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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
TK ABL1 261
AGC AKT1 150
Other AURKA 133
Other AURKB 77
TK BLK 241
CMGC CDC2 4
CMGC CDK4 6
CAMK CHEK1 9
CMGC CSNK2A1 39
TK FGFR1 478
TK FYN 271
CMGC GSK3B 56
TK HCK 241
TKL IRAK4 186
TK ITK 363
TK JAK2 849
TK JAK3 822
TK LCK 245
TK LYN 247
CMGC MAPK1 13
CMGC MAPK10 64
CMGC MAPK14 24
CMGC MAPK8 26
TK MET 1078
Other PLK1 53
AGC PRKCA 339
AGC PRKCB 342
AGC ROCK1 76
AGC ROCK2 92
AGC RPS6KA1 62
TK SRC 270
TK TNK2 150
TK YES1 277
TKL ZAK 16
---FQKVEKIGEGTYGVV---YKARNK-------LTGEVVALKKIRLD--T-ETE---GV--P-STAIR-EISLLKEL--N---HPNIVKLLDVIH--T------ENKLY--LVFEFLHQ---DLKKFMDA--SALT-----------------GIPLPLIKSYLFQLLQGLAFCHS-H---RVLHRDLKPQNLLIN-TEGAIKLADFGLARAF-----GVPVRTY--TH---EVVTLWYRAPEILL---GCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FP-GD-SEIDQLFRI-FRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRS-LLSQMLHYDPNK--RIS-----AKAALAHPFF--------------
---ITMKHKLGGGQYGEV---YEGVWK-------KYSLTVAVKTLK-E--D-TM----EV--E-EFL-K-EAAVMKEI--K---HPNLVQLLGVCT--R------EPPFY--IITEFMTYG--NLLDYLR-----EC--------------NRQEVNAVVLLYMATQISSAMEYLEK-K---NFIHRDLAARNCLVG-ENHLVKVADFGLSRLM-----T--GDTY--TAHAGAKFPIKWTAPESLA----YNKFSIKSDVWAFGVLLWEIATYGMSP---------------YP-GI-DLSQVYELL-EKDYRMERPEGCP-----------------------------------------EKVYE-LMRACWQWNPSD--RPS-----FAEIHQA--F--------------
--F-EYLKLLGKGTFGKV---ILVKEK-------ATGRYYAMKILKKE--V-IVA---KD--E-VAHTLTENRVLQNS--R---HPFLTALKYSFQ--T------HDRLC--FVMEYANGG--ELFFHLS----RER-----------------VFSEDRARFYGAEIVSALDYLHSEK---NVVYRDLKLENLMLD-KDGHIKITDFGLCKEG-----IKDGATM--KT---FCGTPEYLAPEVLE----DNDYGRAVDWWGLGVVMYEMMC-GRLP---------------FY-NQ----DHEKLF-ELILMEEIRFPRTLG---------------------------------------PEAKS-LLSGLLKKDPKQ--RLGGGSEDAKEIMQHRFF--------------
---FEIGRPLGKGKFGNV---YLAREK-------QSKFILALKVLFKA--QLEKA---GV--E-HQLRR-EVEIQSHL--R---HPNILRLYGYFH--D------ATRVY--LILEYAPLG--TVYRELQ----KLS-----------------KFDEQRTATYITELANALSYCHS-K---RVIHRDIKPENLLLG-SAGELKIADFGWSV-------HAPSSRR--TT---LCGTLDYLPPEMIE----GRMHDEKVDLWSLGVLCYEFLV-GKPP---------------FE-AN----TYQETY-KRISRVEFTFPDFVT---------------------------------------EGARD-LISRLLKHNPSQ--RPM-----LREVLEHPWI--------------
---FEIGRPLGKGKFGNV---YLAREK-------KSHFIVALKVLFKS--Q-IEK---EG--V-EHQLRREIEIQAHL--H---HPNILRLYNYFY--D------RRRIY--LILEYAPRG--ELYKELQ----KSC-----------------TFDEQRTATIMEELADALMYCHG-K---KVIHRDIKPENLLLG-LKGELKIADFGWSV-------HAPSLRR--KT---MCGTLDYLPPEMIE----GRMHNEKVDLWCIGVLCYELLV-GNPP---------------FE-SA----SHNETY-RRIVKVDLKFPASVP---------------------------------------MGAQD-LISKLLRHNPSE--RLP-----LAQVSAHPWV--------------
