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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
TK ABL1 261
AGC AKT1 150
AGC AKT3 148
Other AURKA 133
Other AURKB 77
TK AXL 527
CMGC CDC2 4
CMGC CDK4 6
CMGC CDK5 4
CAMK CHEK1 9
TK FGFR1 478
CMGC GSK3A 119
CMGC GSK3B 56
TK ITK 363
TK JAK2 849
TK LCK 245
CMGC MAPK14 24
AGC PDPK1 82
Other PLK1 53
Other PLK3 62
AGC PRKCA 339
AGC ROCK1 76
AGC ROCK2 92
AGC RPS6KA5 49
TK SRC 270
--FQKVEKIGEGTYGVVYKARN---K-------LTGEVVALKKIRLD-T-ETE---GV--PS-TAIR--EISLLKEL--N---HPNIVKLLDVIH--T------ENK------LY--LVFEFLHQ---DLKKFMDA--SALT-----------------GIPLPLIKSYLFQLLQGLAFCHS-HRVLHRDLKPQNLLIN-TEGAIKLADFGLARAF----GVPVRTYTH---EVVTLWYRAPEILL---GCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--QDFSKVVPPLDEDGRSLLSQMLHYDPNK--RIS-----AKAALAHPFF--------------
--ITMKHKLGGGQYGEVYEGVW---K-------KYSLTVAVKTLK-E-D-TM----EV--EE-FL-K--EAAVMKEI--K---HPNLVQLLGVCT--R------EPP------FY--IITEFMTYG--NLLDYLR-----EC--------------NRQEVNAVVLLYMATQISSAMEYLEK-KNFIHRDLAARNCLVG-ENHLVKVADFGLSRLM----T--GDTYTAHAGAKFPIKWTAPESLA----YNKFSIKSDVWAFGVLLWEIATYGMSP---------------YPGI-DLSQVYELLEKDYRMERPEGCP------------------------------EKVYELMRACWQWNPSD--RPS-----FAEIHQA--F--------------
-F-EYLKLLGKGTFGKVILVKE---K-------ATGRYYAMKILKKE-V-IVA---KD--EV-AHTL-TENRVLQNS--R---HPFLTALKYSFQ--T------HDR------LC--FVMEYANGG--ELFFHLS----RER-----------------VFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD-KDGHIKITDFGLCKEG----IKDGATMKT---FCGTPEYLAPEVLE----DNDYGRAVDWWGLGVVMYEMMC-GRLP---------------FYNQ----DHEKLFELILMEEIRFPRTLG----------------------------PEAKSLLSGLLKKDPKQ--RLGGGSEDAKEIMQHRFF--------------
FD--YLKLLGKGTFGKVILVRE---K-------ASGKYYAMKILKKE-V-IIA---KD--EV-AHTL-TESRVLKNT--R---HPFLTSLKYSFQ--T------KDR------LC--FVMEYVNGG--ELFFHLS----RER-----------------VFSEDRTRFYGAEIVSALDYLHS-GKIVYRDLKLENLMLD-KDGHIKITDFGLCKEG----ITDAATMKT---FCGTPEYLAPEVLE----DNDYGRAVDWWGLGVVMYEMMC-GRLP---------------FYNQ----DHEKLFELILMEDIKFPRTLS----------------------------SDAKSLLSGLLIKDPNK--RLGGGPDDAKEIMRHSFF--------------
--FEIGRPLGKGKFGNVYLARE---K-------QSKFILALKVLFKA-QLEKA---GV--EH-QLRR--EVEIQSHL--R---HPNILRLYGYFH--D------ATR------VY--LILEYAPLG--TVYRELQ----KLS-----------------KFDEQRTATYITELANALSYCHS-KRVIHRDIKPENLLLG-SAGELKIADFGWSV------HAPSSRRTT---LCGTLDYLPPEMIE----GRMHDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN----TYQETYKRISRVEFTFPDFVT----------------------------EGARDLISRLLKHNPSQ--RPM-----LREVLEHPWI--------------
--FEIGRPLGKGKFGNVYLARE---K-------KSHFIVALKVLFKS-Q-IEK---EG--VE-HQLR-REIEIQAHL--H---HPNILRLYNYFY--D------RRR------IY--LILEYAPRG--ELYKELQ----KSC-----------------TFDEQRTATIMEELADALMYCHG-KKVIHRDIKPENLLLG-LKGELKIADFGWSV------HAPSLRRKT---MCGTLDYLPPEMIE----GRMHNEKVDLWCIGVLCYELLV-GNPP---------------FESA----SHNETYRRIVKVDLKFPASVP----------------------------MGAQDLISKLLRHNPSE--RLP-----LAQVSAHPWV--------------
