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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK6 203
Other AURKB 77
CMGC CDK2 4
CMGC CDK4 6
CMGC GSK3B 56
CMGC MAPK8 26
CMGC MAPK9 26
TK PTK6 191
-YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEE---GM-PLSTIR-EVAVLRHLETFEHPNVVRLFDVCTVSR-TDRETKLT--LVFEHVDQ---DLTTYLDK--VPEP---GVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVT-SSGQIKLADFGLARI-YSFQMALTS---VVVTLWYRAPEVLL-QSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ---------------PIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
-FEIGRPLGKGKFGNVYLAREKKSHF-IVALKVLFKSQIEK---EG-VEHQLRREIEIQAHLH---HPNILRLYNYFYD------RRRIY--LILEYAPRG--ELYKELQ----KSC---TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-LKGELKIADFGWSV--HAPSLRRKT---MCGTLDYLPPEMIE-GRMHNEKVDLWCIGVLCYELLV-GNPPFESA---SHNETYRRIVKVDLKFPASVP---------------------------------------MGAQDLISKLLRHNPSERLPLAQVSAHPWV
-FQKVEKIGEGTYGVVYKARNKLTGE-VVALKKIRLDTETE---GV-PSTAIR-EISLLKELN---HPNIVKLLDVIHT------ENKLY--LVFEFLHQ---DLKKFMDA--SALT---GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAFGVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
Y-EPVAEIGVGAYGTVYKARDPHSGH-FVALKSVRVPNGGGGGGGL-PISTVR-EVALLRRLEAFEHPNVVRLMDVCATSR-TDREIKVT--LVFEHVDQ---DLRTYLDK--APPP---GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTVKLADFGLARI-YSYQMALTP---VVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR---------------PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL
-YTDTKVIGNGSFGVVYQAKLCDSGE-LVAIKKVLQDKRFK---NR--------ELQIMRKLD---HCNIVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ---TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ-LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF
-YQNLKPIGSGAQGIVCAAYDAILER-NVAIKKLSRPFQNQ---TH-AKRAYR-ELVLMKCVN---HKNIIGLLNVFTPQKSLEEFQDVY--IVMELMDA---NLCQVIQ------M---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLART-AGTSFMMTP---YVVTRYYRAPEVIL-GMGYKENVDLWSVGCIMGEMVC-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYI
-YQQLKPIGSGAQGIVCAAFDTVLGI-NVAVKKLSRPFQNQ---TH-AKRAYR-ELVLLKCVN---HKNIISLLNVFTPQKTLEEFQDVY--LVMELMDA---NLCQVIH------M---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLART-ACTNFMMTP---YVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGELVK-GCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYI
F-TLCRKLGSGYFGEVFEGLWK-DRV-QVAIKVIS-RDNL----LHQQMLQ-S-EIQAMKKLR---HKHILALYAVVSV------GDPVY--IITELMAKG--SLLELLR-----DSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVG-ENTLCKVGDFGLARLI---KEDVYLSHDHNIPYKWTAPEALS-RGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECP-----------------------------------------PSVHKLMLTCWCRDPEQRPCFKALRERL--
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