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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
Other AURKA 133
CMGC CDC2 4
CMGC CDC2L6 20
CMGC CDK4 6
CMGC CDK8 2.7.11.23
Other CHUK 15
CMGC CLK4 159
TK DDR1 572
Other EIF2AK2 267
CMGC GSK3B 56
TK JAK2 849
TK LCK 245
CMGC MAPK10 64
CMGC MAPK14 24
TK MET 1078
TK PTK2 422
TK PTK6 191
TK SRC 270
---FQKVEKIGEGTYGVVYKARNK----------------L-TGE--VVALKKIRLDT-ETE---GV--PSTAIREISLLKELN---HPN----IVKLLDVIH--T-----------------------------ENKLY--LVFEFLHQ---DLKKFMDA-------SALT--------------------GI--PLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN----TEGAI-------------------KLADFGLARAF-----GVPVRTY--TH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RR--AL---------------FPGD-----------SEIDQLFRI----FRTLG---TPDEVVWPGVTSMPDYKPSFPKWAR---------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF---------
---FEIGRPLGKGKFGNVYLAREK----------------Q-SKF--ILALKVLFKAQLEKA---GV--EHQLRREVEIQSHLR---HPN----ILRLYGYFH--D-----------------------------ATRVY--LILEYAPLG--TVYRELQ---------KLS--------------------KF--DEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG----SAGEL-------------------KIADFGWSV-------HAPSSRR--TT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GK--PP---------------FEAN--------------TYQETY----KRISR---VEFTFPDFVT-----------------------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI---------
---YTKIEKIGEGTYGVVYKGRHK----------------T-TGQ--VVAMKKIRLES-EEE---GV--PSTAIREISLLKELR---HPN----IVSLQDVLM--Q-----------------------------DSRLY--LIFEFLSM---DLKKYLDS------IPPGQ--------------------YM--DSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID----DKGTI-------------------KLADFGLARAF-----GIPIRVY--TH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KK--PL---------------FHGD-----------SEIDQLFRI----FRALG---TPNNEVWPEVESLQDYKNTFPKWKP---------------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF---------
EGC-----KVGRGTYGHVYKARRK----------------D-GKDEKEYALKQIEGTG-ISM---SA--C----REIALLRELK---HPN----VIALQKVFL--SH---------------------------SDRKVW--LLFDYAEH---DLWHIIKFHR--ASKANKK--------------------PMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRV-------------------KIADMGFARLFN--SPLKPLADL--DP---VVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLT-SE--PI---------------FHCRQEDI--KTSNPFHHDQLDRI----FSVMG---FPADKDWEDIRKMPEYPTLQKDFRRTTYA------NSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYF---------
--Y-EPVAEIGVGAYGTVYKARDP----------------H-SGH--FVALKSVRVPN-GGGGGGGL--PISTVREVALLRRLEAFEHPN----VVRLMDVCA--TSR------------------------TDREIKVT--LVFEHVDQ---DLRTYLDK-------APPP--------------------GL--PAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT----SGGTV-------------------KLADFGLARI------YSYQMAL--TP---VVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFR-RK--PL---------------FCGN-----------SEADQLGKI----FDLIG---LPPEDDWPRDVSLPRGAFPPRGPR-----------------PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL---------
EGC-----KVGRGTYGHVYKAKRK----------------D-GKDDKDYALKQIEGTG-ISM---SA--C----REIALLRELK---HPN----VISLQKVFL--SH---------------------------ADRKVW--LLFDYAEH---DLWHIIKFHRASKANKKPV--------------------QL--PRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRV-------------------KIADMGFARLFN--SPLKPLADL--DP---VVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLT-SE--PI---------------FHCRQEDI--KTSNPYHHDQLDRI----FNVMG---FPADKDWEDIKKMPEHSTLMKDFRRNTYT------NCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYF---------
