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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
TK ABL1 261
AGC AKT1 150
Other AURKA 133
Other AURKB 77
CMGC CDC2 4
CMGC CDC2L6 20
CMGC CDK4 6
CMGC CDK8 2.7.11.23
CAMK CHEK1 9
Other CHUK 15
CMGC CLK4 159
TK DDR1 572
Other EIF2AK2 267
CMGC GSK3A 119
CMGC GSK3B 56
TK JAK2 849
TK JAK3 822
TK LCK 245
CMGC MAPK10 64
CMGC MAPK14 24
TK MET 1078
Other PLK1 53
TK PTK2 422
TK PTK6 191
AGC ROCK2 92
TK SRC 270
TK YES1 277
---FQKVEKIGEGTYGVVYKARNK----------------L-TGE--VVALKKIRLDT-ETE---GV--PSTAIR-EISLLKELN---HPN----IVKLLDVIH--T-----------------------------ENKLY--LVFEFLHQ---DLKKFMDA-------SALT--------------------GI--PLPLIKSYLFQLLQGLAFCHS-HRVLHRDLKPQNLLIN----TEGAI-------------------KLADFGLARAF-----GVPVRTY--TH---EVVTLWYRAPEILL---GCKYYSTAVDIWSLGCIFAEMVT-RR--AL---------------FPGD-----------SEIDQLFRI----FRTLG---TPDEVVWPGVTSMPDYKPSFPKWAR---------------QDFSKVVPPLDEDGRSLLSQMLHYDPNK--RIS-----AKAALAHPFF---------
---ITMKHKLGGGQYGEVYEGVWK----------------K-YSL--TVAVKTLK-ED-TM----EV--EEFL-K-EAAVMKEIK---HPN----LVQLLGVCT--R-----------------------------EPPFY--IITEFMTYG--NLLDYLR----------EC-----------------NRQEV--NAVVLLYMATQISSAMEYLEK-KNFIHRDLAARNCLVG----ENHLV-------------------KVADFGLSRLM-----T--GDTY--TAHAGAKFPIKWTAPESLA----YNKFSIKSDVWAFGVLLWEIATYGM--SP---------------YPGI-----------DLSQVYELL----EKDYR---MERPEGCP-------------------------------------------EKVYELMRACWQWNPSD--RPS-----FAEIHQA--F---------
--F-EYLKLLGKGTFGKVILVKEK----------------A-TGR--YYAMKILKKEV-IVA---KD--EVAHTLTENRVLQNSR---HPF----LTALKYSFQ--T-----------------------------HDRLC--FVMEYANGG--ELFFHLS---------RER--------------------VF--SEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD----KDGHI-------------------KITDFGLCKEG-----IKDGATM--KT---FCGTPEYLAPEVLE----DNDYGRAVDWWGLGVVMYEMMC-GR--LP---------------FYNQ--------------DHEKLF----ELILM---EEIRFPRTLG-----------------------------------------PEAKSLLSGLLKKDPKQ--RLGGGSEDAKEIMQHRFF---------
---FEIGRPLGKGKFGNVYLAREK----------------Q-SKF--ILALKVLFKAQLEKA---GV--EHQLRR-EVEIQSHLR---HPN----ILRLYGYFH--D-----------------------------ATRVY--LILEYAPLG--TVYRELQ---------KLS--------------------KF--DEQRTATYITELANALSYCHS-KRVIHRDIKPENLLLG----SAGEL-------------------KIADFGWSV-------HAPSSRR--TT---LCGTLDYLPPEMIE----GRMHDEKVDLWSLGVLCYEFLV-GK--PP---------------FEAN--------------TYQETY----KRISR---VEFTFPDFVT-----------------------------------------EGARDLISRLLKHNPSQ--RPM-----LREVLEHPWI---------
---FEIGRPLGKGKFGNVYLAREK----------------K-SHF--IVALKVLFKSQ-IEK---EG--VEHQLRREIEIQAHLH---HPN----ILRLYNYFY--D-----------------------------RRRIY--LILEYAPRG--ELYKELQ---------KSC--------------------TF--DEQRTATIMEELADALMYCHG-KKVIHRDIKPENLLLG----LKGEL-------------------KIADFGWSV-------HAPSLRR--KT---MCGTLDYLPPEMIE----GRMHNEKVDLWCIGVLCYELLV-GN--PP---------------FESA--------------SHNETY----RRIVK---VDLKFPASVP-----------------------------------------MGAQDLISKLLRHNPSE--RLP-----LAQVSAHPWV---------
