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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
TK ABL1 261
Other AURKA 133
CMGC CDC2 4
CMGC CDK4 6
TK FGFR1 478
TK JAK2 849
TK JAK3 822
CMGC MAPK8 26
Other PLK1 53
Other PLK2 82
Other PLK3 62
TK SRC 270
Other TTK 525
--FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLDT-ETE---GV--PSTAIR-EISLLKEL--N---HPNIVKLLDVIH--T------ENKLYLVFEFLHQ-DLKKFMDA-SALT-----------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF----GVPVRTYTH---EVVTLWYRAPEILL----------GCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--
--ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-ED-TM----EV--EEFL-K-EAAVMKEI--K---HPNLVQLLGVCT--R------EPPFYIITEFMTYGNLLDYLR----EC--------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM----T--GDTYTAHAGAKFPIKWTAPESLA-----------YNKFSIKSDVWAFGVLLWEIATYGMSP---------------YPGI-DLSQVYELLEKDYRMERPEGCP-----------------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F--
--FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKAQLEKA---GV--EHQLRR-EVEIQSHL--R---HPNILRLYGYFH--D------ATRVYLILEYAPLGTVYRELQ---KLS-----------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSV------HAPSSRRTT---LCGTLDYLPPEMIE-----------GRMHDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN----TYQETYKRISRVEFTFPDFVT---------------------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI--
--YTKIEKIGEGTYGVVYKGRHK-------TTGQVVAMKKIRLES-EEE---GV--PSTAIR-EISLLKEL--R---HPNIVSLQDVLM--Q------DSRLYLIFEFLSM-DLKKYLDSIPPGQ-----------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF----GIPIRVYTH---EVVTLWYRSPEVLL----------GSARYSTPVDIWSIGTIFAELAT-KKPL---------------FHGD-SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF--
-Y-EPVAEIGVGAYGTVYKARDP-------HSGHFVALKSVRVPN-GGGGGGGL--PISTVR-EVALLRRL--EAFEHPNVVRLMDVCA--TSR-TDREIKVTLVFEHVDQ-DLRTYLDK-APPP-----------------GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI-----YSYQMALTP---VVVTLWYRAPEVLL-----------QSTYATPVDMWSVGCIFAEMFR-RKPL---------------FCGN-SEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR---------------PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL--
-L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-SD-AT----EKDLSDLI-S-EMEMMKMIG-K---HKNIINLLGACT--Q------DGPLYVIVEYASKGNLREYLQ----ARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDI--H-H--IDYYKKTTNGRLPVKWMAPEALF-----------DRIYTHQSDVWSFGVLLWEIFTLGGSP---------------YPGV-PVEELFKLLKEGHRMDKPSNCT-----------------------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL----
--LKFLQQLGKGNFGSVEMCRYDP---LQDNTGEVVAVKKLQ-HS-TE-----EHLRDFE-R-EIEILKSL--Q---HDNIVKYKGVCYSAG------RRNLKLIMEYLPYGSLRDYLQ----KH---------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVL-PQ-D--KEYYKVKEPGESPIFWYAPESLT-----------ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELLKNNGRLPRPDGCP-----------------------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV
-L-KYISQLGKGNFGSVELCRYDP---LGDNTGALVAVKQLQ-HS-GP----DQ-QRDFQ-R-EIQILKAL--H---SDFIVKYRGVSYGPG------RQSLRLVMEYLPSGCLRDFLQ----RH---------------RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLL-PL-D--KDYYVVREPGQSPIFWYAPESLS-----------DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDVPALCRLLELLEEGQRLPAPPACP-----------------------------------------AEVHELMKLCWAPSPQDRPSFSALGP---QL-
--YQNLKPIGSGAQGIVCAAYDA-------ILERNVAIKKLSRPF-QNQ---TH--AKRAYR-ELVLMKCV--N---HKNIIGLLNVFT--PQKSLEEFQDVYIVMELMDA-NLCQVIQ-----M-----------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART-----AGTSFMMTP---YVVTRYYRAPEVIL-----------GMGYKENVDLWSVGCIMGEMVC-HKIL---------------FPGR-DYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYI--
YV--RGRFLGKGGFAKCFEISDA-------DTKEVFAGKIVPKSL-LLK---PH--QREKMSMEISIHRSL--A---HQHVVGFHGFFE--D------NDFVFVVLELCRRRSLLELHK---RRK-----------------ALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKV----EYDGERKKT---LCGTPNYIAPEVLS-----------KKGHSFEVDVWSIGCIMYTLLV-GKPP---------------FETS----CLKETYLRIKKNEYSIPKHIN---------------------------------------PVAASLIQKMLQTDPTARPTINELLNDEFF--
-Y-CRGKVLGKGGFAKCYEMTDL-------TNNKVYAAKIIPHSR-VAK---PH--QREKIDKEIELHRIL--H---HKHVVQFYHYFE--D------KENIYILLEYCSRRSMAHILK---ARK-----------------VLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARL----EPLEHRRRT---ICGTPNYLSPEVLN-----------KQGHGCESDIWALGCVMYTMLL-GRPP---------------FETT----NLKETYRCIREARYTMPSSLL---------------------------------------APAKHLIASMLSKNPEDRPSLDDIIRHDFF--
YL--KGRLLGKGGFARCYEATDT-------ETGSAYAVKVIPQSR-VAK---PH--QREKILNEIELHRDL--Q---HRHIVRFSHHFE--D------ADNIYIFLELCSRKSLAHIWK---ARH-----------------TLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARL----EPPEQRKKT---ICGTPNYVAPEVLL-----------RQGHGPEADVWSLGCVMYTLLC-GSPP---------------FETA----DLKETYRCIKQVHYTLPASLS---------------------------------------LPARQLLAAILRASPRDRPSIDQILRHDFF--
-L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-PG-TM----SP--EAFL-Q-EAQVMKKL--R---HEKLVQLYAVVS---------EEPIYIVTEYMSKGSLLDFLK----GE--------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI----E--DNEYTARQGAKFPIKWTAPEAAL-----------YGRFTIKSDVWSFGILLTELTTKGRVP---------------YPGM-VNREVLDQVERGYRMPCPPECP-----------------------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L--
--YSILKQIGSGGSSKVFQVLNE-------KKQ-IYAIKYVNLEE-ADN---QT--LDSYRN-EIAYLNKL-QQ--HSDKIIRLYDYEI--T------DQYIYMVMECGNI-DLNSWLK---KKK-----------------SIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQ--PDTTSVVKDS---QVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTY-GKTP---------------FQQI---INQISKLHAIIDPNHEIEFPDIPE-------------------------------------KDLQDVLKCCLKRDPKQRISIPELLAHPYV--
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