--W-EMRERLGTGGFGNVCLYQHR----------------E-LDL--KIAIKSCRLEL-STK---NR--ER-WCHEIQIMKKLN---HAN----VVKACDVPE--ELN------------------------ILIHDVPL--LAMEYCSGG--DLRKLLNK------PENCC--------------------GL--KESQILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQ----DVGGKI----------------IHKIIDLGYAKD------VDQGSLC--TS---FVGTLQYLAPELFE-NKPYTATVDYWSFGTMVFECIA-GY--RP---------------FLHHLQPFTWHEKIKKKDPKCIFA----CEEMS---GEVRFSSHLPQPNSLCS-------------------------------LVVEPMENWLQLMLNWDPQQRG-----------GPVDLTLKQ
---YEIVDTLGEGAFGKVVECIDH----------------GMDGM--HVAVKIVKNVG-RYR---EA--ARS---EIQVLEHLNS-TDPNSVFRCVQMLEWFD--H-----------------------------HGHVC--IVFELLGL---STYDFIK---------ENS--------------------FLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFV----KSDYVVKYNSKMKRDERTLKNTDIKVVDFGSA--------TYDDEHH--ST---LVSTRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYYL-GF--TV---------------FQTH-----------DSKEHLAMM----ERILG---PIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFF---------
---LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKG-HPL--LVAVKILR-PD-AT----KNARNDFL-KEVKIMSRLK---DPN----IIRLLGVCV--Q-----------------------------DDPLC--MITDYMENG--DLNQFLS----------AHQLEDKAAEGAPGDGQAAQGPTI--SYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVG----ENFTI-------------------KIADFGMSRNL--Y--A--GDYY--RVQGRAVLPIRWMAWECIL-MGKFTTASDVWAFGVTLWEVLMLCRA-QP---------------FGQL-----------TDEQVIENAGEFFRDQGRQVYLSRPPACP-------------------------------------------QGLYELMLRCWSRESEQRPPFSQLHRFL-----------
--F-KEIELIGSGGFGQVFKAKHR----------------I-DGK--TYVIKRVKYNN-EKA---ER--------EVKALAKLD---HVN----IVHYNGCWD--GFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLF--IQMEFCDKG--TLEQWIEK-------RRGE--------------------KL--DKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLV----DTKQV-------------------KIGDFGLVTS------LKNDGKR--TR---SKGTLRYMSPEQIS-SQDYGKEVDLYALGLILAELLH-VC-DTA---------------FET------------------SKF----FTDLR---DGIISDIFDK------------------------------------------KEKTLLQKLLSKKPEDRPNTSEILR----TLT------
---YTDTKVIGNGSFGVVYQAKLC----------------D-SGE--LVAIKKVLQDK-RFK---NR--------ELQIMRKLD---HCN----IVRLRYFFY--SSG-------------------------EKKDEVYLNLVLDYVPETVYRVA---RHY-----SRAKQ--------------------TL--PVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLD---PDTAVL-------------------KLCDFGSAKQ------LVRGEPN--VS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQ--PI---------------FPGD-----------SGVDQLVEI----IKVLG---TPTREQIREMNPNYTEFKFPQIKAH---------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF---------
---LKFLQQLGKGNFGSVEMCRYDP------------LQDN-TGE--VVAVKKLQ-HS-TE-----EHLRDFE-REIEILKSLQ---HDN----IVKYKGVCYSAG-----------------------------RRNLK--LIMEYLPYG--SLRDYLQ----------KH------------------KERI--DHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVE----NENRV-------------------KIGDFGLTKVL-PQ--D--KEYY--KVKEPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFTYIE--KSKSPPAEFMRMIGNDKQGQM-----------IVFHLIELL----KNNGR---LPRPDGCP-------------------------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV-------