---YTKIEKIGEGTYGVVYKGRHK----------------T-TGQ--VVAMKKIRLES-EEE---GV--PSTAIR-EISLLKELR---HPN----IVSLQDVLM--Q-----------------------------DSRLY--LIFEFLSM---DLKKYLDS------IPPGQ--------------------YM--DSSLVKSYLYQILQGIVFCHS-RRVLHRDLKPQNLLID----DKGTI-------------------KLADFGLARAF-----GIPIRVY--TH---EVVTLWYRSPEVLL---GSARYSTPVDIWSIGTIFAELAT-KK--PL---------------FHGD-----------SEIDQLFRI----FRALG---TPNNEVWPEVESLQDYKNTFPKWKP---------------GSLASHVKNLDENGLDLLSKMLIYDPAK--RIS-----GKMALNHPYF---------
EGC-----KVGRGTYGHVYKARRK----------------D-GKDEKEYALKQIEGTG-ISM---SA--C----R-EIALLRELK---HPN----VIALQKVFL--SH---------------------------SDRKVW--LLFDYAEH---DLWHIIKFHR--ASKANKK--------------------PMQLPRSMVKSLLYQILDGIHYLHA-NWVLHRDLKPANILVMGEGPERGRV-------------------KIADMGFARLFN--SPLKPLADL--DP---VVVTFWYRAPELLL---GARHYTKAIDIWAIGCIFAELLT-SE--PI---------------FHCRQEDI--KTSNPFHHDQLDRI----FSVMG---FPADKDWEDIRKMPEYPTLQKDFRRTTYA------NSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTK--RIT-----SEQALQDPYF---------
--Y-EPVAEIGVGAYGTVYKARDP----------------H-SGH--FVALKSVRVPN-GGGGGGGL--PISTVR-EVALLRRLEAFEHPN----VVRLMDVCA--TSR------------------------TDREIKVT--LVFEHVDQ---DLRTYLDK-------APPP--------------------GL--PAETIKDLMRQFLRGLDFLHA-NCIVHRDLKPENILVT----SGGTV-------------------KLADFGLARI------YSYQMAL--TP---VVVTLWYRAPEVLL----QSTYATPVDMWSVGCIFAEMFR-RK--PL---------------FCGN-----------SEADQLGKI----FDLIG---LPPEDDWPRDVSLPRGAFPPRGPR-----------------PVQSVVPEMEESGAQLLLEMLTFNPHK--RIS-----AFRALQHSYL---------
EGC-----KVGRGTYGHVYKAKRK----------------D-GKDDKDYALKQIEGTG-ISM---SA--C----R-EIALLRELK---HPN----VISLQKVFL--SH---------------------------ADRKVW--LLFDYAEH---DLWHIIKFHRASKANKKPV--------------------QL--PRGMVKSLLYQILDGIHYLHA-NWVLHRDLKPANILVMGEGPERGRV-------------------KIADMGFARLFN--SPLKPLADL--DP---VVVTFWYRAPELLL---GARHYTKAIDIWAIGCIFAELLT-SE--PI---------------FHCRQEDI--KTSNPYHHDQLDRI----FNVMG---FPADKDWEDIKKMPEHSTLMKDFRRNTYT------NCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIK--RIT-----SEQAMQDPYF---------
--W-DLVQTLGEGAYGEVQLAVNR----------------V-TEE--AVAVKIVDMKR-AVD---CP--ENI-KK-EICINKMLN---HEN----VVKFYGHRR--E-----------------------------GNIQY--LFLEYCSGG--ELFDRIE---------PDI--------------------GM--PEPDAQRFFHQLMAGVVYLHG-IGITHRDIKPENLLLD----ERDNL-------------------KISDFGLATVFR---YNNRERLL--NK---MCGTLPYVAPELLK---RREFHAEPVDVWSCGIVLTAMLA-GE--LP---------------WDQP-------------SDSCQEY----SDWKE---KKTYLNPWKKI--D-------------------------------------SAPLALLHKILVENPSA--RIT-----IPDIKKDRW-Y--------
--W-EMRERLGTGGFGNVCLYQHR----------------E-LDL--KIAIKSCRLEL-STK---NR--ER-WCH-EIQIMKKLN---HAN----VVKACDVPE--ELN------------------------ILIHDVPL--LAMEYCSGG--DLRKLLNK------PENCC--------------------GL--KESQILSLLSDIGSGIRYLHE-NKIIHRDLKPENIVLQ----DVGGKI----------------IHKIIDLGYAKD------VDQGSLC--TS---FVGTLQYLAPELFE----NKPYTATVDYWSFGTMVFECIA-GY--RP---------------FLHHLQPFTWHEKIKKKDPKCIFA----CEEMS---GEVRFSSHLPQPNSLCS-------------------------------LVVEPMENWLQLMLNWDPQQ--RG----------------GPVDLTLKQ
