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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK9 203
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK3 4
CMGC CDK5 4
CAMK CHEK1 9
CMGC CLK1 161
CMGC CLK2 163
CMGC CLK4 159
CAMK DAPK1 13
CMGC DYRK1A 150
CMGC DYRK1B 111
CMGC GSK3B 56
TK JAK2 849
CMGC MAPK1 13
CMGC MAPK10 64
CMGC MAPK8 26
STE PAK4 321
CMGC PCTK1 165
AGC PRKCQ 380
AGC RPS6KA1 62
AGC RPS6KA2 59
TK SRC 270
TK YES1 277
----YEKLAKIGQGTFGEV---FKARHR----K-T-GQ---KVALKKVLMENEKEGF--PITALR----EIKILQLL-K-----HEN-----VVNLIEICR--TKASPYNRCKGSIY--LVFDFCEH---DLAGLLS---NVLV---KF---TLSEIKRVMQMLLNGLYYIHR--NKILHRDMKAANVLIT--RDGVL-------------------KLADFGLARAFSL--AKNSQPNRYTN---RVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPI---------------MQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQK--------------------------------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID-----SD-DALNHDFF--
----YTKIEKIGEGTYGVV---YKGRHK----T-T-GQ---VVAMKKIRLESEEEGV--PSTAIR----EISLLKEL-R-----HPN-----IVSLQDVLM--Q--------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ---YM---DSSLVKSYLYQILQGIVFCHS--RRVLHRDLKPQNLLID--DKGTI-------------------KLADFGLARAF------GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPL---------------FHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-----------------------------------GSLASHVKNLDENGLDLLSKMLIYDPAKRIS-----GK-MALNHPYF--
----FQKVEKIGEGTYGVV---YKARNK----L-T-GE---VVALKKIRLDTETEGV--PSTAIR----EISLLKEL-N-----HPN-----IVKLLDVIH--T--------ENKLY--LVFEFLHQ---DLKKFMDA--SALT---GI---PLPLIKSYLFQLLQGLAFCHS--HRVLHRDLKPQNLLIN--TEGAI-------------------KLADFGLARAF------GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-----------------------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AK-AALAHPFF--
----FQKVEKIGEGTYGVV---YKAKNR----E-T-GQ---LVALKKIRLDLEMEGV--PSTAIR----EISLLKEL-K-----HPN-----IVRLLDVVH--N--------ERKLY--LVFEFLSQ---DLKKYMDS--TPGS---EL---PLHLIKSYLFQLLQGVSFCHS--HRVIHRDLKPQNLLIN--ELGAI-------------------KLADFGLARAF------GVPLRTYTH---EVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVT-RKAL---------------FPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTR-----------------------------------KGLEEIVPNLEPEGRDLLMQLLQYDPSQRIT-----AK-TALAHPYF--
----YEKLEKIGEGTYGTV---FKAKNR----E-T-HE---IVALKRVRLDDDDEGV--PSSALR----EICLLKEL-K-----HKN-----IVRLHDVLH--S--------DKKLT--LVFEFCDQ---DLKKYFD---SCNG---DL---DPEIVKSFLFQLLKGLGFCHS--RNVLHRDLKPQNLLIN--RNGEL-------------------KLADFGLARAF------GIPVRCYSA---EVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPL---------------FPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT-----------------------------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AE-EALQHPYF--
---W-DLVQTLGEGAYGEV---QLAVNR----V-T-EE---AVAVKIVDMKRAVDCP--ENI-KK----EICINKML-N-----HEN-----VVKFYGHRR--E--------GNIQY--LFLEYCSGG--ELFDRIE----PDI---GM---PEPDAQRFFHQLMAGVVYLHG--IGITHRDIKPENLLLD--ERDNL-------------------KISDFGLATVFR----YNNRERLLNK---MCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLA-GELP---------------WDQP--SDSCQEYSDWKEKKTYLNPWKKI--D---------------------------------------------------------SAPLALLHKILVENPSARIT-----IP-DIKKDRW-Y-
----YEIVDTLGEGAFGKV---VECIDH----K-AGGR---HVAVKIVKNVDRYCEA--ARS-------EIQVLEHL-NT---TDPNST-FRCVQMLEWFE--H--------HGHIC--IVFELLGL---STYDFIK----ENG---FLP-FRLDHIRKMAYQICKSVNFLHS--NKLTHTDLKPENILFV--QSDYTEAYNPKIKRDERTLINPDIKVVDFGSA---------TYDDEHHST---LVSTRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYYL-GFTV---------------FPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRY--------------------VSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRIT-----LR-EALKHPFF--
