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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
TK ABL1 261
Other AURKA 133
Other AURKB 77
Other CAMKK2 165
CMGC CDC2 4
CMGC CDK3 4
CMGC CDK4 6
CMGC CDK5 4
CMGC CDK6 13
CMGC CDK7 2.7.11.23
CMGC CDK9 2.7.11.23
CAMK CHEK1 9
CAMK CHEK2 220
Other CHUK 15
CMGC CLK1 161
CMGC CLK2 163
CMGC CLK4 159
CAMK DAPK1 13
CMGC DYRK1A 150
CMGC DYRK1B 111
TK FGR 263
TK FYN 271
CMGC GSK3B 56
TK HCK 241
TK JAK2 849
TK JAK3 822
TK LCK 245
CMGC MAPK1 13
CMGC MAPK10 64
CMGC MAPK14 24
CMGC MAPK15 13
CMGC MAPK3 42
TK MUSK 575
TK NTRK2 538
TK NTRK3 538
STE PAK4 321
STE PAK7 449
CMGC PCTK1 165
Other PLK1 53
Other PLK3 62
AGC ROCK2 92
STE SLK 34
TK SRC 270
TK TNK2 150
Other TTK 525
TK YES1 277
----FQKVEKIGEGTYGVVYKARNK-----L-T-GE-VVALKKIRLD--T-ETE---GV--PSTAIR-------------------------EISLLKEL-N-----HPN-----IVKLLDVIH--T--------ENKLY--LVFEFLHQ---DLKKFMDA--SALT-------------------------GI---PLPLIKSYLFQLLQGLAFCHS--HRVLHRDLKPQNLLIN--TEGAI-------------------KLADFGLARAF-------GVPVRTY--------------TH---EVVTLWYRAPEILL----------GCKY--YSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD-----------SEIDQLFRI-FRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-----------------------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNK--RISAKAALAHPFF---------
----ITMKHKLGGGQYGEVYEGVWK-----K-Y-SL-TVAVKTLK-E--D-TM----EV--EEFL-K-------------------------EAAVMKEI-K-----HPN-----LVQLLGVCT--R--------EPPFY--IITEFMTYG--NLLDYLR-----EC----------------------NRQEV---NAVVLLYMATQISSAMEYLEK--KNFIHRDLAARNCLVG--ENHLV-------------------KVADFGLSRLM-------T--GDTY--------------TAHAGAKFPIKWTAPESLA-----------YNK--FSIKSDVWAFGVLLWEIATYGMSP---------------YPGI-----------DLSQVYELL-EKDYRMERPEGCP---------------------------------------------------------------EKVYELMRACWQWNPSD--RPSFAEIHQA--F---------
----FEIGRPLGKGKFGNVYLAREK-----Q-S-KF-ILALKVLFKA--QLEKA---GV--EHQLRR-------------------------EVEIQSHL-R-----HPN-----ILRLYGYFH--D--------ATRVY--LILEYAPLG--TVYRELQ----KLS-------------------------KF---DEQRTATYITELANALSYCHS--KRVIHRDIKPENLLLG--SAGEL-------------------KIADFGWSV---------HAPSSRR--------------TT---LCGTLDYLPPEMIE-----------GRM--HDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN--------------TYQETY-KRISRVEFTFPDFVT-------------------------------------------------------------EGARDLISRLLKHNPSQ--RPMLREVLEHPWI---------
----FEIGRPLGKGKFGNVYLAREK-----K-S-HF-IVALKVLFKS--Q-IEK---EG--VEHQLR------------------------REIEIQAHL-H-----HPN-----ILRLYNYFY--D--------RRRIY--LILEYAPRG--ELYKELQ----KSC-------------------------TF---DEQRTATIMEELADALMYCHG--KKVIHRDIKPENLLLG--LKGEL-------------------KIADFGWSV---------HAPSLRR--------------KT---MCGTLDYLPPEMIE-----------GRM--HNEKVDLWCIGVLCYELLV-GNPP---------------FESA--------------SHNETY-RRIVKVDLKFPASVP-------------------------------------------------------------MGAQDLISKLLRHNPSE--RLPLAQVSAHPWV---------
----YTLKDEIGKGSYGVVKLAYNE-----N-D-NT-YYAMKVLSKK--K-LIR---QA--GFPR-RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKL-D-----HPN-----VVKLVEVLD--DP------NEDHLY--MVFELVNQG--PVMEVPT-----LK-------------------------PL---SEDQARFYFQDLIKGIEYLHY--QKIIHRDIKPSNLLVG--EDGHI-------------------KIADFGVSNEF-------KGSDALL--------------SN---TVGTPAFMAPESLS----------ETRKIFSGKALDVWAMGVTLYCFVF-GQCP---------------FMDE--------------RIMCLH-SKIKSQALEFPDQPDIA-----------------------------------------------------------EDLKDLITRMLDKNPES--RIVVPEIKLHPWV---------
