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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
Other AURKB 77
Other AURKC 43
CMGC CDC2 4
CMGC CDK3 4
CMGC CDK4 6
CMGC CDK5 4
CMGC CDK6 13
CAMK CHEK2 220
Other EIF2AK2 267
CMGC GSK3A 119
CMGC GSK3B 56
TKL IRAK4 186
TK JAK3 822
TK NTRK2 538
TK NTRK3 538
AGC PDPK1 82
CAMK PHKG1 20
CAMK PRKD1 583
CAMK PRKD3 576
TK PTK2 422
TK SRC 270
CAMK STK17A 61
CAMK STK17B 33
Other TLK2 440
---FQKVEKIGEGTYGVVYKARNK-----LTGE-VVALKKIRLDTETE---GV--P-S-TAIR-------EISLLKEL-N---HPNIVKLLDVIH--T-----------------------------ENKLY--LVFEFLHQ---DLKKFMDA--SALT-----------------GIPLPLIKSYLFQLLQGLAFCHSH--RVLHRDLKPQNLLIN-TEGAI---KLADFGLARAF---------GVPVRTY--------------TH---EVVTLWYRAPEILL-----GCKYYSTAVDIWSLGCIFAEMVT-RR-AL-------------FPGD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF-----------
---FEIGRPLGKGKFGNVYLAREK-----KSHF-IVALKVLFKSQIEK---EG--V-E-HQLR------REIEIQAHL-H---HPNILRLYNYFY--D-----------------------------RRRIY--LILEYAPRG--ELYKELQ----KSC-----------------TFDEQRTATIMEELADALMYCHGK--KVIHRDIKPENLLLG-LKGEL---KIADFGWSV-----------HAPSLRR--------------KT---MCGTLDYLPPEMIE------GRMHNEKVDLWCIGVLCYELLV-GN-PP-------------FESA----SHNETYRRIVKVDLKFPASVP--------------------------MGAQDLISKLLRHNPSERLPLAQVSAHPWV-----------
---FEIGRPLGKGKFGNVYLARLK-----ESHF-IVALKVLFKSQIEK---EG--L-E-HQLR------REIEIQAHL-Q---HPNILRLYNYFH--D-----------------------------ARRVY--LILEYAPRG--ELYKELQ----KSE-----------------KLDEQRTATIIEELADALTYCHDK--KVIHRDIKPENLLLG-FRGEV---KIADFGWSV-----------HTPSLRR--------------KT---MCGTLDYLPPEMIE------GRTYDEKVDLWCIGVLCYELLV-GY-PP-------------FESA----SHSETYRRILKVDVRFPLSMP--------------------------LGARDLISRLLRYQPLERLPLAQILKHPWV-----------
---YTKIEKIGEGTYGVVYKGRHK-----TTGQ-VVAMKKIRLESEEE---GV--P-S-TAIR-------EISLLKEL-R---HPNIVSLQDVLM--Q-----------------------------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ-----------------YMDSSLVKSYLYQILQGIVFCHSR--RVLHRDLKPQNLLID-DKGTI---KLADFGLARAF---------GIPIRVY--------------TH---EVVTLWYRSPEVLL-----GSARYSTPVDIWSIGTIFAELAT-KK-PL-------------FHGD-SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF-----------
---FQKVEKIGEGTYGVVYKAKNR-----ETGQ-LVALKKIRLDLEME---GV--P-S-TAIR-------EISLLKEL-K---HPNIVRLLDVVH--N-----------------------------ERKLY--LVFEFLSQ---DLKKYMDS--TPGS-----------------ELPLHLIKSYLFQLLQGVSFCHSH--RVIHRDLKPQNLLIN-ELGAI---KLADFGLARAF---------GVPLRTY--------------TH---EVVTLWYRAPEILL-----GSKFYTTAVDIWSIGCIFAEMVT-RK-AL-------------FPGD-SEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYF-----------
--Y-EPVAEIGVGAYGTVYKARDP-----HSGH-FVALKSVRVPNGGGGGGGL--P-I-STVR-------EVALLRRL-EAFEHPNVVRLMDVCA--TSR------------------------TDREIKVT--LVFEHVDQ---DLRTYLDK--APPP-----------------GLPAETIKDLMRQFLRGLDFLHAN--CIVHRDLKPENILVT-SGGTV---KLADFGLARI----------YSYQMAL--------------TP---VVVTLWYRAPEVLL------QSTYATPVDMWSVGCIFAEMFR-RK-PL-------------FCGN-SEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR--PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL-----------