----YEIVSTLGEGTFGRV---VQCVDH----R-R-GG--ARVALKIIKNVEKYKEA--AR---L----EINVLEKI-NEKDPDNKN----LCVQMFDWFD--Y--------HGHMC--ISFELLGL---STFDFLK----DNN---YLP-YPIHQVRHMAFQLCQAVKFLHD--NKLTHTDLKPENILFV--NSDYELTYNLEKKRDERSVKSTAVRVVDFGSAT---------FDHEHHST---IVSTRHYRAPEVIL-ELGWSQPCDVWSIGCIIFEYYV-GFTL---------------FQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRY--------------------VRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLT-----LG-EALQHPFF--
----YEIVDTLGEGAFGKV---VECIDH----GMD-GM---HVAVKIVKNVGRYREA--ARS-------EIQVLEHL-NS---TDPNSV-FRCVQMLEWFD--H--------HGHVC--IVFELLGL---STYDFIK----ENS---FLP-FQIDHIRQMAYQICQSINFLHH--NKLTHTDLKPENILFV--KSDYVVKYNSKMKRDERTLKNTDIKVVDFGSA---------TYDDEHHST---LVSTRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYYL-GFTV---------------FQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRY--------------------VRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRIT-----LD-EALQHPFF--
----YDTGEELGSGQFAVV---KKCREK----S-T-GL---QYAAKFIKKRRTKSSR--RGVSREDIEREVSILKEI-Q-----HPN-----VITLHEVYE--N--------KTDVI--LILELVAGG--ELFDFLA----EKE---SL---TEEEATEFLKQILNGVYYLHS--LQIAHFDLKPENIMLL--DRNVPKP---------------RIKIIDFGLAHK-------IDFGNEFKN---IFGTPEFVAPEIVN-YEPLGLEADMWSIGVITYILLS-GASP---------------FLGD---TKQETLANVSAVNYEFEDEYFSNTS---------------------------------------------------------ALAKDFIRRLLVKDPKKRMT-----IQ-DSLQHPWI--
----YEIDSLIGKGSFGQV---VKAYDR----V-E-QE---WVAIKIIKNKKAFLNQ--AQI-------EVRLLELMNK-----HDTEMKYYIVHLKRHFM--F--------RNHLC--LVFEMLSY---NLYDLLR-----NT---NFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAI-------------------KIVDFGSSCQ---------LGQRIYQ---YIQSRFYRSPEVLL-GMPYDLAIDMWSLGCILVEMHT-GEPL---------------FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQ-----PY-YALQHSFF--
----YEIDSLIGKGSFGQV---VKAYDH----Q-T-QE---LVAIKIIKNKKAFLNQ--AQI-------ELRLLELMNQ-----HDTEMKYYIVHLKRHFM--F--------RNHLC--LVFELLSY---NLYDLLR-----NT---HFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAI-------------------KIVDFGSSCQ---------LGQRIYQ---YIQSRFYRSPEVLL-GTPYDLAIDMWSLGCILVEMHT-GEPL---------------FSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARIS-----PL-GALQHGFF--
----YTDTKVIGNGSFGVV---YQAKLC----D-S-GE---LVAIKKVLQDKRFKNR------------ELQIMRKL-D-----HCN-----IVRLRYFFY--SSG----EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ---TL---PVIYVKLYMYQLFRSLAYIHS--FGICHRDIKPQNLLLD-PDTAVL-------------------KLCDFGSAKQ-------LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPI---------------FPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-----------------------------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-----PL-EACAHSFF--
----LKFLQQLGKGNFGSV---EMCRYDPLQDN-T-GE---VVAVKKLQ-HSTE--EHLRDFE-R----EIEILKSL-Q-----HDN-----IVKYKGVCYSAG--------RRNLK--LIMEYLPYG--SLRDYLQ-----KH-KERI---DHIKLLQYTSQICKGMEYLGT--KRYIHRDLATRNILVE--NENRV-------------------KIGDFGLTKVL--PQ--D--KEYYKVKEPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCP---------------------------------------------------------------DEIYMIMTECWNNNVNQRPS-----FR-DLA----LRV
----YTNLSYIGEGAYGMV---CSAYDN----V-N-KV---RVAIKKISPFEHQTYC--QRT-LR----EIKILLRF-R-----HEN-----IIGINDIIR--APT---IEQMKDVY--IVQDLMET---DLYKLLK-----TQ---HL---SNDHICYFLYQILRGLKYIHS--ANVLHRDLKPSNLLLN--TTCDL-------------------KICDFGLARVAD---PDHDHTGFLTE---YVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPI---------------FPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKN---------------------------------KVPWNRLFPNADSKALDLLDKMLTFNPHKRIE-----VE-QALAHPYL--
----YQNLKPIGSGAQGIV---CAAYDA----V-L-DR---NVAIKKLSRPFQNQTH--AKRAYR----ELVLMKCV-N-----HKN-----IISLLNVFT--PQKT--LEEFQDVY--LVMELMDA---NLCQVIQ------M---EL---DHERMSYLLYQMLCGIKHLHS--AGIIHRDLKPSNIVVK--SDCTL-------------------KILDFGLART-------AGTSFMMTP---YVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVR-HKIL---------------FPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPK----------------------LFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS-----VD-DALQHPYI--