----YTKIEKIGEGTYGVVYKGRHK-----T-T-GQ-VVAMKKIRLE--S-EEE---GV--PSTAIR-------------------------EISLLKEL-R-----HPN-----IVSLQDVLM--Q--------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ-------------------------YM---DSSLVKSYLYQILQGIVFCHS--RRVLHRDLKPQNLLID--DKGTI-------------------KLADFGLARAF-------GIPIRVY--------------TH---EVVTLWYRSPEVLL----------GSAR--YSTPVDIWSIGTIFAELAT-KKPL---------------FHGD-----------SEIDQLFRI-FRALGTPNNEVWPEVESLQDYKNTFPKWKP-----------------------------------GSLASHVKNLDENGLDLLSKMLIYDPAK--RISGKMALNHPYF---------
----FQKVEKIGEGTYGVVYKAKNR-----E-T-GQ-LVALKKIRLD--L-EME---GV--PSTAIR-------------------------EISLLKEL-K-----HPN-----IVRLLDVVH--N--------ERKLY--LVFEFLSQ---DLKKYMDS--TPGS-------------------------EL---PLHLIKSYLFQLLQGVSFCHS--HRVIHRDLKPQNLLIN--ELGAI-------------------KLADFGLARAF-------GVPLRTY--------------TH---EVVTLWYRAPEILL----------GSKF--YTTAVDIWSIGCIFAEMVT-RKAL---------------FPGD-----------SEIDQLFRI-FRMLGTPSEDTWPGVTQLPDYKGSFPKWTR-----------------------------------KGLEEIVPNLEPEGRDLLMQLLQYDPSQ--RITAKTALAHPYF---------
---Y-EPVAEIGVGAYGTVYKARDP-----H-S-GH-FVALKSVRVP--N-GGGGGGGL--PISTVR-------------------------EVALLRRL-EA--FEHPN-----VVRLMDVCA--TSR---TDREIKVT--LVFEHVDQ---DLRTYLDK--APPP-------------------------GL---PAETIKDLMRQFLRGLDFLHA--NCIVHRDLKPENILVT--SGGTV-------------------KLADFGLARI--------YSYQMAL--------------TP---VVVTLWYRAPEVLL-----------QST--YATPVDMWSVGCIFAEMFR-RKPL---------------FCGN-----------SEADQLGKI-FDLIGLPPEDDWPRDVSLPRGAFPPRGPR-------------------------------------PVQSVVPEMEESGAQLLLEMLTFNPHK--RISAFRALQHSYL---------
----YEKLEKIGEGTYGTVFKAKNR-----E-T-HE-IVALKRVRLD--D-DDE---GV--PSSALR-------------------------EICLLKEL-K-----HKN-----IVRLHDVLH--S--------DKKLT--LVFEFCDQ---DLKKYFD---SCNG-------------------------DL---DPEIVKSFLFQLLKGLGFCHS--RNVLHRDLKPQNLLIN--RNGEL-------------------KLADFGLARAF-------GIPVRCY--------------SA---EVVTLWYRPPDVLF----------GAKL--YSTSIDMWSAGCIFAELANAGRPL---------------FPGN-----------DVDDQLKRI-FRLLGTPTEEQWPSMTKLPDYKPYPMYPAT-----------------------------------TSLVNVVPKLNATGRDLLQNLLKCNPVQ--RISAEEALQHPYF---------
----YECVAEIGEGAYGKVFKARDL-----K-N-GGRFVALKRVRVQ--T-GEE---GM--PLSTIR-------------------------EVAVLRHL-ET--FEHPN-----VVRLFDVCT--VSR---TDRETKLT--LVFEHVDQ---DLTTYLDK--VPEP-------------------------GV---PTETIKDMMFQLLRGLDFLHS--HRVVHRDLKPQNILVT--SSGQI-------------------KLADFGLARI--------YSFQMAL--------------TS---VVVTLWYRAPEVLL-----------QSS--YATPVDLWSVGCIFAEMFR-RKPL---------------FRGS-----------SDVDQLGKI-LDVIGLPGEEDWPRDVALPRQAFHSKSAQ-------------------------------------PIEKFVTDIDELGKDLLLKCLTFNPAK--RISAYSALSHPYF---------
----YEKLDFLGEGQFATVYKARDK-----N-T-NQ-IVAIKKIKLG--H-RSE---AK--DGINRTA----------------------LREIKLLQEL-S-----HPN-----IIGLLDAFG--H--------KSNIS--LVFDFMET---DLEVIIK---DNSL-------------------------VL---TPSHIKAYMLMTLQGLEYLHQ--HWILHRDLKPNNLLLD--ENGVL-------------------KLADFGLAKSF-------GSPNRAY--------------TH---QVVTRWYRAPELLF----------GARM--YGVGVDMWAVGCILAELLL-RVPF---------------LPGD-----------SDLDQLTRI-FETLGTPTEEQWPDMCSLPDYVTFKSFPG------------------------------------IPLHHIFSAAGDDLLDLIQGLFLFNPCA--RITATQALKMKYF---------
