECP-------------------------------------------PELYALMSDCWIYKWED--RPD-----FLTVEQR--M-----------
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