---YEIVDTLGEGAFGKVVECIDH----------------GMDGM--HVAVKIVKNVG-RYR---EA--ARS----EIQVLEHLNS-TDPNSVFRCVQMLEWFD--H-----------------------------HGHVC--IVFELLGL---STYDFIK---------ENS--------------------FLPFQIDHIRQMAYQICQSINFLHH-NKLTHTDLKPENILFV----KSDYVVKYNSKMKRDERTLKNTDIKVVDFGSA--------TYDDEHH--ST---LVSTRHYRAPEVIL----ALGWSQPCDVWSIGCILIEYYL-GF--TV---------------FQTH-----------DSKEHLAMM----ERILG---PIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQ--RIT-----LDEALQHPFF---------
---LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKG-HPL--LVAVKILR-PD-AT----KNARNDFL-K-EVKIMSRLK---DPN----IIRLLGVCV--Q-----------------------------DDPLC--MITDYMENG--DLNQFLS----------AHQLEDKAAEGAPGDGQAAQGPTI--SYPMLLHVAAQIASGMRYLAT-LNFVHRDLATRNCLVG----ENFTI-------------------KIADFGMSRNL--Y--A--GDYY--RVQGRAVLPIRWMAWECIL----MGKFTTASDVWAFGVTLWEVLMLCRA-QP---------------FGQL-----------TDEQVIENAGEFFRDQGRQVYLSRPPACP-------------------------------------------QGLYELMLRCWSRESEQ--RPP-----FSQLHRFL-----------
--F-KEIELIGSGGFGQVFKAKHR----------------I-DGK--TYVIKRVKYNN-EKA---ER---------EVKALAKLD---HVN----IVHYNGCWD--GFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLF--IQMEFCDKG--TLEQWIEK-------RRGE--------------------KL--DKVLALELFEQITKGVDYIHS-KKLIHRDLKPSNIFLV----DTKQV-------------------KIGDFGLVTS------LKNDGKR--TR---SKGTLRYMSPEQIS----SQDYGKEVDLYALGLILAELLH-VC-DTA---------------FET------------------SKF----FTDLR---DGIISDIFDK------------------------------------------KEKTLLQKLLSKKPED--RPN-----TSEILR----TLT------
---YTDIKVIGNGSFGVVYQARLA----------------E-TRE--LVAIKKVLQDK-RFK---NR---------ELQIMRKLD---HCN----IVRLRYFFY--SSG-------------------------EKKDELYLNLVLEYVPETVYRVARHFT--------KAKL--------------------TI--PILYVKVYMYQLFRSLAYIHS-QGVCHRDIKPQNLLVD---PDTAVL-------------------KLCDFGSAKQ------LVRGEPN--VS---YICSRYYRAPELIF---GATDYTSSIDVWSAGCVLAELLL-GQ--PI---------------FPGD-----------SGVDQLVEI----IKVLG---TPTREQIREMNPNYTEFKFPQIKAH---------------PWTKVFKSRTPPEAIALCSSLLEYTPSS--RLS-----PLEACAHSFF---------
---YTDTKVIGNGSFGVVYQAKLC----------------D-SGE--LVAIKKVLQDK-RFK---NR---------ELQIMRKLD---HCN----IVRLRYFFY--SSG-------------------------EKKDEVYLNLVLDYVPETVYRVA---RHY-----SRAKQ--------------------TL--PVIYVKLYMYQLFRSLAYIHS-FGICHRDIKPQNLLLD---PDTAVL-------------------KLCDFGSAKQ------LVRGEPN--VS---YICSRYYRAPELIF---GATDYTSSIDVWSAGCVLAELLL-GQ--PI---------------FPGD-----------SGVDQLVEI----IKVLG---TPTREQIREMNPNYTEFKFPQIKAH---------------PWTKVFRPRTPPEAIALCSRLLEYTPTA--RLT-----PLEACAHSFF---------