----YQNLKPIGSGAQGIV---CAAYDA----I-L-ER---NVAIKKLSRPFQNQTH--AKRAYR----ELVLMKCV-N-----HKN-----IIGLLNVFT--PQKS--LEEFQDVY--IVMELMDA---NLCQVIQ------M---EL---DHERMSYLLYQMLCGIKHLHS--AGIIHRDLKPSNIVVK--SDCTL-------------------KILDFGLART-------AGTSFMMTP---YVVTRYYRAPEVIL-GMGYKENVDLWSVGCIMGEMVC-HKIL---------------FPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEK----------------------LFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRIS-----VD-EALQHPYI--
DNFI-----KIGEGSTGIV---CIATVR----S-S-GK---LVAVKKMDLRKQQRRE--L--LFN----EVVIMRDY-Q-----HEN-----VVEMYNSYL--V--------GDELW--VVMEFLEGG--ALTDIVT-----HT---RM---NEEQIAAVCLAVLQALSVLHA--QGVIHRDIKSDSILLT--HDGRV-------------------KLSDFGFCAQV------SKEVPRRKS---LVGTPYWMAPELIS-RLPYGPEVDIWSLGIMVIEMVD-GEPP---------------YFNEPPLKAMKMIRDNLPPRLKNLHKVS-------------------------------------------------------------PSLKGFLDRLLVRDPAQRAT-----AA-ELLKHPFL--
---Y-IKLDKLGEGTYATV---YKGKSK----L-T-DN---LVALKEIRLEHEEGAP--C-TAIR----EVSLLKDL-K-----HAN-----IVTLHDIIH--T--------EKSLT--LVFEYLDK---DLKQYLD---DCGN---II---NMHNVKLFLFQLLRGLAYCHR--QKVLHRDLKPQNLLIN--ERGEL-------------------KLADFGLARAK------SIPTKTYSN---EVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMAT-GRPL---------------FPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYR----------------------------------AEALLSHAPRLDSDGADLLTKLLQFEGRNRIS-----AE-DAMKHPFF--
--FI--LHKMLGKGSFGKV---FLAEFK----K-T-NQ---FFAIKALKKDVVLMDD--DVECTM---VEKRVLSLAWE-----HPF-----LTHMFCTFQ--T--------KENLF--FVMEYLNGG--DLMYHIQ----SCH---KF---DLSRATFYAAEIILGLQFLHS--KGIVYRDLKLDNILLD--KDGHI-------------------KIADFGMCKEN------MLGDAKTNT---FCGTPDYIAPEILL-GQKYNHSVDWWSFGVLLYEMLI-GQSP---------------FHGQ---DEEELFHSIRMDNPFYPRWLE-------------------------------------------------------------KEAKDLLVKLFVREPEKRLG-----VRGDIRQHPLF--
----FELLKVLGQGSFGKVFLVRKVTRP----D-S-GH---LYAMKVLKKATLKVRD--RVRTKM----ERDILADV-N-----HPF-----VVKLHYAFQ--T--------EGKLY--LILDFLRGG--DLFTRLS----KEV---MF---TEEDVKFYLAELALGLDHLHS--LGIIYRDLKPENILLD--EEGHI-------------------KLTDFGLSKEA------IDHEKKAYS---FCGTVEYMAPEVVN-RQGHSHSADWWSYGVLMFEMLT-GSLP---------------FQGK---DRKETMTLILKAKLGMPQFLS-------------------------------------------------------------TEAQSLLRALFKRNPANRLGSGPDGAE-EIKRHV--FY
----FELLKVLGQGSYGKV---FLVRKV----K-G-SDAGQLYAMKVLKKATLKVRD--RVRSKM----ERDILAEV-N-----HPF-----IVKLHYAFQ--T--------EGKLY--LILDFLRGG--DLFTRLS----KEV---MF---TEEDVKFYLAELALALDHLHS--LGIIYRDLKPENILLD--EEGHI-------------------KITDFGLSKEA------IDHDKRAYS---FCGTIEYMAPEVVN-RRGHTQSADWWSFGVLMFEMLT-GSLP---------------FQGK---DRKETMALILKAKLGMPQFLS-------------------------------------------------------------GEAQSLLRALFKRNPCNRLGAGIDGVE-EIKRHPFF--
---L-RLEVKLGQGCFGEV---WMGTWN------G-TT---RVAIKTLK-PGTM-SP--EAFL-Q----EAQVMKKL-R-----HEK-----LVQLYAVVS-----------EEPIY--IVTEYMSKG--SLLDFLK-----GETGKYL---RLPQLVDMAAQIASGMAYVER--MNYVHRDLRAANILVG--ENLVC-------------------KVADFGLARLI------E--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVP---------------YPGMVNREVLDQVERGYRMPCPPECP---------------------------------------------------------------ESLHDLMCQCWRKEPEERPT-----FE-YLQAF--L--
---L-RLEVKLGQGCFGEV---WMGTWN------G-TT---KVAIKTLK-PGTM-MP--EAFL-Q----EAQIMKKL-R-----HDK-----LVPLYAVVS-----------EEPIY--IVTEFMSKG--SLLDFLK-----EGDGKYL---KLPQLVDMAAQIADGMAYIER--MNYIHRDLRAANILVG--ENLVC-------------------KIADFGLARLI------E--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILQTELVTKGRVP---------------YPGMVNREVLEQVERGYRMPCPQGCP---------------------------------------------------------------ESLHELMNLCWKKDPDERPT-----FE-YIQSFL----
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