-V-ALGKTLGEGEFGAVMEGQL---N-----QDDSILKVAVKTMK-IAI-CT----RSELED-FL-S--EAVCMKEF--D---HPNVMRLIGVCF--Q------GSERESFPAPV--VILPFMKHG--DLHSFLL-----YSRL----------GDQPVYLPTQMLVKFMADIASGMEYLST-KRFIHRDLAARNCMLN-ENMSVCVADFGLSKKI--Y-N--GDYYRQGRIAKMPVKWIAIESLA----DRVYTSKSDVWSFGVTMWEIATRGQTP---------------YPGV-ENSEIYDYLRQGNRLKQPADCL------------------------------DGLYALMSRCWELNPQD--RPS-----FTELREDL----------------
--YTKIEKIGEGTYGVVYKGRH---K-------TTGQVVAMKKIRLE-S-EEE---GV--PS-TAIR--EISLLKEL--R---HPNIVSLQDVLM--Q------DSR------LY--LIFEFLSM---DLKKYLDS-IPPGQ-----------------YMDSSLVKSYLYQILQGIVFCHS-RRVLHRDLKPQNLLID-DKGTIKLADFGLARAF----GIPIRVYTH---EVVTLWYRSPEVLL---GSARYSTPVDIWSIGTIFAELAT-KKPL---------------FHGD-SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP--GSLASHVKNLDENGLDLLSKMLIYDPAK--RIS-----GKMALNHPYF--------------
-Y-EPVAEIGVGAYGTVYKARD---P-------HSGHFVALKSVRVP-N-GGGGGGGL--PI-STVR--EVALLRRL--EAFEHPNVVRLMDVCA--TSR-TDREIK------VT--LVFEHVDQ---DLRTYLDK--APPP-----------------GLPAETIKDLMRQFLRGLDFLHA-NCIVHRDLKPENILVT-SGGTVKLADFGLARI-----YSYQMALTP---VVVTLWYRAPEVLL----QSTYATPVDMWSVGCIFAEMFR-RKPL---------------FCGN-SEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR----PVQSVVPEMEESGAQLLLEMLTFNPHK--RIS-----AFRALQHSYL--------------
--YEKLEKIGEGTYGTVFKAKN---R-------ETHEIVALKRVRLD-D-DDE---GV--PS-SALR--EICLLKEL--K---HKNIVRLHDVLH--S------DKK------LT--LVFEFCDQ---DLKKYFD---SCNG-----------------DLDPEIVKSFLFQLLKGLGFCHS-RNVLHRDLKPQNLLIN-RNGELKLADFGLARAF----GIPVRCYSA---EVVTLWYRPPDVLF---GAKLYSTSIDMWSAGCIFAELANAGRPL---------------FPGN-DVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT--TSLVNVVPKLNATGRDLLQNLLKCNPVQ--RIS-----AEEALQHPYF--------------
-W-DLVQTLGEGAYGEVQLAVN---R-------VTEEAVAVKIVDMK-R-AVD---CP--EN-I-KK--EICINKML--N---HENVVKFYGHRR--E------GNI------QY--LFLEYCSGG--ELFDRIE----PDI-----------------GMPEPDAQRFFHQLMAGVVYLHG-IGITHRDIKPENLLLD-ERDNLKISDFGLATVFR--YNNRERLLNK---MCGTLPYVAPELLK---RREFHAEPVDVWSCGIVLTAMLA-GELP---------------WDQP---SDSCQEYSDWKEKKTYLNPWKKI--D------------------------SAPLALLHKILVENPSA--RIT-----IPDIKKDRW-Y-------------
-L-VLGKPLGEGCFGQVVLAEA---IGLDKDKPNRVTKVAVKMLK-S-D-AT----EKDLSD-LI-S--EMEMMKMIG-K---HKNIINLLGACT--Q------DGP------LY--VIVEYASKG--NLREYLQ-----ARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLAS-KKCIHRDLAARNVLVT-EDNVMKIADFGLARDI--H-H--IDYYKKTTNGRLPVKWMAPEALF----DRIYTHQSDVWSFGVLLWEIFTLGGSP---------------YPGV-PVEELFKLLKEGHRMDKPSNCT------------------------------NELYMMMRDCWHAVPSQ--RPT-----FKQLVEDL----------------
--YTDIKVIGNGSFGVVYQARL---A-------ETRELVAIKKVLQD-K-RFK---NR-----------ELQIMRKL--D---HCNIVRLRYFFY--SSG--EKKDE------LYLNLVLEYVPETVYRVARHFT---KAKL-----------------TIPILYVKVYMYQLFRSLAYIHS-QGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQ-----LVRGEPNVS---YICSRYYRAPELIF---GATDYTSSIDVWSAGCVLAELLL-GQPI---------------FPGD-SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH--PWTKVFKSRTPPEAIALCSSLLEYTPSS--RLS-----PLEACAHSFF--------------