---YEKLEKIGEGTYGTVFKAKNR-----ETHE-IVALKRVRLDDDDE---GV--P-S-SALR-------EICLLKEL-K---HKNIVRLHDVLH--S-----------------------------DKKLT--LVFEFCDQ---DLKKYFD---SCNG-----------------DLDPEIVKSFLFQLLKGLGFCHSR--NVLHRDLKPQNLLIN-RNGEL---KLADFGLARAF---------GIPVRCY--------------SA---EVVTLWYRPPDVLF-----GAKLYSTSIDMWSAGCIFAELANAGR-PL-------------FPGN-DVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF-----------
---YECVAEIGEGAYGKVFKARDL-----KNGGRFVALKRVRVQTGEE---GM--P-L-STIR-------EVAVLRHL-ETFEHPNVVRLFDVCT--VSR------------------------TDRETKLT--LVFEHVDQ---DLTTYLDK--VPEP-----------------GVPTETIKDMMFQLLRGLDFLHSH--RVVHRDLKPQNILVT-SSGQI---KLADFGLARI----------YSFQMAL--------------TS---VVVTLWYRAPEVLL------QSSYATPVDLWSVGCIFAEMFR-RK-PL-------------FRGS-SDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ--PIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF-----------
-YI--MSKTLGSGACGEVKLAFER-----KTCK-KVAIKIISKRKFAI---GS--A-R-EADPALN-VETEIEILKKL-N---HPCIIKIKNFF---D-----------------------------AEDYY--IVLELMEGG--ELFDKVV----GNK-----------------RLKEATCKLYFYQMLLAVQYLHEN--GIIHRDLKPENVLLS-SQEEDCLIKITDFGHSKI----------LGETSLM--------------RT---LCGTPTYLAPEVLVS---VGTAGYNRAVDCWSLGVILFICLS-GY-PP-------------FSEH---RTQVSLKDQITSGKYNFIPEVWAEVS----------------------EKALDLVKKLLVVDPKARFTTEEALRHPWL-----------
--F-KEIELIGSGGFGQVFKAKHR-----IDGK-TYVIKRVKYNNEKA---ER-----------------EVKALAKL-D---HVNIVHYNGCWD--GFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLF--IQMEFCDKG--TLEQWIEK--RRGE-----------------KLDKVLALELFEQITKGVDYIHSK--KLIHRDLKPSNIFLV-DTKQV---KIGDFGLVTS----------LKNDGKR--------------TR---SKGTLRYMSPEQIS------SQDYGKEVDLYALGLILAELLH-VCDTA-------------FET--------SKFFTDLRDGIISDIFDK---------------------------KEKTLLQKLLSKKPEDRPNTSEILR----TLT--------
---YTDIKVIGNGSFGVVYQARLA-----ETRE-LVAIKKVLQDKRFK---NR-----------------ELQIMRKL-D---HCNIVRLRYFFY--SSG-------------------------EKKDELYLNLVLEYVPETVYRVARHFT---KAKL-----------------TIPILYVKVYMYQLFRSLAYIHSQ--GVCHRDIKPQNLLVDPDTAVL---KLCDFGSAKQ----------LVRGEPN--------------VS---YICSRYYRAPELIF-----GATDYTSSIDVWSAGCVLAELLL-GQ-PI-------------FPGD-SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF-----------
---YTDTKVIGNGSFGVVYQAKLC-----DSGE-LVAIKKVLQDKRFK---NR-----------------ELQIMRKL-D---HCNIVRLRYFFY--SSG-------------------------EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ-----------------TLPVIYVKLYMYQLFRSLAYIHSF--GICHRDIKPQNLLLDPDTAVL---KLCDFGSAKQ----------LVRGEPN--------------VS---YICSRYYRAPELIF-----GATDYTSSIDVWSAGCVLAELLL-GQ-PI-------------FPGD-SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF-----------
