|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
TK ABL1 261
CAMK CAMK2A 13
CAMK CAMK2B 14
Other CAMKK2 165
CAMK CASK 12
CMGC CDC2 4
CMGC CDC2L5 705
CMGC CDK11A 438
CMGC CDK15 103
CMGC CDK3 4
CMGC CDK4 6
CMGC CDK5 4
CMGC CDK7 2.7.11.23
CMGC CDK9 2.7.11.23
CMGC CDKL5 13
CMGC CLK1 161
CMGC CLK2 163
CMGC CLK3 156
CMGC CLK4 159
CAMK DCLK3 356
CMGC DYRK1A 150
CMGC DYRK1B 111
CMGC GSK3A 119
CMGC GSK3B 56
CMGC ICK 4
CMGC MAK 4
CMGC MAPK15 13
CMGC MAPK7 55
CMGC PCTK1 165
CMGC PCTK2 192
CMGC PCTK3 172
CMGC PFTK1 117
AGC PKN2 657
AGC ROCK1 76
AGC ROCK2 92
STE SLK 34
TKL TNNI3K 463
Other TTK 525
--FQKVEKIGEGTYGVVYKARNKL-T-GE-VVALKKIRLD--TETE---GV--PSTAIR-------------------------EISLLKEL-N-----HPN-----IVKLLDVIH-T----------ENKLY--LVFEFLHQ---DLK-KFMDA--SALT---GI---PLPLIKSYLFQLLQGLAFCHS--HRVLHRDLKPQNLLIN--TEGAI--------------------KLADFGLARAF------GVPVRTYTH---EVVTLWYRAPEILL----------GCKY---YSTAVDIWSLGCIFAEMVT-RRALFPGD-SEIDQLFRI-FRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-----------------------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNK--RIS-----AKAALAHPFF-
--ITMKHKLGGGQYGEVYEGVWKK-Y-SL-TVAVKTLK-E--DTM----EV--EEFL-K-------------------------EAAVMKEI-K-----HPN-----LVQLLGVCT-R----------EPPFY--IITEFMTYG--NLL-DYLR-----ECNRQEV---NAVVLLYMATQISSAMEYLEK--KNFIHRDLAARNCLVG--ENHLV--------------------KVADFGLSRLM------T--GDTYTAHAGAKFPIKWTAPESLA-----------YNK---FSIKSDVWAFGVLLWEIATYGMSPYPGI-DLSQVYELL-EKDYRMERPEGCP---------------------------------------------------------------EKVYELMRACWQWNPSD--RPS-----FAEIHQA--F-
--YQLFEELGKGAFSVVRRCVKVL-A-GQ-EYAAKIINTK--KLSA---RD--HQKLER-------------------------EARICRLL-K-----HPN-----IVRLHDSIS-E----------EGHHY--LIFDLVTGG--ELF-EDIV----ARE---YY---SEADASHCIQQILEAVLHCHQ--MGVVHRDLKPENLLLA--SKLKGA-----------------AVKLADFGLAIEV------EGEQQAWFG---FAGTPGYLSPEVLR-----------KDP---YGKPVDLWACGVILYILLV-GYPPFWDE----DQHRLY-QQIKAGAYDFPSPEWDTVT---------------------------------------------------------PEAKDLINKMLTINPSK--RIT-----AAEALKHPWI-
--YQLYEDIGKGAFSVVRRCVKLC-T-GH-EYAAKIINTK--KLSA---RD--HQKLER-------------------------EARICRLL-K-----HSN-----IVRLHDSIS-E----------EGFHY--LVFDLVTGG--ELF-EDIV----ARE---YY---SEADASHCIQQILEAVLHCHQ--MGVVHRDLKPENLLLA--SKCKGA-----------------AVKLADFGLAIEV------QGDQQAWFG---FAGTPGYLSPEVLR-----------KEA---YGKPVDIWACGVILYILLV-GYPPFWDE----DQHKLY-QQIKAGAYDFPSPEWDTVT---------------------------------------------------------PEAKNLINQMLTINPAK--RIT-----AHEALKHPWV-
