Protein Surface  Ribbon
Inhibitor F18
  ATP Location
Motifs All P-loop B3 Hinge
C-loop A-loop
Select Anchor
Summary of 3 kinases in KIF 2CLXA_F18 (CDK2, PDB code: 2CLX, chain A)

Multiple sequence alignment of family kinases

Conserved residues:   
                            
Group      Kinase           
CMGC       CDK2         203 
CMGC       CDK9       2.7.11.23 
TK         JAK2         849 



FQKVEKIGEGTYGVVYKARNK----LTGEVVALKKIRLDTETEGV--PSTAIREISLLKELNHPNIVKLLDVIH--T--------ENKLYLVFEFLHQ-DLKKFMDASALT--GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF------GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--
YEKLAKIGQGTFGEVFKARHR----KTGQKVALKKVLMENEKEGF--PITALREIKILQLLKHENVVNLIEICR--TKASPYNRCKGSIYLVFDFCEH-DLAGLLS-NVLV--KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSL--AKNSQPNRYTN---RVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPI---------------MQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF--
LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQ-HSTE--EHLRDFE-REIEILKSLQHDNIVKYKGVCYSAG--------RRNLKLIMEYLPYGSLRDYLQ---KHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVL--PQ--D--KEYYKVKEPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCP-------------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV