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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK6 203
TK ABL1 261
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK5 4
CMGC CSNK2A1 39
CMGC GSK3B 56
TK INSR 1023
CMGC MAPK10 64
CMGC MAPK14 24
CAMK STK17B 33
---YECVAEIGEGAYGKVFKARDL-----KNGGRFVALKRVRVQTGEEGM--PLSTIREVAVLRHL-ETFEHPNVVRLFDVCTVSR-TDRETKLT--LVFEHVDQ---DLTTYLDK--VPEP-----------GVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVT-SSGQI---KLADFGLARI--YSFQMALTS---VVVTLWYRAPEVLL-QSSYATPVDLWSVGCIFAEMFR-RKPLFR-GSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ---------------PIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
---ITMKHKLGGGQYGEVYEGVWK-----KYSL-TVAVKTLK-EDTM-EV--EEFL-KEAAVMKEI-K---HPNLVQLLGVCTR------EPPFY--IITEFMTYG--NLLDYLR-----EC--------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG-ENHLV---KVADFGLSRLM-T--GDTYTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYP-GIDLSQVYELLEKDYRMERPEGCP-----------------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F
---YTKIEKIGEGTYGVVYKGRHK-----TTGQ-VVAMKKIRLESEEEGV--PSTAIREISLLKEL-R---HPNIVSLQDVLMQ------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ-----------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTI---KLADFGLARAF-GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFH-GDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF
---FQKVEKIGEGTYGVVYKARNK-----LTGE-VVALKKIRLDTETEGV--PSTAIREISLLKEL-N---HPNIVKLLDVIHT------ENKLY--LVFEFLHQ---DLKKFMDA--SALT-----------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI---KLADFGLARAF-GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFP-GDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
---YEKLEKIGEGTYGTVFKAKNR-----ETHE-IVALKRVRLDDDDEGV--PSSALREICLLKEL-K---HKNIVRLHDVLHS------DKKLT--LVFEFCDQ---DLKKYFD---SCNG-----------DLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGEL---KLADFGLARAF-GIPVRCYSA---EVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFP-GNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT-------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF
---YQLVRKLGRGKYSEVFEAINI-----TNNE-KVVVKILKPVKKKKIK--R-----EIKILENLRG---GPNIITLADIVKDP----VSRTPA--LVFEHVNNT--DFKQLY-------Q-----------TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKL---RLIDWGLAEF--YHPGQEYNV---RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIF-RKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK-----RWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF
---YTDTKVIGNGSFGVVYQAKLC-----DSGE-LVAIKKVLQDKRFKNR--------ELQIMRKL-D---HCNIVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ-----------TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL---KLCDFGSAKQ--LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFP-GDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF
---ITLLRELGQGSFGMVYEGNARDIIKGEAET-RVAVKTVN-ESAS-LRERIEFL-NEASVMKGF-T---CHHVVRLLGVVSK------GQPTL--VVMELMAHG--DLKSYLR-----SLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVA-HDFTV---KIGDFGMTRDIYE--TDYYRKGGKGLLPVRWMAPESLK-DGVFTTSSDMWSFGVVLWEITSLAEQPYQ-GLSNEQVLKFVMDGGYLDQPDNCP-----------------------------------------ERVTDLMRMCWQFNPKMRPTFLEIVNLL--
---YQNLKPIGSGAQGIVCAAYDA-----VLDR-NVAIKKLSRPFQNQTH--AKRAYRELVLMKCV-N---HKNIISLLNVFTPQKTLEEFQDVY--LVMELMDA---NLCQVIQ------M-----------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL---KILDFGLART--AGTSFMMTP---YVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVR-HKILFP-GRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI
---YQNLSPVGSGAYGSVCAAFDT-----KTGL-RVAVKKLSRPFQSIIH--AKRTYRELRLLKHM-K---HENVIGLLDVFTPARSLEEFNDVY--LVTHLMGA---DLNNIVK-----CQ-----------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCEL---KILDFGLAR----HTDDEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFP-GTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------KMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF
ILT---SKELGRGKFAVVRQCISK-----STGQ-EYAAKFLKKRRRGQDC--RAEILHEIAVLELAKS---CPRVINLHEVYEN------TSEII--LILEYAAGG--EIFSLCLP--ELAE-----------MVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLS-SIYPLGDIKIVDFGMSRK--IGHACELRE---IMGTPEYLAPEILN-YDPITTATDMWNIGIIAYMLLT-HTSPFV-GE---DNQETYLNISQVNVDYSEETFSSVS-----------------------------------QLATDFIQSLLVKNPEKRPTAEICLSHSWL
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