--L-RLVRKLGSGQFGEV---WMGYYK--------NNMKVAIKTLK-E--G-TM----SP--E-AFL-G-EANVMKAL--Q---HERLVRLYAVVT---------KEPIY--IVTEYMARG--CLLDFLK-----TD--------------EGSRLSLPRLIDMSAQIAEGMAYIER-M---NSIHRDLRAANILVS-EALCCKIADFGLARII--------DSEY--TAQEGAKFPIKWTAPEAIH----FGVFTIKADVWSFGVLLMEVVTYGRVP---------------YP-GM-SNPEVIRNL-ERGYRMPRPDTCP-----------------------------------------PELYRGVIAECWRSRPEE--RPT-----FEFLQSV--L--------------
---YTKIEKIGEGTYGVV---YKGRHK-------TTGQVVAMKKIRLE--S-EEE---GV--P-STAIR-EISLLKEL--R---HPNIVSLQDVLM--Q------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ-----------------YMDSSLVKSYLYQILQGIVFCHS-R---RVLHRDLKPQNLLID-DKGTIKLADFGLARAF-----GIPIRVY--TH---EVVTLWYRSPEVLL---GSARYSTPVDIWSIGTIFAELAT-KKPL---------------FH-GD-SEIDQLFRI-FRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------GSLASHVKNLDENGLD-LLSKMLIYDPAK--RIS-----GKMALNHPYF--------------
--Y-EPVAEIGVGAYGTV---YKARDP-------HSGHFVALKSVRVP--N-GGGGGGGL--P-ISTVR-EVALLRRL--EAFEHPNVVRLMDVCA--TSR-TDREIKVT--LVFEHVDQ---DLRTYLDK--APPP-----------------GLPAETIKDLMRQFLRGLDFLHA-N---CIVHRDLKPENILVT-SGGTVKLADFGLARI------YSYQMAL--TP---VVVTLWYRAPEVLL----QSTYATPVDMWSVGCIFAEMFR-RKPL---------------FC-GN-SEADQLGKI-FDLIGLPPEDDWPRDVSLPRGAFPPRGPR---------------PVQSVVPEMEESGAQ-LLLEMLTFNPHK--RIS-----AFRALQHSYL--------------
--W-DLVQTLGEGAYGEV---QLAVNR-------VTEEAVAVKIVDMK--R-AVD---CP--E-NI-KK-EICINKML--N---HENVVKFYGHRR--E------GNIQY--LFLEYCSGG--ELFDRIE----PDI-----------------GMPEPDAQRFFHQLMAGVVYLHG-I---GITHRDIKPENLLLD-ERDNLKISDFGLATVFR---YNNRERLL--NK---MCGTLPYVAPELLK---RREFHAEPVDVWSCGIVLTAMLA-GELP---------------WD-QP---SDSCQEY-SDWKEKKTYLNPWKKI--D-----------------------------------SAPLA-LLHKILVENPSA--RIT-----IPDIKKDRW-Y-------------
---YQLVRKLGRGKYSEV---FEAINI-------TNNEKVVVKILKPV--K-KKK---IK--R-------EIKILENL-RG---GPNIITLADIVK--DP----VSRTPA--LVFEHVNNT--DFKQLY-------Q-----------------TLTDYDIRFYMYEILKALDYCHS-M---GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF------YHPGQEY--NV---RVASRYFKGPELLV---DYQMYDYSLDMWSLGCMLASMIF-RKEP---------------FFHGH-DNYDQLVRI-AKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK-----RWERFVHSENQHLVSPEALD-FLDKLLRYDHQS--RLT-----AREAMEHPYF--------------
--L-VLGKPLGEGCFGQV---VLAEAIGLDKDKPNRVTKVAVKMLK-S--D-AT----EKDLS-DLI-S-EMEMMKMIG-K---HKNIINLLGACT--Q------DGPLY--VIVEYASKG--NLREYLQ-----ARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLAS-K---KCIHRDLAARNVLVT-EDNVMKIADFGLARDI--H--H--IDYY--KKTTNGRLPVKWMAPEALF----DRIYTHQSDVWSFGVLLWEIFTLGGSP---------------YP-GV-PVEELFKLL-KEGHRMDKPSNCT-----------------------------------------NELYM-MMRDCWHAVPSQ--RPT-----FKQLVEDL----------------