---LKFLQQLGKGNFGSVEMCRYDP------------LQDN-TGE--VVAVKKLQ-HS-TE-----EHLRDFE-R-EIEILKSLQ---HDN----IVKYKGVCYSAG-----------------------------RRNLK--LIMEYLPYG--SLRDYLQ----------KH------------------KERI--DHIKLLQYTSQICKGMEYLGT-KRYIHRDLATRNILVE----NENRV-------------------KIGDFGLTKVL-PQ--D--KEYY--KVKEPGESPIFWYAPESLT----ESKFSVASDVWSFGVVLYELFTYIE--KSKSPPAEFMRMIGNDKQGQM-----------IVFHLIELL----KNNGR---LPRPDGCP-------------------------------------------DEIYMIMTECWNNNVNQ--RPS-----FRDLA----LRV-------
--L-KYISQLGKGNFGSVELCRYDP------------LGDN-TGA--LVAVKQLQ-HS-GP----DQ-QRDFQ-R-EIQILKALH---SDF----IVKYRGVSYGPG-----------------------------RQSLR--LVMEYLPSG--CLRDFLQ----------RH------------------RARL--DASRLLLYSSQICKGMEYLGS-RRCVHRDLAARNILVE----SEAHV-------------------KIADFGLAKLL-PL--D--KDYY--VVREPGQSPIFWYAPESLS----DNIFSRQSDVWSFGVVLYELFTYCD--KSCSPSAE--FLRMMGCERDV-P---------ALCRLLELL----EEGQR---LPAPPACP-------------------------------------------AEVHELMKLCWAPSPQD--RPS-----FSALGP---QL--------
---LKLVERLGAGQFGEVWMGYYN------------------GHT--KVAVKSLK-QG-SM----SP--DAFL-A-EANLMKQLQ---HQR----LVRLYAVVT--------------------------------QEPIY--IITEYMENG--SLVDFLK----------TP-----------------SGIKL--TINKLLDMAAQIAEGMAFIEE-RNYIHRDLRAANILVS----DTLSC-------------------KIADFGLARLI-----E--DNEY--TAREGAKFPIKWTAPEAIN----YGTFTIKSDVWSFGILLTEIVTHGR--IP---------------YPGM-----------TNPEVIQNL----ERGYR---MVRPDNCP-------------------------------------------EELYQLMRLCWKERPED--RPT-----FDYLRSV--L---------
---YQNLKPIGSGAQGIVCAAYDA----------------V-LDR--NVAIKKLSRPF-QNQ---TH--AKRAYR-ELVLMKCVN---HKN----IISLLNVFT--PQKT-----------------------LEEFQDVY--LVMELMDA---NLCQVIQ-----------M--------------------EL--DHERMSYLLYQMLCGIKHLHS-AGIIHRDLKPSNIVVK----SDCTL-------------------KILDFGLART------AGTSFMM--TP---YVVTRYYRAPEVIL----GMGYKENVDIWSVGCIMGEMVR-HK--IL---------------FPGR-----------DYIDQWNKV----IEQLG---TPCPEFMKKLQPTVRNYVENRPKYAGLTFPK--LFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAK--RIS-----VDDALQHPYI---------
---YQNLSPVGSGAYGSVCAAFDT----------------K-TGL--RVAVKKLSRPF-QSI---IH--AKRTYR-ELRLLKHMK---HEN----VIGLLDVFT--PARS-----------------------LEEFNDVY--LVTHLMGA---DLNNIVK----------CQ--------------------KL--TDDHVQFLIYQILRGLKYIHS-ADIIHRDLKPSNLAVN----EDCEL-------------------KILDFGLAR--------HTDDEM--TG---YVATRWYRAPEIML---NWMHYNQTVDIWSVGCIMAELLT-GR--TL---------------FPGT-----------DHIDQLKLI----LRLVG---TPGAELLKKISSESARNYIQSLTQMP-------------KMNFANVFIGANPLAVDLLEKMLVLDSDK--RIT-----AAQALAHAYF---------
---VHFNEVIGRGHFGCVYHGTLL-------------DNDG-KKI--HCAVKSLN-RI-TD----IGEVSQFL-T-EGIIMKDFS---HPN----VLSLLGICL-RS-----------------------------EGSPL--VVLPYMKHG--DLRNFIR----------NE------------------THNP--TVKDLIGFGLQVAKGMKYLAS-KKFVHRDLAARNCMLD----EKFTV-------------------KVADFGLARDM--Y--D--KEYYSVHNKTGAKLPVKWMALESLQ----TQKFTTKSDVWSFGVLLWELMTRGA--PP---------------YPDV-----------NTFDITVYL----LQGRR---LLQPEYCP-------------------------------------------DPLYEVMLKCWHPKAEM--RPS-----FSELVSR--I---------