--YTDTKVIGNGSFGVVYQAKL---C-------DSGELVAIKKVLQD-K-RFK---NR-----------ELQIMRKL--D---HCNIVRLRYFFY--SSG--EKKDE------VYLNLVLDYVPETVYRVA---RHYSRAKQ-----------------TLPVIYVKLYMYQLFRSLAYIHS-FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ-----LVRGEPNVS---YICSRYYRAPELIF---GATDYTSSIDVWSAGCVLAELLL-GQPI---------------FPGD-SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH--PWTKVFRPRTPPEAIALCSRLLEYTPTA--RLT-----PLEACAHSFF--------------
--LTFVQEIGSGQFGLVHLGYW---L--------NKDKVAIKTIR-E-G-AM----SE--ED-FI-E--EAEVMMKL--S---HPKLVQLYGVCL--E------QAP------IC--LVFEFMEHG--CLSDYLR-----TQ---------------RGLFAAETLLGMCLDVCEGMAYLEE-ACVIHRDLAARNCLVG-ENQVIKVSDFGMTRFV----L--DDQYTSSTGTKFPVKWASPEVFS----FSRYSSKSDVWSFGVLMWEVFSEGKIP---------------YENR-SNSEVVEDISTGFRLYKPRLAS------------------------------THVYQIMNHCWKERPED--RPA-----FSRLLRQL----------------
--LKFLQQLGKGNFGSVEMCRY---DP---LQDNTGEVVAVKKLQ-H-S-TE-----EHLRD-FE-R--EIEILKSL--Q---HDNIVKYKGVCYSAG------RRN------LK--LIMEYLPYG--SLRDYLQ-----KH---------------KERIDHIKLLQYTSQICKGMEYLGT-KRYIHRDLATRNILVE-NENRVKIGDFGLTKVL-PQ-D--KEYYKVKEPGESPIFWYAPESLT----ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELLKNNGRLPRPDGCP------------------------------DEIYMIMTECWNNNVNQ--RPS-----FRDLA----LRV------------
--LKLVERLGAGQFGEVWMGYY---N--------GHTKVAVKSLK-Q-G-SM----SP--DA-FL-A--EANLMKQL--Q---HQRLVRLYAVVT---------QEP------IY--IITEYMENG--SLVDFLK-----TP--------------SGIKLTINKLLDMAAQIAEGMAFIEE-RNYIHRDLRAANILVS-DTLSCKIADFGLARLI----E--DNEYTAREGAKFPIKWTAPEAIN----YGTFTIKSDVWSFGILLTEIVTHGRIP---------------YPGM-TNPEVIQNLERGYRMVRPDNCP------------------------------EELYQLMRLCWKERPED--RPT-----FDYLRSV--L--------------
--YQNLSPVGSGAYGSVCAAFD---T-------KTGLRVAVKKLSRP-F-QSI---IH--AK-RTYR--ELRLLKHM--K---HENVIGLLDVFT--PARSLEEFND------VY--LVTHLMGA---DLNNIVK-----CQ-----------------KLTDDHVQFLIYQILRGLKYIHS-ADIIHRDLKPSNLAVN-EDCELKILDFGLAR-------HTDDEMTG---YVATRWYRAPEIML---NWMHYNQTVDIWSVGCIMAELLT-GRTL---------------FPGT-DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDK--RIT-----AAQALAHAYF--------------
-F-KFGKILGEGSFSTVVLARE---L-------ATSREYAIKILEKR-H-IIK---EN--KVPYVTR--ERDVMSRL--D---HPFFVKLYFTFQ--D------DEK------LY--FGLSYAKNG--ELLKYIR----KIG-----------------SFDETCTRFYTAEIVSALEYLHG-KGIIHRDLKPENILLN-EDMHIQITDFGTAKVLS--PESKQARANS---FVGTAQYVSPELLT----EKSACKSSDLWALGCIIYQLVA-GLPP---------------FRAG----NEYLIFQKIIKLEYDFPEKFF----------------------------PKARDLVEKLLVLDATK--RLG-----CEEM------EGYGPLKAHPF---