VGG----NKMGEGGFGVVYKGYVN-----NTT---VAVKKLAAMVDIT---TE--ELK-QQFD------QEIKVMAKC-Q---HENLVELLGFSS--D-----------------------------GDDLC--LVYVYMPNG--SLLDRLSC-LDGTP-----------------PLSWHMRCKIAQGAANGINFLHEN--HHIHRDIKSANILLD-EAFTA---KISDFGLARASE-------KFAQTVMT--------------SR---IVGTTAYMAPEALR-------GEITPKSDIYSFGVVLLEIIT-GL-PA-------------VDEH-REPQLLLDIKEEIEDEEKTIEDYIDKKMNDAD--------------STSVEAMYSVASQCLHEKKNKRPDIKKVQQ----LLQ--------
--L-KYISQLGKGNFGSVELCRYDP-LGDNTGA-LVAVKQLQ-HSGP----DQ-QR-D-FQ-R-------EIQILKAL-H---SDFIVKYRGVSYGPG-----------------------------RQSLR--LVMEYLPSG--CLRDFLQ-----RH---------------RARLDASRLLLYSSQICKGMEYLGSR--RCVHRDLAARNILVE-SEAHV---KIADFGLAKLL---PL----D--KDYY--------------VVREPGQSPIFWYAPESLS------DNIFSRQSDVWSFGVVLYELFTYCD-KSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACP----------------------------AEVHELMKLCWAPSPQDRPSFSALGP---QL----------
--I-VLKRELGEGAFGKVFLAECYNLCPEQDKI-LVAVKTLK-DASD----NA-RK-D-FH-R-------EAELLTNL-Q---HEHIVKFYGVCV--E-----------------------------GDPLI--MVFEYMKHG--DLNKFLR-----AHGPDAV---LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQ--HFVHRDLATRNCLVG-ENLLV---KIGDFGMSRDV----Y----S--TDYY--------------RVGGHTMLPIRWMPPESIM------YRKFTTESDVWSLGVVLWEIFTYGK-QP-------------WYQL-SNNEVIECITQGRVLQRPRTCP----------------------------QEVYELMLGCWQREPHMRKNIKGIHTL--L-----------
--I-VLKRELGEGAFGKVFLAECYNLSPTKDKM-LVAVKALK-DPTL----AA-RK-D-FQ-R-------EAELLTNL-Q---HEHIVKFYGVCG--D-----------------------------GDPLI--MVFEYMKHG--DLNKFLR-----AHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQ--HFVHRDLATRNCLVG-ANLLV---KIGDFGMSRDV----Y----S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM------YRKFTTESDVWSFGVILWEIFTYGK-QP-------------WFQL-SNTEVIECITQGRVLERPRVCP----------------------------KEVYDVMLGCWQREPQQRLNIKEIYKIL-------------
--F-KFGKILGEGSFSTVVLAREL-----ATSR-EYAIKILEKRHIIK---EN--K-VPYVTR-------ERDVMSRL-D---HPFFVKLYFTFQ--D-----------------------------DEKLY--FGLSYAKNG--ELLKYIR----KIG-----------------SFDETCTRFYTAEIVSALEYLHGK--GIIHRDLKPENILLN-EDMHI---QITDFGTAKVLS-------PESKQARA--------------NS---FVGTAQYVSPELLT------EKSACKSSDLWALGCIIYQLVA-GL-PP-------------FRAG----NEYLIFQKIIKLEYDFPEKFF--------------------------PKARDLVEKLLVLDATKRLGCEEM------EGYGPLKAHPF
---YEPKEILGRGVSSVVRRCIHK-----PTSQ-EYAVKVIDVTGGGS---FS--P-E-EVRELREATLKEVDILRKVSG---HPNIIQLKDTYE--T-----------------------------NTFFF--LVFDLMKRG--ELFDYLT----EKV-----------------TLSEKETRKIMRALLEVICTLHKL--NIVHRDLKPENILLD-DNMNI---KLTDFGFSCQ----------LEPGERL--------------RE---VCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLA-GS-PP-------------FWHR----KQMLMLRMIMSGNYQFGSPEWDDYS----------------------DTVKDLVSRFLVVQPQNRYTAEEALAHPFF-----------
-PD----EVLGSGQFGIVYGGKHR-----KTGR-DVAIKIIDKLRFPT---KQ--E-S-QLRN-------EVAILQNL-H---HPGVVNLECMFE--T-----------------------------PERVF--VVMEKLHGD--MLEMILS---SEKG-----------------RLPEHITKFLITQILVALRHLHFK--NIVHCDLKPENVLLA-SADPFPQVKLCDFGFARI----------IGEKSFR--------------RS---VVGTPAYLAPEVLR------NKGYNRSLDMWSVGVIIYVSLS-GT-FP-------------FNED------EDIHDQIQNAAFMYPPNPWKEIS----------------------HEAIDLINNLLQVKMRKRYSVDKTLSHPWL-----------
