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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
TK ABL1 261
Other AURKA 133
Other AURKB 77
TK BLK 241
CMGC CDC2 4
CMGC CDK4 6
CMGC CDK5 4
CMGC CDK9 2.7.11.23
CAMK CHEK1 9
CAMK CHEK2 220
Other CHUK 15
CMGC CLK4 159
CMGC CSNK2A1 39
TK FGFR1 478
TK FGR 263
TK FYN 271
CMGC GSK3B 56
TK HCK 241
TKL IRAK4 186
TK JAK1 875
TK JAK2 849
TK JAK3 822
TK LCK 245
TK LYN 247
CMGC MAPK10 64
CMGC MAPK14 24
CMGC MAPK8 26
TK MET 1078
AGC PDPK1 82
Other PLK1 53
Other PLK3 62
AGC PRKCA 339
AGC PRKCD 349
AGC PRKCQ 380
TK PTK6 191
AGC RPS6KB1 91
TK SRC 270
TK SRMS 230
TK TNK2 150
TK YES1 277
TK ZAP70 338
----FQKVEKIGEGTYGVVYKARN---K-------L-TGEVVALKKIRLD--T-ETE---GV--P-S-TAIR------EISLLKEL--N---HPN----IVKLLDVIH--T--------ENK--LY--LVFEFLHQ---DLKKFMDA--SALT-----------------GI--PLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI-------------------KLADFGLARAF------GVPVRTY--TH---EVVTLWYRAPEILL--GCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FP-GD-----------SEIDQLFRI-FRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---------------QDFSKVVPPLDEDGRS-LLSQMLHYDPNKRIS-----AK-AALAHPFF--------------
----ITMKHKLGGGQYGEVYEGVW---K-------K-YSLTVAVKTLK-E--D-TM----EV--E-E-FL-K------EAAVMKEI--K---HPN----LVQLLGVCT--R--------EPP--FY--IITEFMTYG--NLLDYLR-----EC--------------NRQEV--NAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG-ENHLV-------------------KVADFGLSRLM------T--GDTY--TAHAGAKFPIKWTAPESLA---YNKFSIKSDVWAFGVLLWEIATYGMSP---------------YP-GI-----------DLSQVYELL-EKDYRMERPEGCP-------------------------------------------EKVYE-LMRACWQWNPSDRPS-----FA-EIHQA--F--------------
----FEIGRPLGKGKFGNVYLARE---K-------Q-SKFILALKVLFKA--QLEKA---GV--E-H-QLRR------EVEIQSHL--R---HPN----ILRLYGYFH--D--------ATR--VY--LILEYAPLG--TVYRELQ----KLS-----------------KF--DEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGEL-------------------KIADFGWSV--------HAPSSRR--TT---LCGTLDYLPPEMIE---GRMHDEKVDLWSLGVLCYEFLV-GKPP---------------FE-AN--------------TYQETY-KRISRVEFTFPDFVT-----------------------------------------EGARD-LISRLLKHNPSQRPM-----LR-EVLEHPWI--------------
----FEIGRPLGKGKFGNVYLARE---K-------K-SHFIVALKVLFKS--Q-IEK---EG--V-E-HQLR-----REIEIQAHL--H---HPN----ILRLYNYFY--D--------RRR--IY--LILEYAPRG--ELYKELQ----KSC-----------------TF--DEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-LKGEL-------------------KIADFGWSV--------HAPSLRR--KT---MCGTLDYLPPEMIE---GRMHNEKVDLWCIGVLCYELLV-GNPP---------------FE-SA--------------SHNETY-RRIVKVDLKFPASVP-----------------------------------------MGAQD-LISKLLRHNPSERLP-----LA-QVSAHPWV--------------
---L-RLVRKLGSGQFGEVWMGYY---K---------NNMKVAIKTLK-E--G-TM----SP--E-A-FL-G------EANVMKAL--Q---HER----LVRLYAVVT-----------KEP--IY--IVTEYMARG--CLLDFLK-----TD--------------EGSRL--SLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVS-EALCC-------------------KIADFGLARII---------DSEY--TAQEGAKFPIKWTAPEAIH---FGVFTIKADVWSFGVLLMEVVTYGRVP---------------YP-GM-----------SNPEVIRNL-ERGYRMPRPDTCP-------------------------------------------PELYRGVIAECWRSRPEERPT-----FE-FLQSV--L--------------