----YEKLAKIGQGTFGEVFKARHR-----K-T-GQ-KVALKKVLME--N-EKE---GF--PITALR-------------------------EIKILQLL-K-----HEN-----VVNLIEICR--TKASPYNRCKGSIY--LVFDFCEH---DLAGLLS---NVLV-------------------------KF---TLSEIKRVMQMLLNGLYYIHR--NKILHRDMKAANVLIT--RDGVL-------------------KLADFGLARAFSL---AKNSQPNRY--------------TN---RVVTLWYRPPELLL----------GERD--YGPPIDLWGAGCIMAEMWT-RSPI---------------MQGN-----------TEQHQLALI-SQLCGSITPEVWPNVDNYELYEKLELVKGQK--------------------------------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQ--RIDSDDALNHDFF---------
---W-DLVQTLGEGAYGEVQLAVNR-----V-T-EE-AVAVKIVDMK--R-AVD---CP--ENI-KK-------------------------EICINKML-N-----HEN-----VVKFYGHRR--E--------GNIQY--LFLEYCSGG--ELFDRIE----PDI-------------------------GM---PEPDAQRFFHQLMAGVVYLHG--IGITHRDIKPENLLLD--ERDNL-------------------KISDFGLATVFR-----YNNRERLL--------------NK---MCGTLPYVAPELLK----------RREF--HAEPVDVWSCGIVLTAMLA-GELP---------------WDQP-------------SDSCQEY-SDWKEKKTYLNPWKKI--D---------------------------------------------------------SAPLALLHKILVENPSA--RITIPDIKKDRW-Y--------
--YI--MSKTLGSGACGEVKLAFER-----K-T-CK-KVAIKIISKR--K-FAI---GS--AREADPALN-------------------VETEIEILKKL-N-----HPC-----IIKIKNFF---D--------AEDYY--IVLELMEGG--ELFDKVV----GNK-------------------------RL---KEATCKLYFYQMLLAVQYLHE--NGIIHRDLKPENVLLS--SQEEDC----------------LIKITDFGHSKI--------LGETSLM--------------RT---LCGTPTYLAPEVLVS--------VGTAG--YNRAVDCWSLGVILFICLS-GYPP---------------FSEH-------------RTQVSLK-DQITSGKYNFIPEVWAEVS---------------------------------------------------------EKALDLVKKLLVVDPKA--RFTTEEALRHPWL---------
---W-EMRERLGTGGFGNVCLYQHR-----E-L-DL-KIAIKSCRLE--L-STK---NR--ER-WCH-------------------------EIQIMKKL-N-----HAN-----VVKACDVPE--ELN---ILIHDVPL--LAMEYCSGG--DLRKLLNK-PENCC-------------------------GL---KESQILSLLSDIGSGIRYLHE--NKIIHRDLKPENIVLQ--DVGGKI----------------IHKIIDLGYAKD--------VDQGSLC--------------TS---FVGTLQYLAPELFE-----------NKP--YTATVDYWSFGTMVFECIA-GYRP---------------FLHHLQPFTWHEKIKKKDPKCIFA-CEEMSGEVRFSSHLPQPNSLCS---------------------------------------------------LVVEPMENWLQLMLNWDPQQ--RG-----------GPVDLTLKQ
----YEIVDTLGEGAFGKVVECIDH-----K-AGGR-HVAVKIVKNV--D-RYC---EA--ARS----------------------------EIQVLEHL-NT---TDPNST-FRCVQMLEWFE--H--------HGHIC--IVFELLGL---STYDFIK----ENG-------------------------FLP-FRLDHIRKMAYQICKSVNFLHS--NKLTHTDLKPENILFV--QSDYTEAYNPKIKRDERTLINPDIKVVDFGSA----------TYDDEHH--------------ST---LVSTRHYRAPEVIL-----------ALG--WSQPCDVWSIGCILIEYYL-GFTV---------------FPTH-----------DSKEHLAMM-ERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRY--------------------VSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAK--RITLREALKHPFF---------
----YEIVSTLGEGTFGRVVQCVDH-----R-R-GGARVALKIIKNV--E-KYK---EA--AR---L-------------------------EINVLEKI-NEKDPDNKN----LCVQMFDWFD--Y--------HGHMC--ISFELLGL---STFDFLK----DNN-------------------------YLP-YPIHQVRHMAFQLCQAVKFLHD--NKLTHTDLKPENILFV--NSDYELTYNLEKKRDERSVKSTAVRVVDFGSAT----------FDHEHH--------------ST---IVSTRHYRAPEVIL-----------ELG--WSQPCDVWSIGCIIFEYYV-GFTL---------------FQTH-----------DNREHLAMM-ERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRY--------------------VRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAK--RLTLGEALQHPFF---------
