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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
Other AURKA 133
CMGC CDC2 4
CMGC CDK4 6
CMGC MAPK7 55
Other PLK1 53
TK SRC 270
Other TTK 525
--FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT-ETE---GVPSTAIR-EISLLKEL-N---HPNIVKLLDVIHT------ENKLYLVFEFLHQ-DLKKFMDA-SALT---GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF----GVPVRTYTH---EVVTLWYRAPEILL----------GCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
--FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKA---GVEHQLRR-EVEIQSHL-R---HPNILRLYGYFHD------ATRVYLILEYAPLGTVYRELQ---KLS---KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSV------HAPSSRRTT---LCGTLDYLPPEMIE-----------GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN---TYQETYKRISRVEFTFPDFVT----------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI
--YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLES-EEE---GVPSTAIR-EISLLKEL-R---HPNIVSLQDVLMQ------DSRLYLIFEFLSM-DLKKYLDSIPPGQ---YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF----GIPIRVYTH---EVVTLWYRSPEVLL----------GSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP--GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF
-Y-EPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPN-GGGGGGGLPISTVR-EVALLRRL-EAFEHPNVVRLMDVCATSR-TDREIKVTLVFEHVDQ-DLRTYLDK-APPP---GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI-----YSYQMALTP---VVVTLWYRAPEVLL-----------QSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR----PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL
--YEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAF-DVV---TNAKRTLR-ELKILKHF-K---HDNIIAIKDILRPTVPYGEFKSVYVVLDLMES-DLHQIIH---SSQ---PLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTE---YVATRWYRAPELML----------SLHEYTQAIDLWSVGCIFGEMLA-RRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFL
YV--RGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSL-LLK---PHQREKMSMEISIHRSL-A---HQHVVGFHGFFED------NDFVFVVLELCRRRSLLELHK---RRK---ALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKV----EYDGERKKT---LCGTPNYIAPEVLS-----------KKGHSFEVDVWSIGCIMYTLLV-GKPPFETS---CLKETYLRIKKNEYSIPKHIN----------------------------PVAASLIQKMLQTDPTARPTINELLNDEFF
-L-RLEVKLGQGCFGEVWMGTWN-GTTRVAIKTLK-PG-TM----SPEAFL-Q-EAQVMKKL-R---HEKLVQLYAVVS-------EEPIYIVTEYMSKGSLLDFLK----GETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI----E--DNEYTARQGAKFPIKWTAPEAAL-----------YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP------------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L
--YSILKQIGSGGSSKVFQVLNEKKQ-IYAIKYVNLEE-ADN---QTLDSYRN-EIAYLNKLQQ--HSDKIIRLYDYEIT------DQYIYMVMECGNI-DLNSWLK---KKK---SIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQ--PDTTSVVKDS---QVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTY-GKTPFQQI--INQISKLHAIIDPNHEIEFPDIPE--------------------------KDLQDVLKCCLKRDPKQRISIPELLAHPYV
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