--YTLKDEIGKGSYGVVKLAYNEN-D-NT-YYAMKVLSKK--KLIR---QA--GFPR-RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKL-D-----HPN-----VVKLVEVLD-DP--------NEDHLY--MVFELVNQG--PVM-EVPT-----LK---PL---SEDQARFYFQDLIKGIEYLHY--QKIIHRDIKPSNLLVG--EDGHI--------------------KIADFGVSNEF------KGSDALLSN---TVGTPAFMAPESLS----------ETRKIF-SGKALDVWAMGVTLYCFVF-GQCPFMDE----RIMCLH-SKIKSQALEFPDQPDIA-----------------------------------------------------------EDLKDLITRMLDKNPES--RIV-----VPEIKLHPWV-
--YELCEVIGKGPFSVVRRCINRE-T-GQ-QFAVKIVDVA--KFTS---SP--GLSTEDL----------------------KREASICHML-K-----HPH-----IVELLETYS-S----------DGMLY--MVFEFMDGA--DLCFEIVKR-ADAGF---VY---SEAVASHYMRQILEALRYCHD--NNIIHRDVKPHCVLLA--SKENSA-----------------PVKLGGFGVAIQL------GESGLVAGG---RVGTPHFMAPEVVK-----------REP---YGKPVDVWGCGVILFILLS-GCLPFYGT-----KERLF-EGIIKGKYKMNPRQWSHIS---------------------------------------------------------ESAKDLVRRMLMLDPAE--RIT-----VYEALNHPWL-
--YTKIEKIGEGTYGVVYKGRHKT-T-GQ-VVAMKKIRLE--SEEE---GV--PSTAIR-------------------------EISLLKEL-R-----HPN-----IVSLQDVLM-Q----------DSRLY--LIFEFLSM---DLK-KYLDS-IPPGQ---YM---DSSLVKSYLYQILQGIVFCHS--RRVLHRDLKPQNLLID--DKGTI--------------------KLADFGLARAF------GIPIRVYTH---EVVTLWYRSPEVLL----------GSAR---YSTPVDIWSIGTIFAELAT-KKPLFHGD-SEIDQLFRI-FRALGTPNNEVWPEVESLQDYKNTFPKWKP-----------------------------------GSLASHVKNLDENGLDLLSKMLIYDPAK--RIS-----GKMALNHPYF-
-F-DIIGIIGEGTYGQVYKARDKD-T-GE-MVALKKVRLD--NEKE---GF--PITAIR-------------------------EIKILRQL-T-----HQS-----IINMKEIVT-DKEDALDFKKDKGAFY--LVFEYMDH---DLM-GLLE---SGLV---HF---NENHIKSFMRQLMEGLDYCHK--KNFLHRDIKCSNILLN--NRGQI--------------------KLADFGLARLY-----SSEESRPYTN---KVITLWYRPPELLL----------GEER---YTPAIDVWSCGCILGELFT-KKPIFQAN-QELAQLELI-SRICGSPCPAVWPDVIKLPYFNTMKPKKQY----------------------------------RRKLREEFVFIPAAALDLFDYMLALDPSK--RCT-----AEQALQCEF-L
--FQCLNRIEEGTYGVVYRAKDKK-T-DE-IVALKRLKME--KEKE---GF--PITSLR-------------------------EINTILKA-Q-----HPN-----IVTVREIVV-GS--------NMDKIY--IVMNYVEH---DLK-SLME---TMKQ---PF---LPGEVKTLMIQLLRGVKHLHD--NWILHRDLKTSNLLLS--HAGIL--------------------KVGDFGLAREY------GSPLKAYTP---VVVTLWYRAPELLL----------GAKE---YSTAVDMWSVGCIFGELLT-QKPLFPGK-SEIDQINKV-FKDLGTPSEKIWPGYSELPAVKKMTFSEHPY---------------------------------NNLRKRFGALLSDQGFDLMNKFLTYFPGR--RIS-----AEDGLKHEYF-