YV--RGRFLGKGGFAKCFEISD---A-------DTKEVFAGKIVPKS-L-LLK---PH--QR-EKMS-MEISIHRSL--A---HQHVVGFHGFFE--D------NDF------VF--VVLELCRRR--SLLELHK----RRK-----------------ALTEPEARYYLRQIVLGCQYLHR-NRVIHRDLKLGNLFLN-EDLEVKIGDFGLATKV----EYDGERKKT---LCGTPNYIAPEVLS----KKGHSFEVDVWSIGCIMYTLLV-GKPP---------------FETS----CLKETYLRIKKNEYSIPKHIN----------------------------PVAASLIQKMLQTDPTA--RPT-----INELLNDEFF--------------
YL--KGRLLGKGGFARCYEATD---T-------ETGSAYAVKVIPQS-R-VAK---PH--QR-EKIL-NEIELHRDL--Q---HRHIVRFSHHFE--D------ADN------IY--IFLELCSRK--SLAHIWK----ARH-----------------TLLEPEVRYYLRQILSGLKYLHQ-RGILHRDLKLGNFFIT-ENMELKVGDFGLAARL----EPPEQRKKT---ICGTPNYVAPEVLL----RQGHGPEADVWSLGCVMYTLLC-GSPP---------------FETA----DLKETYRCIKQVHYTLPASLS----------------------------LPARQLLAAILRASPRD--RPS-----IDQILRHDFF--------------
-F-NFLMVLGKGSFGKVMLADR---K-------GTEELYAIKILKKD-V-VIQ---DD--DV-ECTM-VEKRVLALL-DK---PPFLTQLHSCFQ--T------VDR------LY--FVMEYVNGG--DLMYHIQ----QVG-----------------KFKEPQAVFYAAEISIGLFFLHK-RGIIYRDLKLDNVMLD-SEGHIKIADFGMCKEH----MMDGVTTRT---FCGTPDYIAPEIIA----YQPYGKSVDWWAYGVLLYEMLA-GQPP---------------FDGE----DEDELFQSIMEHNVSYPKSLS----------------------------KEAVSVCKGLMTKHPAK--RLG-----C---------GPEGERDVREHAFF
--YEVVKVIGRGAFGEVQLVRH---K-------STRKVYAMKLLSKF-E-MIK---RS--DS-AFFW-EERDIMAFA--N---SPWVVQLFYAFQ--D------DRY------LY--MVMEYMPGG--DLVNLMS-----NY-----------------DVPEKWARFYTAEVVLALDAIHS-MGFIHRDVKPDNMLLD-KSGHLKLADFGTCMKM---NKEGMVRCDT---AVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLV-GDTP---------------FYAD----SLVGTYSKIMNHKNSLTFPDDNDIS------------------------KEAKNLICAFLTDREVRLGRNG-----VEEIKRHLFF--------------
--YDVVKVIGRGAFGEVQLVRH---K-------ASQKVYAMKLLSKF-E-MIK---RS--DS-AFFW-EERDIMAFA--N---SPWVVQLFYAFQ--D------DRY------LY--MVMEYMPGG--DLVNLMS-----NY-----------------DVPEKWAKFYTAEVVLALDAIHS-MGLIHRDVKPDNMLLD-KHGHLKLADFGTCMKM---DETGMVHCDT---AVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLV-GDTP---------------FYAD----SLVGTYSKIMDHKNSLCFPEDAEIS------------------------KHAKNLICAFLTDREVRLGRNG-----VEEIRQHPFF--------------
--FELLKVLGTGAYGKVFLVRKISGH-------DTGKLYAMKVLKKA-T-IVQ---KA--KT-TEHTRTERQVLEHI-RQ---SPFLVTLHYAFQ--T------ETK------LH--LILDYINGG--ELFTHLS----QRE-----------------RFTEHEVQIYVGEIVLALEHLHK-LGIIYRDIKLENILLD-SNGHVVLTDFGLSKEF---VADETERAYS---FCGTIEYMAPDIVR--GGDSGHDKAVDWWSLGVLMYELLT-GASP---------------FTVDGEKNSQAEISRRILKSEPPYPQEMS----------------------------ALAKDLIQRLLMKDPKK--RLGCGPRDADEIKEHLFF--------------
-L-RLEVKLGQGCFGEVWMGTW---N--------GTTRVAIKTLK-P-G-TM----SP--EA-FL-Q--EAQVMKKL--R---HEKLVQLYAVVS---------EEP------IY--IVTEYMSKG--SLLDFLK-----GE--------------TGKYLRLPQLVDMAAQIASGMAYVER-MNYVHRDLRAANILVG-ENLVCKVADFGLARLI----E--DNEYTARQGAKFPIKWTAPEAAL----YGRFTIKSDVWSFGILLTELTTKGRVP---------------YPGM-VNREVLDQVERGYRMPCPPECP------------------------------ESLHDLMCQCWRKEPEE--RPT-----FEYLQAF--L--------------
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