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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
CMGC CLK4 159
CMGC GSK3B 56
CMGC MAPK14 24
CMGC MAPK8 26
FQKVEKIGEGTYGVVYKARNKL-TGEVVALKKIRLDTETEGVPSTAIREISLLKELN--HPN----IVKLLDVIHT------ENKLY--LVFEFLHQ---DLKKFMDA--SALTGI--PLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI-------------------KLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
YEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARS---EIQVLEHLNSTDPNSVFRCVQMLEWFDH------HGHVC--IVFELLGL---STYDFIK----ENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFV-KSDYVVKYNSKMKRDERTLKNTDIKVVDFGSA---TYDDEHHSTLVSTRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFF
YTDTKVIGNGSFGVVYQAKLCD-SGELVAIKKVLQDKRFKNR------ELQIMRKLD--HCN----IVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQTL--PVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL-------------------KLCDFGSAKQ-LVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH---------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF
YQNLSPVGSGAYGSVCAAFDTK-TGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK--HEN----VIGLLDVFTPARSLEEFNDVY--LVTHLMGA---DLNNIVK-----CQKL--TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCEL-------------------KILDFGLAR---HTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-------------KMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF
YQNLKPIGSGAQGIVCAAYDAI-LERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN--HKN----IIGLLNVFTPQKSLEEFQDVY--IVMELMDA---NLCQVIQ------MEL--DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL-------------------KILDFGLART-AGTSFMMTPYVVTRYYRAPEVIL-GMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEK--LFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYI
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