YL--NLEKLGEGSYATVYKGISRI-N-GQ-LVALKVISMN--AEEG---VP---FTAIR-------------------------EASLLKGL-K-----HAN-----IVLLHDIIH-T----------KETLT--FVFEYMHT---DLA-QYMS---QHPG---GL---HPHNVRLFMFQLLRGLAYIHH--QHVLHRDLKPQNLLIS--HLGEL--------------------KLADFGLARAK------SIPSQTYSS---EVVTLWYRPPDALL----------GATE---YSSELDIWGAGCIFIEMFQ-GQPLFPGVSNILEQLEKI-WEVLGVPTEDTWPGVSKLPNYNPEWFPLPTP--------------------------------RSLHVVWNRLGRVPEAEDLASQMLKGFPRD--RVS-----AQEALVHDYF-
--FQKVEKIGEGTYGVVYKAKNRE-T-GQ-LVALKKIRLD--LEME---GV--PSTAIR-------------------------EISLLKEL-K-----HPN-----IVRLLDVVH-N----------ERKLY--LVFEFLSQ---DLK-KYMDS--TPGS---EL---PLHLIKSYLFQLLQGVSFCHS--HRVIHRDLKPQNLLIN--ELGAI--------------------KLADFGLARAF------GVPLRTYTH---EVVTLWYRAPEILL----------GSKF---YTTAVDIWSIGCIFAEMVT-RKALFPGD-SEIDQLFRI-FRMLGTPSEDTWPGVTQLPDYKGSFPKWTR-----------------------------------KGLEEIVPNLEPEGRDLLMQLLQYDPSQ--RIT-----AKTALAHPYF-
-Y-EPVAEIGVGAYGTVYKARDPH-S-GH-FVALKSVRVP--NGGGGGGGL--PISTVR-------------------------EVALLRRL-EA--FEHPN-----VVRLMDVCA-TSR-----TDREIKVT--LVFEHVDQ---DLR-TYLDK--APPP---GL---PAETIKDLMRQFLRGLDFLHA--NCIVHRDLKPENILVT--SGGTV--------------------KLADFGLARI-------YSYQMALTP---VVVTLWYRAPEVLL-----------QST---YATPVDMWSVGCIFAEMFR-RKPLFCGN-SEADQLGKI-FDLIGLPPEDDWPRDVSLPRGAFPPRGPR-------------------------------------PVQSVVPEMEESGAQLLLEMLTFNPHK--RIS-----AFRALQHSYL-
--YEKLEKIGEGTYGTVFKAKNRE-T-HE-IVALKRVRLD--DDDE---GV--PSSALR-------------------------EICLLKEL-K-----HKN-----IVRLHDVLH-S----------DKKLT--LVFEFCDQ---DLK-KYFD---SCNG---DL---DPEIVKSFLFQLLKGLGFCHS--RNVLHRDLKPQNLLIN--RNGEL--------------------KLADFGLARAF------GIPVRCYSA---EVVTLWYRPPDVLF----------GAKL---YSTSIDMWSAGCIFAELANAGRPLFPGN-DVDDQLKRI-FRLLGTPTEEQWPSMTKLPDYKPYPMYPAT-----------------------------------TSLVNVVPKLNATGRDLLQNLLKCNPVQ--RIS-----AEEALQHPYF-
--YEKLDFLGEGQFATVYKARDKN-T-NQ-IVAIKKIKLG--HRSE---AK--DGINRTA----------------------LREIKLLQEL-S-----HPN-----IIGLLDAFG-H----------KSNIS--LVFDFMET---DLE-VIIK---DNSL---VL---TPSHIKAYMLMTLQGLEYLHQ--HWILHRDLKPNNLLLD--ENGVL--------------------KLADFGLAKSF------GSPNRAYTH---QVVTRWYRAPELLF----------GARM---YGVGVDMWAVGCILAELLL-RVPFLPGD-SDLDQLTRI-FETLGTPTEEQWPDMCSLPDYVTFKSFPG------------------------------------IPLHHIFSAAGDDLLDLIQGLFLFNPCA--RIT-----ATQALKMKYF-