----YEIVDTLGEGAFGKVVECIDH-----GMD-GM-HVAVKIVKNV--G-RYR---EA--ARS----------------------------EIQVLEHL-NS---TDPNSV-FRCVQMLEWFD--H--------HGHVC--IVFELLGL---STYDFIK----ENS-------------------------FLP-FQIDHIRQMAYQICQSINFLHH--NKLTHTDLKPENILFV--KSDYVVKYNSKMKRDERTLKNTDIKVVDFGSA----------TYDDEHH--------------ST---LVSTRHYRAPEVIL-----------ALG--WSQPCDVWSIGCILIEYYL-GFTV---------------FQTH-----------DSKEHLAMM-ERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRY--------------------VRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQ--RITLDEALQHPFF---------
----YDTGEELGSGQFAVVKKCREK-----S-T-GL-QYAAKFIKKR--R-TKS---SR--RGVSREDI---------------------EREVSILKEI-Q-----HPN-----VITLHEVYE--N--------KTDVI--LILELVAGG--ELFDFLA----EKE-------------------------SL---TEEEATEFLKQILNGVYYLHS--LQIAHFDLKPENIMLL--DRNVPKP---------------RIKIIDFGLAHK--------IDFGNEF--------------KN---IFGTPEFVAPEIVN-----------YEP--LGLEADMWSIGVITYILLS-GASP---------------FLGD--------------TKQETL-ANVSAVNYEFEDEYFSNTS---------------------------------------------------------ALAKDFIRRLLVKDPKK--RMTIQDSLQHPWI---------
----YEIDSLIGKGSFGQVVKAYDR-----V-E-QE-WVAIKIIKNK--K-AFL---NQ--AQI----------------------------EVRLLELMNK-----HDTEMKYYIVHLKRHFM--F--------RNHLC--LVFEMLSY---NLYDLLR-----NT-------------------------NFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAI-------------------KIVDFGSSCQ----------LGQRI--------------YQ---YIQSRFYRSPEVLL-----------GMP--YDLAIDMWSLGCILVEMHT-GEPL---------------FSGA-----------NEVDQMNKI-VEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKT--RIQPYYALQHSFF---------
----YEIDSLIGKGSFGQVVKAYDH-----Q-T-QE-LVAIKIIKNK--K-AFL---NQ--AQI----------------------------ELRLLELMNQ-----HDTEMKYYIVHLKRHFM--F--------RNHLC--LVFELLSY---NLYDLLR-----NT-------------------------HFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAI-------------------KIVDFGSSCQ----------LGQRI--------------YQ---YIQSRFYRSPEVLL-----------GTP--YDLAIDMWSLGCILVEMHT-GEPL---------------FSGS-----------NEVDQMNRI-VEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAA--RISPLGALQHGFF---------
----ITLERRLGTGCFGDVWLGTWN-------G-ST-KVAVKTLK-P--G-TM----SP--KAFL-E-------------------------EAQVMKLL-R-----HDK-----LVQLYAVVS-----------EEPIY--IVTEFMCHG--SLLDFLK-----NP----------------------EGQDL---RLPQLVDMAAQVAEGMAYMER--MNYIHRDLRAANILVG--ERLAC-------------------KIADFGLARLI-------K--DDEY--------------NPCQGSKFPIKWTAPEAAL-----------FGR--FTIKSDVWSFGILLTELITKGRIP---------------YPGM-----------NKREVLEQV-EQGYHMPCPPGCP---------------------------------------------------------------ASLYEAMEQTWRLDPEE--RPTFEYLQSFL-----------
----LQLIKRLGNGQFGEVWMGTWN-------G-NT-KVAIKTLK-P--G-TM----SP--ESFL-E-------------------------EAQIMKKL-K-----HDK-----LVQLYAVVS-----------EEPIY--IVTEYMNKG--SLLDFLK-----DG----------------------EGRAL---KLPNLVDMAAQVAAGMAYIER--MNYIHRDLRSANILVG--NGLIC-------------------KIADFGLARLI-------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----------YGR--FTIKSDVWSFGILLTELVTKGRVP---------------YPGM-----------NNREVLEQV-ERGYRMPCPQDCP---------------------------------------------------------------ISLHELMIHCWKKDPEE--RPTFEYLQSFL-----------