----YTKIEKIGEGTYGVVYKGRH---K-------T-TGQVVAMKKIRLE--S-EEE---GV--P-S-TAIR------EISLLKEL--R---HPN----IVSLQDVLM--Q--------DSR--LY--LIFEFLSM---DLKKYLDS-IPPGQ-----------------YM--DSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTI-------------------KLADFGLARAF------GIPIRVY--TH---EVVTLWYRSPEVLL--GSARYSTPVDIWSIGTIFAELAT-KKPL---------------FH-GD-----------SEIDQLFRI-FRALGTPNNEVWPEVESLQDYKNTFPKWKP---------------GSLASHVKNLDENGLD-LLSKMLIYDPAKRIS-----GK-MALNHPYF--------------
---Y-EPVAEIGVGAYGTVYKARD---P-------H-SGHFVALKSVRVP--N-GGGGGGGL--P-I-STVR------EVALLRRL--EAFEHPN----VVRLMDVCA--TSR---TDREIK--VT--LVFEHVDQ---DLRTYLDK--APPP-----------------GL--PAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTV-------------------KLADFGLARI-------YSYQMAL--TP---VVVTLWYRAPEVLL---QSTYATPVDMWSVGCIFAEMFR-RKPL---------------FC-GN-----------SEADQLGKI-FDLIGLPPEDDWPRDVSLPRGAFPPRGPR-----------------PVQSVVPEMEESGAQ-LLLEMLTFNPHKRIS-----AF-RALQHSYL--------------
----YEKLEKIGEGTYGTVFKAKN---R-------E-THEIVALKRVRLD--D-DDE---GV--P-S-SALR------EICLLKEL--K---HKN----IVRLHDVLH--S--------DKK--LT--LVFEFCDQ---DLKKYFD---SCNG-----------------DL--DPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGEL-------------------KLADFGLARAF------GIPVRCY--SA---EVVTLWYRPPDVLF--GAKLYSTSIDMWSAGCIFAELANAGRPL---------------FP-GN-----------DVDDQLKRI-FRLLGTPTEEQWPSMTKLPDYKPYPMYPAT---------------TSLVNVVPKLNATGRD-LLQNLLKCNPVQRIS-----AE-EALQHPYF--------------
----YEKLAKIGQGTFGEVFKARH---R-------K-TGQKVALKKVLME--N-EKE---GF--P-I-TALR------EIKILQLL--K---HEN----VVNLIEICR--TKASPYNRCKGS--IY--LVFDFCEH---DLAGLLS---NVLV-----------------KF--TLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLIT-RDGVL-------------------KLADFGLARAFSL--AKNSQPNRY--TN---RVVTLWYRPPELLL--GERDYGPPIDLWGAGCIMAEMWT-RSPI---------------MQ-GN-----------TEQHQLALI-SQLCGSITPEVWPNVDNYELYEKLELVKGQK------------RKVKDRLKAYVRDPYALD-LIDKLLVLDPAQRID-----SD-DALNHDFF--------------
---W-DLVQTLGEGAYGEVQLAVN---R-------V-TEEAVAVKIVDMK--R-AVD---CP--E-N-I-KK------EICINKML--N---HEN----VVKFYGHRR--E--------GNI--QY--LFLEYCSGG--ELFDRIE----PDI-----------------GM--PEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNL-------------------KISDFGLATVFR----YNNRERLL--NK---MCGTLPYVAPELLK--RREFHAEPVDVWSCGIVLTAMLA-GELP---------------WD-QP-------------SDSCQEY-SDWKEKKTYLNPWKKI--D-------------------------------------SAPLA-LLHKILVENPSARIT-----IP-DIKKDRW-Y-------------
--YI--MSKTLGSGACGEVKLAFE---R-------K-TCKKVAIKIISKR--K-FAI---GS--A-R-EADPALNVETEIEILKKL--N---HPC----IIKIKNFF---D--------AED--YY--IVLELMEGG--ELFDKVV----GNK-----------------RL--KEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLS-SQEEDC----------------LIKITDFGHSKI-------LGETSLM--RT---LCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLS-GYPP---------------FS-EH-------------RTQVSLK-DQITSGKYNFIPEVWAEVS-------------------------------------EKALD-LVKKLLVVDPKARFT-----TE-EALRHPWL--------------