--YEKLAKIGQGTFGEVFKARHRK-T-GQ-KVALKKVLME--NEKE---GF--PITALR-------------------------EIKILQLL-K-----HEN-----VVNLIEICR-TKASP--YNRCKGSIY--LVFDFCEH---DLA-GLLS---NVLV---KF---TLSEIKRVMQMLLNGLYYIHR--NKILHRDMKAANVLIT--RDGVL--------------------KLADFGLARAFSL--AKNSQPNRYTN---RVVTLWYRPPELLL----------GERD---YGPPIDLWGAGCIMAEMWT-RSPIMQGN-TEQHQLALI-SQLCGSITPEVWPNVDNYELYEKLELVKGQK--------------------------------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQ--RID-----SDDALNHDFF-
--FEILGVVGEGAYGVVLKCRHKE-T-HE-IVAIKKFKDS--EENE---EV--KETTLR-------------------------ELKMLRTL-K-----QEN-----IVELKEAFR-R----------RGKLY--LVFEYVEK---NML-ELLE---EMPN---GV---PPEKVKSYIYQLIKAIHWCHK--NDIVHRDIKPENLLIS--HNDVL--------------------KLCDFGFARNL-----SEGNNANYTE---YVATRWYRSPELLL-----------GAP---YGKSVDMWSVGCILGELSD-GQPLFPGE-SEIDQLFTI-QKVLGPLPSEQMKLFYSNPRFHGLRFPAVNH--------------------------------PQSLERRYLGILNSVLLDLMKNLLKLDPAD--RYL-----TEQCLNHPTF-
--YEIVDTLGEGAFGKVVECIDHK-AGGR-HVAVKIVKNV--DRYC---EA--ARS----------------------------EIQVLEHL-NT---TDPNST-FRCVQMLEWFE-H----------HGHIC--IVFELLGL---STY-DFIK----ENG---FLP-FRLDHIRKMAYQICKSVNFLHS--NKLTHTDLKPENILFV--QSDYTEAYNPKIKR-DERTLINPDIKVVDFGSA---------TYDDEHHST---LVSTRHYRAPEVIL-----------ALG---WSQPCDVWSIGCILIEYYL-GFTVFPTH-DSKEHLAMM-ERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRY--------------------VSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAK--RIT-----LREALKHPFF-
--YEIVSTLGEGTFGRVVQCVDHR-R-GGARVALKIIKNV--EKYK---EA--AR---L-------------------------EINVLEKI-NEKDPDNKN----LCVQMFDWFD-Y----------HGHMC--ISFELLGL---STF-DFLK----DNN---YLP-YPIHQVRHMAFQLCQAVKFLHD--NKLTHTDLKPENILFV--NSDYELTYNLEKKR-DERSVKSTAVRVVDFGSAT---------FDHEHHST---IVSTRHYRAPEVIL-----------ELG---WSQPCDVWSIGCIIFEYYV-GFTLFQTH-DNREHLAMM-ERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRY--------------------VRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAK--RLT-----LGEALQHPFF-
--YEIVGNLGEGTFGKVVECLDHA-R-GKSQVALKIIRNV--GKYR---EA--AR---L-------------------------EINVLKKI-KE--KDKENK--FLCVLMSDWFN-F----------HGHMC--IAFELLGK---NTF-EFLK-----EN---NFQPYPLPHVRHMAYQLCHALRFLHE--NQLTHTDLKPENILFV--NSE-FETLYNEHKSCEEKSVKNTSIRVADFGSAT---------FDHEHHTT---IVATRHYRPPEVIL-----------ELG---WAQPCDVWSIGCILFEYYR-GFTLFQTH-ENREHLVMM-EKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRY--------------------VKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQ--RIT-----LAEALLHPFF-