---LQLIKRLGNGQFGEV---WMGTWN--------GNTKVAIKTLK-P--G-TM----SP--E-SFL-E-EAQIMKKL--K---HDKLVQLYAVVS---------EEPIY--IVTEYMNKG--SLLDFLK-----DG--------------EGRALKLPNLVDMAAQVAAGMAYIER-M---NYIHRDLRSANILVG-NGLICKIADFGLARLI-----E--DNEY--TARQGAKFPIKWTAPEAAL----YGRFTIKSDVWSFGILLTELVTKGRVP---------------YP-GM-NNREVLEQV-ERGYRMPCPQDCP-----------------------------------------ISLHE-LMIHCWKKDPEE--RPT-----FEYLQSFL----------------
---YTDTKVIGNGSFGVV---YQAKLC-------DSGELVAIKKVLQD--K-RFK---NR----------ELQIMRKL--D---HCNIVRLRYFFY--SSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ-----------------TLPVIYVKLYMYQLFRSLAYIHS-F---GICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ------LVRGEPN--VS---YICSRYYRAPELIF---GATDYTSSIDVWSAGCVLAELLL-GQPI---------------FP-GD-SGVDQLVEI-IKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIA-LCSRLLEYTPTA--RLT-----PLEACAHSFF--------------
---LKLEKKLGAGQFGEV---WMATYN--------KHTKVAVKTMK-P--G-SM----SV--E-AFL-A-EANVMKTL--Q---HDKLVKLHAVVT---------KEPIY--IITEFMAKG--SLLDFLK-----SD--------------EGSKQPLPKLIDFSAQIAEGMAFIEQ-R---NYIHRDLRAANILVS-ASLVCKIADFGLARVI-----E--DNEY--TAREGAKFPIKWTAPEAIN----FGSFTIKSDVWSFGILLMEIVTYGRIP---------------YP-GM-SNPEVIRAL-ERGYRMPRPENCP-----------------------------------------EELYN-IMMRCWKNRPEE--RPT-----FEYIQSV--L--------------
VGG----NKMGEGGFGVV---YKGYVN-------NTT--VAVKKLAAM--V-DIT---TE--ELKQQFDQEIKVMAKC--Q---HENLVELLGFSS--D------GDDLC--LVYVYMPNG--SLLDRLSC-LDGTP-----------------PLSWHMRCKIAQGAANGINFLHE-N---HHIHRDIKSANILLD-EAFTAKISDFGLARASE---KFAQTVMT--SR---IVGTTAYMAPEALR-----GEITPKSDIYSFGVVLLEIIT-GLPA---------------VD-EH-REPQLLLDI-KEEIEDEEKTIEDYIDKKMNDAD---------------------------STSVEAMYS-VASQCLHEKKNK--RPD-----IKKVQQ----LLQ-----------
---LTFVQEIGSGQFGLV---HLGYWL--------NKDKVAIKTIR-E--G-AM----SE--E-DFI-E-EAEVMMKL--S---HPKLVQLYGVCL--E------QAPIC--LVFEFMEHG--CLSDYLR-----TQ---------------RGLFAAETLLGMCLDVCEGMAYLEE-A---CVIHRDLAARNCLVG-ENQVIKVSDFGMTRFV-----L--DDQY--TSSTGTKFPVKWASPEVFS----FSRYSSKSDVWSFGVLMWEVFSEGKIP---------------YE-NR-SNSEVVEDI-STGFRLYKPRLAS-----------------------------------------THVYQ-IMNHCWKERPED--RPA-----FSRLLRQL----------------
---LKFLQQLGKGNFGSV---EMCRYDP---LQDNTGEVVAVKKLQ-H--S-TE-----EHLR-DFE-R-EIEILKSL--Q---HDNIVKYKGVCYSAG------RRNLK--LIMEYLPYG--SLRDYLQ-----KH---------------KERIDHIKLLQYTSQICKGMEYLGT-K---RYIHRDLATRNILVE-NENRVKIGDFGLTKVL-PQ--D--KEYY--KVKEPGESPIFWYAPESLT----ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQG-QM-IVFHLIELL-KNNGRLPRPDGCP-----------------------------------------DEIYM-IMTECWNNNVNQ--RPS-----FRDLA----LRV------------