---W-EMRERLGTGGFGNVCLYQH---R-------E-LDLKIAIKSCRLE--L-STK---NR--E-R--WCH------EIQIMKKL--N---HAN----VVKACDVPE--ELN---ILIHDV--PL--LAMEYCSGG--DLRKLLNK-PENCC-----------------GL--KESQILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQ-DVGGKI----------------IHKIIDLGYAKD-------VDQGSLC--TS---FVGTLQYLAPELFE---NKPYTATVDYWSFGTMVFECIA-GYRP---------------FL-HHLQPFTWHEKIKKKDPKCIFA-CEEMSGEVRFSSHLPQPNSLCS-------------------------------LVVEPMEN-WLQLMLNWDPQQRG-----------------GPVDLTLKQ-----
----YEIVDTLGEGAFGKVVECID---H-------GMDGMHVAVKIVKNV--G-RYR---EA--A-R-S---------EIQVLEHL--NS-TDPNSVFRCVQMLEWFD--H--------HGH--VC--IVFELLGL---STYDFIK----ENS-----------------FLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFV-KSDYVVKYNSKMKRDERTLKNTDIKVVDFGSA---------TYDDEHH--ST---LVSTRHYRAPEVIL---ALGWSQPCDVWSIGCILIEYYL-GFTV---------------FQ-TH-----------DSKEHLAMM-ERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFD-LVRRMLEYDPTQRIT-----LD-EALQHPFF--------------
----YQLVRKLGRGKYSEVFEAIN---I-------T-NNEKVVVKILKPV--K-KKK---IK--R-------------EIKILENL-RG---GPN----IITLADIVK--DP------VSRT--PA--LVFEHVNNT--DFKQLY-------Q-----------------TL--TDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKL-------------------RLIDWGLAEF-------YHPGQEY--NV---RVASRYFKGPELLV--DYQMYDYSLDMWSLGCMLASMIF-RKEP---------------FFHGH-----------DNYDQLVRI-AKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK-------RWERFVHSENQHLVSPEALD-FLDKLLRYDHQSRLT-----AR-EAMEHPYF--------------
---L-VLGKPLGEGCFGQVVLAEA---IGLDKDKPN-RVTKVAVKMLK-S--D-AT----EKDLS-D-LI-S------EMEMMKMIG-K---HKN----IINLLGACT--Q--------DGP--LY--VIVEYASKG--NLREYLQ-----ARRPPGLEYCYNPSHNPEEQL--SSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT-EDNVM-------------------KIADFGLARDI---H--H--IDYY--KKTTNGRLPVKWMAPEALF---DRIYTHQSDVWSFGVLLWEIFTLGGSP---------------YP-GV-----------PVEELFKLL-KEGHRMDKPSNCT-------------------------------------------NELYM-MMRDCWHAVPSQRPT-----FK-QLVEDL----------------
----ITLERRLGTGCFGDVWLGTW---N---------GSTKVAVKTLK-P--G-TM----SP--K-A-FL-E------EAQVMKLL--R---HDK----LVQLYAVVS-----------EEP--IY--IVTEFMCHG--SLLDFLK-----NP--------------EGQDL--RLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVG-ERLAC-------------------KIADFGLARLI------K--DDEY--NPCQGSKFPIKWTAPEAAL---FGRFTIKSDVWSFGILLTELITKGRIP---------------YP-GM-----------NKREVLEQV-EQGYHMPCPPGCP-------------------------------------------ASLYE-AMEQTWRLDPEERPT-----FE-YLQSFL----------------
----LQLIKRLGNGQFGEVWMGTW---N---------GNTKVAIKTLK-P--G-TM----SP--E-S-FL-E------EAQIMKKL--K---HDK----LVQLYAVVS-----------EEP--IY--IVTEYMNKG--SLLDFLK-----DG--------------EGRAL--KLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVG-NGLIC-------------------KIADFGLARLI------E--DNEY--TARQGAKFPIKWTAPEAAL---YGRFTIKSDVWSFGILLTELVTKGRVP---------------YP-GM-----------NNREVLEQV-ERGYRMPCPQDCP-------------------------------------------ISLHE-LMIHCWKKDPEERPT-----FE-YLQSFL----------------
