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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK7 203
CMGC CDK2 4
STE MAP2K4 102
AGC PDPK1 82
--YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDG-INRTALREIKLLQEL-SHPNIIGLLDAFGHKSNISLVFDFMET---DLEVIIK-DNSLVLTPSHIKAYMLMTLQGLEYLHQH-WILHRDLKPNNLLLDENGVLKLADFGLAKSF--GSPNRAYTHQVVTRWYRAPELLF---GARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPG-IPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF-----------
--FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPS-TAIR---EISLLKEL-NHPNIVKLLDVIHTENKLYLVFEFLHQ---DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH-RVLHRDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTYTHEVVTLWYRAPEILL---GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF-----------
LK--DLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQ-L-LM---DLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQ---LVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKW-NSVFDQLTQVVKGDPPQLSNSEEREFS----------------------PSFINFVNLCLTKDESKRPKYKELLKHPFI-----------
-F-KFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTR---ERDVMSRL-DHPFFVKLYFTFQDDEKLYFGLSYAKNG--ELLKYIR--KIGSFDETCTRFYTAEIVSALEYLHGK-GIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLT----EKSACKSSDLWALGCIIYQLVAGLPPFRAG---NEYLIFQKIIKLEYDFPEKFF--------------------------PKARDLVEKLLVLDATKRLGCEEM------EGYGPLKAHPF
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