----YTDTKVIGNGSFGVVYQAKLC-----D-S-GE-LVAIKKVLQD--K-RFK---NR---------------------------------ELQIMRKL-D-----HCN-----IVRLRYFFY--SSG----EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ-------------------------TL---PVIYVKLYMYQLFRSLAYIHS--FGICHRDIKPQNLLLD-PDTAVL-------------------KLCDFGSAKQ--------LVRGEPN--------------VS---YICSRYYRAPELIF----------GATD--YTSSIDVWSAGCVLAELLL-GQPI---------------FPGD-----------SGVDQLVEI-IKVLGTPTREQIREMNPNYTEFKFPQIKAH-----------------------------------PWTKVFRPRTPPEAIALCSRLLEYTPTA--RLTPLEACAHSFF---------
----LKLEKKLGAGQFGEVWMATYN-------K-HT-KVAVKTMK-P--G-SM----SV--EAFL-A-------------------------EANVMKTL-Q-----HDK-----LVKLHAVVT-----------KEPIY--IITEFMAKG--SLLDFLK-----SD----------------------EGSKQ---PLPKLIDFSAQIAEGMAFIEQ--RNYIHRDLRAANILVS--ASLVC-------------------KIADFGLARVI-------E--DNEY--------------TAREGAKFPIKWTAPEAIN-----------FGS--FTIKSDVWSFGILLMEIVTYGRIP---------------YPGM-----------SNPEVIRAL-ERGYRMPRPENCP---------------------------------------------------------------EELYNIMMRCWKNRPEE--RPTFEYIQSV--L---------
----LKFLQQLGKGNFGSVEMCRYDP-LQDN-T-GE-VVAVKKLQ-H--S-TE-----EHLRDFE-R-------------------------EIEILKSL-Q-----HDN-----IVKYKGVCYSAG--------RRNLK--LIMEYLPYG--SLRDYLQ-----KH-----------------------KERI---DHIKLLQYTSQICKGMEYLGT--KRYIHRDLATRNILVE--NENRV-------------------KIGDFGLTKVL--PQ---D--KEYY--------------KVKEPGESPIFWYAPESLT-----------ESK--FSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-----------IVFHLIELL-KNNGRLPRPDGCP---------------------------------------------------------------DEIYMIMTECWNNNVNQ--RPSFRDLA----LRV-------
---L-KYISQLGKGNFGSVELCRYDP-LGDN-T-GA-LVAVKQLQ-H--S-GP----DQ-QRDFQ-R-------------------------EIQILKAL-H-----SDF-----IVKYRGVSYGPG--------RQSLR--LVMEYLPSG--CLRDFLQ-----RH-----------------------RARL---DASRLLLYSSQICKGMEYLGS--RRCVHRDLAARNILVE--SEAHV-------------------KIADFGLAKLL--PL---D--KDYY--------------VVREPGQSPIFWYAPESLS-----------DNI--FSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDV-P---------ALCRLLELL-EEGQRLPAPPACP---------------------------------------------------------------AEVHELMKLCWAPSPQD--RPSFSALGP---QL--------
----LKLVERLGAGQFGEVWMGYYN-------G-HT-KVAVKSLK-Q--G-SM----SP--DAFL-A-------------------------EANLMKQL-Q-----HQR-----LVRLYAVVT-----------QEPIY--IITEYMENG--SLVDFLK-----TP----------------------SGIKL---TINKLLDMAAQIAEGMAFIEE--RNYIHRDLRAANILVS--DTLSC-------------------KIADFGLARLI-------E--DNEY--------------TAREGAKFPIKWTAPEAIN-----------YGT--FTIKSDVWSFGILLTEIVTHGRIP---------------YPGM-----------TNPEVIQNL-ERGYRMVRPDNCP---------------------------------------------------------------EELYQLMRLCWKERPED--RPTFDYLRSV--L---------
----YTNLSYIGEGAYGMVCSAYDN-----V-N-KV-RVAIKKISPF--E-HQT---YC--QRT-LR-------------------------EIKILLRF-R-----HEN-----IIGINDIIR--APT---IEQMKDVY--IVQDLMET---DLYKLLK-----TQ-------------------------HL---SNDHICYFLYQILRGLKYIHS--ANVLHRDLKPSNLLLN--TTCDL-------------------KICDFGLARVAD----PDHDHTGFL--------------TE---YVATRWYRAPEIML----------NSKG--YTKSIDIWSVGCILAEMLS-NRPI---------------FPGK-----------HYLDQLNHI-LGILGSPSQEDLNCIINLKARNYLLSLPHKN---------------------------------KVPWNRLFPNADSKALDLLDKMLTFNPHK--RIEVEQALAHPYL---------