FAD----EVLGSGQFGIVYGGKHR-----KTGR-DVAIKVIDKMRFPT---KQ--E-S-QLRN-------EVAILQNL-H---HPGIVNLECMFE--T-----------------------------PERVF--VVMEKLHGD--MLEMILS---SEKS-----------------RLPERITKFMVTQILVALRNLHFK--NIVHCDLKPENVLLA-SAEPFPQVKLCDFGFARI----------IGEKSFR--------------RS---VVGTPAYLAPEVLR------SKGYNRSLDMWSVGVIIYVSLS-GT-FP-------------FNED------EDINDQIQNAAFMYPPNPWREIS----------------------GEAIDLINNLLQVKMRKRYSVDKSLSHPWL-----------
---IELGRCIGEGQFGDVHQGIYM--SPENPAL-AVAIKTCK-NCTS----DSVRE-K-FL-Q-------EALTMRQF-D---HPHIVKLIGVIT--------------------------------ENPVW--IIMELCTLG--ELRSFLQ-----VR---------------KYSLDLASLILYAYQLSTALAYLESK--RFVHRDIAARNVLVS-SNDCV---KLGDFGLSRYM---------E--DSTY--------------YKASKGKLPIKWMAPESIN------FRRFTSASDVWMFGVCMWEILMHGV-KP-------------FQGV-KNNDVIGRIENGERLPMPPNCP----------------------------PTLYSLMTKCWAYDPSRRPRFTELKAQL-------------
--L-RLEVKLGQGCFGEVWMGTWN------GTT-RVAIKTLK-PGTM----SP--E-A-FL-Q-------EAQVMKKL-R---HEKLVQLYAVVS--------------------------------EEPIY--IVTEYMSKG--SLLDFLK-----GE--------------TGKYLRLPQLVDMAAQIASGMAYVERM--NYVHRDLRAANILVG-ENLVC---KVADFGLARLI---------E--DNEY--------------TARQGAKFPIKWTAPEAAL------YGRFTIKSDVWSFGILLTELTTKGR-VP-------------YPGM-VNREVLDQVERGYRMPCPPECP----------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L-----------
LCP---GRELGRGKFAVVRKCIKK-----DSGK-EFAAKFMRKRRKGQ---DC--R-M-EIIH-------EIAVLELAQD---NPWVINLHEVYE--T-----------------------------ASEMI--LVLEYAAGG--EIFDQCVA--DREE-----------------AFKEKDVQRLMRQILEGVHFLHTR--DVVHLDLKPQNILLT-SESPLGDIKIVDFGLSRI----------LKNSEEL--------------RE---IMGTPEYVAPEILS------YDPISMATDMWSIGVLTYVMLT-GI-SP-------------FLGN----DKQETFLNISQMNLSYSEEEFDVLS----------------------ESAVDFIRTLLVKKPEDRATAEECLKHPWL-----------
ILT---SKELGRGKFAVVRQCISK-----STGQ-EYAAKFLKKRRRGQ---DC--R-A-EILH-------EIAVLELAKS---CPRVINLHEVYE--N-----------------------------TSEII--LILEYAAGG--EIFSLCLP--ELAE-----------------MVSENDVIRLIKQILEGVYYLHQN--NIVHLDLKPQNILLS-SIYPLGDIKIVDFGMSRK----------IGHACEL--------------RE---IMGTPEYLAPEILN------YDPITTATDMWNIGIIAYMLLT-HT-SP-------------FVGE----DNQETYLNISQVNVDYSEETFSSVS----------------------QLATDFIQSLLVKNPEKRPTAEICLSHSWL-----------
-YL--LLHLLGRGGFSEVYKAFDL-----TEQR-YVAVKIHQLNKNWR---DE--K-K-ENYHKH--ACREYRIHKEL-D---HPRIVKLYDYFS--L----------------------------DTDSFC--TVLEYCEGN--DLDFYLK----QHK-----------------LMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLV-NGTACGEIKITDFGLSKIMDDD--SYNSVDGMELT--------------SQ---GAGTYWYLPPECFVV--GKEPPKISNKVDVWSVGVIFYQCLY-GR-KP-------------FGHN--QSQQDILQENTILKATEVQFPPKPVVT----------------------PEAKAFIRRCLAYRKEDRIDVQQLACDPYL-----------
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