----YTDTKVIGNGSFGVVYQAKL---C-------D-SGELVAIKKVLQD--K-RFK---NR----------------ELQIMRKL--D---HCN----IVRLRYFFY--SSG----EKKDE--VYLNLVLDYVPETVYRVA---RHYSRAKQ-----------------TL--PVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL-------------------KLCDFGSAKQ-------LVRGEPN--VS---YICSRYYRAPELIF--GATDYTSSIDVWSAGCVLAELLL-GQPI---------------FP-GD-----------SGVDQLVEI-IKVLGTPTREQIREMNPNYTEFKFPQIKAH---------------PWTKVFRPRTPPEAIA-LCSRLLEYTPTARLT-----PL-EACAHSFF--------------
----LKLEKKLGAGQFGEVWMATY---N---------KHTKVAVKTMK-P--G-SM----SV--E-A-FL-A------EANVMKTL--Q---HDK----LVKLHAVVT-----------KEP--IY--IITEFMAKG--SLLDFLK-----SD--------------EGSKQ--PLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVS-ASLVC-------------------KIADFGLARVI------E--DNEY--TAREGAKFPIKWTAPEAIN---FGSFTIKSDVWSFGILLMEIVTYGRIP---------------YP-GM-----------SNPEVIRAL-ERGYRMPRPENCP-------------------------------------------EELYN-IMMRCWKNRPEERPT-----FE-YIQSV--L--------------
-VGG----NKMGEGGFGVVYKGYV---N-------N-TT--VAVKKLAAM--V-DIT---TE--ELK-QQFD-----QEIKVMAKC--Q---HEN----LVELLGFSS--D--------GDD--LC--LVYVYMPNG--SLLDRLSC-LDGTP-----------------PL--SWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLD-EAFTA-------------------KISDFGLARASE----KFAQTVMT--SR---IVGTTAYMAPEALR----GEITPKSDIYSFGVVLLEIIT-GLPA---------------VD-EH-----------REPQLLLDI-KEEIEDEEKTIEDYIDKKMNDAD-----------------------------STSVEAMYS-VASQCLHEKKNKRPD-----IK-KVQQ----LLQ-----------
---L-KRIRDLGEGHFGKVELCRY---DP---EGDN-TGEQVAVKSLK-P--E-SG----GNHIA-D-LK-K------EIEILRNL--Y---HEN----IVKYKGICT-ED---------GGNGIK--LIMEFLPSG--SLKEYLP-----KN---------------KNKI--NLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVE-SEHQV-------------------KIGDFGLTKAI--ET--D--KEYY--TVKDDRDSPVFWYAPECLM---QSKFYIASDVWSFGVTLHELLTYCDSDSSPMALF-LKMIGPTHG-QM-----------TVTRLVNTL-KEGKRLPCPPNCP-------------------------------------------DEVYQ-LMRKCWEFQPSNRTS-----FQ-NLIE---GF-------------
----LKFLQQLGKGNFGSVEMCRY---DP---LQDN-TGEVVAVKKLQ-H--S-TE-----EHLR-D-FE-R------EIEILKSL--Q---HDN----IVKYKGVCYSAG--------RRN--LK--LIMEYLPYG--SLRDYLQ-----KH---------------KERI--DHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVE-NENRV-------------------KIGDFGLTKVL--PQ--D--KEYY--KVKEPGESPIFWYAPESLT---ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQG-QM-----------IVFHLIELL-KNNGRLPRPDGCP-------------------------------------------DEIYM-IMTECWNNNVNQRPS-----FR-DLA----LRV------------
---L-KYISQLGKGNFGSVELCRY---DP---LGDN-TGALVAVKQLQ-H--S-GP----DQ-QR-D-FQ-R------EIQILKAL--H---SDF----IVKYRGVSYGPG--------RQS--LR--LVMEYLPSG--CLRDFLQ-----RH---------------RARL--DASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVE-SEAHV-------------------KIADFGLAKLL--PL--D--KDYY--VVREPGQSPIFWYAPESLS---DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCER-DV-P---------ALCRLLELL-EEGQRLPAPPACP-------------------------------------------AEVHE-LMKLCWAPSPQDRPS-----FS-ALGP---QL-------------