----YQNLKPIGSGAQGIVCAAYDA-----V-L-DR-NVAIKKLSRP--F-QNQ---TH--AKRAYR-------------------------ELVLMKCV-N-----HKN-----IISLLNVFT--PQKT--LEEFQDVY--LVMELMDA---NLCQVIQ------M-------------------------EL---DHERMSYLLYQMLCGIKHLHS--AGIIHRDLKPSNIVVK--SDCTL-------------------KILDFGLART--------AGTSFMM--------------TP---YVVTRYYRAPEVIL-----------GMG--YKENVDIWSVGCIMGEMVR-HKIL---------------FPGR-----------DYIDQWNKV-IEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPK----------------------LFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAK--RISVDDALQHPYI---------
----YQNLSPVGSGAYGSVCAAFDT-----K-T-GL-RVAVKKLSRP--F-QSI---IH--AKRTYR-------------------------ELRLLKHM-K-----HEN-----VIGLLDVFT--PARS--LEEFNDVY--LVTHLMGA---DLNNIVK-----CQ-------------------------KL---TDDHVQFLIYQILRGLKYIHS--ADIIHRDLKPSNLAVN--EDCEL-------------------KILDFGLAR----------HTDDEM--------------TG---YVATRWYRAPEIML----------NWMH--YNQTVDIWSVGCIMAELLT-GRTL---------------FPGT-----------DHIDQLKLI-LRLVGTPGAELLKKISSESARNYIQSLTQMP---------------------------------KMNFANVFIGANPLAVDLLEKMLVLDSDK--RITAAQALAHAYF---------
--YL--LRRQLGQGAYGIVWKAVDR-----R-T-GE-VVAIKKIFDA--F-RDK---TD--AQRTFR-------------------------EITLLQEFGD-----HPN-----IISLLDVIR--AE------NDRDIY--LVFEFMDT---DLNAVIR----KGG-------------------------LL---QDVHVRSIFYQLLRATRFLHS--GHVVHRDQKPSNVLLD--ANCTV-------------------KLCDFGLARSLGD--LPEGPEDQAV--------------TE---YVATRWYRAPEVLL----------SSHR--YTLGVDMWSLGCILGEMLR-GRPL---------------FPGT-----------STLHQLELI-LETIPPPSEEDLLALGSGCRASVLHQLGSRP--------------------------------RQTLDALLPPDTSPEALDLLRRLLVFAPDK--RLSATQALQHPYV---------
----YTQLQYIGEGAYGMVSSAYDH-----V-R-KT-RVAIKKISPF--E-HQT---YC--QRT-LR-------------------------EIQILLRF-R-----HEN-----VIGIRDILR--AST---LEAMRDVY--IVQDLMET---DLYKLLK-----SQ-------------------------QL---SNDHICYFLYQILRGLKYIHS--ANVLHRDLKPSNLLIN--TTCDL-------------------KICDFGLARIAD----PEHDHTGFL--------------TE---YVATRWYRAPEIML----------NSKG--YTKSIDIWSVGCILAEMLS-NRPI---------------FPGK-----------HYLDQLNHI-LGILGSPSQEDLNCIINMKARNYLQSLPSKT---------------------------------KVAWAKLFPKSDSKALDLLDRMLTFNPNK--RITVEEALAHPYL---------
---I-EYVRDIGEGAFGRVFQARAPGLLPYE-P-FT-MVAVKMLK-E--E-AS----ADMQADFQ-R-------------------------EAALMAEF-D-----NPN-----IVKLLGVCA--V--------GKPMC--LLFEYMAYG--DLNEFLR-----SMSPHTVCSLSHSDLSMRAQVSSPGPPPL---SCAEQLCIARQVAAGMAYLSE--RKFVHRDLATRNCLVG--ENMVV-------------------KIADFGLSRNI---Y---S--ADYY--------------KANENDAIPIRWMPPESIF-----------YNR--YTTESDVWAYGVVLWEIFSYGLQP---------------YYGM-----------AHEEVIYYV-RDGNILSCPENCP---------------------------------------------------------------VELYNLMRLCWSKLPAD--RPSFTSIHRIL-----------
---I-VLKRELGEGAFGKVFLAECYNLCPEQ-D-KI-LVAVKTLK-D--A-SD----NA-RKDFH-R-------------------------EAELLTNL-Q-----HEH-----IVKFYGVCV--E--------GDPLI--MVFEYMKHG--DLNKFLR-----AHGPDAV-----------LMAEGNPPTEL---TQSQMLHIAQQIAAGMVYLAS--QHFVHRDLATRNCLVG--ENLLV-------------------KIGDFGMSRDV---Y---S--TDYY--------------RVGGHTMLPIRWMPPESIM-----------YRK--FTTESDVWSLGVVLWEIFTYGKQP---------------WYQL-----------SNNEVIECI-TQGRVLQRPRTCP---------------------------------------------------------------QEVYELMLGCWQREPHM--RKNIKGIHTL--L---------