--YEIVDTLGEGAFGKVVECIDHGMD-GM-HVAVKIVKNV--GRYR---EA--ARS----------------------------EIQVLEHL-NS---TDPNSV-FRCVQMLEWFD-H----------HGHVC--IVFELLGL---STY-DFIK----ENS---FLP-FQIDHIRQMAYQICQSINFLHH--NKLTHTDLKPENILFV--KSDYVVKYNSKMKR-DERTLKNTDIKVVDFGSA---------TYDDEHHST---LVSTRHYRAPEVIL-----------ALG---WSQPCDVWSIGCILIEYYL-GFTVFQTH-DSKEHLAMM-ERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRY--------------------VRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQ--RIT-----LDEALQHPFF-
--YETGRVIGDGNFAVVKECRHRE-T-RQ-AYAMKIIDKS--RLKG---KE--DMV-DS-------------------------EILIIQSL-S-----HPN-----IVKLHEVYE-T----------DMEIY--LILEYVQGG--DLF-DAII----ESV---KF---PEPDAALMIMDLCKALVHMHD--KSIVHRDLKPENLLVQ--RNEDKST----------------TLKLADFGLAK---------HVVRPIFT---VCGTPTYVAPEILS-----------EKG---YGLEVDMWAAGVILYILLC-GFPPFRSP--ERDQDELF-NIIQLGHFEFLPPYWDNIS---------------------------------------------------------DAAKDLVSRLLVVDPKK--RYT-----AHQVLQHPWI-
--YEIDSLIGKGSFGQVVKAYDRV-E-QE-WVAIKIIKNK--KAFL---NQ--AQI----------------------------EVRLLELMNK-----HDTEMKYYIVHLKRHFM-F----------RNHLC--LVFEMLSY---NLY-DLLR-----NT---NFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAI--------------------KIVDFGSSCQ---------LGQRIYQ---YIQSRFYRSPEVLL-----------GMP---YDLAIDMWSLGCILVEMHT-GEPLFSGA-NEVDQMNKI-VEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKT--RIQ-----PYYALQHSFF-
--YEIDSLIGKGSFGQVVKAYDHQ-T-QE-LVAIKIIKNK--KAFL---NQ--AQI----------------------------ELRLLELMNQ-----HDTEMKYYIVHLKRHFM-F----------RNHLC--LVFELLSY---NLY-DLLR-----NT---HFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAI--------------------KIVDFGSSCQ---------LGQRIYQ---YIQSRFYRSPEVLL-----------GTP---YDLAIDMWSLGCILVEMHT-GEPLFSGS-NEVDQMNRI-VEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAA--RIS-----PLGALQHGFF-
--YTDIKVIGNGSFGVVYQARLAE-T-RE-LVAIKKVLQD--KRFK---NR---------------------------------ELQIMRKL-D-----HCN-----IVRLRYFFY-SSG------EKKDELYLNLVLEYVPETVYRVA-RHFT---KAKL---TI---PILYVKVYMYQLFRSLAYIHS--QGVCHRDIKPQNLLVD-PDTAVL--------------------KLCDFGSAKQ-------LVRGEPNVS---YICSRYYRAPELIF----------GATD---YTSSIDVWSAGCVLAELLL-GQPIFPGD-SGVDQLVEI-IKVLGTPTREQIREMNPNYTEFKFPQIKAH-----------------------------------PWTKVFKSRTPPEAIALCSSLLEYTPSS--RLS-----PLEACAHSFF-