--L-KYISQLGKGNFGSV---ELCRYDP---LGDNTGALVAVKQLQ-H--S-GP----DQ-QR-DFQ-R-EIQILKAL--H---SDFIVKYRGVSYGPG------RQSLR--LVMEYLPSG--CLRDFLQ-----RH---------------RARLDASRLLLYSSQICKGMEYLGS-R---RCVHRDLAARNILVE-SEAHVKIADFGLAKLL-PL--D--KDYY--VVREPGQSPIFWYAPESLS----DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCER-DVPALCRLLELL-EEGQRLPAPPACP-----------------------------------------AEVHE-LMKLCWAPSPQD--RPS-----FSALGP---QL-------------
---LKLVERLGAGQFGEV---WMGYYN--------GHTKVAVKSLK-Q--G-SM----SP--D-AFL-A-EANLMKQL--Q---HQRLVRLYAVVT---------QEPIY--IITEYMENG--SLVDFLK-----TP--------------SGIKLTINKLLDMAAQIAEGMAFIEE-R---NYIHRDLRAANILVS-DTLSCKIADFGLARLI-----E--DNEY--TAREGAKFPIKWTAPEAIN----YGTFTIKSDVWSFGILLTEIVTHGRIP---------------YP-GM-TNPEVIQNL-ERGYRMVRPDNCP-----------------------------------------EELYQ-LMRLCWKERPED--RPT-----FDYLRSV--L--------------
---IKLVKRLGAGQFGEV---WMGYYN--------NSTKVAVKTLK-P--G-TM----SV--Q-AFL-E-EANLMKTL--Q---HDKLVRLYAVVT--R------EEPIY--IITEYMAKG--SLLDFLK-----SD--------------EGGKVLLPKLIDFSAQIAEGMAYIER-K---NYIHRDLRAANVLVS-ESLMCKIADFGLARVI-----E--DNEY--TAREGAKFPIKWTAPEAIN----FGCFTIKSDVWSFGILLYEIVTYGKIP---------------YP-GR-TNADVMTAL-SQGYRMPRVENCP-----------------------------------------DELYD-IMKMCWKEKAEE--RPT-----FDYLQSV--L--------------
---YTNLSYIGEGAYGMV---CSAYDN-------VNKVRVAIKKISPF--E-HQT---YC--Q-RT-LR-EIKILLRF--R---HENIIGINDIIR--APT-IEQMKDVY--IVQDLMET---DLYKLLK-----TQ-----------------HLSNDHICYFLYQILRGLKYIHS-A---NVLHRDLKPSNLLLN-TTCDLKICDFGLARVAD--PDHDHTGFL--TE---YVATRWYRAPEIML---NSKGYTKSIDIWSVGCILAEMLS-NRPI---------------FP-GK-HYLDQLNHI-LGILGSPSQEDLNCIINLKARNYLLSLPHKN-----------KVPWNRLFPNADSKALD-LLDKMLTFNPHK--RIE-----VEQALAHPYL--------------
---YQNLKPIGSGAQGIV---CAAYDA-------VLDRNVAIKKLSRP--F-QNQ---TH--A-KRAYR-ELVLMKCV--N---HKNIISLLNVFT--PQKTLEEFQDVY--LVMELMDA---NLCQVIQ------M-----------------ELDHERMSYLLYQMLCGIKHLHS-A---GIIHRDLKPSNIVVK-SDCTLKILDFGLART------AGTSFMM--TP---YVVTRYYRAPEVIL----GMGYKENVDIWSVGCIMGEMVR-HKIL---------------FP-GR-DYIDQWNKV-IEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARD-LLSKMLVIDPAK--RIS-----VDDALQHPYI--------------
---YQNLSPVGSGAYGSV---CAAFDT-------KTGLRVAVKKLSRP--F-QSI---IH--A-KRTYR-ELRLLKHM--K---HENVIGLLDVFT--PARSLEEFNDVY--LVTHLMGA---DLNNIVK-----CQ-----------------KLTDDHVQFLIYQILRGLKYIHS-A---DIIHRDLKPSNLAVN-EDCELKILDFGLAR--------HTDDEM--TG---YVATRWYRAPEIML---NWMHYNQTVDIWSVGCIMAELLT-GRTL---------------FP-GT-DHIDQLKLI-LRLVGTPGAELLKKISSESARNYIQSLTQMP-----------KMNFANVFIGANPLAVD-LLEKMLVLDSDK--RIT-----AAQALAHAYF--------------
