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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK6 203
Other AURKA 133
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK4 6
TK FGFR1 478
TK FGFR3 472
TK INSR 1023
TK JAK2 849
CMGC MAPK11 24
CMGC MAPK14 24
Other PLK2 82
Other PLK3 62
---YECVAEIGEGAYGKVFKARDL-------KNGGRFVALKRVRVQT-GEE---GM--PLSTIR-EVAVLRHL-ETFEHPNVVRLFDVCT--VSR-TDRETKLTLVFEHVDQ-DLTTYLDK-VPEP-----------------GVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARI---YSFQMALTS---VVVTLWYRAPEVLL-QSSYATPVDLWSVGCIFAEMFR-RKPL---------------FRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ----PIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF--
---FEIGRPLGKGKFGNVYLAREK-------QSKF-ILALKVLFKAQLEKA---GV--EHQLRR-EVEIQSHL-R---HPNILRLYGYFH--D------ATRVYLILEYAPLGTVYRELQ---KLS-----------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSV----HAPSSRRTT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN---TYQETYKRISRVEFTFPDFVT----------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI--
---YTKIEKIGEGTYGVVYKGRHK-------TTGQ-VVAMKKIRLES-EEE---GV--PSTAIR-EISLLKEL-R---HPNIVSLQDVLM--Q------DSRLYLIFEFLSM-DLKKYLDSIPPGQ-----------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF--GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPL---------------FHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP--GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF--
---FQKVEKIGEGTYGVVYKARNK-------LTGE-VVALKKIRLDT-ETE---GV--PSTAIR-EISLLKEL-N---HPNIVKLLDVIH--T------ENKLYLVFEFLHQ-DLKKFMDA-SALT-----------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--
--Y-EPVAEIGVGAYGTVYKARDP-------HSGH-FVALKSVRVPN-GGGGGGGL--PISTVR-EVALLRRL-EAFEHPNVVRLMDVCA--TSR-TDREIKVTLVFEHVDQ-DLRTYLDK-APPP-----------------GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI---YSYQMALTP---VVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFR-RKPL---------------FCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR----PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL--
--L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVT-KVAVKMLK-SD-AT----EKDLSDLI-S-EMEMMKMIGK---HKNIINLLGACT--Q------DGPLYVIVEYASKGNLREYLQ----ARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDI-HH--IDYYKKTTNGRLPVKWMAPEALF-DRIYTHQSDVWSFGVLLWEIFTLGGSP---------------YPGVPVEELFKLLKEGHRMDKPSNCT------------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL----
---LTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPV-TVAVKMLK-DD-AT----DKDLSDLV-S-EMEMMKMIGK---HKNIINLLGACT--Q------GGPLYVLVEYAAKGNLREFLR----ARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDV-HN--LDYYKKTTNGRLPVKWMAPEALF-DRVYTHQSDVWSFGVLLWEIFTLGGSP---------------YPGIPVEELFKLLKEGHRMDKPANCT------------------------------HDLYMIMRECWHAAPSQRPTFKQLVEDL----
---ITLLRELGQGSFGMVYEGNARD--IIKGEAET-RVAVKTVN-ES-AS----LRERIEFL-N-EASVMKGF-T---CHHVVRLLGVVS--K------GQPTLVVMELMAHGDLKSYLR----SLRPEA------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDI-YE--TDYYRKGGKGLLPVRWMAPESLK-DGVFTTSSDMWSFGVVLWEITSLAEQP---------------YQGLSNEQVLKFVMDGGYLDQPDNCP------------------------------ERVTDLMRMCWQFNPKMRPTFLEIVNLL----
---LKFLQQLGKGNFGSVEMCRYDP---LQDNTGE-VVAVKKLQ-HS-TE-----EHLRDFE-R-EIEILKSL-Q---HDNIVKYKGVCYSAG------RRNLKLIMEYLPYGSLRDYLQ----KH---------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQD--KEYYKVKEPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCP------------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV
LQG---LRPVGSGAYGSVCSAYDA-------RLRQ-KVAVKKLSRPF-QSL---IH--ARRTYR-ELRLLKHL-K---HENVIGLLDVFT--PATSIEDFSEVYLVTTLMGA-DLNNIVK----CQ-----------------ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR-----QADEEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKAL---------------FPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF--
---YQNLSPVGSGAYGSVCAAFDT-------KTGL-RVAVKKLSRPF-QSI---IH--AKRTYR-ELRLLKHM-K---HENVIGLLDVFT--PARSLEEFNDVYLVTHLMGA-DLNNIVK----CQ-----------------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR-----HTDDEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTL---------------FPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF--
--Y-CRGKVLGKGGFAKCYEMTDL-------TNNK-VYAAKIIPHSR-VAK---PH--QREKIDKEIELHRIL-H---HKHVVQFYHYFE--D------KENIYILLEYCSRRSMAHILK---ARK-----------------VLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARL--EPLEHRRRT---ICGTPNYLSPEVLN-KQGHGCESDIWALGCVMYTMLL-GRPP---------------FETT---NLKETYRCIREARYTMPSSLL----------------------------APAKHLIASMLSKNPEDRPSLDDIIRHDFF--
-YL--KGRLLGKGGFARCYEATDT-------ETGS-AYAVKVIPQSR-VAK---PH--QREKILNEIELHRDL-Q---HRHIVRFSHHFE--D------ADNIYIFLELCSRKSLAHIWK---ARH-----------------TLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARL--EPPEQRKKT---ICGTPNYVAPEVLL-RQGHGPEADVWSLGCVMYTLLC-GSPP---------------FETA---DLKETYRCIKQVHYTLPASLS----------------------------LPARQLLAAILRASPRDRPSIDQILRHDFF--
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