---I-VLKRELGEGAFGKVFLAECYNLSPTK-D-KM-LVAVKALK-D--P-TL----AA-RKDFQ-R-------------------------EAELLTNL-Q-----HEH-----IVKFYGVCG--D--------GDPLI--MVFEYMKHG--DLNKFLR-----AHGPDAMIL--------VDGQPRQAKGEL---GLSQMLHIASQIASGMVYLAS--QHFVHRDLATRNCLVG--ANLLV-------------------KIGDFGMSRDV---Y---S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM-----------YRK--FTTESDVWSFGVILWEIFTYGKQP---------------WFQL-----------SNTEVIECI-TQGRVLERPRVCP---------------------------------------------------------------KEVYDVMLGCWQREPQQ--RLNIKEIYKIL-----------
DNFI-----KIGEGSTGIVCIATVR-----S-S-GK-LVAVKKMDLR--K-QQR---RE--L--LFN-------------------------EVVIMRDY-Q-----HEN-----VVEMYNSYL--V--------GDELW--VVMEFLEGG--ALTDIVT-----HT-------------------------RM---NEEQIAAVCLAVLQALSVLHA--QGVIHRDIKSDSILLT--HDGRV-------------------KLSDFGFCAQV-------SKEVPRR--------------KS---LVGTPYWMAPELIS-----------RLP--YGPEVDIWSLGIMVIEMVD-GEPP---------------YFNE-----------PPLKAMKMI-RDNLPPRLKNLHKVS-------------------------------------------------------------PSLKGFLDRLLVRDPAQ--RATAAELLKHPFL---------
ANFI-----KIGEGSTGIVCIATEK-----H-T-GK-QVAVKKMDLR--K-QQR---RE--L--LFN-------------------------EVVIMRDY-H-----HDN-----VVDMYSSYL--V--------GDELW--VVMEFLEGG--ALTDIVT-----HT-------------------------RM---NEEQIATVCLSVLRALSYLHN--QGVIHRDIKSDSILLT--SDGRI-------------------KLSDFGFCAQV-------SKEVPKR--------------KS---LVGTPYWMAPEVIS-----------RLP--YGTEVDIWSLGIMVIEMID-GEPP---------------YFNE-----------PPLQAMRRI-RDSLPPRVKDLHK----VS---------------------------------------------------------SVLRGFLDLMLVREPSQ--RATAQELLGHPFL---------
---Y-IKLDKLGEGTYATVYKGKSK-----L-T-DN-LVALKEIRLE--H-EEG---AP--C-TAIR-------------------------EVSLLKDL-K-----HAN-----IVTLHDIIH--T--------EKSLT--LVFEYLDK---DLKQYLD---DCGN-------------------------II---NMHNVKLFLFQLLRGLAYCHR--QKVLHRDLKPQNLLIN--ERGEL-------------------KLADFGLARAK-------SIPTKTY--------------SN---EVVTLWYRPPDILL----------GSTD--YSTQIDMWGVGCIFYEMAT-GRPL---------------FPGS-----------TVEEQLHFI-FRILGTPTEETWPGILSNEEFKTYNYPKYR----------------------------------AEALLSHAPRLDSDGADLLTKLLQFEGRN--RISAEDAMKHPFF---------
--YV--RGRFLGKGGFAKCFEISDA-----D-T-KE-VFAGKIVPKS--L-LLK---PH--QREKMS------------------------MEISIHRSL-A-----HQH-----VVGFHGFFE--D--------NDFVF--VVLELCRRR--SLLELHK----RRK-------------------------AL---TEPEARYYLRQIVLGCQYLHR--NRVIHRDLKLGNLFLN--EDLEV-------------------KIGDFGLATKV-------EYDGERK--------------KT---LCGTPNYIAPEVLS-----------KKG--HSFEVDVWSIGCIMYTLLV-GKPP---------------FETS--------------CLKETY-LRIKKNEYSIPKHIN-------------------------------------------------------------PVAASLIQKMLQTDPTA--RPTINELLNDEFF---------
--YL--KGRLLGKGGFARCYEATDT-----E-T-GS-AYAVKVIPQS--R-VAK---PH--QREKIL------------------------NEIELHRDL-Q-----HRH-----IVRFSHHFE--D--------ADNIY--IFLELCSRK--SLAHIWK----ARH-------------------------TL---LEPEVRYYLRQILSGLKYLHQ--RGILHRDLKLGNFFIT--ENMEL-------------------KVGDFGLAARL-------EPPEQRK--------------KT---ICGTPNYVAPEVLL-----------RQG--HGPEADVWSLGCVMYTLLC-GSPP---------------FETA--------------DLKETY-RCIKQVHYTLPASLS-------------------------------------------------------------LPARQLLAAILRASPRD--RPSIDQILRHDFF---------