--YTDTKVIGNGSFGVVYQAKLCD-S-GE-LVAIKKVLQD--KRFK---NR---------------------------------ELQIMRKL-D-----HCN-----IVRLRYFFY-SSG------EKKDEVYLNLVLDYVPETVYRVA----RHYSRAKQ---TL---PVIYVKLYMYQLFRSLAYIHS--FGICHRDIKPQNLLLD-PDTAVL--------------------KLCDFGSAKQ-------LVRGEPNVS---YICSRYYRAPELIF----------GATD---YTSSIDVWSAGCVLAELLL-GQPIFPGD-SGVDQLVEI-IKVLGTPTREQIREMNPNYTEFKFPQIKAH-----------------------------------PWTKVFRPRTPPEAIALCSRLLEYTPTA--RLT-----PLEACAHSFF-
--YTTIRQLGDGTYGSVLLGRSIE-S-GE-LIAIKKMKRK--FYSW---EE--C-MNLR-------------------------EVKSLKKL-N-----HAN-----VVKLKEVIR-E----------NDHLY--FIFEYMKE---NLY-QLIK---ERNK---LF---PESAIRNIMYQILQGLAFIHK--HGFFHRDLKPENLLCM--GPELV--------------------KIADFGLARE-------IRSKPPYTD---YVSTRWYRAPEVLL----------RSTN---YSSPIDVWAVGCIMAEVYT-LRPLFPGA-SEIDTIFKI-CQVLGTPKKTDWPEGYQLSSAMNFRWPQCV----------------------------------PNNLKTLIPNASSEAVQLLRDMLQWDPKK--RPT-----ASQALRYPYF-
--YTTMRQLGDGTYGSVLMGKSNE-S-GE-LVAIKRMKRK--FYSW---DE--CM-NLR-------------------------EVKSLKKL-N-----HAN-----VIKLKEVIR-E----------NDHLY--FIFEYMKE---NLY-QLMK---DRNK---LF---PESVIRNIMYQILQGLAFIHK--HGFFHRDMKPENLLCM--GPELV--------------------KIADFGLARE-------LRSQPPYTD---YVSTRWYRAPEVLL----------RSSV---YSSPIDVWAVGSIMAELYM-LRPLFPGT-SEVDEIFKI-CQVLGTPKKSDWPEGYQLASSMNFRFPQCV----------------------------------PINLKTLIPNASNEAIQLMTEMLNWDPKK--RPT-----ASQALKHPYF-
YL--LRRQLGQGAYGIVWKAVDRR-T-GE-VVAIKKIFDA--FRDK---TD--AQRTFR-------------------------EITLLQEFGD-----HPN-----IISLLDVIR-AE--------NDRDIY--LVFEFMDT---DLN-AVIR----KGG---LL---QDVHVRSIFYQLLRATRFLHS--GHVVHRDQKPSNVLLD--ANCTV--------------------KLCDFGLARSLGD-LPEGPEDQAVTE---YVATRWYRAPEVLL----------SSHR---YTLGVDMWSLGCILGEMLR-GRPLFPGT-STLHQLELI-LETIPPPSEEDLLALGSGCRASVLHQLGSRP--------------------------------RQTLDALLPPDTSPEALDLLRRLLVFAPDK--RLS-----ATQALQHPYV-
--YEIIETIGNGAYGVVSSARRRL-T-GQ-QVAIKKIPNA--FDVV---TN--AKRTLR-------------------------ELKILKHF-K-----HDN-----IIAIKDILR-PTVP----YGEFKSVY--VVLDLMES---DLH-QIIH----SSQ---PL---TLEHVRYFLYQLLRGLKYMHS--AQVIHRDLKPSNLLVN--ENCEL--------------------KIGDFGMARGLCT--SPAEHQYFMTE---YVATRWYRAPELML----------SLHE---YTQAIDLWSVGCIFGEMLA-RRQLFPGK-NYVHQLQLI-MMVLGTPSPAVIQAVGAERVRAYIQSLPPRQ---------------------------------PVPWETVYPGADRQALSLLGRMLRFEPSA--RIS-----AAAALRHPFL-