----LKLVERLGAGQFGEVWMGYY---N---------GHTKVAVKSLK-Q--G-SM----SP--D-A-FL-A------EANLMKQL--Q---HQR----LVRLYAVVT-----------QEP--IY--IITEYMENG--SLVDFLK-----TP--------------SGIKL--TINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSC-------------------KIADFGLARLI------E--DNEY--TAREGAKFPIKWTAPEAIN---YGTFTIKSDVWSFGILLTEIVTHGRIP---------------YP-GM-----------TNPEVIQNL-ERGYRMVRPDNCP-------------------------------------------EELYQ-LMRLCWKERPEDRPT-----FD-YLRSV--L--------------
----IKLVKRLGAGQFGEVWMGYY---N---------NSTKVAVKTLK-P--G-TM----SV--Q-A-FL-E------EANLMKTL--Q---HDK----LVRLYAVVT--R--------EEP--IY--IITEYMAKG--SLLDFLK-----SD--------------EGGKV--LLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVS-ESLMC-------------------KIADFGLARVI------E--DNEY--TAREGAKFPIKWTAPEAIN---FGCFTIKSDVWSFGILLYEIVTYGKIP---------------YP-GR-----------TNADVMTAL-SQGYRMPRVENCP-------------------------------------------DELYD-IMKMCWKEKAEERPT-----FD-YLQSV--L--------------
----YQNLKPIGSGAQGIVCAAYD---A-------V-LDRNVAIKKLSRP--F-QNQ---TH--A-K-RAYR------ELVLMKCV--N---HKN----IISLLNVFT--PQKT--LEEFQD--VY--LVMELMDA---NLCQVIQ------M-----------------EL--DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL-------------------KILDFGLART-------AGTSFMM--TP---YVVTRYYRAPEVIL---GMGYKENVDIWSVGCIMGEMVR-HKIL---------------FP-GR-----------DYIDQWNKV-IEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPK--LFPDSLFPADSEHNKLKASQARD-LLSKMLVIDPAKRIS-----VD-DALQHPYI--------------
----YQNLSPVGSGAYGSVCAAFD---T-------K-TGLRVAVKKLSRP--F-QSI---IH--A-K-RTYR------ELRLLKHM--K---HEN----VIGLLDVFT--PARS--LEEFND--VY--LVTHLMGA---DLNNIVK-----CQ-----------------KL--TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCEL-------------------KILDFGLAR---------HTDDEM--TG---YVATRWYRAPEIML--NWMHYNQTVDIWSVGCIMAELLT-GRTL---------------FP-GT-----------DHIDQLKLI-LRLVGTPGAELLKKISSESARNYIQSLTQMP-------------KMNFANVFIGANPLAVD-LLEKMLVLDSDKRIT-----AA-QALAHAYF--------------
----YQNLKPIGSGAQGIVCAAYD---A-------I-LERNVAIKKLSRP--F-QNQ---TH--A-K-RAYR------ELVLMKCV--N---HKN----IIGLLNVFT--PQKS--LEEFQD--VY--IVMELMDA---NLCQVIQ------M-----------------EL--DHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL-------------------KILDFGLART-------AGTSFMM--TP---YVVTRYYRAPEVIL---GMGYKENVDLWSVGCIMGEMVC-HKIL---------------FP-GR-----------DYIDQWNKV-IEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEK--LFPDVLFPADSEHNKLKASQARD-LLSKMLVIDASKRIS-----VD-EALQHPYI--------------
----VHFNEVIGRGHFGCVYHGTL---L----DNDG-KKIHCAVKSLN-R--I-TD----IGEVS-Q-FL-T------EGIIMKDF--S---HPN----VLSLLGICL-RS--------EGS--PL--VVLPYMKHG--DLRNFIR-----NE---------------THNP--TVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLD-EKFTV-------------------KVADFGLARDM---Y--D--KEYYSVHNKTGAKLPVKWMALESLQ---TQKFTTKSDVWSFGVLLWELMTRGAPP---------------YP-DV-----------NTFDITVYL-LQGRRLLQPEYCP-------------------------------------------DPLYE-VMLKCWHPKAEMRPS-----FS-ELVSR--I--------------
---F-KFGKILGEGSFSTVVLARE---L-------A-TSREYAIKILEKR--H-IIK---EN--K-VPYVTR------ERDVMSRL--D---HPF----FVKLYFTFQ--D--------DEK--LY--FGLSYAKNG--ELLKYIR----KIG-----------------SF--DETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLN-EDMHI-------------------QITDFGTAKVLS----PESKQARA--NS---FVGTAQYVSPELLT---EKSACKSSDLWALGCIIYQLVA-GLPP---------------FR-AG--------------NEYLIF-QKIIKLEYDFPEKFF-----------------------------------------PKARD-LVEKLLVLDATKRLG-----CE-EM------EGYGPLKAHPF---