---YQNLKPIGSGAQGIV---CAAYDA-------ILERNVAIKKLSRP--F-QNQ---TH--A-KRAYR-ELVLMKCV--N---HKNIIGLLNVFT--PQKSLEEFQDVY--IVMELMDA---NLCQVIQ------M-----------------ELDHERMSYLLYQMLCGIKHLHS-A---GIIHRDLKPSNIVVK-SDCTLKILDFGLART------AGTSFMM--TP---YVVTRYYRAPEVIL----GMGYKENVDLWSVGCIMGEMVC-HKIL---------------FP-GR-DYIDQWNKV-IEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARD-LLSKMLVIDASK--RIS-----VDEALQHPYI--------------
---VHFNEVIGRGHFGCV---YHGTLL----DNDGKKIHCAVKSLN-R--I-TD----IGEVS-QFL-T-EGIIMKDF--S---HPNVLSLLGICL-RS------EGSPL--VVLPYMKHG--DLRNFIR-----NE---------------THNPTVKDLIGFGLQVAKGMKYLAS-K---KFVHRDLAARNCMLD-EKFTVKVADFGLARDM--Y--D--KEYYSVHNKTGAKLPVKWMALESLQ----TQKFTTKSDVWSFGVLLWELMTRGAPP---------------YP-DV-NTFDITVYL-LQGRRLLQPEYCP-----------------------------------------DPLYE-VMLKCWHPKAEM--RPS-----FSELVSR--I--------------
-YV--RGRFLGKGGFAKC---FEISDA-------DTKEVFAGKIVPKS--L-LLK---PH--Q-REKMSMEISIHRSL--A---HQHVVGFHGFFE--D------NDFVF--VVLELCRRR--SLLELHK----RRK-----------------ALTEPEARYYLRQIVLGCQYLHR-N---RVIHRDLKLGNLFLN-EDLEVKIGDFGLATKV-----EYDGERK--KT---LCGTPNYIAPEVLS----KKGHSFEVDVWSIGCIMYTLLV-GKPP---------------FE-TS----CLKETY-LRIKKNEYSIPKHIN---------------------------------------PVAAS-LIQKMLQTDPTA--RPT-----INELLNDEFF--------------
--F-NFLMVLGKGSFGKV---MLADRK-------GTEELYAIKILKKD--V-VIQ---DD--D-VECTMVEKRVLALL-DK---PPFLTQLHSCFQ--T------VDRLY--FVMEYVNGG--DLMYHIQ----QVG-----------------KFKEPQAVFYAAEISIGLFFLHK-R---GIIYRDLKLDNVMLD-SEGHIKIADFGMCKEH-----MMDGVTT--RT---FCGTPDYIAPEIIA----YQPYGKSVDWWAYGVLLYEMLA-GQPP---------------FD-GE----DEDELF-QSIMEHNVSYPKSLS---------------------------------------KEAVS-VCKGLMTKHPAK--RLG-----C---------GPEGERDVREHAFF
--F-NFLMVLGKGSFGKV---MLSERK-------GTDELYAVKILKKD--V-VIQ---DD--D-VECTMVEKRVLALP-GK---PPFLTQLHSCFQ--T------MDRLY--FVMEYVNGG--DLMYHIQ----QVG-----------------RFKEPHAVFYAAEIAIGLFFLQS-K---GIIYRDLKLDNVMLD-SEGHIKIADFGMCKEN-----IWDGVTT--KT---FCGTPDYIAPEIIA----YQPYGKSVDWWAFGVLLYEMLA-GQAP---------------FE-GE----DEDELF-QSIMEHNVAYPKSMS---------------------------------------KEAVA-ICKGLMTKHPGK--RLG-----C---------GPEGERDIKEHAFF
---YEVVKVIGRGAFGEV---QLVRHK-------STRKVYAMKLLSKF--E-MIK---RS--D-SAFFWEERDIMAFA--N---SPWVVQLFYAFQ--D------DRYLY--MVMEYMPGG--DLVNLMS-----NY-----------------DVPEKWARFYTAEVVLALDAIHS-M---GFIHRDVKPDNMLLD-KSGHLKLADFGTCMKM----NKEGMVRC--DT---AVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLV-GDTP---------------FY-AD----SLVGTY-SKIMNHKNSLTFPDDNDIS-----------------------------------KEAKN-LICAFLTDREVRLGRNG-----VEEIKRHLFF--------------