-Y-IKLDKLGEGTYATVYKGKSKL-T-DN-LVALKEIRLE--HEEG---AP--C-TAIR-------------------------EVSLLKDL-K-----HAN-----IVTLHDIIH-T----------EKSLT--LVFEYLDK---DLK-QYLD---DCGN---II---NMHNVKLFLFQLLRGLAYCHR--QKVLHRDLKPQNLLIN--ERGEL--------------------KLADFGLARAK------SIPTKTYSN---EVVTLWYRPPDILL----------GSTD---YSTQIDMWGVGCIFYEMAT-GRPLFPGS-TVEEQLHFI-FRILGTPTEETWPGILSNEEFKTYNYPKYR----------------------------------AEALLSHAPRLDSDGADLLTKLLQFEGRN--RIS-----AEDAMKHPFF-
-Y-IKLEKLGEGTYATVYKGRSKL-T-EN-LVALKEIRLE--HEEG---AP--C-TAIR-------------------------EVSLLKDL-K-----HAN-----IVTLHDIVH-T----------DKSLT--LVFEYLDK---DLK-QYMD---DCGN---IM---SMHNVKLFLYQILRGLAYCHR--RKVLHRDLKPQNLLIN--EKGEL--------------------KLADFGLARAK------SVPTKTYSN---EVVTLWYRPPDVLL----------GSSE---YSTQIDMWGVGCIFFEMAS-GRPLFPGS-TVEDELHLI-FRLLGTPSQETWPGISSNEEFKNYNFPKYK----------------------------------PQPLINHAPRLDSEGIELITKFLQYESKK--RVS-----AEEAMKHVYF-
--YVKLDKLGEGTYATVFKGRSKL-T-EN-LVALKEIRLE--HEEG---AP--C-TAIR-------------------------EVSLLKNL-K-----HAN-----IVTLHDLIH-T----------DRSLT--LVFEYLDS---DLK-QYLD----HCG---NL--MSMHNVKIFMFQLLRGLAYCHH--RKILHRDLKPQNLLIN--ERGEL--------------------KLADFGLARAK------SVPTKTYSN---EVVTLWYRPPDVLL----------GSTE---YSTPIDMWGVGCIHYEMAT-GRPLFPGS-TVKEELHLI-FRLLGTPTEETWPGVTAFSEFRTYSFPCYL----------------------------------PQPLINHAPRLDTDGIHLLSSLLLYESKS--RMS-----AEAALSHSYF-
--YEKLEKLGEGSYATVYKGKSKV-N-GK-LVALKVIRLQ--EEEG---TP--F-TAIR-------------------------EASLLKGL-K-----HAN-----IVLLHDIIH-T----------KETLT--LVFEYVHT---DLC-QYMD---KHPG---GL---HPDNVKLFLFQLLRGLSYIHQ--RYILHRDLKPQNLLIS--DTGEL--------------------KLADFGLARAK------SVPSHTYSN---EVVTLWYRPPDVLL----------GSTE---YSTCLDMWGVGCIFVEMIQ-GVAAFPGMKDIQDQLERI-FLVLGTPNEDTWPGVHSLPHFKPERFTLYSS--------------------------------KNLRQAWNKLSYVNHAEDLASKLLQCSPKN--RLS-----AQAALSHEYF-
FR--CCAVLGRGHFGKVLLAEYKN-T-NE-MFAIKALKKG--DIVA---RD--EVDSLM------------------------CEKRIFETV-NS--VRHPF-----LVNLFACFQ-T----------KEHVC--FVMEYAAGG--DLM-MHIH-----TD---VF---SEPRAVFYAACVVLGLQYLHE--HKIVYRDLKLDNLLLD--TEGFV--------------------KIADFGLCKEG------MGYGDRTST---FCGTPEFLAPEVLT-----------ETS---YTRAVDWWGLGVLIYEMLV-GESPFPGD----DEEEVF-DSIVNDEVRYPRFLS-------------------------------------------------------------TEAISIMRRLLRRNPER--RLGASEKDAEDVKKHPFF-