--YV--RGRFLGKGGFAKCFEISD---A-------D-TKEVFAGKIVPKS--L-LLK---PH--Q-R-EKMS-----MEISIHRSL--A---HQH----VVGFHGFFE--D--------NDF--VF--VVLELCRRR--SLLELHK----RRK-----------------AL--TEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLN-EDLEV-------------------KIGDFGLATKV------EYDGERK--KT---LCGTPNYIAPEVLS---KKGHSFEVDVWSIGCIMYTLLV-GKPP---------------FE-TS--------------CLKETY-LRIKKNEYSIPKHIN-----------------------------------------PVAAS-LIQKMLQTDPTARPT-----IN-ELLNDEFF--------------
--YL--KGRLLGKGGFARCYEATD---T-------E-TGSAYAVKVIPQS--R-VAK---PH--Q-R-EKIL-----NEIELHRDL--Q---HRH----IVRFSHHFE--D--------ADN--IY--IFLELCSRK--SLAHIWK----ARH-----------------TL--LEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFIT-ENMEL-------------------KVGDFGLAARL------EPPEQRK--KT---ICGTPNYVAPEVLL---RQGHGPEADVWSLGCVMYTLLC-GSPP---------------FE-TA--------------DLKETY-RCIKQVHYTLPASLS-----------------------------------------LPARQ-LLAAILRASPRDRPS-----ID-QILRHDFF--------------
---F-NFLMVLGKGSFGKVMLADR---K-------G-TEELYAIKILKKD--V-VIQ---DD--D-V-ECTM-----VEKRVLALL-DK---PPF----LTQLHSCFQ--T--------VDR--LY--FVMEYVNGG--DLMYHIQ----QVG-----------------KF--KEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLD-SEGHI-------------------KIADFGMCKEH------MMDGVTT--RT---FCGTPDYIAPEIIA---YQPYGKSVDWWAYGVLLYEMLA-GQPP---------------FD-GE--------------DEDELF-QSIMEHNVSYPKSLS-----------------------------------------KEAVS-VCKGLMTKHPAKRLG-----C----------GPEGERDVREHAFF
--FI--FHKVLGKGSFGKVLLGEL---K-------G-RGEYFAIKALKKD--V-VLI---DD--D-V-ECTM-----VEKRVLTLA-AE---NPF----LTHLICTFQ--T--------KDH--LF--FVMEFLNGG--DLMYHIQ----DKG-----------------RF--ELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLD-RDGHI-------------------KIADFGMCKEN------IFGESRA--ST---FCGTPDYIAPEILQ---GLKYTFSVDWWSFGVLLYEMLI-GQSP---------------FH-GD--------------DEDELF-ESIRVDTPHYPRWIT-----------------------------------------KESKD-ILEKLFEREPTKRLG----VTG-NIKIHPFF--------------
--FI--LHKMLGKGSFGKVFLAEF---K-------K-TNQFFAIKALKKD--V-VLM---DD--D-V-ECTM-----VEKRVLSLA-WE---HPF----LTHMFCTFQ--T--------KEN--LF--FVMEYLNGG--DLMYHIQ----SCH-----------------KF--DLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLD-KDGHI-------------------KIADFGMCKEN------MLGDAKT--NT---FCGTPDYIAPEILL---GQKYNHSVDWWSFGVLLYEMLI-GQSP---------------FH-GQ--------------DEEELF-HSIRMDNPFYPRWLE-----------------------------------------KEAKD-LLVKLFVREPEKRLG-----VRGDIRQHPLF--------------
---F-TLCRKLGSGYFGEVFEGLW---K---------DRVQVAIKVIS-R--D-NL----LH-QQ-M-LQ-S------EIQAMKKL--R---HKH----ILALYAVVS--V--------GDP--VY--IITELMAKG--SLLELLR-----DS--------------DEKVL--PVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVG-ENTLC-------------------KVGDFGLARLI---------KEDV--YLSHDHNIPYKWTAPEALS---RGHYSTKSDVWSFGILLHEMFSRGQVP---------------YP-GM-----------SNHEAFLRV-DAGYRMPCPLECP-------------------------------------------PSVHK-LMLTCWCRDPEQRPC-----FK-ALRERL----------------