-YV--RGRFLGKGGFAKCFEISDA----------------D-TKE--VFAGKIVPKSL-LLK---PH--QREKMSMEISIHRSLA---HQH----VVGFHGFFE--D-----------------------------NDFVF--VVLELCRRR--SLLELHK---------RRK--------------------AL--TEPEARYYLRQIVLGCQYLHR-NRVIHRDLKLGNLFLN----EDLEV-------------------KIGDFGLATKV-----EYDGERK--KT---LCGTPNYIAPEVLS----KKGHSFEVDVWSIGCIMYTLLV-GK--PP---------------FETS--------------CLKETY----LRIKK---NEYSIPKHIN-----------------------------------------PVAASLIQKMLQTDPTA--RPT-----INELLNDEFF---------
---IELGRCIGEGQFGDVHQGIYM-------------SPEN-PAL--AVAIKTCK-NC-TS----DSVREKFL-Q-EALTMRQFD---HPH----IVKLIGVIT--------------------------------ENPVW--IIMELCTLG--ELRSFLQ----------VR------------------KYSL--DLASLILYAYQLSTALAYLES-KRFVHRDIAARNVLVS----SNDCV-------------------KLGDFGLSRYM-----E--DSTY--YKASKGKLPIKWMAPESIN----FRRFTSASDVWMFGVCMWEILMHGV--KP---------------FQGV-----------KNNDVIGRI----ENGER---LPMPPNCP-------------------------------------------PTLYSLMTKCWAYDPSR--RPR-----FTELKAQL-----------
--F-TLCRKLGSGYFGEVFEGLWK------------------DRV--QVAIKVIS-RD-NL----LH-QQMLQ-S-EIQAMKKLR---HKH----ILALYAVVS--V-----------------------------GDPVY--IITELMAKG--SLLELLR----------DS-----------------DEKVL--PVSELLDIAWQVAEGMCYLES-QNYIHRDLAARNILVG----ENTLC-------------------KVGDFGLARLI--------KEDV--YLSHDHNIPYKWTAPEALS----RGHYSTKSDVWSFGILLHEMFSRGQ--VP---------------YPGM-----------SNHEAFLRV----DAGYR---MPCPLECP-------------------------------------------PSVHKLMLTCWCRDPEQ--RPC-----FKALRERL-----------
---YDVVKVIGRGAFGEVQLVRHK----------------A-SQK--VYAMKLLSKFE-MIK---RS--DSAFFWEERDIMAFAN---SPW----VVQLFYAFQ--D-----------------------------DRYLY--MVMEYMPGG--DLVNLMS----------NY--------------------DV--PEKWAKFYTAEVVLALDAIHS-MGLIHRDVKPDNMLLD----KHGHL-------------------KLADFGTCMKM----DETGMVHC--DT---AVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLV-GD--TP---------------FYAD--------------SLVGTY----SKIMD---HKNSLCFPEDAEIS-------------------------------------KHAKNLICAFLTDREVRLGRNG-----VEEIRQHPFF---------
--L-RLEVKLGQGCFGEVWMGTWN------------------GTT--RVAIKTLK-PG-TM----SP--EAFL-Q-EAQVMKKLR---HEK----LVQLYAVVS--------------------------------EEPIY--IVTEYMSKG--SLLDFLK----------GE-----------------TGKYL--RLPQLVDMAAQIASGMAYVER-MNYVHRDLRAANILVG----ENLVC-------------------KVADFGLARLI-----E--DNEY--TARQGAKFPIKWTAPEAAL----YGRFTIKSDVWSFGILLTELTTKGR--VP---------------YPGM-----------VNREVLDQV----ERGYR---MPCPPECP-------------------------------------------ESLHDLMCQCWRKEPEE--RPT-----FEYLQAF--L---------
--L-RLEVKLGQGCFGEVWMGTWN------------------GTT--KVAIKTLK-PG-TM----MP--EAFL-Q-EAQIMKKLR---HDK----LVPLYAVVS--------------------------------EEPIY--IVTEFMSKG--SLLDFLK----------EG-----------------DGKYL--KLPQLVDMAAQIADGMAYIER-MNYIHRDLRAANILVG----ENLVC-------------------KIADFGLARLI-----E--DNEY--TARQGAKFPIKWTAPEAAL----YGRFTIKSDVWSFGILQTELVTKGR--VP---------------YPGM-----------VNREVLEQV----ERGYR---MPCPQGCP-------------------------------------------ESLHELMNLCWKKDPDE--RPT-----FEYIQSFL-----------
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