--YEVVKVIGRGAFGEVQLVRHKS-T-RK-VYAMKLLSKF--EMIK---RS--DSAFFW------------------------EERDIMAFA-N-----SPW-----VVQLFYAFQ-D----------DRYLY--MVMEYMPGG--DLV-NLMS-----NY---DV---PEKWARFYTAEVVLALDAIHS--MGFIHRDVKPDNMLLD--KSGHL--------------------KLADFGTCMKM-----NKEGMVRCDT---AVGTPDYISPEVLKS-------QGGDGY---YGRECDWWSVGVFLYEMLV-GDTPFYAD----SLVGTY-SKIMNHKNSLTFPDDNDIS---------------------------------------------------------KEAKNLICAFLTDREVRLGRNG-----VEEIKRHLFF-
--YDVVKVIGRGAFGEVQLVRHKA-S-QK-VYAMKLLSKF--EMIK---RS--DSAFFW------------------------EERDIMAFA-N-----SPW-----VVQLFYAFQ-D----------DRYLY--MVMEYMPGG--DLV-NLMS-----NY---DV---PEKWAKFYTAEVVLALDAIHS--MGLIHRDVKPDNMLLD--KHGHL--------------------KLADFGTCMKM-----DETGMVHCDT---AVGTPDYISPEVLKS-------QGGDGF---YGRECDWWSVGVFLYEMLV-GDTPFYAD----SLVGTY-SKIMDHKNSLCFPEDAEIS---------------------------------------------------------KHAKNLICAFLTDREVRLGRNG-----VEEIRQHPFF-
--WEIIGELGDGAFGKVYKAQNKE-T-SV-LAAAKVIDTK--SEEE---LE--DYM--V-------------------------EIDILASC-D-----HPN-----IVKLLDAFY-Y----------ENNLW--ILIEFCAGG--AVD-AVML---ELER---PL---TESQIQVVCKQTLDALNYLHD--NKIIHRDLKAGNILFT--LDGDI--------------------KLADFGVSAKN------TRTIQRRDS---FIGTPYWMAPEVVMCE------TSKDRP---YDYKADVWSLGITLIEMAE-IEPPHHEL-NPMRVLLKI-AKSEPPTLAQPSRWS-------------------------------------------------------------SNFKDFLKKCLEKNVDA--RWT-----TSQLLQHPFV-
--IEFHEIIGSGSFGKVYKGRCR----NK-IVAIKRYR-ANTYCS----KSDVDMFC-R-------------------------EVSILCQL-N-----HPC-----VIQFVGACLND----------PSQFA--IVTQYISGG--SLF-SLLH-----EQ-KRIL---DLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLY--EDGHA--------------------VVADFGESRFL--Q---S--LD-EDNMTKQPGNLRWMAPEVFT-----------QCT--RYTIKADVFSYALCLWEILT-GEIPFAHL-KPAAAAADMAYHHIRPPIGYSIP---------------------------------------------------------------KPISSLLIRGWNACPEG--RPE-----FSEVVMKL---
--YSILKQIGSGGSSKVFQVLNEK-K-Q--IYAIKYVNLE--EADN---QT--LDSYRN-------------------------EIAYLNKLQQ----HSDK-----IIRLYDYEI-T----------DQYIY--MVMECGNI---DLN-SWLK----KKK---SI---DPWERKSYWKNMLEAVHTIHQ--HGIVHSDLKPANFLIV---DGML--------------------KLIDFGIANQMQ----PDTTSVVKDS---QVGTVNYMPPEAIKDMSSSRENGKSKSK---ISPKSDVWSLGCILYYMTY-GKTPFQQI---INQISKL-HAIIDPNHEIEFPDIPE-----------------------------------------------------------KDLQDVLKCCLKRDPKQ--RIS-----IPELLAHPYV-
|