----FELLRVLGKGGYGKVFQVRKVTGA-------N-TGKIFAMKVLKKA--M-IVR---NA--K-D-TAHTK----AERNILEEV--K---HPF----IVDLIYAFQ--T--------GGK--LY--LILEYLSGG--ELFMQLE----REG-----------------IF--MEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLN-HQGHV-------------------KLTDFGLCKES------IHDGTVT--HT---FCGTIEYMAPEILM---RSGHNRAVDWWSLGALMYDMLT-GAPP---------------FT-GE--------------NRKKTI-DKILKCKLNLPPYLT-----------------------------------------QEARD-LLKKLLKRNAASRLGAGPGDAG-EVQAHPFF--------------
---L-RLEVKLGQGCFGEVWMGTW---N---------GTTRVAIKTLK-P--G-TM----SP--E-A-FL-Q------EAQVMKKL--R---HEK----LVQLYAVVS-----------EEP--IY--IVTEYMSKG--SLLDFLK-----GE--------------TGKYL--RLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG-ENLVC-------------------KVADFGLARLI------E--DNEY--TARQGAKFPIKWTAPEAAL---YGRFTIKSDVWSFGILLTELTTKGRVP---------------YP-GM-----------VNREVLDQV-ERGYRMPCPPECP-------------------------------------------ESLHD-LMCQCWRKEPEERPT-----FE-YLQAF--L--------------
--FA--LGRKLGEGYFGEVWEGLW---L---------GSLPVAIKVIK-S--A-NM----K--LT-D-LA-K------EIQTLKGL--R---HER----LIRLHAVCS--G--------GEP--VY--IVTELMRKG--NLQAFLG-----TP--------------EGRAL--RLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVD-DGLAC-------------------KVADFGLARLL------K--DDIY--SPSSSSKIPVKWTAPEAAN---YRVFSQKSDVWSFGVLLHEVFTYGQCP---------------YE-GM-----------TNHETLQQI-MRGYRLPRPAACP-------------------------------------------AEVYV-LMLECWRSSPEERPS-----FA-TLREKL----------------
---L-RLLEKLGDGSFGVVRRGEW---D----APSG-KTVSVAVKCLK-PDVL-SQ----PEAMD-D-FI-R------EVNAMHSL--D---HRN----LIRLYGVVL-----------TPP--MK--MVTELAPLG--SLLDRLR-----KH---------------QGHF--LLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLA-TRDLV-------------------KIGDFGLMRAL--PQ--N--DDHY--VMQEHRKVPFAWCAPESLK---TRTFSHASDTWMFGVTLWEMFTYGQEP---------------WI-GL-----------NGSQILHKIDKEGERLPRPEDCP-------------------------------------------QDIYN-VMVQCWAHKPEDRPT-----FV-ALRDF--L--------------
---L-RLEVKLGQGCFGEVWMGTW---N---------GTTKVAIKTLK-P--G-TM----MP--E-A-FL-Q------EAQIMKKL--R---HDK----LVPLYAVVS-----------EEP--IY--IVTEFMSKG--SLLDFLK-----EG--------------DGKYL--KLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVG-ENLVC-------------------KIADFGLARLI------E--DNEY--TARQGAKFPIKWTAPEAAL---YGRFTIKSDVWSFGILQTELVTKGRVP---------------YP-GM-----------VNREVLEQV-ERGYRMPCPQGCP-------------------------------------------ESLHE-LMNLCWKKDPDERPT-----FE-YIQSFL----------------
LIAD----IELGCGNFGSVRQGVY---R-----MRK-KQIDVAIKVLK-Q--G-TE----KADTE-E-MM-R------EAQIMHQL--D---NPY----IVRLIGVCQ-----------AEA--LM--LVMEMAGGG--PLHKFLV-----GK---------------REEI--PVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLV-NRHYA-------------------KISDFGLSKAL--GA--D--DSYY--TARSAGKWPLKWYAPECIN---FRKFSSRSDVWSYGVTMWEALSYGQKP---------------YK-KM-----------KGPEVMAFI-EQGKRMECPPECP-------------------------------------------PELYA-LMSDCWIYKWEDRPD-----FL-TVEQR--M--------------
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