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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
CMGC CDC2 4
CMGC CDK3 4
CMGC CDK4 6
CMGC CDK5 4
CMGC CDK6 13
CMGC CDK9 2.7.11.23
CMGC CLK2 163
CMGC GSK3B 56
CAMK PIM1 38
STE STK24 24
-FQKVEKIGEGTYGVVYKARNKLTGE-VVALKKIRLDTETE---GVPSTAIR----EISLLKELN-----HPN--IVKLLDVIHT--------ENKLY--LVFEFLHQ---DLKKFMDA--SALTGI--PLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI-------------------KLADFGLARAF----GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
-YTKIEKIGEGTYGVVYKGRHKTTGQ-VVAMKKIRLESEEE---GVPSTAIR----EISLLKELR-----HPN--IVSLQDVLMQ--------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQYM--DSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTI-------------------KLADFGLARAF----GIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP---------------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF
-FQKVEKIGEGTYGVVYKAKNRETGQ-LVALKKIRLDLEME---GVPSTAIR----EISLLKELK-----HPN--IVRLLDVVHN--------ERKLY--LVFEFLSQ---DLKKYMDS--TPGSEL--PLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLIN-ELGAI-------------------KLADFGLARAF----GVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVT-RKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTR---------------KGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYF
Y-EPVAEIGVGAYGTVYKARDPHSGH-FVALKSVRVPNGGGGGGGLPISTVR----EVALLRRLEA--FEHPN--VVRLMDVCATSR---TDREIKVT--LVFEHVDQ---DLRTYLDK--APPPGL--PAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTV-------------------KLADFGLARI-----YSYQMALTPVVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR-----------------PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL
-YEKLEKIGEGTYGTVFKAKNRETHE-IVALKRVRLDDDDE---GVPSSALR----EICLLKELK-----HKN--IVRLHDVLHS--------DKKLT--LVFEFCDQ---DLKKYFD---SCNGDL--DPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGEL-------------------KLADFGLARAF----GIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT---------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF
-YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEE---GMPLSTIR----EVAVLRHLET--FEHPN--VVRLFDVCTVSR---TDRETKLT--LVFEHVDQ---DLTTYLDK--VPEPGV--PTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVT-SSGQI-------------------KLADFGLARI-----YSFQMALTSVVVTLWYRAPEVLL-QSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ-----------------PIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
-YEKLAKIGQGTFGEVFKARHRKTGQ-KVALKKVLMENEKE---GFPITALR----EIKILQLLK-----HEN--VVNLIEICRTKASPYNRCKGSIY--LVFDFCEH---DLAGLLS---NVLVKF--TLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLIT-RDGVL-------------------KLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQK------------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF
-YEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYK---EAAR---L----EINVLEKINEKDPDNKN-LCVQMFDWFDY--------HGHMC--ISFELLGL---STFDFLK----DNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFV-NSDYELTYNLEKKRDERSVKSTAVRVVDFGSAT-------FDHEHHSTIVSTRHYRAPEVIL-ELGWSQPCDVWSIGCIIFEYYV-GFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFF
-YTDTKVIGNGSFGVVYQAKLCDSGE-LVAIKKVLQDKRFK---NR----------ELQIMRKLD-----HCN--IVRLRYFFYSSG----EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQTL--PVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL-------------------KLCDFGSAKQ-----LVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH---------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF
-YQVGPLLGSGGFGSVYSGIRVSDNL-PVAIKHVEKDRISD---WGELPNGTRVPMEVVLLKKVS-----SGFSGVIRLLDWFER--------PDSFV--LILERPEPV-QDLFDFIT----ERGAL--QEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGEL-------------------KLIDFGSGA------LLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEHD---------EEIIRGQVFFRQRVS-----------------------------------------SECQHLIRWCLALRPSDRPTFEEIQNHPWM
-FTKLEKIGKGSFGEVFKGIDNRTQK-VVAIKIIDLEEAED---EIEDIQ-Q----EITVLSQCD-----SPY--VTKYYGSYLK--------DTKLW--IIMEYLGGG--SALDLLE-----PGPL--DETQIATILREILKGLDYLHSEKKIHRDIKAANVLLS-EHGEV-------------------KLADFGVAGQL----TDTQIKRNTFVGTPFWMAPEVIK-QSAYDSKADIWSLGITAIELAR-GEPPHSELHPMKVLFLIPKNNPPTLEGNYS-------------------------------------------KPLKEFVEACLNKEPSFRPTAKELLKHKFI
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