---LKLVERLGAGQFGEVWMGYYN------------------GHT--KVAVKSLK-QG-SM----SP--DAFL-AEANLMKQLQ---HQR----LVRLYAVVT--------------------------------QEPIY--IITEYMENG--SLVDFLK----------TP-----------------SGIKL--TINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS----DTLSC-------------------KIADFGLARLI-----E--DNEY--TAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGR--IP---------------YPGM-----------TNPEVIQNL----ERGYR---MVRPDNCP-------------------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L---------
---YQNLKPIGSGAQGIVCAAYDA----------------V-LDR--NVAIKKLSRPF-QNQ---TH--AKRAYRELVLMKCVN---HKN----IISLLNVFT--PQKT-----------------------LEEFQDVY--LVMELMDA---NLCQVIQ-----------M--------------------EL--DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK----SDCTL-------------------KILDFGLART------AGTSFMM--TP---YVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVR-HK--IL---------------FPGR-----------DYIDQWNKV----IEQLG---TPCPEFMKKLQPTVRNYVENRPKYAGLTFPK--LFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI---------
---YQNLSPVGSGAYGSVCAAFDT----------------K-TGL--RVAVKKLSRPF-QSI---IH--AKRTYRELRLLKHMK---HEN----VIGLLDVFT--PARS-----------------------LEEFNDVY--LVTHLMGA---DLNNIVK----------CQ--------------------KL--TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN----EDCEL-------------------KILDFGLAR--------HTDDEM--TG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GR--TL---------------FPGT-----------DHIDQLKLI----LRLVG---TPGAELLKKISSESARNYIQSLTQMP-------------KMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF---------
---VHFNEVIGRGHFGCVYHGTLL-------------DNDG-KKI--HCAVKSLN-RI-TD----IGEVSQFL-TEGIIMKDFS---HPN----VLSLLGICL-RS-----------------------------EGSPL--VVLPYMKHG--DLRNFIR----------NE------------------THNP--TVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLD----EKFTV-------------------KVADFGLARDM--Y--D--KEYYSVHNKTGAKLPVKWMALESLQ-TQKFTTKSDVWSFGVLLWELMTRGA--PP---------------YPDV-----------NTFDITVYL----LQGRR---LLQPEYCP-------------------------------------------DPLYEVMLKCWHPKAEMRPSFSELVSR--I---------
---IELGRCIGEGQFGDVHQGIYM-------------SPEN-PAL--AVAIKTCK-NC-TS----DSVREKFL-QEALTMRQFD---HPH----IVKLIGVIT--------------------------------ENPVW--IIMELCTLG--ELRSFLQ----------VR------------------KYSL--DLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVS----SNDCV-------------------KLGDFGLSRYM-----E--DSTY--YKASKGKLPIKWMAPESIN-FRRFTSASDVWMFGVCMWEILMHGV--KP---------------FQGV-----------KNNDVIGRI----ENGER---LPMPPNCP-------------------------------------------PTLYSLMTKCWAYDPSRRPRFTELKAQL-----------
--F-TLCRKLGSGYFGEVFEGLWK------------------DRV--QVAIKVIS-RD-NL----LH-QQMLQ-SEIQAMKKLR---HKH----ILALYAVVS--V-----------------------------GDPVY--IITELMAKG--SLLELLR----------DS-----------------DEKVL--PVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVG----ENTLC-------------------KVGDFGLARLI--------KEDV--YLSHDHNIPYKWTAPEALS-RGHYSTKSDVWSFGILLHEMFSRGQ--VP---------------YPGM-----------SNHEAFLRV----DAGYR---MPCPLECP-------------------------------------------PSVHKLMLTCWCRDPEQRPCFKALRERL-----------
--L-RLEVKLGQGCFGEVWMGTWN------------------GTT--RVAIKTLK-PG-TM----SP--EAFL-QEAQVMKKLR---HEK----LVQLYAVVS--------------------------------EEPIY--IVTEYMSKG--SLLDFLK----------GE-----------------TGKYL--RLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG----ENLVC-------------------KVADFGLARLI-----E--DNEY--TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGR--VP---------------YPGM-----------VNREVLDQV----ERGYR---MPCPPECP-------------------------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L---------
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