----YDVVKVIGRGAFGEVQLVRHK-----A-S-QK-VYAMKLLSKF--E-MIK---RS--DSAFFW------------------------EERDIMAFA-N-----SPW-----VVQLFYAFQ--D--------DRYLY--MVMEYMPGG--DLVNLMS-----NY-------------------------DV---PEKWAKFYTAEVVLALDAIHS--MGLIHRDVKPDNMLLD--KHGHL-------------------KLADFGTCMKM------DETGMVHC--------------DT---AVGTPDYISPEVLKS-------QGGDGF--YGRECDWWSVGVFLYEMLV-GDTP---------------FYAD--------------SLVGTY-SKIMDHKNSLCFPEDAEIS---------------------------------------------------------KHAKNLICAFLTDREVRLGRNGVEEIRQHPFF---------
----WEIIGELGDGAFGKVYKAQNK-----E-T-SV-LAAAKVIDTK--S-EEE---LE--DYM--V-------------------------EIDILASC-D-----HPN-----IVKLLDAFY--Y--------ENNLW--ILIEFCAGG--AVDAVML---ELER-------------------------PL---TESQIQVVCKQTLDALNYLHD--NKIIHRDLKAGNILFT--LDGDI-------------------KLADFGVSAKN-------TRTIQRR--------------DS---FIGTPYWMAPEVVMCE------TSKDRP--YDYKADVWSLGITLIEMAE-IEPP---------------HHEL-----------NPMRVLLKI-AKSEPPTLAQPSRWS-------------------------------------------------------------SNFKDFLKKCLEKNVDA--RWTTSQLLQHPFV---------
---L-RLEVKLGQGCFGEVWMGTWN-------G-TT-RVAIKTLK-P--G-TM----SP--EAFL-Q-------------------------EAQVMKKL-R-----HEK-----LVQLYAVVS-----------EEPIY--IVTEYMSKG--SLLDFLK-----GE----------------------TGKYL---RLPQLVDMAAQIASGMAYVER--MNYVHRDLRAANILVG--ENLVC-------------------KVADFGLARLI-------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----------YGR--FTIKSDVWSFGILLTELTTKGRVP---------------YPGM-----------VNREVLDQV-ERGYRMPCPPECP---------------------------------------------------------------ESLHDLMCQCWRKEPEE--RPTFEYLQAF--L---------
---L-RLLEKLGDGSFGVVRRGEWD--APSG-K-TV-SVAVKCLK-PDVL-SQ----PEAMDDFI-R-------------------------EVNAMHSL-D-----HRN-----LIRLYGVVL-----------TPPMK--MVTELAPLG--SLLDRLR-----KH-----------------------QGHF---LLGTLSRYAVQVAEGMGYLES--KRFIHRDLAARNLLLA--TRDLV-------------------KIGDFGLMRAL--PQ---N--DDHY--------------VMQEHRKVPFAWCAPESLK-----------TRT--FSHASDTWMFGVTLWEMFTYGQEP---------------WIGL-----------NGSQILHKIDKEGERLPRPEDCP---------------------------------------------------------------QDIYNVMVQCWAHKPED--RPTFVALRDF--L---------
----YSILKQIGSGGSSKVFQVLNE-----K-K-Q--IYAIKYVNLE--E-ADN---QT--LDSYRN-------------------------EIAYLNKLQQ----HSDK-----IIRLYDYEI--T--------DQYIY--MVMECGNI---DLNSWLK----KKK-------------------------SI---DPWERKSYWKNMLEAVHTIHQ--HGIVHSDLKPANFLIV---DGML-------------------KLIDFGIANQMQ-----PDTTSVVK--------------DS---QVGTVNYMPPEAIKDMSSSRENGKSKSK--ISPKSDVWSLGCILYYMTY-GKTP---------------FQQI-------------INQISKL-HAIIDPNHEIEFPDIPE-----------------------------------------------------------KDLQDVLKCCLKRDPKQ--RISIPELLAHPYV---------
---L-RLEVKLGQGCFGEVWMGTWN-------G-TT-KVAIKTLK-P--G-TM----MP--EAFL-Q-------------------------EAQIMKKL-R-----HDK-----LVPLYAVVS-----------EEPIY--IVTEFMSKG--SLLDFLK-----EG----------------------DGKYL---KLPQLVDMAAQIADGMAYIER--MNYIHRDLRAANILVG--ENLVC-------------------KIADFGLARLI-------E--DNEY--------------TARQGAKFPIKWTAPEAAL-----------YGR--FTIKSDVWSFGILQTELVTKGRVP---------------YPGM-----------VNREVLEQV-ERGYRMPCPQGCP---------------------------------------------------------------ESLHELMNLCWKKDPDE--RPTFEYIQSFL-----------
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