---YDVVKVIGRGAFGEV---QLVRHK-------ASQKVYAMKLLSKF--E-MIK---RS--D-SAFFWEERDIMAFA--N---SPWVVQLFYAFQ--D------DRYLY--MVMEYMPGG--DLVNLMS-----NY-----------------DVPEKWAKFYTAEVVLALDAIHS-M---GLIHRDVKPDNMLLD-KHGHLKLADFGTCMKM----DETGMVHC--DT---AVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLV-GDTP---------------FY-AD----SLVGTY-SKIMDHKNSLCFPEDAEIS-----------------------------------KHAKN-LICAFLTDREVRLGRNG-----VEEIRQHPFF--------------
---FELLKVLGQGSFGKVFLVRKVTRP-------DSGHLYAMKVLKKA--T-LKV---RD--R-VRTKM-ERDILADV--N---HPFVVKLHYAFQ--T------EGKLY--LILDFLRGG--DLFTRLS----KEV-----------------MFTEEDVKFYLAELALGLDHLHS-L---GIIYRDLKPENILLD-EEGHIKLTDFGLSKEA-----IDHEKKA--YS---FCGTVEYMAPEVVN----RQGHSHSADWWSYGVLMFEMLT-GSLP---------------FQ-GK----DRKETM-TLILKAKLGMPQFLS---------------------------------------TEAQS-LLRALFKRNPAN--RLGSGPDGAEEIKRHV--FY------------
--L-RLEVKLGQGCFGEV---WMGTWN--------GTTRVAIKTLK-P--G-TM----SP--E-AFL-Q-EAQVMKKL--R---HEKLVQLYAVVS---------EEPIY--IVTEYMSKG--SLLDFLK-----GE--------------TGKYLRLPQLVDMAAQIASGMAYVER-M---NYVHRDLRAANILVG-ENLVCKVADFGLARLI-----E--DNEY--TARQGAKFPIKWTAPEAAL----YGRFTIKSDVWSFGILLTELTTKGRVP---------------YP-GM-VNREVLDQV-ERGYRMPCPPECP-----------------------------------------ESLHD-LMCQCWRKEPEE--RPT-----FEYLQAF--L--------------
--L-RLLEKLGDGSFGVV---RRGEWD----APSGKTVSVAVKCLK-PDVL-SQ----PEAMD-DFI-R-EVNAMHSL--D---HRNLIRLYGVVL---------TPPMK--MVTELAPLG--SLLDRLR-----KH---------------QGHFLLGTLSRYAVQVAEGMGYLES-K---RFIHRDLAARNLLLA-TRDLVKIGDFGLMRAL-PQ--N--DDHY--VMQEHRKVPFAWCAPESLK----TRTFSHASDTWMFGVTLWEMFTYGQEP---------------WI-GL-NGSQILHKIDKEGERLPRPEDCP-----------------------------------------QDIYN-VMVQCWAHKPED--RPT-----FVALRDF--L--------------
--L-RLEVKLGQGCFGEV---WMGTWN--------GTTKVAIKTLK-P--G-TM----MP--E-AFL-Q-EAQIMKKL--R---HDKLVPLYAVVS---------EEPIY--IVTEFMSKG--SLLDFLK-----EG--------------DGKYLKLPQLVDMAAQIADGMAYIER-M---NYIHRDLRAANILVG-ENLVCKIADFGLARLI-----E--DNEY--TARQGAKFPIKWTAPEAAL----YGRFTIKSDVWSFGILQTELVTKGRVP---------------YP-GM-VNREVLEQV-ERGYRMPCPQGCP-----------------------------------------ESLHE-LMNLCWKKDPDE--RPT-----FEYIQSFL----------------
--L-QFFENCGGGSFGSV---YRAKWI-------SQDKEVAVKKL-----------------L-KIE-K-EAEILSVL--S---HRNIIQFYGVIL--E------PPNYG--IVTEYASLG--SLYDYIN-----SN--------------RSEEMDMDHIMTWATDVAKGMHYLHM-EAPVKVIHRDLKSRNVVIA-ADGVLKICDFGASRFH----------NH--TTHMSLVGTFPWMAPEVIQ----SLPVSETCDTYSYGVVLWEMLTR-EVP---------------FK-GL-EGLQVAWLVVEKNERLTIPSSCP-----------------------------------------RSFAE-LLHQCWEADAKK--RPS-----FKQIISIL----------------
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