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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
Other AURKA 133
CMGC CDC2 4
CMGC GSK3A 119
CMGC GSK3B 56
STE MAP2K1 68
CMGC MAPK14 24
Other NEK2 8
FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT-ETEGVPSTAIREISLLKELNHPNIVKLLDVIHT------ENKLY--LVFEFLHQ---DLKKFMDA--SALTGIPLPLIKSYLFQLLQGLAFCHS-H-----RVLHRDLKPQNLLIN-TEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF-
FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHD------ATRVY--LILEYAPLG--TVYRELQ----KLSKFDEQRTATYITELANALSYCHS-K-----RVIHRDIKPENLLLG-SAGELKIADFGWSV--HAPSSRRTTLCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLVGKPPFEAN---TYQETYKRISRVEFTFPDFVT-----------------------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI-
YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLES-EEEGVPSTAIREISLLKELRHPNIVSLQDVLMQ------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQYMDSSLVKSYLYQILQGIVFCHS-R-----RVLHRDLKPQNLLID-DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP---------------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF-
YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDK-RFKNR------ELQIMRKLDHCNIVRLRYFFYSSG--EKKDELYLNLVLEYVPETVYRVARHFT---KAKLTIPILYVKVYMYQLFRSLAYIHS-Q-----GVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQ-LVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH---------------PWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF-
YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK-RFKNR------ELQIMRKLDHCNIVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS-F-----GICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ-LVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH---------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF-
FEKISELGAGNGGVVFKVSHKPSGL-VMARKLIHLE-IKPAIRNQIIRELQVLHECNSPYIVGFYGAFYS------DGEIS--ICMEHMDGG--SLDQVLK----KAGRIPEQILGKVSIAVIKGLTYLREKH-----KIMHRDVKPSNILVN-SRGEIKLCDFGVSG--QLIDSMANSFVGTRSYMSPERLQ-GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI-
YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPF-QSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVY--LVTHLMGA---DLNNIVK-----CQKLTDDHVQFLIYQILRGLKYIHS-A-----DIIHRDLKPSNLAVN-EDCELKILDFGLAR---HTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-------------KMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF-
YEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGS-MTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDR----TNTTLY--IVMEYCEGG--DLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHR-RSDGGHTVLHRDLKPANVFLD-GKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMN-RMSYNEKSDIWSLGCLLYELCALMPPFTAF---SQKELAGKIREGKFRRIPYRY---S-------------------------------------DELNEIITRMLNLKDYHRPSVEEILENPL-I
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