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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
AGC AKT1 150
Other AURKA 133
Other AURKB 77
Other AURKC 43
CMGC CDC2 4
CMGC CDK4 6
CMGC CDK5 4
CMGC CDK9 2.7.11.23
CMGC GSK3B 56
CMGC MAPK10 64
CMGC MAPK14 24
AGC PDPK1 82
Other PLK1 53
Other PLK2 82
Other PLK3 62
AGC PRKCD 349
AGC PRKCQ 380
--FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT-ETE---GVPS-TAIR-EISLLKEL-N---HPNIVKLLDVIHT--------ENKLY--LVFEFLHQ---DLKKFMDA--SALTGIPLPLIKSYLFQLLQGLAFCHS-HRVLHRDLKPQNLLIN-TEGAIKLADFGLARAF----GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AK-AALAHPFF-----------
-F-EYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEV-IVA---KDEV-AHTLTENRVLQNS-R---HPFLTALKYSFQT--------HDRLC--FVMEYANGG--ELFFHLS----RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD-KDGHIKITDFGLCKEG----IKDGATMKTFCGTPEYLAPEVLE-DNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQ---DHEKLFELILMEEIRFPRTLG---------------------------------------PEAKSLLSGLLKKDPKQRLGGGSEDAK-EIMQHRFF-----------
--FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKA---GVEH-QLRR-EVEIQSHL-R---HPNILRLYGYFHD--------ATRVY--LILEYAPLG--TVYRELQ----KLSKFDEQRTATYITELANALSYCHS-KRVIHRDIKPENLLLG-SAGELKIADFGWSV------HAPSSRRTTLCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN---TYQETYKRISRVEFTFPDFVT---------------------------------------EGARDLISRLLKHNPSQRPM-----LR-EVLEHPWI-----------
--FEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQ-IEK---EGVE-HQLRREIEIQAHL-H---HPNILRLYNYFYD--------RRRIY--LILEYAPRG--ELYKELQ----KSCTFDEQRTATIMEELADALMYCHG-KKVIHRDIKPENLLLG-LKGELKIADFGWSV------HAPSLRRKTMCGTLDYLPPEMIE-GRMHNEKVDLWCIGVLCYELLV-GNPPFESA---SHNETYRRIVKVDLKFPASVP---------------------------------------MGAQDLISKLLRHNPSERLP-----LA-QVSAHPWV-----------
--FEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQ-IEK---EGLE-HQLRREIEIQAHL-Q---HPNILRLYNYFHD--------ARRVY--LILEYAPRG--ELYKELQ----KSEKLDEQRTATIIEELADALTYCHD-KKVIHRDIKPENLLLG-FRGEVKIADFGWSV------HTPSLRRKTMCGTLDYLPPEMIE-GRTYDEKVDLWCIGVLCYELLV-GYPPFESA---SHSETYRRILKVDVRFPLSMP---------------------------------------LGARDLISRLLRYQPLERLP-----LA-QILKHPWV-----------
--YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLES-EEE---GVPS-TAIR-EISLLKEL-R---HPNIVSLQDVLMQ--------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQYMDSSLVKSYLYQILQGIVFCHS-RRVLHRDLKPQNLLID-DKGTIKLADFGLARAF----GIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------GSLASHVKNLDENGLDLLSKMLIYDPAKRIS-----GK-MALNHPYF-----------
-Y-EPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPN-GGGGGGGLPI-STVR-EVALLRRL-EAFEHPNVVRLMDVCATSR---TDREIKVT--LVFEHVDQ---DLRTYLDK--APPPGLPAETIKDLMRQFLRGLDFLHA-NCIVHRDLKPENILVT-SGGTVKLADFGLARI-----YSYQMALTPVVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR---------------PVQSVVPEMEESGAQLLLEMLTFNPHKRIS-----AF-RALQHSYL-----------
--YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDD-DDE---GVPS-SALR-EICLLKEL-K---HKNIVRLHDVLHS--------DKKLT--LVFEFCDQ---DLKKYFD---SCNGDLDPEIVKSFLFQLLKGLGFCHS-RNVLHRDLKPQNLLIN-RNGELKLADFGLARAF----GIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT-------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AE-EALQHPYF-----------
--YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMEN-EKE---GFPI-TALR-EIKILQLL-K---HENVVNLIEICRTKASPYNRCKGSIY--LVFDFCEH---DLAGLLS---NVLVKFTLSEIKRVMQMLLNGLYYIHR-NKILHRDMKAANVLIT-RDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQK----------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID-----SD-DALNHDFF-----------
--YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK-RFK---NR--------ELQIMRKL-D---HCNIVRLRYFFYSSG----EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS-FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ-----LVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-----PL-EACAHSFF-----------
--YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPF-QNQ---THAK-RAYR-ELVLMKCV-N---HKNIISLLNVFTPQKT--LEEFQDVY--LVMELMDA---NLCQVIQ------MELDHERMSYLLYQMLCGIKHLHS-AGIIHRDLKPSNIVVK-SDCTLKILDFGLART-----AGTSFMMTPYVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS-----VD-DALQHPYI-----------
--YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPF-QSI---IHAK-RTYR-ELRLLKHM-K---HENVIGLLDVFTPARS--LEEFNDVY--LVTHLMGA---DLNNIVK-----CQKLTDDHVQFLIYQILRGLKYIHS-ADIIHRDLKPSNLAVN-EDCELKILDFGLAR-------HTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------KMNFANVFIGANPLAVDLLEKMLVLDSDKRIT-----AA-QALAHAYF-----------
-F-KFGKILGEGSFSTVVLARELATSREYAIKILEKRH-IIK---ENKVPYVTR-ERDVMSRL-D---HPFFVKLYFTFQD--------DEKLY--FGLSYAKNG--ELLKYIR----KIGSFDETCTRFYTAEIVSALEYLHG-KGIIHRDLKPENILLN-EDMHIQITDFGTAKVLS--PESKQARANSFVGTAQYVSPELLT-EKSACKSSDLWALGCIIYQLVA-GLPPFRAG---NEYLIFQKIIKLEYDFPEKFF---------------------------------------PKARDLVEKLLVLDATKRLG-----CE-EM------EGYGPLKAHPF
YV--RGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSL-LLK---PHQR-EKMSMEISIHRSL-A---HQHVVGFHGFFED--------NDFVF--VVLELCRRR--SLLELHK----RRKALTEPEARYYLRQIVLGCQYLHR-NRVIHRDLKLGNLFLN-EDLEVKIGDFGLATKV----EYDGERKKTLCGTPNYIAPEVLS-KKGHSFEVDVWSIGCIMYTLLV-GKPPFETS---CLKETYLRIKKNEYSIPKHIN---------------------------------------PVAASLIQKMLQTDPTARPT-----IN-ELLNDEFF-----------
-Y-CRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSR-VAK---PHQR-EKIDKEIELHRIL-H---HKHVVQFYHYFED--------KENIY--ILLEYCSRR--SMAHILK----ARKVLTEPEVRYYLRQIVSGLKYLHE-QEILHRDLKLGNFFIN-EAMELKVGDFGLAARL----EPLEHRRRTICGTPNYLSPEVLN-KQGHGCESDIWALGCVMYTMLL-GRPPFETT---NLKETYRCIREARYTMPSSLL---------------------------------------APAKHLIASMLSKNPEDRPS-----LD-DIIRHDFF-----------
YL--KGRLLGKGGFARCYEATDTETGSAYAVKVIPQSR-VAK---PHQR-EKILNEIELHRDL-Q---HRHIVRFSHHFED--------ADNIY--IFLELCSRK--SLAHIWK----ARHTLLEPEVRYYLRQILSGLKYLHQ-RGILHRDLKLGNFFIT-ENMELKVGDFGLAARL----EPPEQRKKTICGTPNYVAPEVLL-RQGHGPEADVWSLGCVMYTLLC-GSPPFETA---DLKETYRCIKQVHYTLPASLS---------------------------------------LPARQLLAAILRASPRDRPS-----ID-QILRHDFF-----------
FI--FHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDV-VLI---DDDV-ECTMVEKRVLTLAAE---NPFLTHLICTFQT--------KDHLF--FVMEFLNGG--DLMYHIQ----DKGRFELYRATFYAAEIMCGLQFLHS-KGIIYRDLKLDNVLLD-RDGHIKIADFGMCKEN----IFGESRASTFCGTPDYIAPEILQ-GLKYTFSVDWWSFGVLLYEMLI-GQSPFHGD---DEDELFESIRVDTPHYPRWIT---------------------------------------KESKDILEKLFEREPTKRLG----VTG-NIKIHPFF-----------
FI--LHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDV-VLM---DDDV-ECTMVEKRVLSLAWE---HPFLTHMFCTFQT--------KENLF--FVMEYLNGG--DLMYHIQ----SCHKFDLSRATFYAAEIILGLQFLHS-KGIVYRDLKLDNILLD-KDGHIKIADFGMCKEN----MLGDAKTNTFCGTPDYIAPEILL-GQKYNHSVDWWSFGVLLYEMLI-GQSPFHGQ---DEEELFHSIRMDNPFYPRWLE---------------------------------------KEAKDLLVKLFVREPEKRLG-----VRGDIRQHPLF-----------
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