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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
Other AURKA 133
CMGC CDC2 4
CMGC CDK4 6
CMGC GSK3A 119
CMGC GSK3B 56
TK LCK 245
CMGC MAPK1 13
CMGC MAPK10 64
CMGC MAPK14 24
-FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT-ETE---GVPSTAIREISLLKELN---HPNIVKLLDVIHT------ENKLY--LVFEFLHQ---DLKKFMDA--SALT---GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAF---GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
-FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKA---GVEHQLRREVEIQSHLR---HPNILRLYGYFHD------ATRVY--LILEYAPLG--TVYRELQ----KLS---KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGELKIADFGWSV-----HAPSSRRTT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN---TYQETYKRISRVEFTFPDFVT---------------------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI
-YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLES-EEE---GVPSTAIREISLLKELR---HPNIVSLQDVLMQ------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ---YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAF---GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF
Y-EPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPN-GGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSR-TDREIKVT--LVFEHVDQ---DLRTYLDK--APPP---GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTVKLADFGLARI----YSYQMALTP---VVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR---------------PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL
-YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDK-RFK---NR------ELQIMRKLD---HCNIVRLRYFFYSSG--EKKDELYLNLVLEYVPETVYRVARHFT---KAKL---TIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQ----LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF
-YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK-RFK---NR------ELQIMRKLD---HCNIVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ---TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ----LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF
-LKLVERLGAGQFGEVWMGYYN-GHTKVAVKSLK-QG-SM----SPDAFL-AEANLMKQLQ---HQRLVRLYAVVT-------QEPIY--IITEYMENG--SLVDFLK-----TPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSCKIADFGLARLI---E--DNEYTAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCP-----------------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L
-YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE-HQT---YCQRT-LREIKILLRFR---HENIIGINDIIRAPT-IEQMKDVY--IVQDLMET---DLYKLLK-----TQ---HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-TTCDLKICDFGLARVADPDHDHTGFLTE---YVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKN-----------KVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL
-YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPF-QNQ---THAKRAYRELVLMKCVN---HKNIISLLNVFTPQKTLEEFQDVY--LVMELMDA---NLCQVIQ------M---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLART----AGTSFMMTP---YVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI
-YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPF-QSI---IHAKRTYRELRLLKHMK---HENVIGLLDVFTPARSLEEFNDVY--LVTHLMGA---DLNNIVK-----CQ---KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLAR------HTDDEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------KMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF
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